Einar P V Wilder-Smith

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi request reprint Aquagenic wrinkling of the palms is due to vasoconstriction of palmar skin vasculature
    E P Wilder-Smith
    National University of Singapore, Neurology, Department of Medicine, National University Hospital NUH, 10th Floor, NUHS Tower Block, 1E Kent Ridge Road, Singapore 119228, Singapore Electronic address
    Med Hypotheses 81:963-5. 2013
  2. pmc Dissociative paraplegia after epidural anesthesia: a case report
    Dusan Hirjak
    Structural Neuroimaging Group, Department of General Psychiatry, Heidelberg University Hospital, Voßstraße 4, Heidelberg, D 69115, Germany
    J Med Case Rep 7:56. 2013
  3. pmc Two randomized controlled clinical trials to study the effectiveness of prednisolone treatment in preventing and restoring clinical nerve function loss in leprosy: the TENLEP study protocols
    Inge Wagenaar
    Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    BMC Neurol 12:159. 2012
  4. ncbi request reprint Symptoms associated with electrophysiologically verified carpal tunnel syndrome in Asian patients
    E P Wilder-Smith
    Division of Neurology, National University Hospital, Singapore
    J Hand Surg Br 31:326-30. 2006
  5. pmc Heart rate changes during partial seizures: a study amongst Singaporean patients
    E Wilder-Smith
    National University Hospital, Division of Neurology, 5 Lower Kent Ridge Road, 1109074, Sinapore
    BMC Neurol 1:5. 2001
  6. ncbi request reprint Comparison of a simple method for quantitation of intraepidermal nerve fibres with a standard image analysis method using hypothenar skin
    Einar P V Wilder-Smith
    Department of Medicine Division of Neurology, Yong Loo Lin School of Medicine, 5 Lower Kent Ridge Road, 119074 Singapore, Singapore
    J Neurol 253:1011-5. 2006
  7. ncbi request reprint Diagnosing carpal tunnel syndrome--clinical criteria and ancillary tests
    Einar P Wilder-Smith
    Neurophysiological Section, National University Hospital, Singapore
    Nat Clin Pract Neurol 2:366-74. 2006
  8. ncbi request reprint Medial thenar recording in normal subjects and carpal tunnel syndrome
    Einar P V Wilder Smith
    Neurology, Yong Loo Lin School of Medicine, National University Singapore, Singapore
    Clin Neurophysiol 118:757-61. 2007
  9. pmc Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects
    E P Wilder-Smith
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Histopathology 51:674-80. 2007
  10. ncbi request reprint Sensory distribution indicates severity of median nerve damage in carpal tunnel syndrome
    E P Wilder-Smith
    Neurology, Yong Loo Lin School of Medicine, National University, 5 Lower Kent Ridge Road, Singapore, Singapore
    Clin Neurophysiol 119:1619-25. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Aquagenic wrinkling of the palms is due to vasoconstriction of palmar skin vasculature
    E P Wilder-Smith
    National University of Singapore, Neurology, Department of Medicine, National University Hospital NUH, 10th Floor, NUHS Tower Block, 1E Kent Ridge Road, Singapore 119228, Singapore Electronic address
    Med Hypotheses 81:963-5. 2013
    ....
  2. pmc Dissociative paraplegia after epidural anesthesia: a case report
    Dusan Hirjak
    Structural Neuroimaging Group, Department of General Psychiatry, Heidelberg University Hospital, Voßstraße 4, Heidelberg, D 69115, Germany
    J Med Case Rep 7:56. 2013
    ..Over the last decades case reports have described patients with similar personality traits, psychopathological characteristics, history and symptoms...
  3. pmc Two randomized controlled clinical trials to study the effectiveness of prednisolone treatment in preventing and restoring clinical nerve function loss in leprosy: the TENLEP study protocols
    Inge Wagenaar
    Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    BMC Neurol 12:159. 2012
    ....
  4. ncbi request reprint Symptoms associated with electrophysiologically verified carpal tunnel syndrome in Asian patients
    E P Wilder-Smith
    Division of Neurology, National University Hospital, Singapore
    J Hand Surg Br 31:326-30. 2006
    ..The semi-quantitative clinical and neurophysiological scales correlated well (Pearson 0.645, P<0.001)...
  5. pmc Heart rate changes during partial seizures: a study amongst Singaporean patients
    E Wilder-Smith
    National University Hospital, Division of Neurology, 5 Lower Kent Ridge Road, 1109074, Sinapore
    BMC Neurol 1:5. 2001
    ..We determine frequency, magnitude and type of ictal heart rate changes during partial seizures in non-Caucasian patients in Singapore...
  6. ncbi request reprint Comparison of a simple method for quantitation of intraepidermal nerve fibres with a standard image analysis method using hypothenar skin
    Einar P V Wilder-Smith
    Department of Medicine Division of Neurology, Yong Loo Lin School of Medicine, 5 Lower Kent Ridge Road, 119074 Singapore, Singapore
    J Neurol 253:1011-5. 2006
    ..To compare a simpler method for counting intraepidermal nerve fibres with a standard computer based image analysis method in normal subjects with skin taken from the hypothenar region...
  7. ncbi request reprint Diagnosing carpal tunnel syndrome--clinical criteria and ancillary tests
    Einar P Wilder-Smith
    Neurophysiological Section, National University Hospital, Singapore
    Nat Clin Pract Neurol 2:366-74. 2006
    ..Supplementary tests of small nerve fiber function and measurement of intracarpal pressure might, in the future, improve early recognition of CTS, especially in the absence of well-defined symptoms...
  8. ncbi request reprint Medial thenar recording in normal subjects and carpal tunnel syndrome
    Einar P V Wilder Smith
    Neurology, Yong Loo Lin School of Medicine, National University Singapore, Singapore
    Clin Neurophysiol 118:757-61. 2007
    ..We then compare sensitivity and specificity of this novel site with other nerve conduction parameters in supporting a diagnosis of CTS...
  9. pmc Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects
    E P Wilder-Smith
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Histopathology 51:674-80. 2007
    ..Recent evidence suggests that keratinocytes may act as thermal receptors via TRPV1. The aim was to investigate epidermal TRPV1 expression in patients with neuropathic conditions associated with pain...
  10. ncbi request reprint Sensory distribution indicates severity of median nerve damage in carpal tunnel syndrome
    E P Wilder-Smith
    Neurology, Yong Loo Lin School of Medicine, National University, 5 Lower Kent Ridge Road, Singapore, Singapore
    Clin Neurophysiol 119:1619-25. 2008
    ..This study identifies the clinical and electrophysiological findings that correlate with the distribution of sensory symptoms in an Asian population with CTS...
  11. doi request reprint Nerve damage in leprosy and its management
    Einar P Wilder-Smith
    National University Singapore, Yong Loo Lin School of Medicine, Singapore
    Nat Clin Pract Neurol 4:656-63. 2008
    ..Early detection and treatment of nerve-function impairment are crucial for outcome, so special emphasis is given to developments in detecting and treating nerve impairment in leprosy early...
  12. doi request reprint Stimulated skin wrinkling for predicting intraepidermal nerve fibre density
    Einar P Wilder-Smith
    Division of Neurology, National University Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
    Clin Neurophysiol 120:953-8. 2009
    ..To determine the usefulness of stimulated skin wrinkling using EMLA and water immersion in detecting abnormal intraepidermal nerve fibre density...
  13. ncbi request reprint The NORSE (new-onset refractory status epilepticus) syndrome: defining a disease entity
    E P V Wilder-Smith
    Division of Neurology, Department of Medicine, National University Hospital, Singapore
    Ann Acad Med Singapore 34:417-20. 2005
    ..To characterise a homogeneous group of patients with new-onset refractory status epilepticus (NORSE syndrome)...
  14. ncbi request reprint Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in a Chinese family: clinical, radiological and skin biopsy features
    E Wilder-Smith
    Division of Neurology, National University of Singapore, Singapore
    J Clin Neurosci 11:304-7. 2004
    ..A novel finding is the suggestion of a direct correlation between clinical disease severity and the quantity of ultrastructural pathognomonic granular osmophilic material (GOM) seen on skin biopsy...
  15. ncbi request reprint Water immersion wrinkling--physiology and use as an indicator of sympathetic function
    Einar P V Wilder-Smith
    Dept of Medicine, Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, 119074 Singapore
    Clin Auton Res 14:125-31. 2004
    ..This review discusses the physiology of water immersion wrinkling and explores its potential as an indicator of limb sympathetic dysfunction...
  16. ncbi request reprint Vasomotor dysfunction in carpal tunnel syndrome
    Einar P V Wilder-Smith
    Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
    Muscle Nerve 28:582-6. 2003
    ..73 identified CTS in 69% with 68% specificity. Testing for vasomotor dysfunction in CTS allows for more comprehensive neurophysiological testing, which is heavily biased towards large nerve fibers...
  17. ncbi request reprint Spinocerebellar ataxia type 3 presenting as an L-DOPA responsive dystonia phenotype in a Chinese family
    E Wilder-Smith
    Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Republic of Singapore
    J Neurol Sci 213:25-8. 2003
    ..SCA 3 should be considered a differential diagnosis in adult patients who present with DRD phenotype and with a positive family history...
  18. ncbi request reprint Relationship of inspiratory flow rate and volume on digit tip skin and ulnar artery vasoconstrictor responses in healthy adults
    Einar Wilder-Smith
    Division of Neurology, National University of Singapore, 5 Lower Kent Ridge Road, 119072 Singapore
    Microvasc Res 69:95-100. 2005
    ..Correlation of inspiratory flow rate to vasoconstriction was consistently better than with inspiratory volume. Both digit tip and ulnar vasoconstrictor responses were maximal with greatest respiratory effort...
  19. ncbi request reprint Reflex vasoconstrictor responses of the healthy human fingertip skin. Normal range, repeatability, and influencing factors
    E P Wilder-Smith
    Division of Neurology, 5 Lower Kent Ridge Road, National University Hospital, S 119072, Singapore
    Microvasc Res 69:101-5. 2005
    ..The SVCR repeatability and range of variation seen in this study compare favorably with tests of heart rate variability, thermal threshold detection, and motor nerve conduction...
  20. ncbi request reprint Paraneoplastic progressive supranuclear palsy syndrome in a patient with B-cell lymphoma
    J H Tan
    Division of Neurology, Department of Medicine, National University Hospital, Singapore
    Parkinsonism Relat Disord 11:187-91. 2005
    ..A paraneoplastic cause should be considered if disease progression is unusually rapid...
  21. ncbi request reprint Water immersion and EMLA cause similar digit skin wrinkling and vasoconstriction
    Einar Wilder-Smith
    Division of Neurology, Department of Medicine, National University Singapore, Singapore
    Microvasc Res 66:68-72. 2003
    ..170). These data further support that water immersion skin wrinkling is mediated by vasoconstriction. The EMLA cream patch test may develop into a useful screening test for hand sympathetic vasoconstrictor function...
  22. ncbi request reprint Effect of hand position on digit and ulnar artery vasoconstrictor reflexes
    Einar P Wilder-Smith
    Dept of Medicine, Division of Neurology, National University of Singapore
    Clin Auton Res 15:302-4. 2005
    ..All subjects felt the pronation position more comfortable and an added benefit of this position was significantly shorter testing time...
  23. ncbi request reprint Water-immersion wrinkling is due to vasoconstriction
    Einar P V Wilder-Smith
    Department of Medicine, Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
    Muscle Nerve 27:307-11. 2003
    ..Our data show that water-immersion wrinkling is a function of digit pulp vasoconstriction. This test of sympathetic function can now be quantified using parameters of blood flow velocity, enabling its more widespread and accurate use...
  24. ncbi request reprint EEG-based mental fatigue measurement using multi-class support vector machines with confidence estimate
    Kai Quan Shen
    Department of Mechanical Engineering, National University of Singapore, EA, 07 08, 9 Engineering Drive 1, Singapore, Singapore
    Clin Neurophysiol 119:1524-33. 2008
    ..Automatic measurement and monitoring of mental fatigue are invaluable for preventing mental-fatigue related accidents. We test an EEG-based mental-fatigue monitoring system using a probabilistic-based support vector-machines (SVM) method...
  25. ncbi request reprint Frequency-domain EEG source analysis for acute tonic cold pain perception
    Shiyun Shao
    Department of Mechanical Engineering, National University of Singapore, Singapore
    Clin Neurophysiol 123:2042-9. 2012
    ..To investigate electrocortical responses to tonic cold pain by frequency-domain electroencephalogram (EEG) source analysis, and to identify potential electrocortical indices of acute tonic pain...
  26. doi request reprint Effect of pain perception on the heartbeat evoked potential
    Shiyun Shao
    Department of Mechanical Engineering, National University of Singapore, Singapore
    Clin Neurophysiol 122:1838-45. 2011
    ..To investigate the effect of acute tonic pain on the heartbeat-evoked potential (HEP) and to test whether or not pain perception can be reflected by the HEP...
  27. ncbi request reprint Characteristic EEG differences between voluntary recumbent sleep onset in bed and involuntary sleep onset in a driving simulator
    Mervyn V M Yeo
    Division of Bioengineering, National University of Singapore, Singapore
    Clin Neurophysiol 118:1315-23. 2007
    ..To investigate the differences in electroencephalographic (EEG) characteristics for voluntary sleep onset in bed sleeping and involuntary sleep onset in driving...
  28. ncbi request reprint Spindle coma from acute midbrain infarction
    Raymond C S Seet
    Division of Neurology, National University Hospital, Singapore
    Neurology 64:2159-60. 2005
  29. ncbi request reprint Topical botulinum toxin to treat hyperhidrosis? No sweat!
    Erle C H Lim
    Division of Neurology, Yong Loo Lin School of Medicine, National University of Singapore National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
    Med Hypotheses 67:27-32. 2006
    ..We examine the rationale and feasibility for such a treatment modality and route of administration...
  30. ncbi request reprint Dystonia gravidarum: a new entity?
    Erle Chuen Hian Lim
    Division of Neurology, National University Hospital, Singapore
    Mov Disord 21:69-70. 2006
    ..Dystonia, on the other hand, has not been described to occur de novo in pregnancy. This association should be considered in women of reproductive age who present with cervical dystonia...
  31. ncbi request reprint A feature selection method for multilevel mental fatigue EEG classification
    Kai Quan Shen
    Department of Mechanical Engineering, National University of Singapore 117576, Singapore
    IEEE Trans Biomed Eng 54:1231-7. 2007
    ..1% using all 304 features. The results also show that 17 key features (out of 24 top-ranked features) are consistent between the subjects using RF with RFE, which is superior to the set of 64 features as determined by RF with INIT...
  32. ncbi request reprint Computer-based versus pen-and-paper testing: students' perception
    Erle C H Lim
    Department of Medicine, National University of Singapore, Singapore
    Ann Acad Med Singapore 35:599-603. 2006
    ..Since 2004, our medical school has utilised CBT to conduct 2 papers for the third- and final-year assessments - Paper 3, with 30 multiple choice questions featuring clinical vignettes, and the modified essay question (MEQ) paper...
  33. doi request reprint Automatic EEG artifact removal: a weighted support vector machine approach with error correction
    Shi Yun Shao
    Department of Mechanical Engineering, National University of Singapore, Singapore 117576, Singapore
    IEEE Trans Biomed Eng 56:336-44. 2009
    ..Qualitative evaluation of the reconstructed EEG epochs also demonstrates that after artifact removal inherent brain activities are largely preserved...
  34. ncbi request reprint Acute transverse myelitis following dengue virus infection
    Raymond C S Seet
    Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
    J Clin Virol 35:310-2. 2006
    ..Further studies need to be performed to elucidate the mechanisms of spinal neurological damage in dengue...
  35. ncbi request reprint A blessing in disguise: resolution of tardive dyskinesia with development of cervical myelitis
    Erle Chuen Hian Lim
    Division of Neurology, National University Hospital, Singapore
    Mov Disord 21:120-2. 2006
    ....
  36. ncbi request reprint Generalised myoclonus evolving into epilepsia partialis continua due to a cingulate gyrus lesion: case report and review of the literature
    Erle C H Lim
    Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
    Parkinsonism Relat Disord 10:447-9. 2004
    ..The lack of clear declarative clinical and EEG features highlights the melding of the fields of epileptology and movement disorders...
  37. ncbi request reprint Re: Carpal tunnel syndrome and work, Dias et al. Journal of Hand Surgery 2004; 29(4): 329-333
    Erle Chuen Hian Lim
    J Hand Surg Br 30:99. 2005