Genomes and Genes


Siok Bian Ng


Affiliation: National University of Singapore
Country: Singapore


  1. Ng S, Chung T, Kato S, Nakamura S, Takahashi E, Ko Y, et al. Epstein-Barr virus-associated primary nodal T/NK-cell lymphoma shows a distinct molecular signature and copy number changes. Haematologica. 2018;103:278-287 pubmed publisher
    ..Upregulation of PD-L1 indicates that it may be possible to use anti-PD1 immunotherapy in this distinctive entity. In addition, loss of 14q11.2 may be a potentially useful diagnostic marker of T-cell lineage. ..
  2. de Mel S, Hue S, Jeyasekharan A, Chng W, Ng S. Molecular pathogenic pathways in extranodal NK/T cell lymphoma. J Hematol Oncol. 2019;12:33 pubmed publisher
  3. Hong G, Fan S, Phyu T, Maheshwari P, Hoppe M, Phuong H, et al. Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma. J Vis Exp. 2019;: pubmed publisher
    ..Multiplexing minimizes sample utilization and provides spatial information for each marker of interest. ..
  4. de Mel S, Soon G, Mok Y, Chung T, Jeyasekharan A, Chng W, et al. The Genomics and Molecular Biology of Natural Killer/T-Cell Lymphoma: Opportunities for Translation. Int J Mol Sci. 2018;19: pubmed publisher
    ..Herein, we present an overview of the molecular biology and genomic landscape of ENKTL with a focus on the most promising translational opportunities. ..
  5. Ng S, Ohshima K, Selvarajan V, Huang G, Choo S, Miyoshi H, et al. Prognostic implication of morphology, cyclinE2 and proliferation in EBV-associated T/NK lymphoproliferative disease in non-immunocompromised hosts. Orphanet J Rare Dis. 2014;9:165 pubmed publisher
    ..High cyclin E2 expression was also significantly associated with shorter survival (p = 0.0002). Our data suggests the potential role of monomorphic morphology, high cyclin E2 and Ki67 expression as adverse prognostic factors for TNKLPD. ..