M W Chee

Summary

Affiliation: Singapore General Hospital
Country: Singapore

Publications

  1. ncbi request reprint Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance
    Michael W L Chee
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, 7 Hospital Drive, 01 11, Singapore 169611, Singapore
    Neuroimage 31:419-28. 2006
  2. ncbi request reprint Auditory and visual word processing studied with fMRI
    M W Chee
    MGH NMR Center, Massachusetts General Hospital, Charlestown USA
    Hum Brain Mapp 7:15-28. 1999
  3. pmc Functional neuroimaging and behavioral correlates of capacity decline in visual short-term memory after sleep deprivation
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke National University of Singapore Graduate Medical School and Singapore Health Services, Singapore 169611
    Proc Natl Acad Sci U S A 104:9487-92. 2007
  4. ncbi request reprint Age-related changes in object processing and contextual binding revealed using fMR adaptation
    Michael W L Chee
    SingHealth, Singapore
    J Cogn Neurosci 18:495-507. 2006
  5. doi request reprint Lapsing during sleep deprivation is associated with distributed changes in brain activation
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke National University of Singapore Graduate Medical School, Singapore
    J Neurosci 28:5519-28. 2008
  6. doi request reprint Functional neuroimaging insights into how sleep and sleep deprivation affect memory and cognition
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, Singapore
    Curr Opin Neurol 21:417-23. 2008
  7. pmc Left insula activation: a marker for language attainment in bilinguals
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Singapore General Hospital, Singapore 169611
    Proc Natl Acad Sci U S A 101:15265-70. 2004
  8. ncbi request reprint Recognition memory for studied words is determined by cortical activation differences at encoding but not during retrieval
    Michael W L Chee
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, Singapore, Singapore
    Neuroimage 22:1456-65. 2004
  9. ncbi request reprint Functional imaging of working memory after 24 hr of total sleep deprivation
    Michael W L Chee
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, Singapore 169611, Singapore
    J Neurosci 24:4560-7. 2004
  10. ncbi request reprint Word frequency and subsequent memory effects studied using event-related fMRI
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Singapore General Hospital, Singapore, 169611, Singapore
    Neuroimage 20:1042-51. 2003

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance
    Michael W L Chee
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, 7 Hospital Drive, 01 11, Singapore 169611, Singapore
    Neuroimage 31:419-28. 2006
    ....
  2. ncbi request reprint Auditory and visual word processing studied with fMRI
    M W Chee
    MGH NMR Center, Massachusetts General Hospital, Charlestown USA
    Hum Brain Mapp 7:15-28. 1999
    ..Individual subjects showed differences in the activation of the inferior frontal region while performing the same task, even though they showed similar response latency and accuracy...
  3. pmc Functional neuroimaging and behavioral correlates of capacity decline in visual short-term memory after sleep deprivation
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke National University of Singapore Graduate Medical School and Singapore Health Services, Singapore 169611
    Proc Natl Acad Sci U S A 104:9487-92. 2007
    ....
  4. ncbi request reprint Age-related changes in object processing and contextual binding revealed using fMR adaptation
    Michael W L Chee
    SingHealth, Singapore
    J Cogn Neurosci 18:495-507. 2006
    ..These findings suggest that the elderly have difficulty with simultaneous processing of objects and backgrounds that, in turn, could contribute to deficient contextual binding...
  5. doi request reprint Lapsing during sleep deprivation is associated with distributed changes in brain activation
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke National University of Singapore Graduate Medical School, Singapore
    J Neurosci 28:5519-28. 2008
    ..These findings reveal for the first time some of the neural consequences of the interaction between efforts to maintain wakefulness and processes that initiate involuntary sleep in sleep-deprived persons...
  6. doi request reprint Functional neuroimaging insights into how sleep and sleep deprivation affect memory and cognition
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, Singapore
    Curr Opin Neurol 21:417-23. 2008
    ..The review summarizes current knowledge about what fMRI has revealed regarding the neurobehavioral correlates of sleep deprivation and sleep-dependent memory consolidation...
  7. pmc Left insula activation: a marker for language attainment in bilinguals
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Singapore General Hospital, Singapore 169611
    Proc Natl Acad Sci U S A 101:15265-70. 2004
    ..Although unequal bilinguals kept apace with equal bilinguals in the simple PWM task, the differential cortical activations suggest that more optimal engagement of PWM in the latter may correlate with better second-language attainment...
  8. ncbi request reprint Recognition memory for studied words is determined by cortical activation differences at encoding but not during retrieval
    Michael W L Chee
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, Singapore, Singapore
    Neuroimage 22:1456-65. 2004
    ..This observation is consistent with a dual process account of episodic memory...
  9. ncbi request reprint Functional imaging of working memory after 24 hr of total sleep deprivation
    Michael W L Chee
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, Singapore 169611, Singapore
    J Neurosci 24:4560-7. 2004
    ..Our findings provide neural correlates to explain why task performance in relatively more complex tasks is better preserved relative to simpler ones after SD...
  10. ncbi request reprint Word frequency and subsequent memory effects studied using event-related fMRI
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Singapore General Hospital, Singapore, 169611, Singapore
    Neuroimage 20:1042-51. 2003
    ..These findings suggest the specific brain regions where less commonly encountered words are processed in a manner that facilitates their subsequent recognition...
  11. ncbi request reprint Seeing how we think about words using BOLD contrast fMR imaging
    M W Chee
    Cognitive Neuroscience Laboratory, SingHealth Research Facilities Singapore General Hospital
    Ann Acad Med Singapore 32:490-4. 2003
    ..Issues such as the lateralisation of language function, brain plasticity in health, ageing and neurological disease, and as well as how 2 different languages are processed, may all be evaluated by fMRI...
  12. ncbi request reprint Dissociating language and word meaning in the bilingual brain
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School and SingHealth Research Facilities, 7th Hospital Drive, 01 11, Singapore 169611, Singapore
    Trends Cogn Sci 10:527-9. 2006
    ..This work should stimulate further research examining the role of subcortical areas in language processing and in context-appropriate language production...
  13. ncbi request reprint Comparison of block and event-related fMRI designs in evaluating the word-frequency effect
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Singapore General Hospital, Singapore
    Hum Brain Mapp 18:186-93. 2003
    ..The detection of a frequency effect with the event-related design also suggests that stimulus-order predictability may not be as serious a concern in block designs as might be supposed...
  14. ncbi request reprint Reproducibility of the word frequency effect: comparison of signal change and voxel counting
    Michael W L Chee
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, c o Singapore General Hospital, 7 Hospital Drive 01 11, Singapore 169856
    Neuroimage 18:468-82. 2003
    ..These findings suggest that with existing techniques, fMRI may be used to track changes in brain activation stemming from improvement in language proficiency at the group level but not at the individual level...
  15. ncbi request reprint Common and segregated neuronal networks for different languages revealed using functional magnetic resonance adaptation
    Michael W L Chee
    SingHealth Research Facilities, Singapore General Hospital
    J Cogn Neurosci 15:85-97. 2003
    ..Together, the experiments suggest that while the networks for Chinese and English word processing have shared components, there are also components that may be language specific...
  16. ncbi request reprint Processing of visually presented sentences in Mandarin and English studied with fMRI
    M W Chee
    Cognitive Neuroscience Laboratory, Singapore General Hospital, Singapore
    Neuron 23:127-37. 1999
    ..Proficient bilinguals exposed to both languages early in life utilize common neuroanatomical regions during the conceptual and syntactic processing of written language irrespective of their differences in surface features...
  17. doi request reprint Lapsing when sleep deprived: neural activation characteristics of resistant and vulnerable individuals
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, Singapore 169857, Singapore
    Neuroimage 51:835-43. 2010
    ..A major contributor to performance degradation in SD appears to be a reduction in top-down biasing of attention that is independent of task difficulty...
  18. ncbi request reprint Relative language proficiency modulates BOLD signal change when bilinguals perform semantic judgments. Blood oxygen level dependent
    M W Chee
    Cognitive Neuroscience Laboratory, Singapore General Hospital, 20 College Road, Singapore 169856, Singapore
    Neuroimage 13:1155-63. 2001
    ..The results highlight the importance of taking into consideration nature of task and relative language proficiency when drawing inferences from functional imaging studies of bilinguals...
  19. ncbi request reprint Reproducibility of changes in behaviour and fMRI activation associated with sleep deprivation in a working memory task
    Julian Lim
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, Singapore
    Sleep 30:61-70. 2007
    ..In this study, we assessed the reproducibility of fMRI activation and performance on a working memory task before and after 24 hours of sleep deprivation (SD)...
  20. ncbi request reprint Inter-relationships between attention, activation, fMR adaptation and long-term memory
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School and SingHealth, No 7 Hospital Drive Blk B 01 11 Singapore 169611, Singapore
    Neuroimage 37:1487-95. 2007
    ..This may reflect stronger engagement of attention at encoding...
  21. pmc Sleep deprivation impairs object-selective attention: a view from the ventral visual cortex
    Julian Lim
    Neuroscience and Behavioral Disorders Program, Duke NUS Graduate Medical School, Singapore, Singapore
    PLoS ONE 5:e9087. 2010
    ..Here, we evaluated the effects of SD on the top-down biasing of activation of ventral visual cortex and on functional connectivity between cognitive control and other brain regions...
  22. ncbi request reprint Neural correlates of symbolic and non-symbolic arithmetic
    Vinod Venkatraman
    Cognitive Neuroscience Laboratory, Singapore General Hospital, 7 Hospital Drive, 01 11, Singapore 169611, Singapore
    Neuropsychologia 43:744-53. 2005
    ..In contrast to recent findings, we found no significant activation for exact addition condition in left, language-related areas...
  23. doi request reprint Sleep deprivation and its effects on object-selective attention
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, Singapore
    Neuroimage 49:1903-10. 2010
    ..Sleep deprivation may affect object-selective attention in addition to exerting a task-independent deficit in attention...
  24. ncbi request reprint Frequency of concrete words modulates prefrontal activation during semantic judgments
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Singapore General Hospital, Singapore 169856
    Neuroimage 16:259-68. 2002
    ..These findings suggest that retrieval effort modulates left prefrontal activity when deliberate access to semantics is required...
  25. ncbi request reprint Face encoding and psychometric testing in healthy dextrals with right hemisphere language
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Singapore General Hospital
    Neurology 59:1928-34. 2002
    ..To document how right hemisphere language dominance in neurologically normal right-handed individuals affects lateralization of face encoding and level of performance in neuropsychological tests...
  26. ncbi request reprint Stimulus repetition and hemodynamic response refractoriness in event-related fMRI
    Chun Siong Soon
    Cognitive Neuroscience Laboratory, Singapore General Hospital, Singapore
    Hum Brain Mapp 20:1-12. 2003
    ..However, designs using intermediate ISI may be more appropriate if the expected difference in responses is small and if the number of suitable stimuli is limited...
  27. pmc Sleep deprivation and interference by emotional distracters
    Lisa Y M Chuah
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School Singapore, Singapore
    Sleep 33:1305-13. 2010
    ..We determined if sleep deprivation would amplify the effect of negative emotional distracters on working memory...
  28. ncbi request reprint Effect of language switching on arithmetic: a bilingual FMRI study
    Vinod Venkatraman
    SingHealth Research Facilities, Singapore
    J Cogn Neurosci 18:64-74. 2006
    ..These results considerably strengthen the notion that exact processing relies on verbal and language-related networks, whereas approximate processing engages parietal circuits typically involved in magnitude-related processing...
  29. ncbi request reprint Sleep deprivation elevates expectation of gains and attenuates response to losses following risky decisions
    Vinod Venkatraman
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, Singapore
    Sleep 30:603-9. 2007
    ..Using a gambling task, we investigated how 24 hours of sleep deprivation modulates the neural response to the making of risky decisions with potentially loss-bearing outcomes...
  30. ncbi request reprint The neural basis of interindividual variability in inhibitory efficiency after sleep deprivation
    Y M Lisa Chuah
    Cognitive Neuroscience Laboratory, Singapore Health Services, Singapore, 169611
    J Neurosci 26:7156-62. 2006
    ..These persons also showed a larger rise in such activation both here and in the right insula after sleep deprivation relative to those whose inhibitory efficiency declined...
  31. doi request reprint Cholinergic augmentation modulates visual task performance in sleep-deprived young adults
    Lisa Y M Chuah
    Cognitive Neuroscience Laboratory, Duke National University of Singapore Graduate Medical School, Singapore
    J Neurosci 28:11369-77. 2008
    ..Cholinergic augmentation can alleviate these deficits in individuals vulnerable to the effects of sleep deprivation, but it may have neutral or negative effects on those resistant to sleep deprivation...
  32. pmc Donepezil improves episodic memory in young individuals vulnerable to the effects of sleep deprivation
    Lisa Y M Chuah
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, Singapore
    Sleep 32:999-1010. 2009
    ..We investigated if donepezil, a long-acting orally administered cholinesterase inhibitor, would reduce episodic memory deficits associated with 24 h of sleep deprivation...
  33. doi request reprint Hippocampal region-specific contributions to memory performance in normal elderly
    Karren H M Chen
    Cognitive Neuroscience Laboratory, Neuroscience and Behavioral Disorders Program, Duke NUS Graduate Medical School Singapore, Singapore
    Brain Cogn 72:400-7. 2010
    ..These associations were independent of age, sex, education and speed of processing and support the notion of functional differentiation along the long axis of the hippocampus...
  34. doi request reprint Cognitive function and brain structure correlations in healthy elderly East Asians
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School Singapore, 7 Hospital Drive, Block B, 01 11, Singapore 169611, Singapore
    Neuroimage 46:257-69. 2009
    ....
  35. ncbi request reprint Cortical areas involved in object, background, and object-background processing revealed with functional magnetic resonance adaptation
    Joshua O S Goh
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, Singapore 169611, Singapore
    J Neurosci 24:10223-8. 2004
    ....
  36. ncbi request reprint Dissociation of cortical regions modulated by both working memory load and sleep deprivation and by sleep deprivation alone
    Wei Chieh Choo
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, Singapore 169611, Singapore
    Neuroimage 25:579-87. 2005
    ..These findings represent a step toward identifying how different brain regions exhibit varying vulnerability to the deleterious effects of SD on working memory...
  37. ncbi request reprint Functional neuroimaging of sleep deprived healthy volunteers and persons with sleep disorders: a brief review
    Lisa Y M Chuah
    Cognitive Neuroscience Lab, Duke NUS Graduate Medical School, Singapore
    Ann Acad Med Singapore 37:689-94. 2008
    ....
  38. doi request reprint fMR-adaptation and the bilingual brain
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, No 7 Hospital Drive, Blk B 01 11, Singapore 169611, Singapore
    Brain Lang 109:75-9. 2009
    ....
  39. ncbi request reprint fMRI study of maintenance and manipulation processes within working memory in first-episode schizophrenia
    Hao Yang Tan
    Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Republic of Singapore
    Am J Psychiatry 162:1849-58. 2005
    ..In this study of first-episode schizophrenia patients, the authors evaluated the extent to which the two working memory processes are affected early in the course of schizophrenia...
  40. pmc Contextual interference in recognition memory with age
    Angela H Gutchess
    Beckman Institute, University of Illinois, Urbana Champaign, IL, USA
    Neuroimage 35:1338-47. 2007
    ..This suggests that high-performing elderly may compensate for the disruption of the cognitive control network by recruiting additional frontal resources to overcome cognitive control deficits that affect recognition memory...
  41. pmc Investigation and validation of intersite fMRI studies using the same imaging hardware
    Bradley P Sutton
    Bioengineering Department, University of Illinois at Urbana Champaign, 1304 W Springfield Avenue, Urbana, IL 61801, USA
    J Magn Reson Imaging 28:21-8. 2008
    ..By comparing identical imaging hardware and software, we provide a benchmark for future multisite comparisons...
  42. ncbi request reprint Strategic differences in algebraic problem solving: neuroanatomical correlates
    Kerry Lee
    National Institute of Education, Nanyang Technological University, Singapore
    Brain Res 1155:163-71. 2007
    ..These findings suggest that the two strategies are effected using similar processes but impose different attentional demands...
  43. ncbi request reprint Cortical effects of anticipation and endogenous modulation of visceral pain assessed by functional brain MRI in irritable bowel syndrome patients and healthy controls
    Guang Hui Song
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Pain 126:79-90. 2006
    ..The aberrant activation of endogenous pain inhibition appears to involve circuitry relating to anticipation as well as pain processing itself...