Shufeng Zhou

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi Herbal bioactivation: the good, the bad and the ugly
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, 117543
    Life Sci 74:935-68. 2004
  2. ncbi Herbal modulation of P-glycoprotein
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Drug Metab Rev 36:57-104. 2004
  3. ncbi Drug bioactivation, covalent binding to target proteins and toxicity relevance
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Drug Metab Rev 37:41-213. 2005
  4. ncbi Effect of coenzyme Q10 on warfarin hydroxylation in rat and human liver microsomes
    Qingyu Zhou
    Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Republic of Singapore
    Curr Drug Metab 6:67-81. 2005
  5. ncbi Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice
    Yihuai Gao
    Institute of Food, Nutrition and Human Health, Massey University, Auckland, New Zealand
    Immunol Invest 34:171-98. 2005
  6. ncbi Prediction of herb-drug metabolic interactions: a simulation study
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Phytother Res 19:464-71. 2005
  7. ncbi Separation and detection methods for covalent drug-protein adducts
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543, Singapore
    J Chromatogr B Analyt Technol Biomed Life Sci 797:63-90. 2003
  8. ncbi Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Clin Pharmacokinet 44:279-304. 2005
  9. ncbi Pharmacokinetic interactions of drugs with St John's wort
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore
    J Psychopharmacol 18:262-76. 2004
  10. ncbi Predicting pharmacokinetic herb-drug interactions
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Drug Metabol Drug Interact 20:143-58. 2004

Collaborators

Detail Information

Publications66

  1. ncbi Herbal bioactivation: the good, the bad and the ugly
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, 117543
    Life Sci 74:935-68. 2004
    ..The safety and quality of herbal medicine should be ensured through greater research, pharmacovigilance, greater regulatory control and better communication between patients and health professionals...
  2. ncbi Herbal modulation of P-glycoprotein
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Drug Metab Rev 36:57-104. 2004
    ..Further studies are needed to explore the relative role of Pgp and CYP3A4 modulation by herbs and the mechanism for the interplay of these two important proteins in herb-drug interactions...
  3. ncbi Drug bioactivation, covalent binding to target proteins and toxicity relevance
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Drug Metab Rev 37:41-213. 2005
    ....
  4. ncbi Effect of coenzyme Q10 on warfarin hydroxylation in rat and human liver microsomes
    Qingyu Zhou
    Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Republic of Singapore
    Curr Drug Metab 6:67-81. 2005
    ..A moderate increase in the total clearance of warfarin enantiomers could occur with coadministration of CoQ(10)in humans...
  5. ncbi Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice
    Yihuai Gao
    Institute of Food, Nutrition and Human Health, Massey University, Auckland, New Zealand
    Immunol Invest 34:171-98. 2005
    ..The overall findings indicated that Ganopoly had antitumor activity with a broad spectrum of immuno-modulating activities and may represent a novel promising immunotherapeutic agent in cancer treatment...
  6. ncbi Prediction of herb-drug metabolic interactions: a simulation study
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Phytother Res 19:464-71. 2005
    ..However, many herb- and drug-related factors may cause difficulties with the prediction, and thus in vivo animal and human studies are always necessary...
  7. ncbi Separation and detection methods for covalent drug-protein adducts
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543, Singapore
    J Chromatogr B Analyt Technol Biomed Life Sci 797:63-90. 2003
    ..Furthermore, a brief discussion of the application of these techniques to individual drugs and their target proteins will be outlined...
  8. ncbi Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Clin Pharmacokinet 44:279-304. 2005
    ..The clinical significance of CYP3A inhibition for drug safety and efficacy warrants closer understanding of the mechanisms for each inhibitor. Furthermore, such inactivation may be exploited for therapeutic gain in certain circumstances...
  9. ncbi Pharmacokinetic interactions of drugs with St John's wort
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore
    J Psychopharmacol 18:262-76. 2004
    ..Because the potential interaction of St John's wort with other drugs is a major safety concern, additional systematic research on herb-drug interactions and appropriate regulation in herbal safety and efficacy is needed...
  10. ncbi Predicting pharmacokinetic herb-drug interactions
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Drug Metabol Drug Interact 20:143-58. 2004
    ..However, many herb- and drug-related factors may cause difficulties with the prediction, and well-designed human studies are always necessary...
  11. ncbi Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore
    Curr Drug Metab 5:415-42. 2004
    ..Most CYP3A4 inactivators are also PgP substrates/inhibitors, confounding the in vitro-in vivo extrapolation. Clinicians should have good knowledge on these CYP3A4 inactivators and avoid their combination use...
  12. ncbi Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Block S4, 18 Science Drive 4, S 117543, Singapore
    Eur J Pharm Sci 24:513-24. 2005
    ..05) inhibited its BL to AP flux, with an estimated Ki of 130 microM. These data indicate that the transport of DMXAA across Caco-2 monolayers was through a passive process, whereas the transport of DMXAA-G was mediated by MRP1/2...
  13. ncbi Preclinical factors affecting the interindividual variability in the clearance of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid
    Shufeng Zhou
    Division of Pharmacology and Clinical Pharmacology, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biochem Pharmacol 65:1853-65. 2003
    ..Further study is needed to examine the genotype-phenotype relationship, and the result, together with therapeutic drug monitoring may provide a useful strategy for optimizing DMXAA treatment...
  14. ncbi Clinical pharmacogenomics of thiopurine S-methyltransferase
    Shufeng Zhou
    Department ofPharmacy, Faculty of Science, National University of Singapore, Singapore
    Curr Clin Pharmacol 1:119-28. 2006
    ..Identification of the TPMT mutant alleles allows physicians to tailor the dosage of the thiopurine drugs to the genotype of the patient or to use alternatives, improving therapeutic outcome...
  15. ncbi Interactions of herbs with cytochrome P450
    Shufeng Zhou
    Department of Pharmacy, Faculty of Science, National University of Singapore, Republic of Singapore
    Drug Metab Rev 35:35-98. 2003
    ....
  16. ncbi Determination of thalidomide in transport buffer for Caco-2 cell monolayers by high-performance liquid chromatography with ultraviolet detection
    Shufeng Zhou
    Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, The University of Auckland, 85 Park Road, Grafton Private Bag 92019, New Zealand
    J Chromatogr B Analyt Technol Biomed Life Sci 785:165-73. 2003
    ..These results indicate that the transport of thalidomide by Caco-2 monolayers was rapid, which might involve an energy-dependent mechanism...
  17. ncbi Ganoderma lucidum polysaccharide fractions accelerate healing of acetic acid-induced ulcers in rats
    Yihuai Gao
    Institute of Food, Nutrition and Human Health, Massey University, Auckland, New Zealand
    J Med Food 7:417-21. 2004
    ..These results indicates that G. lucidum PS is an active component with healing efficacy on acetic acid-induced ulcers in the rat, which may represent a useful herbal preparation for the prevention and treatment of peptic ulcers...
  18. ncbi St. John's Wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats
    Zeping Hu
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Pharm Res 22:902-14. 2005
    ..In conclusion, co-administered SJW significantly ameliorated the toxicities induced by CPT-11. The protective effect of SJW may be partially due to pharmacokinetic interaction between CPT-11 and SJW...
  19. ncbi A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza
    Jing Zhang
    Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543
    J Pharmacol Exp Ther 317:1285-94. 2006
    ..The permeability coefficients in the BL to AP direction were significantly higher in MDCKII cells overexpressing PgP. These findings indicate that CTS is a substrate for PgP that can pump CTS into the luminal side...
  20. ncbi Transport of thalidomide by the human intestinal caco-2 monolayers
    Shufeng Zhou
    Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Eur J Drug Metab Pharmacokinet 30:49-61. 2005
    ..These results indicated that thalidomide was rapidly transported by Caco-2 monolayers, and this might involve a saturable energy-dependent transporter...
  21. ncbi Non-specific binding of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in liver microsomes from various species
    Shufeng Zhou
    Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    J Pharm Pharmacol 54:997-1003. 2002
    ..These results indicate that the non-specific binding of DMXAA to microsomes is insignificant and has little impact on the enzyme kinetic estimation in-vitro...
  22. ncbi The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling
    Wee Guan Lim
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Cell Signal 18:1473-81. 2006
    ..Our results also suggest that the very C-terminus of PRK1, which is the least conserved among members of the protein kinase C superfamily, is a potential drug target for pharmacological intervention of RhoA-mediated signaling pathways...
  23. ncbi Metabolism and transport of oxazaphosphorines and the clinical implications
    Jing Zhang
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Drug Metab Rev 37:611-703. 2005
    ..A better understanding of the factors that affect the metabolism and transport of oxazaphosphorines is important for their optional use in cancer chemotherapy...
  24. ncbi Alteration of the pharmacokinetics of COL-3, a matrix metalloproteinase inhibitor, due to acute gastrointestinal toxicity of doxorubicin
    Jing Li
    Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
    Pharm Res 22:1954-63. 2005
    ..The present study was to examine the potential pharmacokinetic interactions and toxicity profile following their coadministration in rats...
  25. ncbi Determination of thalidomide by high performance liquid chromatography: plasma pharmacokinetic studies in the rat
    XiaoXia Yang
    Department of Pharmacy, Faculty of Science, National University of Singapore
    J Pharm Biomed Anal 39:299-304. 2005
    ..Further studies are warranted to explore the pharmacokinetic and pharmacodynamic interactions between CPT-11 and thalidomide...
  26. ncbi A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia
    Wenbo Tang
    New Zealand Institute of Natural Medicine Research, Auckland, New Zealand
    J Med Food 8:53-8. 2005
    ..51; df = 1; P = .002). Ganopoly was well tolerated in the study patients. These findings indicated that Ganopoly was significantly superior to placebo with respect to the clinical improvement of symptoms in neurasthenia...
  27. ncbi Novel agents that potentially inhibit irinotecan-induced diarrhea
    XiaoXia Yang
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Curr Med Chem 12:1343-58. 2005
    ..Further studies are needed to identify the molecular targets associated with CPT-11 toxicity and safe and effective agents for alleviating CPT-11-induced diarrhea...
  28. ncbi Determination of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide in Caco-2 monolayers by liquid chromatography with fluorescence detection: application to transport studies
    Shufeng Zhou
    Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Chromatogr B Analyt Technol Biomed Life Sci 809:87-97. 2004
    ..DMXAA across Caco-2 monolayers was through a passive transcellular process, whereas the transport of DMXAA-G was mediated by MRP1/2...
  29. ncbi 5,6-dimethylxanthenone-4-acetic acid (DMXAA): a new biological response modifier for cancer therapy
    Shufeng Zhou
    Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University ofAuckland, New Zealand
    Invest New Drugs 20:281-95. 2002
    ..Further studies are required to explore the molecular targets of DMXAA and mechanisms for the interactions with other drugs co-administered during combination treatment, which may allow for the optimisation of DMXAA-based chemotherapy...
  30. ncbi Preclinical factors influencing the relative contributions of Phase I and II enzymes to the metabolism of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid
    Shufeng Zhou
    Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biochem Pharmacol 65:109-20. 2003
    ..However, clinical studies are important to verify the conclusions drawn from in vitro data...
  31. ncbi The very C-terminus of protein kinase Cepsilon is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1
    Yimin Zhu
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Drive, 117597, Singapore
    Cell Signal 18:807-18. 2006
    ....
  32. ncbi Effect of omeprazole on the hydroxylation of warfarin enantiomers in human: in-vitro studies with liver microsomes and cDNA-expressed cytochrome P450 isozymes
    Qingyu Zhou
    Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Republic of Singapore
    Curr Drug Metab 6:399-411. 2005
    ....
  33. ncbi Gender differences in the metabolism and pharmacokinetics of the experimental anticancer agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    Shufeng Zhou
    Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Cancer Chemother Pharmacol 49:126-32. 2002
    ..In addition, the in vitro metabolism and plasma protein binding of DMXAA in male and female mice, rats and humans were investigated...
  34. ncbi Strain differences in the liver microsomal metabolism of the experimental anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid in mice
    Shufeng Zhou
    Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    J Chromatogr B Analyt Technol Biomed Life Sci 776:231-6. 2002
    ....
  35. ncbi Simultaneous determination of the lactone and carboxylate forms of irinotecan (CPT-11) and its active metabolite SN-38 by high-performance liquid chromatography: application to plasma pharmacokinetic studies in the rat
    XiaoXia Yang
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543, Singapore
    J Chromatogr B Analyt Technol Biomed Life Sci 821:221-8. 2005
    ..01) smaller in rats with coadministered thalidomide, as compared to rats receiving CPT-11 alone. Further studies are needed to explore the underlying mechanisms for the observed kinetic interaction between CPT-11 and thalidomide...
  36. ncbi Human multidrug resistance associated protein 4 confers resistance to camptothecins
    Quan Tian
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543, Singapore
    Pharm Res 22:1837-53. 2005
    ..Other anticancer agents such as paclitaxel, cyclophosphamide, and carboplatin were also included...
  37. ncbi Insights into oxazaphosphorine resistance and possible approaches to its circumvention
    Jing Zhang
    Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
    Drug Resist Updat 8:271-97. 2005
    ....
  38. ncbi Inhibition of human CYP1A2 oxidation of 5,6-dimethyl-xanthenone-4-acetic acid by acridines: a molecular modelling study
    James W Paxton
    Department of Pharmacology and Clinical Pharmacology, Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand
    Clin Exp Pharmacol Physiol 32:633-9. 2005
    ....
  39. ncbi Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models: the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation
    Shufeng Zhou
    Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Drug Metab Rev 34:751-90. 2002
    ..These data indicate that preclincial pharmacokinetic studies using both in vitro and in vivo models play an important but different role in predicting pharmacokinetics and drug interactions in patients...
  40. ncbi Herb-drug interactions: a literature review
    Zeping Hu
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Drugs 65:1239-82. 2005
    ..Herbs should be appropriately labeled to alert consumers to potential interactions when concomitantly used with drugs, and to recommend a consultation with their general practitioners and other medical carers...
  41. ncbi 6-methylhydroxylation of the anti-cancer agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by flavin-containing monooxygenase 3
    Shufeng Zhou
    Division of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand
    Eur J Drug Metab Pharmacokinet 27:179-83. 2002
    ..The results of this study indicate that human FMO3 has the capacity to form 6-OH-MXAA, but plays a lesser important role for this reaction than CYP1A2 that has been demonstrated to catalyse 6-OH-MXAA formation...
  42. ncbi Pharmacokinetics of recombinant human endostatin in rats
    Xiao Xia Yang
    Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543, Singapore
    Curr Drug Metab 7:565-76. 2006
    ..rh-Endo exhibited a linear pharmacokinetics in rats and it is mainly excreted through the urine...
  43. doi Mechanism-based enterohepatic circulation model of mycophenolic acid and its glucuronide metabolite: assessment of impact of cyclosporine dose in Asian renal transplant patients
    Wai Ping Yau
    Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Republic of Singapore
    J Clin Pharmacol 49:684-99. 2009
    ..Simulations revealed that T(bile) and tau(gall) influenced the time of occurrence and maximum concentration of the second peak, as well as the extent of EHC, for MPA and MPAG...
  44. ncbi Thalidomide in cancer treatment: a potential role in the elderly?
    Shufeng Zhou
    Division of Pharmacology and Clinical Pharmacology, School of Medicine, The University of Auckland, Auckland, New Zealand
    Drugs Aging 19:85-100. 2002
    ..The exact role of thalidomide in the treatment of cancer and cancer cachexia in the elderly remains to be elucidated. However, it may have some value as part of a multimodality anticancer therapy, rather than as a single agent...
  45. ncbi Use of in vitro critical inhibitory concentration, a novel approach to predict in vivo synergistic bactericidal effect of combined amikacin and piperacillin against Pseudomonas aeruginosa in a systemic rat infection model
    Eli Chan
    Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Republic of Singapore
    Pharm Res 23:729-41. 2006
    ....
  46. ncbi Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat
    Yihuai Gao
    New Zealand Institute of Natural Medicines, Auckland, New Zealand
    Life Sci 72:731-45. 2002
    ..05-1.0 mg/ml increased the c-Myc protein expression. These findings indicated that GLPS produced a mucosal healing effect in the rat model, perhaps due partly to the suppression of TNF-alpha and induction of c-myc and ODC gene...
  47. doi GSK3beta modulates PACAP-induced neuritogenesis in PC12 cells by acting downstream of Rap1 in a caveolae-dependent manner
    Weishi Zhang
    Department of Biochemistry, Yong Loo Lin of Medicine, The National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore
    Cell Signal 21:237-45. 2009
    ..These results reveal an important role of caveolae in the signal transduction of PACAP and that GSK3beta is a critical regulator in PACAP-induced neuronal differentiation...
  48. ncbi Significant intestinal excretion, one source of variability in pharmacokinetics of COL-3, a chemically modified tetracycline
    Jing Li
    Department of Pharmacy, National University of Singapore, Singapore 117543, Republic of Singapore
    Pharm Res 22:397-404. 2005
    ..This study was undertaken to examine the disposition of COL-3, a chemically modified tetracycline, in order to elucidate its major route of elimination as one possible source of the variability in pharmacokinetics of COL-3 in vivo...
  49. ncbi Bioactivation and hepatotoxicity of nitroaromatic drugs
    Urs A Boelsterli
    Molecular Toxicology Lab, Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore
    Curr Drug Metab 7:715-27. 2006
    ..Most likely one of the next paradigm shifts will include the identification of determinants of susceptibility to nitroaromatic drug-induced hepatotoxicity...
  50. ncbi Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats
    Li zi Zhao
    Institute of Clinical Pharmacology, Sun Yat Sen University, Guangzhou, China
    Curr Drug Metab 7:577-87. 2006
    ..Further study is needed to explore the potential for gingko-drug interactions and the clinical impact...
  51. ncbi An interethnic comparison of polymorphisms of the genes encoding drug-metabolizing enzymes and drug transporters: experience in Singapore
    Balram Chowbay
    Laboratory of Clinical Pharmacology, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore
    Drug Metab Rev 37:327-78. 2005
    ..As such, dose requirements of certain drugs may not be optimal for Asian populations, and a second look at the factors responsible for this difference is necessary...
  52. ncbi Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study
    Hui chang Bi
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, 74 Zhongshan Road II, Guangzhou 510080, China
    Rapid Commun Mass Spectrom 19:2911-7. 2005
    ..The validated LC/MS/MS method has been successfully used in a pharmacokinetic study in healthy volunteers treated with oral adefovir dipivoxil at 10 and 20 mg...
  53. pmc Phenotyping and genotyping study of thiopurine S-methyltransferase in healthy Chinese children: a comparison of Han and Yao ethnic groups
    Jian Ping Zhang
    Department of Pharmacology, Zhongshan Medical College, Guangzhou 510080, PR China
    Br J Clin Pharmacol 58:163-8. 2004
    ..The current study was conducted to compare both phenotype and genotype of TPMT in healthy Han and Yao Chinese children...
  54. ncbi Phenotyping and genotyping studies of thiopurine S-methyltransferase in Kazaks
    Hong Wei
    Department of Clinical Pharmacy, Shenzhen Children s Hospital, Shenzhen, People s Republic of China
    Pharm Res 22:1762-6. 2005
    ..This study was conducted to investigate the thiopurine S-methyltransferase (TPMT) activity distribution and gene mutations in Kazaks, and compared the results with those of other ethnic groups...
  55. ncbi The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals
    Yimin Zhu
    Department of Biochemistry, Faculty of Science, The National University of Singapore, Singapore, Singapore
    Cancer Res 65:4520-4. 2005
    ..Therefore, developing selective activators instead of inhibitors of PKCalpha might provide effective pharmacological interventions for the treatment of certain endocrine tumors...
  56. ncbi Rapid determination of common mutations in glutathione S-transferase gene by PCR-based methods in healthy Chinese
    Shi long Zhong
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
    Clin Chim Acta 364:205-8. 2006
    ..The frequency of common GST mutations in Uygur Chinese is unknown. We investigated the common mutations of GSTM1, GSTT1, and GSTP1 in Uygur (N=154) Chinese and compare with Han Chinese (N=196)...
  57. ncbi Effects of water-soluble Ganoderma lucidum polysaccharides on the immune functions of patients with advanced lung cancer
    Yihuai Gao
    Institute of Food, Nutrition and Human Health, Massey University, New Zealand
    J Med Food 8:159-68. 2005
    ..Further studies are needed to explore the efficacy and safety of Ganopoly used alone or in combination with chemotherapy/radiotherapy in lung cancer patients...
  58. ncbi Approximate entropy of fetal heart rate variability as a predictor of fetal distress in women at term pregnancy
    Xiaotian Li
    Dept of Maternal and Fetal Medicine, Obstetrics and Gynecology Hospital, Fudan University, 419 Fangxie Road, Shanghai, China
    Acta Obstet Gynecol Scand 84:837-43. 2005
    ....
  59. ncbi Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis
    Qi Chen
    Department of Biochemistry and Center for Biopharmaceutical Research, School of Life Sciences, Sun Yat Sen University, Guangzhou, Peoples Republic of China
    Int J Cancer 114:675-82. 2005
    ..Further studies on the effects of harmine derivatives on key regulators for tumor cell apoptosis are needed...
  60. ncbi A comparison of glutathione S-transferase mutant frequencies in healthy Han and Uygur Chinese
    Shi long Zhong
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, P R China
    Eur J Drug Metab Pharmacokinet 30:181-5. 2005
    ..This study was to compare the frequencies of genetic polymorphisms of GSTM1, GSTT1, and GSTP1 in Uygur Chinese with those in Han Chinese...
  61. ncbi Design of new oxazaphosphorine anticancer drugs
    Jun Liang
    Department of Pharmacology and Toxicology, Australian Institute of Chinese Medicine, Carlingford, New South Wales, Australia
    Curr Pharm Des 13:963-78. 2007
    ..The synthesis and development of novel oxazaphosphorine analogs with favourable pharmacokinetic and pharmacodynamic properties still constitutes a great challenge for medicinal chemists and cancer pharmacologists...
  62. ncbi Cyp1A1-mediated activation of thalidomide and suppression of embryo fibroblast proliferation
    Shufeng Zhou
    Drug Metab Dispos 31:1072; author reply 1072. 2003
  63. ncbi Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients
    Yihuai Gao
    Institute of Food, Nutrition and Human Health, Massey University, New Zealand
    Immunol Invest 32:201-15. 2003
    ..5 +/- 11.8% vs 26.6 +/- 8.3%). The present study indicates that Ganopoly enhanced the immune responses in patients with advanced-stage cancer. Clinical evaluations of response and toxicity are ongoing...
  64. ncbi Correspondence re: J. Lu et al., thalidomide metabolites in mice and patients with multiple myeloma. Clin. Cancer Res., 9: 1680-1688, 2003
    Shufeng Zhou
    Clin Cancer Res 9:5429; author reply 5429. 2003
  65. ncbi Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers
    Guo Ping Zhong
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, 74 Zhongshan Road II, Guangzhou 510080, China
    J Mass Spectrom 40:1462-71. 2005
    ..0 min) for metformin and gliclazide compared to the methods reported in the literature. The presented method had acceptable accuracy, precision and sensitivity and was used in clinical bioequivalence study...