Toan Thang Phan

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi request reprint Smad3 signalling plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions
    T T Phan
    Department of Surgery, National University of Singapore, Singapore
    J Pathol 207:232-42. 2005
  2. ncbi request reprint Dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring
    Toan Thang Phan
    Department of Plastic Surgery, Singapore General Hospital, National University of Singapore
    J Trauma 54:1212-24. 2003
  3. ncbi request reprint Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars
    Toan Thang Phan
    Department of Plastic Surgery, Singapore General Hospital
    J Trauma 57:1032-7. 2004
  4. ncbi request reprint Evaluation of cell culture on the polyurethane-based membrane (Tegaderm): implication for tissue engineering of skin
    T T Phan
    Department of Plastic Surgery, Singapore General Hospital, Republic of Singapore
    Cell Tissue Bank 6:91-7. 2005
  5. ncbi request reprint Fibroblasts cocultured with keloid keratinocytes: normal fibroblasts secrete collagen in a keloidlike manner
    Ivor Jiun Lim
    Division of Plastic Surgery, Department of Surgery, National University of Singapore, Singapore 119074
    Am J Physiol Cell Physiol 283:C212-22. 2002
  6. ncbi request reprint Differences in collagen production between normal and keloid-derived fibroblasts in serum-media co-culture with keloid-derived keratinocytes
    Toan Thang Phan
    Department of Plastic Surgery, Singapore General Hospital, Singapore
    J Dermatol Sci 29:26-34. 2002
  7. doi request reprint Umbilical cord lining stem cells as a novel and promising source for ocular surface regeneration
    Hasan Mahmud Reza
    Singapore Eye Research Institute, Singapore, Singapore
    Stem Cell Rev 7:935-47. 2011
  8. doi request reprint Keloid fibroblasts are more sensitive to Wnt3a treatment in terms of elevated cellular growth and fibronectin expression
    Alvin Wen Choong Chua
    Skin Bank Unit, Singapore General Hospital, Singapore
    J Dermatol Sci 64:199-209. 2011
  9. ncbi request reprint Upregulation of secretory connective tissue growth factor (CTGF) in keratinocyte-fibroblast coculture contributes to keloid pathogenesis
    Ying Ting Khoo
    Department of Surgery, National University of Singapore, Singapore
    J Cell Physiol 208:336-43. 2006
  10. doi request reprint Metabolically functional hepatocyte-like cells from human umbilical cord lining epithelial cells
    Han Hui Cheong
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Assay Drug Dev Technol 11:130-8. 2013

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Smad3 signalling plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions
    T T Phan
    Department of Surgery, National University of Singapore, Singapore
    J Pathol 207:232-42. 2005
    ..This finding suggests the suppression of Smad signalling as a novel approach in keloid therapy...
  2. ncbi request reprint Dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring
    Toan Thang Phan
    Department of Plastic Surgery, Singapore General Hospital, National University of Singapore
    J Trauma 54:1212-24. 2003
    ..The phytochemical compounds are well known as potential anticancer agents. We have investigated the inhibitory effects of compounds on keloid fibroblasts (KF) and hypertrophic scar-derived fibroblasts (HSF)...
  3. ncbi request reprint Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars
    Toan Thang Phan
    Department of Plastic Surgery, Singapore General Hospital
    J Trauma 57:1032-7. 2004
    ..This study assessed the effects of quercetin on the transforming growth factor (TGF)-beta/Smad-signaling pathway in keloid-derived fibroblasts, which may be an important biologic mechanism of this proliferative scarring...
  4. ncbi request reprint Evaluation of cell culture on the polyurethane-based membrane (Tegaderm): implication for tissue engineering of skin
    T T Phan
    Department of Plastic Surgery, Singapore General Hospital, Republic of Singapore
    Cell Tissue Bank 6:91-7. 2005
    ..In this study, we evaluate cell culture characteristics of three different cell types, human epidermal keratinocytes, human dermal fibroblasts and pig bone marrow mesenchymal stem cells on Tegaderm membrane...
  5. ncbi request reprint Fibroblasts cocultured with keloid keratinocytes: normal fibroblasts secrete collagen in a keloidlike manner
    Ivor Jiun Lim
    Division of Plastic Surgery, Department of Surgery, National University of Singapore, Singapore 119074
    Am J Physiol Cell Physiol 283:C212-22. 2002
    ....
  6. ncbi request reprint Differences in collagen production between normal and keloid-derived fibroblasts in serum-media co-culture with keloid-derived keratinocytes
    Toan Thang Phan
    Department of Plastic Surgery, Singapore General Hospital, Singapore
    J Dermatol Sci 29:26-34. 2002
    ..Taken with previous results, this study demonstrates a good correlation between both serum and serum-free co-culture systems, and supports the significance of epithelial-mesenchymal interactions in keloid pathogenesis...
  7. doi request reprint Umbilical cord lining stem cells as a novel and promising source for ocular surface regeneration
    Hasan Mahmud Reza
    Singapore Eye Research Institute, Singapore, Singapore
    Stem Cell Rev 7:935-47. 2011
    ..Our results suggest that CLEC-muc is a novel stem cell that can be ex vivo expanded for corneal epithelial regeneration in the treatment of various eye diseases...
  8. doi request reprint Keloid fibroblasts are more sensitive to Wnt3a treatment in terms of elevated cellular growth and fibronectin expression
    Alvin Wen Choong Chua
    Skin Bank Unit, Singapore General Hospital, Singapore
    J Dermatol Sci 64:199-209. 2011
    ..We hypothesize that Wnt signalling is upregulated in keloid fibroblasts (KFs) and this promotes cellular growth, migration and extracellular matrix (ECM) production in such fibroblasts...
  9. ncbi request reprint Upregulation of secretory connective tissue growth factor (CTGF) in keratinocyte-fibroblast coculture contributes to keloid pathogenesis
    Ying Ting Khoo
    Department of Surgery, National University of Singapore, Singapore
    J Cell Physiol 208:336-43. 2006
    ..Thus, revealing the therapeutic potentials for inhibitors that are selective for these factors in controlling CTGF expression in fibrotic conditions...
  10. doi request reprint Metabolically functional hepatocyte-like cells from human umbilical cord lining epithelial cells
    Han Hui Cheong
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Assay Drug Dev Technol 11:130-8. 2013
    ..After 4 h of incubation with testosterone, UPLC/MS/MS detected 2α-, 6β-, 15β-, and 16β-hydroxytestosterone. UCLECs are able to differentiate into HLCs that express liver-specific markers, and have functional metabolic capabilities...
  11. doi request reprint Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro
    Pearl P C Toh
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Exp Dermatol 19:987-93. 2010
    ..It would appear that down-regulation of MT isoforms in proliferating KF, in particular MT-2A, enhances keloidogenesis with the possible involvement of the NF-κB signalling pathway...
  12. doi request reprint Characterization of a novel umbilical cord lining cell with CD227 positivity and unique pattern of P63 expression and function
    Hasan Mahmud Reza
    Singapore Eye Research Institute, Singapore, Singapore
    Stem Cell Rev 7:624-38. 2011
    ..Our results suggest that CLEC-muc is a novel stem cell-like population that can be further differentiated by BMP4 to generate specific cell-types probably destined to form non-keratinized epithelia...
  13. ncbi request reprint Characterization of human umbilical cord lining-derived epithelial cells and transplantation potential
    Yue Zhou
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Cell Transplant 20:1827-41. 2011
    ..This study has characterized the immunological properties of CLECs and tested a potential therapeutic application in the treatment of a type 1 diabetes mouse model...
  14. pmc Biosafety assessment of site-directed transgene integration in human umbilical cord-lining cells
    Jaichandran Sivalingam
    Division of Medical Sciences, Laboratory of Applied Human Genetics, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore, Republic of Singapore
    Mol Ther 18:1346-56. 2010
    ..Pre-evaluated clonal populations of phiC31 integrase-modified CLECs could be useful as bioimplants for monogenic diseases such as hemophilia...
  15. ncbi request reprint Directing stem cells into the keratinocyte lineage in vitro
    Boon Chin Heng
    Stem Cell Laboratory, Faculty of Dentistry, National University of Singapore, Singapore
    Exp Dermatol 14:1-16. 2005
    ..Hence, this review critically examines the various strategies that could be employed to direct the commitment and differentiation of stem cells into the keratinocyte lineage in vitro...
  16. pmc Insights gained from the reverse engineering of gene networks in keloid fibroblasts
    Brandon N S Ooi
    Graduate Programme in Bioengineering, National University of Singapore, Singapore
    Theor Biol Med Model 8:13. 2011
    ..This study aims to highlight some of the issues involved in working with experimental data, and at the same time gain some insights into the transcriptional regulatory mechanism present in keloid fibroblasts...
  17. ncbi request reprint Epithelial and mesenchymal stem cells from the umbilical cord lining membrane
    Ivor J Lim
    Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore CellResearch Corporation Pte Ltd, Singapore
    Cell Transplant 23:497-503. 2014
    ..Cord lining stem cells are strongly positioned to be the future of cell therapy and regenerative medicine. ..