Research Topics
Species | Einar P V Wilder-SmithSummaryAffiliation: National University of Singapore Country: Singapore Publications
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Detail Information
Publications
Heart rate changes during partial seizures: a study amongst Singaporean patientsE Wilder-Smith
National University Hospital, Division of Neurology, 5 Lower Kent Ridge Road, 1109074, Sinapore
BMC Neurol 1:5. 2001..We determine frequency, magnitude and type of ictal heart rate changes during partial seizures in non-Caucasian patients in Singapore...
Paraneoplastic progressive supranuclear palsy syndrome in a patient with B-cell lymphomaJ H Tan
Division of Neurology, Department of Medicine, National University Hospital, Singapore
Parkinsonism Relat Disord 11:187-91. 2005..A paraneoplastic cause should be considered if disease progression is unusually rapid...
Effect of hand position on digit and ulnar artery vasoconstrictor reflexesEinar P Wilder-Smith
Dept of Medicine, Division of Neurology, National University of Singapore
Clin Auton Res 15:302-4. 2005..All subjects felt the pronation position more comfortable and an added benefit of this position was significantly shorter testing time...
Sensory distribution indicates severity of median nerve damage in carpal tunnel syndromeE P Wilder-Smith
Neurology, Yong Loo Lin School of Medicine, National University, 5 Lower Kent Ridge Road, Singapore, Singapore
Clin Neurophysiol 119:1619-25. 2008..This study identifies the clinical and electrophysiological findings that correlate with the distribution of sensory symptoms in an Asian population with CTS...
The NORSE (new-onset refractory status epilepticus) syndrome: defining a disease entityE P V Wilder-Smith
Division of Neurology, Department of Medicine, National University Hospital, Singapore
Ann Acad Med Singapore 34:417-20. 2005..To characterise a homogeneous group of patients with new-onset refractory status epilepticus (NORSE syndrome)...
Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjectsE P Wilder-Smith
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Histopathology 51:674-80. 2007..Recent evidence suggests that keratinocytes may act as thermal receptors via TRPV1. The aim was to investigate epidermal TRPV1 expression in patients with neuropathic conditions associated with pain...
Medial thenar recording in normal subjects and carpal tunnel syndromeEinar P V Wilder Smith
Neurology, Yong Loo Lin School of Medicine, National University Singapore, Singapore
Clin Neurophysiol 118:757-61. 2007..We then compare sensitivity and specificity of this novel site with other nerve conduction parameters in supporting a diagnosis of CTS...
Symptoms associated with electrophysiologically verified carpal tunnel syndrome in Asian patientsE P Wilder-Smith
Division of Neurology, National University Hospital, Singapore
J Hand Surg Br 31:326-30. 2006..The semi-quantitative clinical and neurophysiological scales correlated well (Pearson 0.645, P<0.001)...
Diagnosing carpal tunnel syndrome--clinical criteria and ancillary testsEinar P Wilder-Smith
Neurophysiological Section, National University Hospital, Singapore
Nat Clin Pract Neurol 2:366-74. 2006..Supplementary tests of small nerve fiber function and measurement of intracarpal pressure might, in the future, improve early recognition of CTS, especially in the absence of well-defined symptoms...
Reflex vasoconstrictor responses of the healthy human fingertip skin. Normal range, repeatability, and influencing factorsE P Wilder-Smith
Division of Neurology, 5 Lower Kent Ridge Road, National University Hospital, S 119072, Singapore
Microvasc Res 69:101-5. 2005..The SVCR repeatability and range of variation seen in this study compare favorably with tests of heart rate variability, thermal threshold detection, and motor nerve conduction...
Relationship of inspiratory flow rate and volume on digit tip skin and ulnar artery vasoconstrictor responses in healthy adultsEinar Wilder-Smith
Division of Neurology, National University of Singapore, 5 Lower Kent Ridge Road, 119072 Singapore
Microvasc Res 69:95-100. 2005..Correlation of inspiratory flow rate to vasoconstriction was consistently better than with inspiratory volume. Both digit tip and ulnar vasoconstrictor responses were maximal with greatest respiratory effort...
Water-immersion wrinkling is due to vasoconstrictionEinar P V Wilder-Smith
Department of Medicine, Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
Muscle Nerve 27:307-11. 2003..Our data show that water-immersion wrinkling is a function of digit pulp vasoconstriction. This test of sympathetic function can now be quantified using parameters of blood flow velocity, enabling its more widespread and accurate use...
Water immersion and EMLA cause similar digit skin wrinkling and vasoconstrictionEinar Wilder-Smith
Division of Neurology, Department of Medicine, National University Singapore, Singapore
Microvasc Res 66:68-72. 2003..170). These data further support that water immersion skin wrinkling is mediated by vasoconstriction. The EMLA cream patch test may develop into a useful screening test for hand sympathetic vasoconstrictor function...
Spinocerebellar ataxia type 3 presenting as an L-DOPA responsive dystonia phenotype in a Chinese familyE Wilder-Smith
Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Republic of Singapore
J Neurol Sci 213:25-8. 2003..SCA 3 should be considered a differential diagnosis in adult patients who present with DRD phenotype and with a positive family history...
Vasomotor dysfunction in carpal tunnel syndromeEinar P V Wilder-Smith
Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
Muscle Nerve 28:582-6. 2003..73 identified CTS in 69% with 68% specificity. Testing for vasomotor dysfunction in CTS allows for more comprehensive neurophysiological testing, which is heavily biased towards large nerve fibers...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in a Chinese family: clinical, radiological and skin biopsy featuresE Wilder-Smith
Division of Neurology, National University of Singapore, Singapore
J Clin Neurosci 11:304-7. 2004..A novel finding is the suggestion of a direct correlation between clinical disease severity and the quantity of ultrastructural pathognomonic granular osmophilic material (GOM) seen on skin biopsy...
Water immersion wrinkling--physiology and use as an indicator of sympathetic functionEinar P V Wilder-Smith
Dept of Medicine, Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, 119074 Singapore
Clin Auton Res 14:125-31. 2004..This review discusses the physiology of water immersion wrinkling and explores its potential as an indicator of limb sympathetic dysfunction...
Stimulated skin wrinkling for predicting intraepidermal nerve fibre densityEinar P Wilder-Smith
Division of Neurology, National University Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
Clin Neurophysiol 120:953-8. 2009..To determine the usefulness of stimulated skin wrinkling using EMLA and water immersion in detecting abnormal intraepidermal nerve fibre density...
Nerve damage in leprosy and its managementEinar P Wilder-Smith
National University Singapore, Yong Loo Lin School of Medicine, Singapore
Nat Clin Pract Neurol 4:656-63. 2008..Early detection and treatment of nerve-function impairment are crucial for outcome, so special emphasis is given to developments in detecting and treating nerve impairment in leprosy early...
Comparison of a simple method for quantitation of intraepidermal nerve fibres with a standard image analysis method using hypothenar skinEinar P V Wilder-Smith
Department of Medicine Division of Neurology, Yong Loo Lin School of Medicine, 5 Lower Kent Ridge Road, 119074 Singapore, Singapore
J Neurol 253:1011-5. 2006..To compare a simpler method for counting intraepidermal nerve fibres with a standard computer based image analysis method in normal subjects with skin taken from the hypothenar region...
EEG-based mental fatigue measurement using multi-class support vector machines with confidence estimateKai Quan Shen
Department of Mechanical Engineering, National University of Singapore, EA, 07 08, 9 Engineering Drive 1, Singapore, Singapore
Clin Neurophysiol 119:1524-33. 2008..Automatic measurement and monitoring of mental fatigue are invaluable for preventing mental-fatigue related accidents. We test an EEG-based mental-fatigue monitoring system using a probabilistic-based support vector-machines (SVM) method...
Frequency-domain EEG source analysis for acute tonic cold pain perceptionShiyun Shao
Department of Mechanical Engineering, National University of Singapore, Singapore
Clin Neurophysiol 123:2042-9. 2012..To investigate electrocortical responses to tonic cold pain by frequency-domain electroencephalogram (EEG) source analysis, and to identify potential electrocortical indices of acute tonic pain...
Effect of pain perception on the heartbeat evoked potentialShiyun Shao
Department of Mechanical Engineering, National University of Singapore, Singapore
Clin Neurophysiol 122:1838-45. 2011..To investigate the effect of acute tonic pain on the heartbeat-evoked potential (HEP) and to test whether or not pain perception can be reflected by the HEP...
Topical botulinum toxin to treat hyperhidrosis? No sweat!Erle C H Lim
Division of Neurology, Yong Loo Lin School of Medicine, National University of Singapore National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
Med Hypotheses 67:27-32. 2006..We examine the rationale and feasibility for such a treatment modality and route of administration...
Characteristic EEG differences between voluntary recumbent sleep onset in bed and involuntary sleep onset in a driving simulatorMervyn V M Yeo
Division of Bioengineering, National University of Singapore, Singapore
Clin Neurophysiol 118:1315-23. 2007..To investigate the differences in electroencephalographic (EEG) characteristics for voluntary sleep onset in bed sleeping and involuntary sleep onset in driving...
Spindle coma from acute midbrain infarctionRaymond C S Seet
Division of Neurology, National University Hospital, Singapore
Neurology 64:2159-60. 2005
Dystonia gravidarum: a new entity?Erle Chuen Hian Lim
Division of Neurology, National University Hospital, Singapore
Mov Disord 21:69-70. 2006..Dystonia, on the other hand, has not been described to occur de novo in pregnancy. This association should be considered in women of reproductive age who present with cervical dystonia...
A feature selection method for multilevel mental fatigue EEG classificationKai Quan Shen
Department of Mechanical Engineering, National University of Singapore 117576, Singapore
IEEE Trans Biomed Eng 54:1231-7. 2007..1% using all 304 features. The results also show that 17 key features (out of 24 top-ranked features) are consistent between the subjects using RF with RFE, which is superior to the set of 64 features as determined by RF with INIT...
Computer-based versus pen-and-paper testing: students' perceptionErle C H Lim
Department of Medicine, National University of Singapore, Singapore
Ann Acad Med Singapore 35:599-603. 2006..Since 2004, our medical school has utilised CBT to conduct 2 papers for the third- and final-year assessments - Paper 3, with 30 multiple choice questions featuring clinical vignettes, and the modified essay question (MEQ) paper...
A blessing in disguise: resolution of tardive dyskinesia with development of cervical myelitisErle Chuen Hian Lim
Division of Neurology, National University Hospital, Singapore
Mov Disord 21:120-2. 2006....
Automatic EEG artifact removal: a weighted support vector machine approach with error correctionShi Yun Shao
Department of Mechanical Engineering, National University of Singapore, Singapore 117576, Singapore
IEEE Trans Biomed Eng 56:336-44. 2009..Qualitative evaluation of the reconstructed EEG epochs also demonstrates that after artifact removal inherent brain activities are largely preserved...
Generalised myoclonus evolving into epilepsia partialis continua due to a cingulate gyrus lesion: case report and review of the literatureErle C H Lim
Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
Parkinsonism Relat Disord 10:447-9. 2004..The lack of clear declarative clinical and EEG features highlights the melding of the fields of epileptology and movement disorders...
Acute transverse myelitis following dengue virus infectionRaymond C S Seet
Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
J Clin Virol 35:310-2. 2006..Further studies need to be performed to elucidate the mechanisms of spinal neurological damage in dengue...
Re: Carpal tunnel syndrome and work, Dias et al. Journal of Hand Surgery 2004; 29(4): 329-333Erle Chuen-Hian Lim
J Hand Surg [Br] 30:99. 2005
