S G Lim

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi request reprint Viral quasi-species evolution during hepatitis Be antigen seroconversion
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, National University Hospital, Singapore
    Gastroenterology 133:951-8. 2007
  2. doi request reprint Telbivudine: a hepatitis B-specific antiviral
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, National University Hospital, Department of Medicine, Yong Yoo Lin School of Medicine, National University of Singapore, Singapore and Principal Investigator, Immunovirology Group, Centre for Molecular Medicine, Co principal investigator, Institute of Molecular and Cell Biology, Biopolis, Singapore
    Expert Rev Clin Pharmacol 1:217-29. 2008
  3. ncbi request reprint Patient preferences for hepatitis B therapy
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, National University Health System, Singapore
    Antivir Ther 18:663-70. 2013
  4. pmc Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma
    Weijie Poh
    Department of Pharmacy, National University of Singapore, Singapore
    Mol Cancer 11:14. 2012
  5. ncbi request reprint Clinical trial: effects of adefovir dipivoxil therapy in Asian and Caucasian patients with chronic hepatitis B
    S G Lim
    National University Hospital, Singapore
    Aliment Pharmacol Ther 26:1419-28. 2007
  6. ncbi request reprint Referral patterns and waiting times for liver transplantation in Singapore
    S G Lim
    Department of Gastroenterology and Hepatology, National University Hospital, 5 Lower Kent Ridge Road, Singapore
    Singapore Med J 47:599-603. 2006
  7. ncbi request reprint A randomized, placebo-controlled trial of thymosin-alpha1 and lymphoblastoid interferon for HBeAg-positive chronic hepatitis B
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, National University Hospital, Singapore
    Antivir Ther 11:245-53. 2006
  8. ncbi request reprint Use of an in vitro model and yeast two-hybrid system to investigate the pathogenesis of hepatitis C
    Seng Gee Lim
    Institute of Molecular and Cell Biology, Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, 119074 Singapore, Singapore
    Intervirology 49:44-50. 2006
  9. doi request reprint Clinical trial: a phase II, randomized study evaluating the safety, pharmacokinetics and anti-viral activity of clevudine for 12 weeks in patients with chronic hepatitis B
    S G Lim
    Department of Gastroenterology and Hepatology, National University Hospital, Yong Yoo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Rd, Singapore 119074
    Aliment Pharmacol Ther 27:1282-92. 2008
  10. doi request reprint Clinical outcomes of lamivudine-adefovir therapy in chronic hepatitis B cirrhosis
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, Yong Yoo Lin School of Medicine, National University of Singapore, Singapore
    J Clin Gastroenterol 45:818-23. 2011

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Viral quasi-species evolution during hepatitis Be antigen seroconversion
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, National University Hospital, Singapore
    Gastroenterology 133:951-8. 2007
    ....
  2. doi request reprint Telbivudine: a hepatitis B-specific antiviral
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, National University Hospital, Department of Medicine, Yong Yoo Lin School of Medicine, National University of Singapore, Singapore and Principal Investigator, Immunovirology Group, Centre for Molecular Medicine, Co principal investigator, Institute of Molecular and Cell Biology, Biopolis, Singapore
    Expert Rev Clin Pharmacol 1:217-29. 2008
    ..Thus, telbivudine is a useful addition to the current landscape of hepatitis B therapeutic agents. ..
  3. ncbi request reprint Patient preferences for hepatitis B therapy
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, National University Health System, Singapore
    Antivir Ther 18:663-70. 2013
    ..Little is known about patient preferences for selection of chronic hepatitis B (CHB) treatment. This issue is important as it affects the therapeutic choices available for patients and, in the long term, the health of CHB patients...
  4. pmc Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma
    Weijie Poh
    Department of Pharmacy, National University of Singapore, Singapore
    Mol Cancer 11:14. 2012
    ..Here, we studied the mechanistic role of its co-receptor klotho-beta (KLB) in driving elevated FGFR4 activity in HCC progression...
  5. ncbi request reprint Clinical trial: effects of adefovir dipivoxil therapy in Asian and Caucasian patients with chronic hepatitis B
    S G Lim
    National University Hospital, Singapore
    Aliment Pharmacol Ther 26:1419-28. 2007
    ..Two-thirds of the 350 million people infected with chronic hepatitis B virus live in the Asia-Pacific region. AIM To compare the effects of adefovir dipivoxil therapy between Asian and Caucasian patients with chronic hepatitis B...
  6. ncbi request reprint Referral patterns and waiting times for liver transplantation in Singapore
    S G Lim
    Department of Gastroenterology and Hepatology, National University Hospital, 5 Lower Kent Ridge Road, Singapore
    Singapore Med J 47:599-603. 2006
    ..This paper aims to review these parameters in the Singapore National Liver Transplant Programme...
  7. ncbi request reprint A randomized, placebo-controlled trial of thymosin-alpha1 and lymphoblastoid interferon for HBeAg-positive chronic hepatitis B
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, National University Hospital, Singapore
    Antivir Ther 11:245-53. 2006
    ..8% improvement in HBeAg loss rates using combination therapy over interferon monotherapy. This could clinically indicate a potential important difference that would need confirmation in subsequent trials...
  8. ncbi request reprint Use of an in vitro model and yeast two-hybrid system to investigate the pathogenesis of hepatitis C
    Seng Gee Lim
    Institute of Molecular and Cell Biology, Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, 119074 Singapore, Singapore
    Intervirology 49:44-50. 2006
    ..These studies allow us to examine the pathogenesis of HCV infection in more detail...
  9. doi request reprint Clinical trial: a phase II, randomized study evaluating the safety, pharmacokinetics and anti-viral activity of clevudine for 12 weeks in patients with chronic hepatitis B
    S G Lim
    Department of Gastroenterology and Hepatology, National University Hospital, Yong Yoo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Rd, Singapore 119074
    Aliment Pharmacol Ther 27:1282-92. 2008
    ..Clevudine is a polymerase inhibitor that has the unusual feature of delayed viral rebound after therapy in some patients which may be related to its pharmacokinetics...
  10. doi request reprint Clinical outcomes of lamivudine-adefovir therapy in chronic hepatitis B cirrhosis
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, Yong Yoo Lin School of Medicine, National University of Singapore, Singapore
    J Clin Gastroenterol 45:818-23. 2011
    ..To determine the clinical outcome of chronic hepatitis B cirrhotics on antiviral therapy...
  11. pmc Fatal hepatitis B reactivation following discontinuation of nucleoside analogues for chronic hepatitis B
    S G Lim
    Division of Gastroenterology, Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Gut 51:597-9. 2002
    ....
  12. doi request reprint Prevention of hepatocellular carcinoma in hepatitis B virus infection
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, National University Health System, Yong Yoo Lin School of Medicine, National University of Singapore, Singapore
    J Gastroenterol Hepatol 24:1352-7. 2009
    ..First-generation oral antiviral (lamivudine) reduces HCC risk, particularly in cirrhotics. Long-term outcome data with newer, more potent HBV antivirals that have a higher genetic barrier to drug resistance are eagerly awaited...
  13. ncbi request reprint Adefovir dipivoxil as the rescue therapy for lamivudine-resistant hepatitis B post liver transplant
    C T Wai
    Singapore Liver Transplant Program, National University Hospital, Singapore
    Transplant Proc 36:2313-4. 2004
    ..Our aim was to evaluate the use of adefovir dipivoxil (ADV) as a rescue therapy for posttransplant HBV patients who developed lamivudine resistance...
  14. ncbi request reprint MELD may not be the better system for organ allocation in liver transplantation patients in Singapore
    Y M Lee
    Department of Gastroenterology and Hepatology, National University Hospital, 5 Lower Kent Ridge Road, Singapore
    Singapore Med J 47:592-4. 2006
    ..However, a higher MELD may be associated with poorer outcome post-liver transplantation. The aim of this study was to determine if MELD should be implemented as the system for organ allocation for liver transplantation in Singapore...
  15. ncbi request reprint Long-term results of liver transplant in patients with chronic viral hepatitis-related liver disease in Singapore
    C T Wai
    Department of Gastroenterology and Hepatology, National University Hospital, 5 Lower Kent Ridge Road, Singapore
    Singapore Med J 47:588-91. 2006
    ..Their long-term results post-transplant may be affected by recurrence of the viral illness. This study aims to evaluate the long-term results and survival in patients transplanted for CHB- and CHC-related liver disease...
  16. ncbi request reprint Bilirubin appears to be the only independent variable affecting mortality on liver transplant waiting list if waiting time exceeds 1 year
    Y M Lee
    Department of Medicine, National University of Singapore, Singapore
    Transplant Proc 37:4365-6. 2005
    ..We wanted to identify the factors affecting mortality on the liver transplant waiting list in Singapore where waiting time for liver transplant exceeds 1 year...
  17. ncbi request reprint Renal impairment and diabetes mellitus after liver transplant
    D S Sutedja
    Singapore Liver Transplant Program, National University Hospital, Singapore
    Transplant Proc 36:2324-7. 2004
    ..One of the major concerns in liver transplant patients who survive past 1 year posttransplant is the development of chronic diseases...
  18. ncbi request reprint Liver transplantation in Singapore 1990-2004
    C T Wai
    Department of Gastroenterology and Hepatology, National University Hospital, 5 Lower Kent Ridge Road, Singapore
    Singapore Med J 47:580-3. 2006
    ..Since the first liver transplant done in Singapore in 1990, results have been improving. We review the overall results of liver transplantation over the last 15 years...
  19. ncbi request reprint Long-term post-liver transplant complications of renal impairment and diabetes mellitus: data from Singapore
    D S Sutedja
    Department of Gastroenterology and Hepatology, National University Hospital, 5 Lower Kent Ridge Road, Singapore
    Singapore Med J 47:604-8. 2006
    ..Patients who survive the initial post-liver transplantation period face the development of chronic diseases in the long run. We studied two important complications of liver transplantation, namely: renal impairment and diabetes mellitus...
  20. ncbi request reprint Liver transplantation for hepatocellular carcinoma in Singapore
    C T Wai
    Department of Gastroenterology and Hepatology, National University Hospital, 5 Lower Kent Ridge Road, Singapore
    Singapore Med J 47:584-7. 2006
    ..Liver transplantation offers the benefits of complete tumour removal with prevention of both decompensation and recurrence post-operation. This paper aims to review results of liver transplantation for patients with HCC in Singapore...
  21. ncbi request reprint Successful listing of patients for liver transplant was related to participation of referring doctor in the transplant program
    C T Wai
    Singapore Liver Transplant Program, National University Hospital, Singapore
    Transplant Proc 36:2230-1. 2004
    ..Therefore, patients from nontransplant centers may not be referred in a timely fashion for transplants. Our aim was to evaluate the pattern of referral for liver transplantation and their outcomes in Singapore...
  22. ncbi request reprint The MELD score may help to determine optimum time for liver transplantation
    Y M Lee
    Department of Medicine, National University Hospital, Singapore
    Transplant Proc 36:3057-9. 2004
    ..Aim: Our aim was to determine if there is a pretransplant MELD score beyond which liver transplantation is prohibitive...
  23. ncbi request reprint Treatment of steroid-resistant acute liver transplant rejection with basiliximab
    M L Fernandes
    Liver Transplant Unit, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Transplant Proc 37:2179-80. 2005
    ..In this report, we describe the use of Basiliximab as rescue therapy in a case of acute steroid-resistant rejection in an adult living related liver transplant recipient...
  24. ncbi request reprint Prophylactic lamivudine prevents hepatitis B reactivation in chemotherapy patients
    L L Lim
    Department of Medicine, National University Hospital, Singapore
    Aliment Pharmacol Ther 16:1939-44. 2002
    ..Few studies have characterized the efficacy of lamivudine in the treatment of chemotherapy-induced hepatitis B virus reactivation...
  25. ncbi request reprint Utility of the Health Belief Model in predicting compliance of screening in patients with chronic hepatitis B
    C T Wai
    Division of Gastroenterology, Department of Medicine, National University Hospital, Singapore
    Aliment Pharmacol Ther 21:1255-62. 2005
    ..Regular surveillance is recommended for patients with chronic hepatitis B, to select candidates for anti-viral therapy and detect early complications. However, factors that determine compliance are not well studied...
  26. doi request reprint Resolution of adefovir-related nephrotoxicity by adefovir dose-reduction in patients with chronic hepatitis B
    J L Hartono
    Department of Gastroenterology and Hepatology, National University of Singapore, Singapore
    Aliment Pharmacol Ther 37:710-9. 2013
    ..Chronic hepatitis B patients (CHB) treated with adefovir were followed up to evaluate nephrotoxicity and its outcome...
  27. doi request reprint How big is the financial burden of hepatitis B to society? A cost-of-illness study of hepatitis B infection in Singapore
    S C Ong
    Department of Pharmacy, National University of Singapore, Singapore
    J Viral Hepat 16:53-63. 2009
    ..4:1) and DC patients (2.7:1). The results of this study suggest that the management of HBV infection poses more than a medical challenge as it is a sizeable economic burden from both the payer and societal perspectives...
  28. ncbi request reprint Identification and molecular characterisation of the complete genome of a Singapore isolate of hepatitis C virus: sequence comparison with other strains and phylogenetic analysis
    S P Lim
    Collaborative anti viral Research, Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Virus Genes 23:89-95. 2001
    ..9%). Phylogenetic analysis revealed that it was most closely related to the Taiwan strain, HCV-TW and another Japanese strain, HCV-K1-R1...
  29. ncbi request reprint Clinical drug trials: practical problems of phase III
    S M Saw
    Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive, Singapore 117597
    Ann Acad Med Singapore 29:598-605. 2000
    ..The main practical problems encountered in the initiation, design, conduct and completion of both investigator-initiated and sponsor-initiated phase III clinical drug trials will be reviewed...
  30. ncbi request reprint The hepatitis C virus core protein interacts with NS5A and activates its caspase-mediated proteolytic cleavage
    P Y Goh
    Collaborative Anti Viral Research Group, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    Virology 290:224-36. 2001
    ..In cells infected by the HCV, core may provide the intrinsic apoptotic signal, which produces truncated forms of NS5A. The biological function of core-NS5A interaction and the downstream effect of NS5A cleavage are discussed...
  31. ncbi request reprint The majority of hepatitis B carriers are not on regular surveillance in Singapore
    C T Wai
    Division of Gastroenterology, Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Singapore Med J 45:423-6. 2004
    ..However, there have been few studies evaluating the follow-up of HBV carriers. This study seeks to determine the proportion of HBV carriers on regular follow-up in Singapore and the impact on hepatitis B disease...
  32. ncbi request reprint Genome-wide expression profiling of RNA interference of hepatitis B virus gene expression and replication
    Y Li
    Department of Biochemistry, National University of Singapore, 8 Medical Drive, S117597, Singapore
    Cell Mol Life Sci 61:2113-24. 2004
    ..No significant off-target gene regulation was observed in either cell line. Our findings thus indicate that siRNA can specifically mediate the down-regulation of viral gene expression leading to a reduction in virion production...
  33. ncbi request reprint Successful treatment of Xylohypha bantiana brain abscess mimicking invasive cerebral aspergillosis in a liver transplant recipient
    Y M Lee
    Division of Gastroenterology, Department of Medicine, National University Hospital, Singapore, Singapore 119074
    J Infect 47:348-51. 2003
    ..We report a Xylophypha bantiana cerebral abscess in a liver transplant recipient initially identified as a branching mould on histology that had a successful outcome due to aggressive appropriate treatment...
  34. doi request reprint Cultural adaptation and validation of a questionnaire for use in hepatitis B patients
    S C Ong
    Department of Pharmacy, National University of Singapore, Singapore
    J Viral Hepat 16:272-8. 2009
    ..In conclusion, our results showed that the culturally adapted HQLQ has good validity and reliability, making it a potentially useful outcome measure in the evaluation of HBV patients in Singapore...
  35. ncbi request reprint Palliation of malignant gastric outlet obstruction caused by gastric cancer with self-expandable metal stents
    C T Wai
    Department of Medicine, National University Hospital, Singapore
    Surg Laparosc Endosc Percutan Tech 11:161-4. 2001
    ..Patients who are not expected to survive beyond 1 month and those with linitus plastica and associated gastric dysmotility may not be appropriate candidates for such a procedure...
  36. ncbi request reprint The future of liver transplantation in Singapore
    J Isaac
    Singapore Med J 47:564-5. 2006