Research Topics
| John M LukSummaryAffiliation: National University of Singapore Country: Singapore Publications
| Collaborators
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Detail Information
Publications
A protein-based set of reference markers for liver tissues and hepatocellular carcinomaStella Sun
Department of Surgery, LKS Faculty of Medicine, Jockey Club Clinical Research Centre, The University of Hong Kong, Pokfulam, Hong Kong
BMC Cancer 9:309. 2009..This is the first study employed 2-DE analysis to screen for potential reference markers and aims to correlate the abundance of these proteins with their level of transcript expression...- Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parametersKe Hao
1Rosetta Inpharmatics LLC, Merck Research Laboratories, Seattle, WA, USA
BMC Cancer 9:389. 2009..However, the results are not consistent due to lack of systemic approach to establish a prediction model incorporating all these parameters... - Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein markerLei Chen
Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
Ann Surg Oncol 17:2518-25. 2010..We applied SELDI-TOF-MS ProteinChip technology to identify serum profile for distinguishing HCC and liver cirrhosis (LC) and to compare the accuracy of SELDI-TOF-MS profile and alpha-fetoprotein (AFP) level in HCC diagnosis... - DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survivalJohn M Luk
Cancer Science Institute and Department of Pharmacology, National University of Singapore, 117597, Singapore
J Biol Chem 286:30706-13. 2011..In conclusion, our findings suggest that coordinate up-regulation of the DLK1-DIO3 miRNA cluster at 14q32.2 may define a novel molecular (stem cell-like) subtype of HCC associated with poor prognosis... 
Proteomics of hepatocellular carcinoma in Chinese patientsJohn M Luk
Department of Pharmacology, Cancer Science Institute, National University of Singapore, Singapore
OMICS 15:261-6. 2011....- Global regulation on microRNA in hepatitis B virus-associated hepatocellular carcinomaAngela M Liu
Department of Pharmacology, Cancer Science Institute, National University of Singapore, Singapore
OMICS 15:187-91. 2011..This study provides molecular clues that may contribute to the global changes of miRNA expression in HCC... - Discovery of lamin B1 and vimentin as circulating biomarkers for early hepatocellular carcinomaKwong Fai Wong
Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
Methods Mol Biol 909:295-310. 2012..Focus is emphasized on the methods for sample preservation and low-abundance protein enrichment... - Regulators of mammalian Hippo pathway in cancerAngela M Liu
Department of Pharmacology, National University of Singapore, Singapore
Biochim Biophys Acta 1826:357-64. 2012..Understanding of the mammalian Hippo pathway regulation may shed new insights to allow us selecting the right oncogenic targets and designing effective drugs for cancer treatments... - Osteopontin as potential biomarker and therapeutic target in gastric and liver cancersDong xing Cao
Dong Xing Cao, Zhi Jie Li, Xiao Ou Jiang, Yick Liang Lum, Ester Khin, John M Luk, Department of Pharmacology and Department of Surgery, National University Health System, National University of Singapore, Singapore 117597, Singapore
World J Gastroenterol 18:3923-30. 2012..Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies... - Targeting YAP and Hippo signaling pathway in liver cancerAngela M Liu
Department of Pharmacology, National University of Singapore, 117597, Singapore
Expert Opin Ther Targets 14:855-68. 2010..Recently, YAP has been implicated as a bona fide oncogene in solid tumors, but little is known about its exact molecular mechanism in carcinogenesis... - Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivoPeramaiyan Rajendran
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
Cancer Prev Res (Phila) 5:631-43. 2012..Overall, our results suggest for the first time that celastrol exerts its antiproliferative and proapoptotic effects through suppression of STAT3 signaling in HCC both in vitro and in vivo... - Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agentsKwong Fai Wong
Cancer Science Institute of SingaporeDepartments of PharmacologySurgery, National University Health System, National University of Singapore, Singapore
Clin Exp Pharmacol Physiol 39:311-20. 2012..5. Triptolide derivatives with improved water solubility have emerged as promising drug candidates. Clinical trials are being conducted on the derivatives to provide encyclopaedic knowledge on triptolide pharmacokinetics in patients... - An update on targeting Hippo-YAP signaling in liver cancerAngela M Liu
Department of Oncology, Nanjing Medical University, Nanjing, China
Expert Opin Ther Targets 16:243-7. 2012..This knowledge provides a basis for rational design of therapeutics against cancer that depends upon Hippo-YAP signaling for growth... - Prophylactic uses of integrin CD18-betaA peptide in a murine polymicrobial peritonitis modelKwong Fai Wong
Department of Pharmacology and Surgery, National University Hospital System, National University of Singapore, Singapore 117597, Singapore
World J Gastroenterol 16:2648-56. 2010..To evaluate the prophylactic properties of integrin CD18-betaA peptide in a murine model of abdominal polymicrobial peritonitis and sepsis...