R Soong

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. pmc Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
    R Soong
    Oncology Research Institute, National University of Singapore, Singapore
    Ann Oncol 19:915-9. 2008
  2. pmc The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome
    R Soong
    Oncology Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Br J Cancer 100:676-9. 2009
  3. ncbi Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics
    Richie Soong
    National University of Singapore, Oncology Research Institute and Department of Pathology, 10 Medical Drive, MD11 Level 5, Singapore 117597, Republic of Singapore
    Pharmacogenomics 6:835-47. 2005
  4. doi Denaturing high performance liquid chromatography for the detection of microsatellite instability using bethesda and pentaplex marker panels
    Richie Soong
    Oncology Research Institute, National University of Singapore, 117456 Singapore
    Diagn Mol Pathol 17:127-33. 2008
  5. doi KRAS and BRAF mutation analysis can be reliably performed on aspirated cytological specimens of metastatic colorectal carcinoma
    N K B Pang
    Divisions of Cytopathology, Department of Pathology, National University Health System, Singapore
    Cytopathology 22:358-64. 2011
  6. pmc Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours
    M Salto-Tellez
    Department of Pathology, Yong Loo Lin Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore
    Br J Cancer 96:776-82. 2007
  7. ncbi RUNX3 protein is overexpressed in human basal cell carcinomas
    M Salto-Tellez
    Department of Pathology, National University Hospital, Yong Loo Lin Medical School, National University of Singapore NUS, Singapore, Singapore
    Oncogene 25:7646-9. 2006
  8. pmc Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study
    Feng Zhu
    Department of Medicine, National University of Singapore, Singapore, Singapore
    BMC Gastroenterol 9:76. 2009
  9. doi Meta-analysis of genetic polymorphisms and gastric cancer risk: variability in associations according to race
    Marie Loh
    Cancer Science Institute of Singapore, National University of Singapore, 28 Medical Drive, Center of Life Science Level 2, Singapore 117456, Singapore
    Eur J Cancer 45:2562-8. 2009
  10. doi CD133 expression predicts for non-response to chemotherapy in colorectal cancer
    Chee W Ong
    Department of Pathology, National University Health System and Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Mod Pathol 23:450-7. 2010

Collaborators

Detail Information

Publications32

  1. pmc Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
    R Soong
    Oncology Research Institute, National University of Singapore, Singapore
    Ann Oncol 19:915-9. 2008
    ..It is unclear whether this occurs because such tumours have better prognosis or they are more sensitive to 5-FU treatment...
  2. pmc The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome
    R Soong
    Oncology Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Br J Cancer 100:676-9. 2009
    ..025). These results support a role for RUNX3 as a tumour suppressor in colorectal cancer...
  3. ncbi Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics
    Richie Soong
    National University of Singapore, Oncology Research Institute and Department of Pathology, 10 Medical Drive, MD11 Level 5, Singapore 117597, Republic of Singapore
    Pharmacogenomics 6:835-47. 2005
    ..In this article, the current trends in FP pharmacogenetics and pharmacogenomics are reviewed based on the advances made to date and the challenges faced in realizing their full potential...
  4. doi Denaturing high performance liquid chromatography for the detection of microsatellite instability using bethesda and pentaplex marker panels
    Richie Soong
    Oncology Research Institute, National University of Singapore, 117456 Singapore
    Diagn Mol Pathol 17:127-33. 2008
    ..In conclusion, DHPLC provides a sensitive and specific alternative for routine MSI analysis that is free of the stutter peaks observed with CE and which can be used with either the Bethesda or pentaplex mononucleotide marker panels...
  5. doi KRAS and BRAF mutation analysis can be reliably performed on aspirated cytological specimens of metastatic colorectal carcinoma
    N K B Pang
    Divisions of Cytopathology, Department of Pathology, National University Health System, Singapore
    Cytopathology 22:358-64. 2011
    ..Most analyses are made on pretreatment biopsy or resection specimens. There is a scarcity of published studies on the suitability of cytological samples for KRAS testing in this setting...
  6. pmc Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours
    M Salto-Tellez
    Department of Pathology, Yong Loo Lin Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore
    Br J Cancer 96:776-82. 2007
    ....
  7. ncbi RUNX3 protein is overexpressed in human basal cell carcinomas
    M Salto-Tellez
    Department of Pathology, National University Hospital, Yong Loo Lin Medical School, National University of Singapore NUS, Singapore, Singapore
    Oncogene 25:7646-9. 2006
    ..Our results indicate that although the deregulation of Wnt signalling could contribute to the pathogenesis of a subset of BCC, RUNX3 appears to be a universal downstream mediator of a constitutively active Shh pathway in BCC...
  8. pmc Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study
    Feng Zhu
    Department of Medicine, National University of Singapore, Singapore, Singapore
    BMC Gastroenterol 9:76. 2009
    ..A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC...
  9. doi Meta-analysis of genetic polymorphisms and gastric cancer risk: variability in associations according to race
    Marie Loh
    Cancer Science Institute of Singapore, National University of Singapore, 28 Medical Drive, Center of Life Science Level 2, Singapore 117456, Singapore
    Eur J Cancer 45:2562-8. 2009
    ..Consolidated panels of polymorphisms associated with gastric cancer risk were identified in Asians and Caucasians. The results caution against the assumption that genetic risk factors are consistent between races...
  10. doi CD133 expression predicts for non-response to chemotherapy in colorectal cancer
    Chee W Ong
    Department of Pathology, National University Health System and Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Mod Pathol 23:450-7. 2010
    ..Our results show for the first time that CD133+ colorectal tumors are more resistant to 5-fluorouracil-based chemotherapy...
  11. doi The positive impact of cytological specimens for EGFR mutation testing in non-small cell lung cancer: a single South East Asian laboratory's analysis of 670 cases
    B Pang
    Cancer Science Institute, National University of Singapore, Singapore City, Singapore
    Cytopathology 23:229-36. 2012
    ..To assess the association between unsatisfactory outcomes and the quantity of DNA extracted from cytological versus histological samples...
  12. doi Detection of BRAF V600E mutation by pyrosequencing
    Yi Hui Tan
    Oncology Research Institute, National University of Singapore, Singapore
    Pathology 40:295-8. 2008
    ..Here we describe a method for detecting this mutation based upon pyrosequencing technology...
  13. ncbi A warfarin-dosing model in Asians that uses single-nucleotide polymorphisms in vitamin K epoxide reductase complex and cytochrome P450 2C9
    Lai San Tham
    Department of Haematology Oncology, National University Hospital, and Translational Interface, Oncology Research Institute, Singapore
    Clin Pharmacol Ther 80:346-55. 2006
    ..The aims of this study were to derive a pharmacogenetics-based dosing algorithm by use of retrospective information and to validate it through a data-splitting method in a separate cohort of equal size...
  14. doi RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression
    Manish Mani Subramaniam
    Oncology Research Institute, National University of Singapore, Singapore, Republic of Singapore
    Breast Cancer Res Treat 113:113-21. 2009
    ..Here, we hypothesize that inactivation of RUNX3 occurring in ductal carcinoma in situ (DCIS) represent early event in breast carcinogenesis...
  15. doi MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer
    Kin Wai Lai
    Cancer Science Institute of Singapore, Centre for Life Sciences 02 15, 28 Medical Drive, National University of Singapore, Singapore 117456, Singapore
    Eur J Cancer 46:1456-63. 2010
    ..Accumulating evidence indicates that RUNX3 is an important tumour suppressor that is inactivated in many cancer types. This study aimed to assess the role of microRNA (miRNA) in the regulation of RUNX3...
  16. doi Pharmacodynamic effects of seliciclib, an orally administered cell cycle modulator, in undifferentiated nasopharyngeal cancer
    Wen Son Hsieh
    Department of Hematology Oncology, National University Hospital, Oncology Research Institute, School of Computing, and Department of Head and Neck Surgery, National University of Singapore, Singapore
    Clin Cancer Res 15:1435-42. 2009
    ..The pharmacodynamic effects of seliciclib, a cyclin-dependent kinase (CDK) inhibitor, were studied in patients with nasopharyngeal carcinoma...
  17. doi RUNX3 inactivation in colorectal polyps arising through different pathways of colonic carcinogenesis
    Manish M Subramaniam
    Faculty of Medicine, Oncology Research Institute, National University of Singapore, Singapore
    Am J Gastroenterol 104:426-36. 2009
    ..We hypothesized that RUNX3 inactivation by promoter hypermethylation in colorectal polyps is an early molecular event in colorectal carcinogenesis...
  18. ncbi Interethnic variability of warfarin maintenance requirement is explained by VKORC1 genotype in an Asian population
    Soo Chin Lee
    Department of Haematology Oncology, National University Hospital, Oncology Research Institute, National University of Singapore, Singapore
    Clin Pharmacol Ther 79:197-205. 2006
    ..Vitamin K epoxide reductase complex 1 (VKORC1) is the target enzyme of warfarin, and VKORC1 intronic variants and haplotypes have recently been shown to influence VKORC1 activity and warfarin requirements...
  19. ncbi Detection of epidermal growth factor receptor variations by partially denaturing HPLC
    Tan Min Chin
    Department of Haematology and Oncology, National University Hospital, Singapore
    Clin Chem 53:62-70. 2007
    ..We have developed a partially denaturing HPLC (pDHPLC) assay that is superior to direct sequencing with respect to detection limits, costs, and time requirements...
  20. ncbi Implications of dihydropyrimidine dehydrogenase on 5-fluorouracil pharmacogenetics and pharmacogenomics
    Lori K Mattison
    Department of Pharmacology and Toxicology, Room 101, Volker Hall, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Pharmacogenomics 3:485-92. 2002
    ..This article reviews the basis and discusses the challenges of pharmacogenetic and pharmacogenomic testing of DPD for the determination of 5-FU efficacy and toxicity...
  21. ncbi Identification of potentially useful combinations of epidermal growth factor receptor tyrosine kinase antagonists with conventional cytotoxic agents using median effect analysis
    Daniel R Budman
    Experimental Therapeutics Section, Don Monti Division of Oncology, North Shore University Hospital, New York University, Manhasset, NY, USA
    Anticancer Drugs 17:921-8. 2006
    ..These experiments suggest further studies of the dual kinase inhibitor with selected cytotoxics such as 5'-deoxy-5-fluorouridine are warranted...
  22. ncbi Quantification of CK20 gene and protein expression in colorectal cancer by RT-PCR and immunohistochemistry reveals inter- and intratumour heterogeneity
    Silke Lassmann
    Pathologisches Institut, Universitatsklinikum Freiburg, Albertstrasse 19, 79104 Freiburg, Germany
    J Pathol 198:198-206. 2002
    ..This suggests a promising supportive role for quantitative RT-PCR in molecular pathology...
  23. ncbi Capecitabine induces rapid, sustained response in two patients with extensive oral verrucous carcinoma
    Anastasios Salesiotis
    Lombardi Cancer Center, Georgetown University, Washington DC 20007, USA
    Clin Cancer Res 9:580-5. 2003
    ..We describe rapid and dramatic response to oral capecitabine in two patients with advanced refractory VC...
  24. ncbi Improved indicators for assessing the reliability of detection and quantification by kinetic PCR
    Richie Soong
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Clin Chem 49:973-6. 2003
  25. ncbi E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7
    William M Boedefeld
    Department of Surgery, University of Alabama at Birmingham, 35243, USA
    Mol Carcinog 43:13-7. 2005
    ..These results suggest E1A-F is overexpressed in early stages of human CRC development and may be an important factor in the overexpression of COX-2 and MMP-7...
  26. ncbi Simultaneous detection of variable number tandem repeats, single nucleotide polymorphisms, and allelic imbalance in the thymidylate synthase gene enhancer region using denaturing high-performance liquid chromatography
    Hany Ezzeldin
    Department of Clinical Pharmacology, University of Alabama at Birmingham, Comprehensive Cancer Center, Birmingham, AL 35294, USA
    Anal Biochem 334:276-83. 2004
    ..This DHPLC method was developed to permit the rapid, sensitive, and accurate identification of the TSER genotype (VNTRs, SNPs, and AI) in clinical protocols where response to flouropyrimidines may be correlated with TSER polymorphisms...
  27. ncbi Dasatinib induces a response in malignant thymoma
    Charles Chuah
    J Clin Oncol 24:e56-8. 2006
  28. doi An improved quality control for bisulfite-PCR-based DNA methylation analysis: cycle threshold value
    Pei Woon Ang
    School of Surgery, University of Western Australia, Nedlands, Australia
    Clin Chem Lab Med 46:1117-21. 2008
    ..Here, we tested whether cycle threshold (Ct) values from real-time quantitative PCR correlate better with the reliability of bisulfite-PCR methylation analyses than spectrophotometric concentrations...
  29. pmc Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer
    Martin J Heslin
    Surgical Oncology Research Laboratory, Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Ann Surg 241:941-6; discussion 946-7. 2005
    ..Also, to evaluate the expression of 15-LOX-1 in human normal mucosa, adenoma, and carcinoma with correlation to overall survival...
  30. ncbi Phase II evaluation of docetaxel-modulated capecitabine in previously treated patients with non-small cell lung cancer
    Tamila Kindwall-Keller
    Division of Hematology Oncology, Arthur G James Cancer Hospital, Ohio State University, 320 West Tenth Avenue, Columbus, OH 43210, USA
    Clin Cancer Res 11:1870-6. 2005
    ....
  31. ncbi Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression
    Xue Zhang
    Mayo Clinic Cancer Center, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Biochem Cell Biol 85:337-46. 2007
    ..This may also provide insight into the mechanism underlying the downregulation of DPYD in some colorectal cancers...
  32. ncbi Effect of blood sample handling and reverse transcriptase-polymerase chain reaction assay sensitivity on detection of CK20 expression in healthy donor blood
    Femke Vlems
    Department of Surgery, UMC St Radboud, Nijmegen, The Netherlands
    Diagn Mol Pathol 11:90-7. 2002
    ..Quantitative analysis revealed that CK20 was expressed at a high level in the granulocyte samples. The results demonstrate that differences in assay sensitivity and sample handling influence CK20 detection in blood...