Tien Yin Wong

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. pmc Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo
    M Kamran Ikram
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1001184. 2010
  2. pmc Global prevalence and major risk factors of diabetic retinopathy
    Joanne W Y Yau
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
    Diabetes Care 35:556-64. 2012
  3. pmc Impact of migration and acculturation on prevalence of type 2 diabetes and related eye complications in Indians living in a newly urbanised society
    Yingfeng Zheng
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    PLoS ONE 7:e34829. 2012
  4. doi request reprint Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization: an evidence-based systematic review
    Tien Y Wong
    Singapore Eye Research Institute, Singapore National Eye Centre, National University of Singapore, Singapore Electronic address
    Am J Ophthalmol 157:9-25.e12. 2014
  5. doi request reprint Structural changes in the retinal microvasculature and renal function
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 54:2970-6. 2013
  6. ncbi request reprint Accuracy of diabetic retinopathy screening by trained non-physician graders using non-mydriatic fundus camera
    Mayuri Bhargava
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Singapore Med J 53:715-9. 2012
  7. doi request reprint Retinal microvasculature as a model to study the manifestations of hypertension
    Carol Yim Lui Cheung
    Singapore Eye Research Institute, 11 Third Hospital Ave, Singapore 168751, Singapore
    Hypertension 60:1094-103. 2012
  8. pmc Language barrier and its relationship to diabetes and diabetic retinopathy
    Yingfeng Zheng
    Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Ave, 05 00, Singapore, 168751, Singapore
    BMC Public Health 12:781. 2012
  9. pmc Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion)
    Christopher M Reid
    School of Public Health and Preventive Medicine, Monash University, Melbourne Australia
    BMC Neurol 12:3. 2012
  10. pmc Early retinal arteriolar changes and peripheral neuropathy in diabetes
    Jie Ding
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Diabetes Care 35:1098-104. 2012

Collaborators

Detail Information

Publications132 found, 100 shown here

  1. pmc Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo
    M Kamran Ikram
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1001184. 2010
    ..These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular disease...
  2. pmc Global prevalence and major risk factors of diabetic retinopathy
    Joanne W Y Yau
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
    Diabetes Care 35:556-64. 2012
    ..To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes...
  3. pmc Impact of migration and acculturation on prevalence of type 2 diabetes and related eye complications in Indians living in a newly urbanised society
    Yingfeng Zheng
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    PLoS ONE 7:e34829. 2012
    ..Asian Indians are among the fastest growing migration groups across Asia and the world, but the impact of migration and acculturation on diabetes and diabetes-related eye complications among Indians living in urban Asia remains unclear...
  4. doi request reprint Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization: an evidence-based systematic review
    Tien Y Wong
    Singapore Eye Research Institute, Singapore National Eye Centre, National University of Singapore, Singapore Electronic address
    Am J Ophthalmol 157:9-25.e12. 2014
    ..To summarize the epidemiology of pathologic myopia and myopic choroidal neovascularization (CNV) and their impact on vision...
  5. doi request reprint Structural changes in the retinal microvasculature and renal function
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 54:2970-6. 2013
    ..To evaluate the associations between chronic kidney disease (CKD) and microalbuminuria, and a comprehensive range of retinal microvascular abnormalities including traditional and new retinal vascular measures...
  6. ncbi request reprint Accuracy of diabetic retinopathy screening by trained non-physician graders using non-mydriatic fundus camera
    Mayuri Bhargava
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Singapore Med J 53:715-9. 2012
    ..We compared the agreement of diabetic retinopathy (DR) assessment between trained non-physician graders (NPGs) and family physicians (FPs) in a primary healthcare setting...
  7. doi request reprint Retinal microvasculature as a model to study the manifestations of hypertension
    Carol Yim Lui Cheung
    Singapore Eye Research Institute, 11 Third Hospital Ave, Singapore 168751, Singapore
    Hypertension 60:1094-103. 2012
    ....
  8. pmc Language barrier and its relationship to diabetes and diabetic retinopathy
    Yingfeng Zheng
    Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Ave, 05 00, Singapore, 168751, Singapore
    BMC Public Health 12:781. 2012
    ..We examined the associations of English proficiency with type-2 diabetes (T2DM) and diabetic retinopathy (DR) in Asian Indians living in Singapore, an urban city where English is the predominant language of communication...
  9. pmc Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion)
    Christopher M Reid
    School of Public Health and Preventive Medicine, Monash University, Melbourne Australia
    BMC Neurol 12:3. 2012
    ....
  10. pmc Early retinal arteriolar changes and peripheral neuropathy in diabetes
    Jie Ding
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Diabetes Care 35:1098-104. 2012
    ..To examine the association between early retinal arteriolar abnormalities and diabetic peripheral neuropathy (DPN)...
  11. doi request reprint Prevalence of and risk factors for age-related macular degeneration in a multiethnic Asian cohort
    Chui Ming Gemmy Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, National University of Singapore, Singapore
    Arch Ophthalmol 130:480-6. 2012
    ..To describe the prevalence of and risk factors for age-related macular degeneration (AMD) in a multiethnic Asian cohort of Chinese, Malay, and Indian persons...
  12. ncbi request reprint Review of key findings from the Singapore Malay Eye Study (SiMES-1)
    M Rosman
    Singapore National Eye Centre, Singapore, Singapore
    Singapore Med J 53:82-7. 2012
    ..This study highlights the key epidemiological findings from the Singapore Malay Eye Study (SiMES-1)...
  13. ncbi request reprint Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors
    Tien Yin Wong
    Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin, USA
    Ophthalmology 111:1183-90. 2004
    ....
  14. doi request reprint Lipids and diabetic retinopathy
    Laurence S Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Ave, 05 00, 168751, Singapore
    Expert Opin Biol Ther 12:93-105. 2012
    ..The association between hyperlipidemia or dyslipidemia and DR has been investigated extensively, but a conclusive link remains elusive. This review summarizes the current knowledge regarding lipids and DR...
  15. ncbi request reprint Associations between the metabolic syndrome and retinal microvascular signs: the Atherosclerosis Risk In Communities study
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 45:2949-54. 2004
    ..To examine the cross-sectional relationship of the metabolic syndrome (hypertension, hyperglycemia, central obesity, and dyslipidemia) and retinal microvascular abnormalities in middle-aged men and women...
  16. ncbi request reprint Retinopathy and risk of congestive heart failure
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    JAMA 293:63-9. 2005
    ..The pathogenesis of CHF is uncertain, but microvascular disease has been hypothesized as a possible factor...
  17. ncbi request reprint Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the Atherosclerosis Risk in Communities & Cardiovascular Health studies
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Ophthalmology 112:540-7. 2005
    ..To examine the associations of retinal vein occlusion and arteriolar emboli with cardiovascular disease...
  18. ncbi request reprint Estrogen replacement therapy and retinal vascular caliber
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Ophthalmology 112:553-8. 2005
    ..It is unclear if estrogen replacement therapy (ERT) has an effect on the retinal circulation. In the current study, we examine the association of ERT, female reproductive factors, and retinal vascular caliber...
  19. ncbi request reprint Systemic associations of retinal microvascular signs: a review of recent population-based studies
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne
    Ophthalmic Physiol Opt 25:195-204. 2005
    ....
  20. ncbi request reprint Is early age-related maculopathy related to cognitive function? The Atherosclerosis Risk in Communities Study
    Tien Yin Wong
    Singapore Eye Research Institute and Department of Ophthalmology, National University of Singapore, Singapore
    Am J Ophthalmol 134:828-35. 2002
    ..We describe the association between cognitive function and ARM in middle-aged persons...
  21. ncbi request reprint A prospective cohort study of retinal arteriolar narrowing and mortality
    Tien Yin Wong
    Department of Ophthalmology, University of Melbourne, Victoria, Australia
    Am J Epidemiol 159:819-25. 2004
    ....
  22. ncbi request reprint Retinal vessel diameters and their associations with age and blood pressure
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 44:4644-50. 2003
    ..To describe the cross-sectional relationship between retinal arteriolar and venular diameters with age and blood pressure...
  23. ncbi request reprint Retinal microvascular abnormalities and cognitive impairment in middle-aged persons: the Atherosclerosis Risk in Communities Study
    Tien Yin Wong
    Department of Ophthalmology, University of Wisconsin, Madison, USA
    Stroke 33:1487-92. 2002
    ..Here, we examine the relation of retinal microvascular abnormalities with cognitive function in middle-aged persons free of stroke...
  24. ncbi request reprint Racial differences in the prevalence of hypertensive retinopathy
    Tien Yin Wong
    Department of Ophthalmology, Singapore National Eye Center and National University of Singapore
    Hypertension 41:1086-91. 2003
    ....
  25. ncbi request reprint Refractive errors, axial ocular dimensions, and age-related cataracts: the Tanjong Pagar survey
    Tien Yin Wong
    Department of Ophthalmology, National University of Singapore, Singapore
    Invest Ophthalmol Vis Sci 44:1479-85. 2003
    ..To describe the relationship of refractive errors and axial ocular dimensions and age-related cataract...
  26. ncbi request reprint The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health Study
    Tien Yin Wong
    Singapore Eye Research Institute, Singapore, Republic of Singapore
    Ophthalmology 110:658-66. 2003
    ..To describe the prevalence of retinal microvascular characteristics and their associations with atherosclerosis in elderly, nondiabetic persons...
  27. ncbi request reprint Retinal microvascular abnormalities and 10-year cardiovascular mortality: a population-based case-control study
    Tien Yin Wong
    Singapore National Eye Center and National University of Singapore, Singapore, Republic of Singapore
    Ophthalmology 110:933-40. 2003
    ..Retinal microvascular abnormalities reflect persistent arteriolar damage from hypertension and independently predict stroke. We examined their associations with long-term cardiovascular mortality...
  28. ncbi request reprint Cerebral white matter lesions, retinopathy, and incident clinical stroke
    Tien Yin Wong
    Department of Ophthalmology, University of Wisconsin, Madison, USA
    JAMA 288:67-74. 2002
    ..White matter lesions (WMLs) detected on cerebral imaging scans have been hypothesized to have a microvascular etiology and to precede the development of clinical stroke. However, few clinical data are available to support these hypotheses...
  29. ncbi request reprint Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons
    Tien Yin Wong
    Department of Ophthalmology, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    JAMA 287:2528-33. 2002
    ..Microvascular processes have been hypothesized to play a role in the pathogenesis of type 2 diabetes mellitus, but prospective clinical data regarding this hypothesis are unavailable...
  30. ncbi request reprint Retinal microvascular changes and MRI signs of cerebral atrophy in healthy, middle-aged people
    T Y Wong
    Singapore National Eye Center and National University of Singapore
    Neurology 61:806-11. 2003
    ..To examine the relation of retinal microvascular abnormalities and MRI signs of cerebral atrophy in healthy middle-aged people...
  31. pmc Risk factors of acute endophthalmitis after cataract extraction: a case-control study in Asian eyes
    T Y Wong
    Department of Ophthalmology, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Republic of Singapore
    Br J Ophthalmol 88:29-31. 2004
    ..To describe risk factors of acute endophthalmitis after cataract extraction in an Asian population...
  32. ncbi request reprint Retinal arteriolar emboli: epidemiology and risk of stroke
    Tien Yin Wong
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Curr Opin Ophthalmol 13:142-6. 2002
    ..Whether carotid ultrasound and other vascular imaging studies should be performed routinely for all patients with asymptomatic retinal emboli remains uncertain...
  33. ncbi request reprint Refractive errors and 10-year incidence of age-related maculopathy
    Tien Yin Wong
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Invest Ophthalmol Vis Sci 43:2869-73. 2002
    ..To describe the relationship of refractive errors to the 10-year incidence of age-related maculopathy (ARM) in a defined white population...
  34. ncbi request reprint Is retinal photography useful in the measurement of stroke risk?
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria
    Lancet Neurol 3:179-83. 2004
    ..Retinal photography provides such an opportunity...
  35. ncbi request reprint Retinal arteriolar diameter and risk for hypertension
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, East Melbourne Victoria, Australia
    Ann Intern Med 140:248-55. 2004
    ..Narrowing of the small arterioles has been hypothesized to contribute to the pathogenesis of hypertension, but prospective clinical data are lacking...
  36. ncbi request reprint Retinal arteriolar narrowing and left ventricular remodeling: the multi-ethnic study of atherosclerosis
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    J Am Coll Cardiol 50:48-55. 2007
    ..This study sought to examine the relationships of retinal vascular signs with left ventricular (LV) mass, volume, and concentric remodeling...
  37. ncbi request reprint BMI and retinal vascular caliber in children
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
    Obesity (Silver Spring) 15:209-15. 2007
    ..In adult populations, changes in retinal vascular caliber have been linked with obesity and metabolic syndrome. We examined the association of BMI and weight with retinal vascular caliber in children...
  38. doi request reprint Effect of blood pressure on the retinal vasculature in a multi-ethnic Asian population
    V Swetha E Jeganathan
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
    Hypertens Res 32:975-82. 2009
    ..0001); furthermore, the magnitude of this effect was similar across the three racial/ethnic groups. The effect of blood pressure on the retinal vasculature was similar across three major racial/ethnic groups in Asia...
  39. ncbi request reprint Visual impairment, age-related eye diseases, and cognitive function: the Singapore Malay Eye study
    Shin Yeu Ong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Arch Ophthalmol 130:895-900. 2012
    ..To describe the associations of visual impairment and major age-related eye diseases with cognitive function in an older Asian population...
  40. doi request reprint Distribution and determinants of ocular biometric parameters in an Asian population: the Singapore Malay eye study
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 51:103-9. 2010
    ..To examine the distribution and systemic determinants of ocular biometry as measured using partial laser interferometry in an adult Asian population...
  41. doi request reprint Evidence of retinal vascular narrowing in glaucomatous eyes in an Asian population
    Nishani Amerasinghe
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 49:5397-402. 2008
    ..To examine the relationship between retinal vascular caliber and glaucoma in an Asian population...
  42. doi request reprint Smoking, socioeconomic factors, and age-related cataract: The Singapore Malay Eye study
    Renyi Wu
    Singapore Eye Research Institute, Singapore
    Arch Ophthalmol 128:1029-35. 2010
    ..To describe the relationship of smoking, sex, and socioeconomic factors with age-related cataract in Malay adults in Singapore...
  43. doi request reprint Are myopic eyes less likely to have diabetic retinopathy?
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore
    Ophthalmology 117:524-30. 2010
    ..Eyes with myopia may be less likely to develop diabetic retinopathy (DR). The relationship between refractive error, ocular biometry, and DR therefore was investigated...
  44. doi request reprint Differential associations of myopia with major age-related eye diseases: the Singapore Indian Eye Study
    Chen Wei Pan
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore
    Ophthalmology 120:284-91. 2013
    ..To determine the associations of myopia and axial length (AL) with major age-related eye diseases, including age-related macular degeneration (AMD), diabetic retinopathy (DR), age-related cataract, and primary open-angle glaucoma (POAG)...
  45. ncbi request reprint Relationship of axial length and retinal vascular caliber in children
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Am J Ophthalmol 144:658-662. 2007
    ..In this study, we re-examined this relationship in a cohort of children, while controlling for the effects of ocular magnification...
  46. doi request reprint The relationship of body fatness indices and retinal vascular caliber in children
    Ling Jun Li
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Int J Pediatr Obes 6:267-74. 2011
    ..To examine the association between body fatness indices and retinal vascular calibre in Singapore Chinese children...
  47. ncbi request reprint Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Thanh Tan Nguyen
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
    Diabetes Care 31:544-9. 2008
    ..To examine the relationship of retinal vascular caliber with diabetes, glycemia, and diabetic retinopathy...
  48. doi request reprint Peripheral artery disease and glaucoma: the singapore malay eye study
    V Swetha E Jeganathan
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Arch Ophthalmol 127:888-93. 2009
    ..To examine the relationship between peripheral artery disease (PAD) and glaucoma...
  49. doi request reprint Retinal vascular tortuosity, blood pressure, and cardiovascular risk factors
    Carol Yim Lui Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ophthalmology 118:812-8. 2011
    ..To examine the relationship of retinal vascular tortuosity to age, blood pressure, and other cardiovascular risk factors...
  50. pmc Prevalence of refractive error in Singaporean Chinese children: the strabismus, amblyopia, and refractive error in young Singaporean Children (STARS) study
    Mohamed Dirani
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 51:1348-55. 2010
    ..To determine the prevalence of refractive error types in Singaporean Chinese children aged 6 to 72 months...
  51. ncbi request reprint Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53726 2397, USA
    Arch Ophthalmol 125:534-43. 2007
    ..To investigate the relationship of subclinical atherosclerotic cardiovascular disease (CVD) and its risk factors with age-related macular degeneration (AMD) in the Multiethnic Study of Atherosclerosis...
  52. pmc Diabetic retinopathy in a multi-ethnic cohort in the United States
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Melbourne, Victoria 3002, Australia
    Am J Ophthalmol 141:446-455. 2006
    ..To describe the prevalence and risk factors of diabetic retinopathy in a multi-ethnic US population of whites, blacks, hispanics, and chinese...
  53. doi request reprint Differential association of retinal arteriolar and venular caliber with diabetes and retinopathy
    Andrew S H Tsai
    Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore
    Diabetes Res Clin Pract 94:291-8. 2011
    ..To describe the relationship of retinal arteriolar and venular caliber with diabetes, retinopathy and hyperglycemia, in an Asian Indian population...
  54. pmc Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
    Rajkumar Dorajoo
    Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
    PLoS ONE 8:e67650. 2013
    ..C-reactive protein (CRP) levels are associated with cardiovascular disease and systemic inflammation. We assessed whether CRP-associated loci were associated with serum CRP and retinal markers of microvascular disease, in Asian populations...
  55. doi request reprint The association between socioeconomic status and overweight/obesity in a Malay population in Singapore
    Charumathi Sabanayagam
    Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Asia Pac J Public Health 21:487-96. 2009
    ..05 for all SES variables). Lower SES was positively associated with overweight/obesity in Malay women, and the association was in the opposite direction in Malay men...
  56. doi request reprint Branch retinal vein occlusion and optic nerve head topographic parameters: the Singapore Indian eye study
    Errol Wei en Chan
    Department of Ophthalmology, National University Hospital, National University Health System, Singapore, Singapore
    Br J Ophthalmol 97:611-6. 2013
    ..To examine the association between branch retinal vein occlusion (BRVO) and quantitative optic disc topographic parameters...
  57. doi request reprint Prevalence and risk factors for age-related macular degeneration in Indians: a comparative study in Singapore and India
    Chui Ming Gemmy Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Am J Ophthalmol 155:764-73, 773.e1-3. 2013
    ..To compare the prevalence and risk factors for age-related macular degeneration (AMD) in 2 Indian populations, 1 living in urban Singapore and 1 in rural central India...
  58. ncbi request reprint Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study
    Tien Yin Wong
    Department of Ophthalmology, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    JAMA 287:1153-9. 2002
    ..Microvascular processes have been hypothesized to play a greater role in the development of coronary heart disease (CHD) in women than in men; however, prospective clinical data are limited...
  59. doi request reprint Familial correlation of retinal vascular caliber in Singapore Chinese
    Ling Jun Li
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 54:5638-42. 2013
    ..Our study aimed to explore the heritability of retinal vascular caliber among Singapore Chinese families...
  60. doi request reprint Myopia, axial length, and age-related cataract: the Singapore Malay eye study
    Chen Wei Pan
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 54:4498-502. 2013
    ..To describe the associations of myopia and axial length (AL) with age-related cataract in an Asian population in Singapore...
  61. doi request reprint Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians
    Xiang Li
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 54:3650-6. 2013
    ..To investigate potential racial/ethnic differences in retinal vascular geometric parameters in a multiethnic Asian population (Chinese, Malay, and Indian) free of clinical diseases...
  62. doi request reprint Retinal microvascular caliber and chronic kidney disease in an Asian population
    Charumathi Sabanayagam
    Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Am J Epidemiol 169:625-32. 2009
    ..Retinal venular diameter was not associated with chronic kidney disease. These data suggest that retinal arteriolar narrowing is associated with chronic kidney disease, independent of diabetes and hypertension...
  63. doi request reprint Influence of refractive error on optic disc topographic parameters: the singapore malay eye study
    Ren Yi Wu
    Singapore Eye Research Institute and Singapore National Eye Center, Singapore, Republic of Singapore
    Am J Ophthalmol 152:81-6. 2011
    ..To examine the relationship between refractive error and optic disc topographic parameters and retinal nerve fiber layer (RNFL) thickness...
  64. doi request reprint Myopia and cognitive dysfunction: the singapore malay eye study
    Shin Yeu Ong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 54:799-803. 2013
    ..To investigate a possible relationship between refractive error and cognitive function...
  65. pmc FTO variants are associated with obesity in the Chinese and Malay populations in Singapore
    Jonathan T Tan
    Center for Molecular Epidemiology, National University of Singapore, Singapore, Singapore
    Diabetes 57:2851-7. 2008
    ..The aim of this study was to examine the effects of FTO variants on obesity and type 2 diabetes in Southeast Asian populations...
  66. doi request reprint Prevalence and risk factors of retinopathy in an Asian population without diabetes: the Singapore Malay Eye Study
    V Swetha E Jeganathan
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Arch Ophthalmol 128:40-5. 2010
    ..To describe the prevalence and risk factors of retinopathy in an Asian population without diabetes...
  67. ncbi request reprint Quantitative retinal venular caliber and risk of cardiovascular disease in older persons: the cardiovascular health study
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Arch Intern Med 166:2388-94. 2006
    ..Small vessel disease may contribute to the risk of cardiovascular disease in older persons. We describe the relation of retinal vascular caliber to incident coronary heart disease (CHD) and stroke in elderly persons...
  68. ncbi request reprint Distribution and associations of retinal vascular caliber with ethnicity, gender, and birth parameters in young children
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 48:1018-24. 2007
    ..To describe the distribution of retinal vascular calibers and their associations with ethnicity, gender, and birth parameters in children...
  69. ncbi request reprint Influence of intraocular pressure on retinal vascular caliber measurements in children
    Kristin de Haseth
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Am J Ophthalmol 143:1040-2. 2007
    ..To determine whether intraocular pressure (IOP) influences retinal vascular caliber in young children, in order to provide a better understanding of its physiological determinants...
  70. doi request reprint Prevalence of diabetes mellitus, glycemic control, and associated factors in a Malay population in Singapore
    Charumathi Sabanayagam
    Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Asia Pac J Public Health 21:385-98. 2009
    ..Nearly 1 in 5 middle-aged Malay adults living in a developed Asian society had diabetes mellitus and a substantial proportion had suboptimal glycemic control...
  71. pmc Traditional and novel cardiovascular risk factors for retinal vein occlusion: the multiethnic study of atherosclerosis
    Ning Cheung
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 49:4297-302. 2008
    ..To describe the prevalence of retinal vein occlusion (RVO) and its association with cardiovascular, inflammatory, and hematologic risk factors in a multiethnic cohort...
  72. doi request reprint Corneal biomechanical properties and retinal vascular caliber in children
    Laurence Lim
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 50:121-5. 2009
    ..To examine the relationship between corneal biomechanical properties and retinal vascular caliber in Singaporean children in a cross-sectional study of 257 healthy subjects from the Singapore Cohort Study of Risk Factors for Myopia...
  73. doi request reprint Serum cystatin C and prediabetes in non-obese US adults
    Charumathi Sabanayagam
    Office of Clinical Sciences, Duke NUS Graduate Medical School, Singapore, Singapore
    Eur J Epidemiol 28:311-6. 2013
    ..1) or by race-ethnicity (p = 0.6). Our findings suggest that elevated levels of serum cystatin C are associated with prediabetes in a nationally representative sample of non-obese US adults...
  74. pmc Retinal vascular geometry in Asian persons with diabetes and retinopathy
    Carol Yim Lui Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    J Diabetes Sci Technol 6:595-605. 2012
    ..Our purpose was to examine the relationship of retinal vascular parameters with diabetes and retinopathy in an older Asian population...
  75. doi request reprint Cardiovascular risk factors, inflammation, and corneal arcus: the singapore malay eye study
    Renyi Wu
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Am J Ophthalmol 150:581-587.e1. 2010
    ..To examine the relationship of corneal arcus with cardiovascular risk factors and inflammation in Malay adults living in Singapore...
  76. doi request reprint Retinal vascular fractal dimension and its relationship with cardiovascular and ocular risk factors
    Carol Y Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Am J Ophthalmol 154:663-674.e1. 2012
    ..To examine the influence of a range of cardiovascular risk factors and ocular conditions on retinal vascular fractal dimension in the Singapore Malay Eye Study...
  77. doi request reprint Association of narrow angles with anterior chamber area and volume measured with anterior-segment optical coherence tomography
    Ren Yi Wu
    Singapore National Eye Centre, 11 Third Hospital Ave, Singapore 168751
    Arch Ophthalmol 129:569-74. 2011
    ..To describe the measurement of anterior chamber area and anterior chamber volume by anterior-segment optical coherence tomography and to investigate the association of these parameters with the presence of narrow angles...
  78. doi request reprint A new method to measure peripheral retinal vascular caliber over an extended area
    Carol Yim Lui Cheung
    Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Microcirculation 17:495-503. 2010
    ..To describe a new computer-assisted method to measure retinal vascular caliber over an extended area of the fundus...
  79. doi request reprint Determinants of angle closure in older Singaporeans
    Raghavan Lavanya
    Department of Glaucoma, Singapore National Eye Center and Eye Research Institute, 11 Third Hospital Ave, Singapore 168751
    Arch Ophthalmol 126:686-91. 2008
    ..To investigate systemic and ocular risk factors for angle closure (AC) in older Singaporeans and to determine if these risk factors are different in men vs women and in Chinese vs non-Chinese persons...
  80. doi request reprint Blood pressure and retinal microvascular characteristics during pregnancy: Growing Up in Singapore Towards Healthy Outcomes (GUSTO) Study
    Ling Jun Li
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore
    Hypertension 60:223-30. 2012
    ..Elevated blood pressure is associated with a range of retinal arteriolar changes in pregnant women, providing evidence for an impact of blood pressure on the microcirculation during pregnancy...
  81. pmc Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism
    Qiao Fan
    School of Public Health, National University of Singapore, Singapore, Singapore
    PLoS Genet 7:e1002402. 2011
    ..This highlights the potential role of variants in PDGFRA in the genetic etiology of corneal astigmatism across diverse Asian populations...
  82. doi request reprint Prevalence and risk factors for refractive errors in Indians: the Singapore Indian Eye Study (SINDI)
    Chen Wei Pan
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Invest Ophthalmol Vis Sci 52:3166-73. 2011
    ..To determine the prevalence and risk factors for refractive errors in middle-aged to elderly Singaporeans of Indian ethnicity...
  83. doi request reprint Literacy is an independent risk factor for vision impairment and poor visual functioning
    Yingfeng Zheng
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 52:7634-9. 2011
    ..The authors therefore investigated the independent contribution of limited literacy on visual impairment and visual function in a large eye survey in Singapore...
  84. doi request reprint Relation of age-related cataract with obesity and obesity genes in an Asian population
    Laurence S Lim
    Singapore Eye Research Institute, Singapore
    Am J Epidemiol 169:1267-74. 2009
    ..30, 95% CI: 1.08, 1.55). These results do not support a causal association between obesity and cortical or PSC cataract. The FTO gene may be involved in the pathogenesis of nuclear cataract...
  85. doi request reprint C-reactive protein, body mass index, and diabetic retinopathy
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 51:4458-63. 2010
    ..The purpose of this study was to determine the relationship between CRP, BMI, and existing DR...
  86. ncbi request reprint Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53726 2336, USA
    Ophthalmology 113:373-80. 2006
    ..To describe the prevalence of age-related macular degeneration (AMD) in 4 racial/ethnic groups (white, black, Hispanic, and Chinese) that participated in the second examination of the Multi-ethnic Study of Atherosclerosis (MESA)...
  87. doi request reprint Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study
    Sophie Louise Rogers
    Centre for Eye Research, University of Melbourne, 32 Gisborne St, Victoria 3002, Australia
    Diabetes Care 31:761-3. 2008
    ..Venular caliber did not predict incident retinopathy. Our findings suggest that retinal arteriolar dilatation is a specific sign of diabetic microvascular dysfunction and may be a preclinical marker of diabetic retinopathy...
  88. doi request reprint Corneal arcus is a sign of cardiovascular disease, even in low-risk persons
    Marcus Ang
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore
    Am J Ophthalmol 152:864-71.e1. 2011
    ..To examine the association of corneal arcus to cardiovascular disease (CVD) in an adult, ethnic Indian population...
  89. ncbi request reprint Age-related macular degeneration and risk for stroke
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia
    Ann Intern Med 145:98-106. 2006
    ..Age-related macular degeneration (AMD) affects 7 million persons 40 years of age and older in the United States. Risk factors for the disease are similar to those for stroke...
  90. doi request reprint Relationship of ocular biometry and retinal vascular caliber in preschoolers
    Ling Jun Li
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Invest Ophthalmol Vis Sci 52:9561-6. 2011
    ..To systematically examine the association between ocular biometry and retinal vascular caliber in Singapore Chinese preschoolers aged 48 to 72 months...
  91. ncbi request reprint Relationship of retinal vascular caliber with optic disc diameter in children
    Ning Cheung
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 48:4945-8. 2007
    ..To describe the relationships of retinal vascular caliber to optic disc diameter in children...
  92. doi request reprint C-reactive protein and age-related macular degeneration and cataract: the singapore malay eye study
    Pui Yi Boey
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 51:1880-5. 2010
    ..In persons without diabetes, higher CRP was associated with AMD. These data suggest only a weak link between systemic inflammation and AMD and cataract in Asian people...
  93. doi request reprint Are obesity and anthropometry risk factors for diabetic retinopathy? The diabetes management project
    Mohamed Dirani
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
    Invest Ophthalmol Vis Sci 52:4416-21. 2011
    ..To investigate the relationship between anthropometric parameters and diabetic retinopathy (DR) in adults with diabetes...
  94. doi request reprint Effect of corneal arcus on central corneal thickness, intraocular pressure, and primary open-angle glaucoma: the Singapore Malay Eye Study
    Renyi Wu
    Singapore Eye Research Institute, Singapore
    Arch Ophthalmol 128:1455-61. 2010
    ..To examine the association of corneal arcus with central corneal thickness (CCT), intraocular pressure (IOP), and the prevalence of primary open-angle glaucoma...
  95. doi request reprint Fractal analysis of retinal microvasculature and coronary heart disease mortality
    Gerald Liew
    Centre for Vision Research, Department of Ophthalmology, University of Sydney, Sydney, NSW, Australia
    Eur Heart J 32:422-9. 2011
    ..Fractal analysis provides a global assessment of vascular network architecture. We examined the relationship of retinal vascular fractal dimension (D(f)) with coronary heart disease (CHD) mortality...
  96. doi request reprint Is there a clear threshold for fasting plasma glucose that differentiates between those with and without neuropathy and chronic kidney disease?: the Singapore Prospective Study Program
    Ei Ei Khaing Nang
    Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Am J Epidemiol 169:1454-62. 2009
    ..Ascertaining these individuals may require development and application of novel screening strategies...
  97. pmc Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA)
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Invest Ophthalmol Vis Sci 47:2341-50. 2006
    ..To describe the relationship of retinal arteriolar and venular caliber with cardiovascular risk factors, including inflammatory biomarkers, in a multiethnic population of whites, blacks, Hispanics, and Chinese...
  98. ncbi request reprint Hypertensive retinopathy signs as risk indicators of cardiovascular morbidity and mortality
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne 3002, Australia
    Br Med Bull 73:57-70. 2005
    ..These data support the concept that an assessment of retinal vascular changes may provide further information for vascular risk stratification in persons with hypertension...
  99. ncbi request reprint Revised formulas for summarizing retinal vessel diameters
    Michael D Knudtson
    Department of Ophthalmology, University of Wisconsin, Madison, WI 53726, USA
    Curr Eye Res 27:143-9. 2003
    ....