Bor Luen Tang

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. doi request reprint Membrane trafficking components in cytokinesis
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, Singapore, Republic of Singapore
    Cell Physiol Biochem 30:1097-108. 2012
  2. doi request reprint Is unconventional secretion inhibited during cell division by Cdk1 activity?
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, NUS Graduate School of Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore
    J Cell Physiol 228:915-6. 2013
  3. doi request reprint The cell biology of Chikungunya virus infection
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine and NUS Graduate School of Integrative Sciences and Engineering, National University of Singapore, Singapore 117597, Singapore
    Cell Microbiol 14:1354-63. 2012
  4. doi request reprint Rabs and cancer cell motility
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Cell Motil Cytoskeleton 66:365-70. 2009
  5. doi request reprint Sirt1's complex roles in neuroprotection
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore
    Cell Mol Neurobiol 29:1093-103. 2009
  6. ncbi request reprint COPII and exit from the endoplasmic reticulum
    Bor Luen Tang
    Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochim Biophys Acta 1744:293-303. 2005
  7. pmc Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Cell Adh Migr 3:118-28. 2009
  8. ncbi request reprint Biomarkers of mild cognitive impairment and Alzheimer's disease
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical, Drive, Singapore 117597
    Ann Acad Med Singapore 37:406-10. 2008
  9. ncbi request reprint Genetic manipulation of neural stem cells for transplantation into the injured spinal cord
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Garden City, Singapore
    Cell Mol Neurobiol 27:75-85. 2007
  10. ncbi request reprint SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
    Bor Luen Tang
    Department of Biochemistry and Programme in Neurobiology and Aging, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Neurobiol Aging 27:501-5. 2006

Collaborators

  • Martin E Schwab
  • Wanjin Hong
  • Ya Wang
  • Ting Wang
  • Qi Zeng
  • Ludger Johannes
  • Rajeev Kumar
  • Jianxing Song
  • Lei Lu
  • Patrick Tan
  • Heike Grabsch
  • Hong Liao
  • Thierry Galli
  • Catherine J Pallen
  • Liu Yang
  • E Soriano
  • Yee Kong Ng
  • Tian le Xu
  • D Hunt
  • Felicia Yu Hsuan Teng
  • Christelle En Lin Chua
  • Yanan Chen
  • Ee Ling Ng
  • Yi Shan Lim
  • Bin Qi Gan
  • Felicia Y H Teng
  • Selina Aulia
  • Catherine Hong Huan Hor
  • Lingzhi Li
  • Jun Meng
  • Fengyi Liang
  • Wan Jie Chia
  • Choon Bing Low
  • Qingsong Hou
  • Anchen Guo
  • Guihua Tai
  • Ana Mingorance
  • Minfen Li
  • Bruno Goud
  • Du yu Nie
  • Frédéric Mallard
  • Heinrich Horstmann
  • Haiping Liu
  • Cherry Ee Lin Ng
  • Min Goo Lee
  • Hong Huan Hor
  • Fanny Ng
  • Junhong Tang
  • Wenhao Xia
  • Jun Jie Ng
  • Lay Keng Tan
  • Yong Hui Wu
  • Yih Cherng Liou
  • Debra Cross
  • Kumaresan Ganesan
  • Yansong Zhu
  • Oi Lian Kon
  • Jiong Tao
  • Veena Gopalakrishnan
  • Siew Hong Leong
  • Kooi Hoong Chong
  • Belinda M T Ling
  • Xavier Fontana
  • Jose A Del Río
  • Jiahai Shi
  • Ferran Burgaya
  • Marta Solé
  • Jesús M Ureña
  • John R Bethea
  • Patrick N Anderson
  • Zheng Wei
  • Brian Popko
  • Yasuo Takeda
  • Chao yang Wang
  • Beng Ti Ang
  • Tao Xiang
  • Melitta Schachner
  • Zhi Cheng Xiao
  • Kazutada Watanabe
  • Zhi Hong Zhou
  • Gang Xu
  • Eng Ang Ling
  • Li Zeng
  • Catherine Faivre-Sarrailh
  • Xu Yue
  • Cherry E L Ng
  • Claude Antony
  • Daniele Tenza
  • Chee Peng Ng
  • Agnes Saint-Pol

Detail Information

Publications77

  1. doi request reprint Membrane trafficking components in cytokinesis
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, Singapore, Republic of Singapore
    Cell Physiol Biochem 30:1097-108. 2012
    ..Although a good deal of details remains to be deciphered, cytokinesis in eukaryotes could essentially be visualized as a specialized cellular event requiring complex spatial and temporal regulated processes of membrane traffic...
  2. doi request reprint Is unconventional secretion inhibited during cell division by Cdk1 activity?
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, NUS Graduate School of Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore
    J Cell Physiol 228:915-6. 2013
    ..Is unconventional secretion therefore similarly inhibited during cell division like conventional secretion? The story may yet turn out to be more complicated...
  3. doi request reprint The cell biology of Chikungunya virus infection
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine and NUS Graduate School of Integrative Sciences and Engineering, National University of Singapore, Singapore 117597, Singapore
    Cell Microbiol 14:1354-63. 2012
    ....
  4. doi request reprint Rabs and cancer cell motility
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Cell Motil Cytoskeleton 66:365-70. 2009
    ..We discuss highlights in the recent literature that point towards a role for Rab-mediated membrane traffic in cancer cell migration and invasion...
  5. doi request reprint Sirt1's complex roles in neuroprotection
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore
    Cell Mol Neurobiol 29:1093-103. 2009
    ..One needs to be cautious in extrapolating results derived from short-term observations to a longer-term context, and in assessing efficacies of Sirt1-based therapeutic approaches in treating neurodegenerative diseases...
  6. ncbi request reprint COPII and exit from the endoplasmic reticulum
    Bor Luen Tang
    Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochim Biophys Acta 1744:293-303. 2005
    ..Together, elucidation of COPII-mediated ER export has painted a fascinating picture of molecular complexity for an essential process in all eukaryotic cells...
  7. pmc Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Cell Adh Migr 3:118-28. 2009
    ..Detail understanding of factors that influence these neuronal trafficking processes will open up novel therapeutic avenues for preventing or delaying the onset of symptomatic AD...
  8. ncbi request reprint Biomarkers of mild cognitive impairment and Alzheimer's disease
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical, Drive, Singapore 117597
    Ann Acad Med Singapore 37:406-10. 2008
    ..These biomarkers, along with clinical assessment, neuropsychological testing and neuroimaging could achieve a much higher diagnostic accuracy for AD and related disorders in the future...
  9. ncbi request reprint Genetic manipulation of neural stem cells for transplantation into the injured spinal cord
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Garden City, Singapore
    Cell Mol Neurobiol 27:75-85. 2007
    ..These experiments resulted in some interesting observations, which we discuss here in the light of recent advances in development of cell-based engraftment therapy for spinal cord injuries...
  10. ncbi request reprint SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
    Bor Luen Tang
    Department of Biochemistry and Programme in Neurobiology and Aging, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Neurobiol Aging 27:501-5. 2006
    ..Recent elucidation of the role of the protein deacetylase SIRT1 in cell survival and data associating IGF-1 with the regulation of SIRT1 expression may provide a direction towards resolving this issue...
  11. doi request reprint Leptin as a neuroprotective agent
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochem Biophys Res Commun 368:181-5. 2008
    ..The relative ease of leptin's accessibility to the brain by peripheral administration makes it a potential drug candidate in the development of therapeutics for brain injuries and neurodegeneration...
  12. ncbi request reprint SIRT2, tubulin deacetylation, and oligodendroglia differentiation
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore
    Cell Motil Cytoskeleton 65:179-82. 2008
    ..Novel findings now indicate that SIRT2 is specifically enriched in brain oligodendroglia, where it functions specifically in modulating the oligodendrocyte cytoskeleton during its differentiation and maturation...
  13. ncbi request reprint Molecular genetic determinants of human brain size
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochem Biophys Res Commun 345:911-6. 2006
    ..Understanding the mechanism for developmental control of brain organogenesis by these genes, and others such as FOXP2, shall provide fresh perspectives on the evolution of human intelligence...
  14. ncbi request reprint Alzheimer's disease: channeling APP to non-amyloidogenic processing
    Bor Luen Tang
    Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochem Biophys Res Commun 331:375-8. 2005
    ....
  15. pmc REST regulation of neural development: From outside-in?
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Cell Adh Migr 3:1-2. 2009
    ..These defects can be rescued by exogenous laminin. The findings shed new light on a previously underemphasized aspect of REST function, namely extracellular matrix regulation during neural differentiation...
  16. doi request reprint Sirt1's systemic protective roles and its promise as a target in antiaging medicine
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 117597
    Transl Res 157:276-84. 2011
    ....
  17. doi request reprint Concepts of protein sorting or targeting signals and membrane topology in undergraduate teaching*
    Bor Luen Tang
    Department of Biochemistry, National University of Singapore, Singapore 117597, Republic of Singapore
    Biochem Mol Biol Educ 33:188-93. 2005
    ..Such knowledge is essential, particularly for undergraduates or fresh graduates embarking on research projects in a cell and molecular biology laboratory...
  18. ncbi request reprint Emerging aspects of membrane traffic in neuronal dendrite growth
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore
    Biochim Biophys Acta 1783:169-76. 2008
    ..Emerging membrane traffic processes and components that contribute specifically to dendritic growth are discussed...
  19. doi request reprint Is Rab25 a tumor promoter or suppressor--context dependency on RCP status?
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health Service, National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore
    Tumour Biol 31:359-61. 2010
    ..Elevation of Rab25 alone may sequester endogenous RCP, and attenuates its activating effect on other oncogenic products, such as mutant Ras...
  20. ncbi request reprint SIRT1 and neuronal diseases
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Mol Aspects Med 29:187-200. 2008
    ..As neuronal degeneration is a major pathophysiological aspect of human aging, understanding the mechanism of SIRT1 neuroprotection promises novel strategies in clinical intervention of neurodegenerative diseases...
  21. ncbi request reprint Novel modulators of amyloid-beta precursor protein processing
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Neurochem 100:314-23. 2007
    ....
  22. doi request reprint Is systemic activation of Sirt1 beneficial for ageing-associated metabolic disorders?
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, Singapore
    Biochem Biophys Res Commun 391:6-10. 2010
    ..A deeper understanding of the mechanistic underpinnings of Sirt1's metabolic functions is necessary to effectively design Sirt1-based therapeutic interventions for metabolic disorders...
  23. doi request reprint Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells
    Ee Ling Ng
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Cell Physiol 221:716-28. 2009
    ..Given that EGFR signaling modulates astrocyte development and oncogenesis of multiple cell types, Rab22B may thus have specific developmental or pathophysiological roles in cell types which it is enriched in...
  24. ncbi request reprint Open brain gene product Rab23: expression pattern in the adult mouse brain and functional characterization
    Anchen Guo
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Neurosci Res 83:1118-27. 2006
    ..Expression of Rab23 in the adult brain is suggestive, however, of having a postnatal function beyond its role in embryonic development...
  25. pmc Dephosphorylation-dependent inhibitory activity of juxtanodin on filamentous actin disassembly
    Jun Meng
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Biol Chem 285:28838-49. 2010
    ..Specific phosphorylation of JN might serve as an important mechanism regulating JN functions...
  26. doi request reprint AMIGO is expressed in multiple brain cell types and may regulate dendritic growth and neuronal survival
    Yanan Chen
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore
    J Cell Physiol 227:2217-29. 2012
    ..AMIGO therefore likely plays important roles in dendritic outgrowth during development, and could modulate the survival of developing and adult neurons...
  27. doi request reprint Cell autonomous function of Nogo and reticulons: The emerging story at the endoplasmic reticulum
    Felicia Yu Hsuan Teng
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Cell Physiol 216:303-8. 2008
    ..This role is apparently not essential for cell viability under normal growth conditions, but may be manifested under certain stress conditions...
  28. ncbi request reprint Syntaxin 9 is enriched in skin hair follicle epithelium and interacts with the epidermal growth factor receptor
    Ya Wang
    Department of Biochemistry, Yong Lou Lin School of Medicine, National University of Singapore, MD7, 8 Medical Drive, Singapore 117597
    Traffic 7:216-26. 2006
    ..Syn 9 may therefore have a role in EGF receptor transport and signaling in certain epithelial cell types...
  29. doi request reprint Non-classical membrane trafficking processes galore
    Christelle En Lin Chua
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore
    J Cell Physiol 227:3722-30. 2012
    ..The routes of intracellular membrane transport and communications between eukaryotic organelles now appear far more complex that one would have imagined 10 years ago...
  30. ncbi request reprint Myelin-associated glycoprotein-mediated signaling in central nervous system pathophysiology
    Yanan Chen
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Mol Neurobiol 34:81-91. 2006
    ..This article discusses new findings in MAG-forward and -reverse signaling and its role in CNS pathophysiology...
  31. ncbi request reprint AMIGO and friends: an emerging family of brain-enriched, neuronal growth modulating, type I transmembrane proteins with leucine-rich repeats (LRR) and cell adhesion molecule motifs
    Yanan Chen
    Department of Biochemistry and Programme in Neurobiology and Aging, National University of Singapore, Singapore
    Brain Res Rev 51:265-74. 2006
    ..Current knowledge and recent findings pertaining to the functions of this interesting group of proteins in the nervous system are discussed...
  32. ncbi request reprint Why do Nogo/Nogo-66 receptor gene knockouts result in inferior regeneration compared to treatment with neutralizing agents?
    Felicia Yu Hsuan Teng
    Department of Biochemistry and Programme in Neurobiology and Aging, National University of Singapore, Singapore
    J Neurochem 94:865-74. 2005
    ..These possibilities include effects of IN-1 and NEP1-40 on the CNS beyond neutralization of Nogo and NgR functions, and the latter's possible role in the CNS beyond that of neuronal growth inhibition...
  33. ncbi request reprint Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria?
    Felicia Yu Hsuan Teng
    Department of Biochemistry and Programme in Neurobiology and Aging, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochem Biophys Res Commun 328:1-5. 2005
    ..In any case, whether Abeta is produced locally in the mitochondria and the function for mitochondrial Abeta, if produced, is yet unclear...
  34. doi request reprint Rab35--a vesicular traffic-regulating small GTPase with actin modulating roles
    Christelle En Lin Chua
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    FEBS Lett 584:1-6. 2010
    ..This can occur via activation of the Rho family of GTPases, or through the engagement of its effector fascin, an actin bundling protein...
  35. ncbi request reprint Rab22B's role in trans-Golgi network membrane dynamics
    Ee Ling Ng
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochem Biophys Res Commun 361:751-7. 2007
    ..Over-expression of Rab22BSN inhibits the cell surface transport of the vesicular stomatitis virus G protein. Thus, Rab22B may have a role in anterograde exit from the TGN...
  36. doi request reprint Linking membrane dynamics and trafficking to autophagy and the unfolded protein response
    Christelle En Lin Chua
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, NUS Graduate School of Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore
    J Cell Physiol 228:1638-40. 2013
    ..The notion provides further explanations as to why elevation of Rab1/Ypt1p levels could counter the cytotoxicity of α-synuclein, and a similar mode of protection may well be at work against other stresses...
  37. ncbi request reprint Syntaxin 16 is enriched in neuronal dendrites and may have a role in neurite outgrowth
    Christelle En Lin Chua
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Mol Membr Biol 25:35-45. 2008
    ..Syntaxin 16 may thus play a role in neurite outgrowth and perhaps other specific dendritic anterograde/retrograde traffic...
  38. doi request reprint Syntaxin 16: unraveling cellular physiology through a ubiquitous SNARE molecule
    Yanan Chen
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 117597, Singapore
    J Cell Physiol 225:326-32. 2010
    ..Further, we speculate on some possible pathophysiological roles of Syx16...
  39. doi request reprint Emerging cues mediating astroglia lineage restriction of progenitor cells in the injured/diseased adult CNS
    Felicia Yu Hsuan Teng
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Republic of Singapore
    Differentiation 77:121-7. 2009
    ..Understanding the molecular basis of glia lineage restriction of neural progenitors in the injured or diseased CNS would provide handles to improving the success of stem cell-based transplantation therapy...
  40. ncbi request reprint SNAREs in neurons--beyond synaptic vesicle exocytosis (Review)
    Ya Wang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Mol Membr Biol 23:377-84. 2006
    ..Here, we review and discuss the neuron-specific physiology and possible pathology of these and other (such as SNAP-29 and Vti1a-beta) members of the SNARE family...
  41. doi request reprint Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer
    Qingsong Hou
    National Cancer Centre, Department of Biochemistry, National University of Singapore, Duke NUS Graduate Medical School, and Genome Institute of Singapore, Singapore, Singapore
    Cancer Res 68:4623-30. 2008
    ....
  42. doi request reprint Nogo-A and Nogo-66 receptor in amyotrophic lateral sclerosis
    Felicia Yu Hsuan Teng
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    J Cell Mol Med 12:1199-204. 2008
    ..Understanding the intricate interplay among Nogo isoforms, NgR and p75(NTR) in ALS disease progression may provide important, therapeutically exploitable information...
  43. doi request reprint Neural differentiation and potential use of stem cells from the human umbilical cord for central nervous system transplantation therapy
    Choon Bing Low
    Department of Biochemistry, Yong Loo Lin School of Medicine, Singapore, Republic of Singapore
    J Neurosci Res 86:1670-9. 2008
    ....
  44. ncbi request reprint Axonal regeneration in adult CNS neurons--signaling molecules and pathways
    Felicia Yu Hsuan Teng
    Department of Biochemistry Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    J Neurochem 96:1501-8. 2006
    ..We discuss these signaling pathways and mechanisms, in conjunction with other recent reports of regeneration enhancement and also within the context of what is known about aiding regeneration of injured CNS axons...
  45. doi request reprint Intercellular organelle trafficking by membranous nanotube connections: a possible new role in cellular rejuvenation?
    Yi Shan Lim
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, Singapore 117597
    Cell Commun Adhes 19:39-44. 2012
    ..These findings have intriguing implications in cell biology and regenerative medicine...
  46. doi request reprint Rabs, SNAREs and α-synuclein--membrane trafficking defects in synucleinopathies
    Christelle En Lin Chua
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Brain Res Rev 67:268-81. 2011
    ..Here, we summarize and discuss recent findings in this regard, and their implications in the molecular aspects of synucleinopathy...
  47. ncbi request reprint The amyloid precursor protein and postnatal neurogenesis/neuroregeneration
    Yanan Chen
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Biochem Biophys Res Commun 341:1-5. 2006
    ..Interestingly, these two apparently related neurogenic/neuroregenerative functions of APP involve two separate domains of the molecule...
  48. doi request reprint Rabs and other small GTPases in ciliary transport
    Yi Shan Lim
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biol Cell 103:209-21. 2011
    ..We highlight and discuss recent findings on how Rabs and other small GTPases mediate ciliogenesis and ciliary traffic...
  49. ncbi request reprint alpha-synuclein and Parkinson's disease: the first roadblock
    Christelle En Lin Chua
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Cell Mol Med 10:837-46. 2006
    ..We discuss these recent results and the emerging pathophysiological interaction of alpha-synuclein with components of neuronal membrane traffic...
  50. ncbi request reprint Nogo-A expression in mouse central nervous system neurons
    Haiping Liu
    NCA Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore, Singapore
    Neurosci Lett 328:257-60. 2002
    ..Our results provide a conclusive demonstration of the expression of Nogo-A in CNS neurons, which suggests that Nogo-A may have distinct endogenous roles in neurons other than its known ability to inhibit neurite growth...
  51. ncbi request reprint Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16
    Ya Wang
    Department of Biochemistry and Neurobiology Program, National University of Singapore, MD7, 8 Medical Drive, Singapore, 117597, Republic of Singapore
    Mol Membr Biol 22:313-25. 2005
    ....
  52. ncbi request reprint Rab23: what exactly does it traffic?
    Ya Wang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore
    Traffic 7:746-50. 2006
    ..Rab23 is also expressed in adult mouse neurons and may thus have functions beyond embryonic developmental stages and Shh signaling. We discuss these new findings and explore the myriad of possibilities whereby Rab23 may function...
  53. doi request reprint Rab GTPases and their roles in brain neurons and glia
    Ee Ling Ng
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Brain Res Rev 58:236-46. 2008
    ..We summarized and discussed recent findings on the roles played by Rabs in neurons and glia in the central nervous system, and speculate on future directions...
  54. doi request reprint Sirt1’s beneficial roles in neurodegenerative diseases - a chaperonin containing TCP-1 (CCT) connection?
    Bin Qi Gan
    Department of Biochemistry, National University of Singapore, Singapore
    Aging Cell 9:924-9. 2010
    ..Other than alterations in gene expression profile, another major way whereby Sirt1 activation may counter neural aging could be to promote neuronal survival via prevention of toxic aggregate formation through CCT...
  55. ncbi request reprint Cdh1-APC/C, cyclin B-Cdc2, and Alzheimer's disease pathology
    Selina Aulia
    Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochem Biophys Res Commun 339:1-6. 2006
    ..Cdh1 thus play an active role in maintaining the terminally differentiated, non-cycling state of postmitotic neurons--a function that could become impaired in Alzheimer's and other neurodegenerative diseases...
  56. ncbi request reprint Inter- and intracellular interactions of Nogo: new findings and hypothesis
    Felicia Y H Teng
    Department of Biochemistry and Neurobiology Program, National University of Singapore, Singapore
    J Neurochem 89:801-6. 2004
    ....
  57. ncbi request reprint No go for brain tumors?
    Felicia Yu Hsuan Teng
    Department of Biochemistry and Programme in Neurobiology and Aging, National University of Singapore, Singapore 117597, Republic of Singapore
    J Mol Neurosci 25:1-6. 2005
    ..On the other hand, extracellular domains of Nogo might inhibit the migration and invasion of CNS tumors. Depending on the physiological context, Nogo isoforms might therefore be antitumorigenic or have tumor-suppressing activities...
  58. ncbi request reprint NF-kappaB signaling in neurite growth and neuronal survival
    Felicia Yu Hsuan Teng
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University ofSingapore, 8 Medical Drive, Singapore 117597
    Rev Neurosci 21:299-313. 2010
    ....
  59. ncbi request reprint Inhibitors of neuronal regeneration: mediators and signaling mechanisms
    Bor Luen Tang
    NCA Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
    Neurochem Int 42:189-203. 2003
    ..Rho-family GTPases and their effectors modulate the activities of actin modifying molecules such as cofilin and profilin, resulting in cytoskeletal changes associated with growth cone extension or retraction...
  60. doi request reprint Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation
    Christelle En Lin Chua
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 117597, Singapore
    Cell Mol Life Sci 68:3349-58. 2011
    ..We summarize here what is now known about the involvement of Rabs in autophagy, and discuss plausible mechanisms with future perspectives...
  61. doi request reprint The cystic fibrosis transmembrane conductance regulator's expanding SNARE interactome
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Traffic 12:364-71. 2011
    ..We summarize here the SNAREs that interact with CFTR and discuss the roles of these SNAREs in the intracellular trafficking of CFTR and CFTR-associated pathophysiology...
  62. ncbi request reprint Emerging roles for Rab family GTPases in human cancer
    Wan Jie Chia
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochim Biophys Acta 1795:110-6. 2009
    ..We summarized here recent integrin on Rab25 and other Rabs implicated to be involved in a variety of human cancers, and discussed plausible mechanisms of how dysregulation of Rab expression could be tumorigenic or tumor suppressive...
  63. ncbi request reprint Structural characterization of the human Nogo-A functional domains. Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration
    Minfen Li
    Department of Biological Sciences, National University of Singapore, Singapore
    Eur J Biochem 271:3512-22. 2004
    ..Our results provide the first structural insights into Nogo-A functional domains and may have implications in further designs of peptide mimetics that would enhance CNS neuronal regeneration...
  64. ncbi request reprint Nogo signaling and non-physical injury-induced nervous system pathology
    Felicia Yu Hsuan Teng
    Department of Biochemistry and Neurobiology Programme, National University of Singapore, Republic of Singapore
    J Neurosci Res 79:273-8. 2005
    ..We speculate on possible linkages between the effect of aberrant elevation of Nogo levels and the signaling consequences that could lead to nervous system pathology...
  65. doi request reprint Rab GTPases regulating receptor trafficking at the late endosome-lysosome membranes
    Ee Ling Ng
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Cell Biochem Funct 30:515-23. 2012
    ..Better knowledge of EGFR and M6PR traffic in this regard may aid in understanding the pathological processes, such as oncogenic transformations associated with these receptors...
  66. pmc Sonic hedgehog as a chemoattractant for adult NPCs
    Catherine Hong Huan Hor
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Cell Adh Migr 4:1-3. 2010
    ..Functions of Shh in regulating the migration and survival of neural progenitor cells in the adult central nervous system are suggestive of its potential roles in neural regeneration and CNS oncogenesis...
  67. ncbi request reprint Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration
    Cherry Ee Lin Ng
    NCA Lab, Institute of Molecular and Cell Biology, Singapore, Republic of Singapore
    J Neurosci Res 67:559-65. 2002
    ..Together, these proteins provide new molecular handles for the design of therapeutic interventions for CNS injuries and neurodegenerative diseases, as well as possible leads to anticancer strategies...
  68. ncbi request reprint Environmental enrichment and neurodegenerative diseases
    Lingzhi Li
    Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochem Biophys Res Commun 334:293-7. 2005
    ..How all these findings would translate to disease settings in human patients are unclear, but they do provide useful leads for further clinical and paraclinical investigations...
  69. doi request reprint Unique intracellular trafficking processes associated with neural cell adhesion molecule and its intracellular signaling
    Yanan Chen
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore
    Cell Commun Adhes 17:69-74. 2010
    ..Here, the authors discuss these rather unique (though not without precedence and analogues) receptor trafficking activities that are associated with NCAM and NCAM signaling...
  70. ncbi request reprint Ultrastructural characterization of endoplasmic reticulum--Golgi transport containers (EGTC)
    Heinrich Horstmann
    Membrane Biology Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Republic of Singapore
    J Cell Sci 115:4263-73. 2002
    ....
  71. ncbi request reprint Neuritogenesis: polarization of constitutive exocytosis by effectors of Rho-family GTPases?
    Felicia Y H Teng
    NCA Lab, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
    Biochem Biophys Res Commun 294:923-5. 2002
    ..We discuss below, with some extrapolations, of what has recently come to light, and what more is needed to construct a coherent picture...
  72. ncbi request reprint Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions
    Ana Mingorance
    Development and Regeneration of the CNS, Barcelona Science Park IRBB, University of Barcelona, E 08028 Barcelona, Spain
    Mol Cell Neurosci 26:34-49. 2004
    ..In conclusion, our results show that Nogo and its receptor might play key roles during development of hippocampal connections and that they are implicated in neuronal plasticity in the adult...
  73. pmc Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization
    Du yu Nie
    Department of Clinical Research, Singapore General Hospital, Singapore
    EMBO J 22:5666-78. 2003
    ..Our results demonstrate that Nogo-A interacts in trans with axonal Caspr at CNS paranodes, an interaction that may have a role in modulating axon-glial junction architecture and possibly K(+)-channel localization during development...
  74. pmc Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network
    Guihua Tai
    Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Singapore
    Mol Biol Cell 15:4011-22. 2004
    ..Further studies indicated that syntaxin 5 and syntaxin 16 exerted their role in EE/RE-TGN transport in an additive manner. The kinetics of inhibition exhibited by syntaxin 16 and syntaxin 5 antibodies is similar...
  75. ncbi request reprint Nogo-66 and myelin-associated glycoprotein (MAG) inhibit the adhesion and migration of Nogo-66 receptor expressing human glioma cells
    Hong Liao
    Department of Clinical Research, Singapore General Hospital, Singapore
    J Neurochem 90:1156-62. 2004
    ..Nogo-66 and MAG may therefore modulate glioma growth and migration by acting through the NgR, a phenomenon that has potential therapeutic implications...
  76. pmc Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform
    Frédéric Mallard
    UMR144 Curie CNRS, Institut Curie, F 75248 Paris Cedex 05, France
    J Cell Biol 156:653-64. 2002
    ....
  77. doi request reprint Rab23 regulates differentiation of ATDC5 chondroprogenitor cells
    Liu Yang
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 283:10649-57. 2008
    ..Because the phenotypes of Rab23 mutations in mice and humans include defects in cartilage and bone development, our study suggests that Rab23 is involved in the control of Sox9 expression via Gli1 protein...