M-L Ng

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. pmc Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage
    Karen Caiyun Chen
    Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, MD4, 5 Science Drive 2, Singapore 117597, Singapore
    Virol J 10:169. 2013
  2. pmc Molecular profiling of T-helper immune genes during dengue virus infection
    Jincheng Chen
    Department of Microbiology, Yong Loo Lin School of Medicine, 5 Science Drive 2, National University of Singapore, 117597 Singapore
    Virol J 5:165. 2008
  3. ncbi request reprint Transport and budding at two distinct sites of visible nucleocapsids of West Nile (Sarafend) virus
    M L Ng
    Department of Microbiology, National University of Singapore, Singapore
    J Med Virol 65:758-64. 2001
  4. pmc Topographic changes in SARS coronavirus-infected cells at late stages of infection
    M L Ng
    Department of Microbiology, National University of Singapore, Singapore
    Emerg Infect Dis 10:1907-14. 2004
  5. ncbi request reprint Proliferative growth of SARS coronavirus in Vero E6 cells
    M L Ng
    Department of Microbiology, 5 Science Drive 2, National University of Singapore, 117597, Singapore
    J Gen Virol 84:3291-303. 2003
  6. ncbi request reprint Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes)
    Mah Lee Ng
    Department of Microbiology, National University of Singapore, Singapore
    J Altern Complement Med 8:581-9. 2002
  7. ncbi request reprint Early events of SARS coronavirus infection in vero cells
    M L Ng
    Department of Microbiology, Faculty of Medicine, 5 Science Drive 2, National University of Singapore, Singapore 117597
    J Med Virol 71:323-31. 2003
  8. ncbi request reprint The glycosylation site in the envelope protein of West Nile virus (Sarafend) plays an important role in replication and maturation processes
    J Li
    Flavivirology Laboratory, Department of Microbiology, 5 Science Drive 2, National University of Singapore, Singapore 117597
    J Gen Virol 87:613-22. 2006
  9. ncbi request reprint Identifying the region influencing the cis-mode of maturation of West Nile (Sarafend) virus using chimeric infectious clones
    J Li
    Flavivirology Laboratory, Department of Microbiology, National University of Singapore, Singapore 117597, Singapore
    Biochem Biophys Res Commun 334:714-20. 2005
  10. ncbi request reprint Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein
    J J H Chu
    Flavivirology Laboratory, Department of Microbiology, 5 Science Drive 2, National University of Singapore, Singapore 117597, Singapore
    J Gen Virol 86:405-12. 2005

Collaborators

  • J Li
  • Yee Joo Tan
  • Justin Jang Hann Chu
  • Karen Caiyun Chen
  • Jincheng Chen
  • Jang Hann J Chu
  • Sehaam Khan
  • Jason Wei Ming Lee
  • J J H Chu
  • Raghavan Bhuvanakantham
  • Wee Lee Koh
  • Yiu Wing Kam
  • Raymond Tzer Pin Lin
  • Lisa Fp Ng
  • Cern Cher S Chiang
  • R Bhuvanakantham
  • R Rajamanonmani
  • J Lescar

Detail Information

Publications16

  1. pmc Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage
    Karen Caiyun Chen
    Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, MD4, 5 Science Drive 2, Singapore 117597, Singapore
    Virol J 10:169. 2013
    ..A comparative analysis of the genomic and replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central and South African (ECSA) lineage was performed...
  2. pmc Molecular profiling of T-helper immune genes during dengue virus infection
    Jincheng Chen
    Department of Microbiology, Yong Loo Lin School of Medicine, 5 Science Drive 2, National University of Singapore, 117597 Singapore
    Virol J 5:165. 2008
    ..Profiling genes obtained from this study may serve as potential biomarkers and the modulation of Th immune responses during dengue virus infection has important implications in disease outcome...
  3. ncbi request reprint Transport and budding at two distinct sites of visible nucleocapsids of West Nile (Sarafend) virus
    M L Ng
    Department of Microbiology, National University of Singapore, Singapore
    J Med Virol 65:758-64. 2001
    ..Although maturation at the plasma membrane was the dominant mode, during late infection, intracellular maturation into large vacuoles was also observed...
  4. pmc Topographic changes in SARS coronavirus-infected cells at late stages of infection
    M L Ng
    Department of Microbiology, National University of Singapore, Singapore
    Emerg Infect Dis 10:1907-14. 2004
    ..Thickening of the actin filaments at the cell edge provided the bending force to extrude the virus particles...
  5. ncbi request reprint Proliferative growth of SARS coronavirus in Vero E6 cells
    M L Ng
    Department of Microbiology, 5 Science Drive 2, National University of Singapore, 117597, Singapore
    J Gen Virol 84:3291-303. 2003
    ..By 24 to 30 h p.i., crystalline arrays of the extracellular virus particles were seen commonly at the cell surface...
  6. ncbi request reprint Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes)
    Mah Lee Ng
    Department of Microbiology, National University of Singapore, Singapore
    J Altern Complement Med 8:581-9. 2002
    ..The goal is to document whether the efficacy of the antitumor property is still expressed through this route of administration...
  7. ncbi request reprint Early events of SARS coronavirus infection in vero cells
    M L Ng
    Department of Microbiology, Faculty of Medicine, 5 Science Drive 2, National University of Singapore, Singapore 117597
    J Med Virol 71:323-31. 2003
    ..These could be the virus genomes together with the helical nucleocapsids. They were no longer in large vacuoles but packaged into smaller vacuoles in the cytoplasm, and occasionally in small groups...
  8. ncbi request reprint The glycosylation site in the envelope protein of West Nile virus (Sarafend) plays an important role in replication and maturation processes
    J Li
    Flavivirology Laboratory, Department of Microbiology, 5 Science Drive 2, National University of Singapore, Singapore 117597
    J Gen Virol 87:613-22. 2006
    ..This defect was corrected by the expression of wild-type envelope protein in trans. The pWNS-S154A virus matured intracellularly instead of at the plasma membrane as shown for the parental WN(S)V...
  9. ncbi request reprint Identifying the region influencing the cis-mode of maturation of West Nile (Sarafend) virus using chimeric infectious clones
    J Li
    Flavivirology Laboratory, Department of Microbiology, National University of Singapore, Singapore 117597, Singapore
    Biochem Biophys Res Commun 334:714-20. 2005
    ..Transmission electron microscopy analyses performed in Vero cells infected with these chimeric viruses disclosed that the 5' end of the WN(S)V genome plays a major role in influencing the process of maturation at the plasma membrane...
  10. ncbi request reprint Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein
    J J H Chu
    Flavivirology Laboratory, Department of Microbiology, 5 Science Drive 2, National University of Singapore, Singapore 117597, Singapore
    J Gen Virol 86:405-12. 2005
    ..The data also suggest that similar attachment molecule(s) or receptor(s) were used by WNV and Den 2 virus for entry into C6/36 mosquito cells...
  11. ncbi request reprint Immunization of flavivirus West Nile recombinant envelope domain III protein induced specific immune response and protection against West Nile virus infection
    Jang Hann J Chu
    Flavivirology Laboratory, Department of Microbiology, 5 Science Drive 2, National University of Singapore, Singapore 117597
    J Immunol 178:2699-705. 2007
    ..Overall, this study highlighted that recombinant WNV E DIII protein delivered in combination with CpG adjuvant to mice generated a Th1 immune response type against WNV and can serve as a potential vaccine to prevent WNV infection...
  12. ncbi request reprint Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells
    Justin Jang Hann Chu
    Flavivirology Laboratory, Department of Microbiology, 5 Science Drive 2, National University of Singapore, Singapore 117597
    J Biol Chem 279:54533-41. 2004
    ..The identification of alpha(v)beta(3) integrin as a receptor for WNV provides insight into virus-receptor interaction, hence creating opportunities in the development of anti-viral strategies against WNV infection...
  13. ncbi request reprint Expression of the severe acute respiratory syndrome coronavirus 3a protein and the assembly of coronavirus-like particles in the baculovirus expression system
    Sehaam Khan
    Collaborative Antiviral Research Group, Institute of Molecular and Cell Biology, Proteos, Singapore
    Methods Mol Biol 379:35-50. 2007
    ..Expression of viral proteins was confirmed by Western blot analysis and the formation of VLPs was studied by transmission electron microscopy...
  14. ncbi request reprint Quantifying the specific binding between West Nile virus envelope domain III protein and the cellular receptor alphaVbeta3 integrin
    Jason Wei Ming Lee
    Flavivirology Laboratory, Department of Microbiology, National University of Singapore, Singapore 117597
    J Biol Chem 281:1352-60. 2006
    ..These experiments provided an insight to quantitate virus-receptor interaction. Force measurement using atomic force microscopy can serve to quantitatively analyze the effect of candidate drugs that modulate virus-host receptor affinity...
  15. ncbi request reprint Analysis of self-association of West Nile virus capsid protein and the crucial role played by Trp 69 in homodimerization
    Raghavan Bhuvanakantham
    Flavivirology Laboratory, Department of Microbiology, 5 Science Drive 2, National University of Singapore, Singapore 117597, Singapore
    Biochem Biophys Res Commun 329:246-55. 2005
    ..The results of this study pinpoint a critical residue in the C protein that potentially plays a role in stabilizing the homotypic interaction...
  16. pmc Molecular mechanisms of West Nile virus pathogenesis in brain cell
    Wee Lee Koh
    National University of Singapore, Singapore
    Emerg Infect Dis 11:629-32. 2005
    ..These changes may be useful as potential biomarkers and elucidate novel mechanisms behind the neuropathology of infection with this virus...