Deidre Anne De Silva
Affiliation: Singapore General Hospital
De Silva D, Woon F, Chen C, Chang H, Wong M. Serum erythrocyte sedimentation rate is higher among ethnic South Asian compared to ethnic Chinese ischemic stroke patients. Is this attributable to metabolic syndrome or central obesity?. J Neurol Sci. 2009;276:126-9 pubmed publisher
..As the higher inflammatory state is independent of demographic and risk factors, we propose an underlying genetic or cultural basis for the ethnic difference. ..
De Silva D, Ancalan M, Doshi K, Chang H, Wong M, Chen C. Intracranial large artery disease in Alzheimer's disease and vascular dementia among ethnic Asians. Eur J Neurol. 2009;16:643-5 pubmed publisher
..We suggest that ethnic Asian dementia patients are a potential group to investigate if ICLAD is associated with clinical symptoms or prognosis and if treatment strategies targeted at ICLAD retard the progression of cognitive impairment. ..
De Silva D, Woon F, Lee M, Chen C, Chang H, Wong M. Metabolic syndrome is associated with intracranial large artery disease among ethnic Chinese patients with stroke. J Stroke Cerebrovasc Dis. 2009;18:424-7 pubmed publisher
..This validation provides a basis for further investigation into the pathophysiologic link between MetS and ICLAD. ..
Koh G, Yen S, Tay A, Cheong A, Ng Y, De Silva D, et al
. Singapore Tele-technology Aided Rehabilitation in Stroke (STARS) trial: protocol of a randomized clinical trial on tele-rehabilitation for stroke patients. BMC Neurol. 2015;15:161 pubmed publisher
..This trial protocol was registered under ClinicalTrials.gov on 18 July 2013 as study title "The Singapore Tele-technology Aided Rehabilitation in Stroke (STARS) Study" (ID: The STARS Study, ClinicalTrials.gov Identifier: NCT01905917 ). ..
Fabiaña N, Chen C, Venketasubramanian N, Lee C, Wong K, De Silva D. Sex and the treatment effect in the Chinese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES) trial. J Clin Neurosci. 2016;33:269-270 pubmed publisher
..In the randomized controlled trial of NeuroAiD versus placebo following ischemic stroke, there was a trend for sex influencing the treatment effect of NeuroAiD in improving functional outcome following ischemic stroke (p=0.075). ..
De Silva D, Woon F, Pin L, Chen C, Chang H, Wong M. Intracranial large artery disease among OCSP subtypes in ethnic South Asian ischemic stroke patients. J Neurol Sci. 2007;260:147-9 pubmed
..Clinical axioms using OSCP subtypes based on Caucasian data may be misleading if applied to ethnic South Asians. ..
De Silva D, Wong M, Lee M, Chen C, Chang H. Amphetamine-associated ischemic stroke: clinical presentation and proposed pathogenesis. J Stroke Cerebrovasc Dis. 2007;16:185-6 pubmed
..The presence of microembolic signals supports acute thrombosis at the site of vasculitis/vasospasm with distal embolism...
De Silva D, Churilov L, Olivot J, Christensen S, Lansberg M, Mlynash M, et al
. Greater effect of stroke thrombolysis in the presence of arterial obstruction. Ann Neurol. 2011;70:601-5 pubmed publisher
..001). The treatment effect of IV tPA over placebo was greater with baseline arterial obstruction, supporting arterial obstruction status as a consideration in selecting patients more likely to benefit from IV thrombolysis. ..