Yung-Seng Lee

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. doi request reprint Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective
    Yung Seng Lee
    Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore
    Diabetes Metab Res Rev 28:26-31. 2012
  2. ncbi request reprint Consequences of childhood obesity
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, and The Children s Medical Institute, National University Hospital, Singapore
    Ann Acad Med Singapore 38:75-7. 2009
  3. ncbi request reprint The role of genes in the current obesity epidemic
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, and University Children s Medical Institute, National University Hospital, Singapore
    Ann Acad Med Singapore 38:45-3. 2009
  4. ncbi request reprint The role of leptin-melanocortin system and human weight regulation: lessons from experiments of nature
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, and The Children s Medical Institute, National University Hospital, Singapore
    Ann Acad Med Singapore 38:34-11. 2009
  5. doi request reprint Association of raised liver transaminases with physical inactivity, increased waist-hip ratio, and other metabolic morbidities in severely obese children
    Yung Seng Lee
    Departments of Paediatrics, National University Hospital, Singapore
    J Pediatr Gastroenterol Nutr 47:172-8. 2008
  6. ncbi request reprint Novel melanocortin 4 receptor gene mutations in severely obese children
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, and The Children s Medical Institute, National University Hospital, Singapore
    Clin Endocrinol (Oxf) 68:529-35. 2008
  7. ncbi request reprint The role of melanocortin 3 receptor gene in childhood obesity
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, and The Children s Medical Institute, National University Hospital, Singapore
    Diabetes 56:2622-30. 2007
  8. ncbi request reprint Prevalence of ICA and GAD antibodies at initial presentation of type 1 diabetes mellitus in Singapore children
    Y S Lee
    Department of Paediatrics, National University of Singapore
    J Pediatr Endocrinol Metab 14:767-72. 2001
  9. ncbi request reprint A distinctive type of metaphyseal chondrodysplasia with characteristic thickening of the distal ulna and radius: possible metaphyseal chondrodysplasia-Rosenberg
    Yung Seng Lee
    Paediatric Endocrine Section, Department of Paediatrics, National University of Singapore, Singapore
    Am J Med Genet A 119:50-6. 2003
  10. ncbi request reprint Maternal thyrotoxicosis causing central hypothyroidism in infants
    Y S Lee
    Department of Paediatrics, National University Hospital, Singapore
    J Paediatr Child Health 38:206-8. 2002

Detail Information

Publications19

  1. doi request reprint Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective
    Yung Seng Lee
    Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore
    Diabetes Metab Res Rev 28:26-31. 2012
    ....
  2. ncbi request reprint Consequences of childhood obesity
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, and The Children s Medical Institute, National University Hospital, Singapore
    Ann Acad Med Singapore 38:75-7. 2009
    ..The incidence of childhood obesity is rising across the globe, and obesity related co-morbidities are increasing concomitantly in the paediatric population...
  3. ncbi request reprint The role of genes in the current obesity epidemic
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, and University Children s Medical Institute, National University Hospital, Singapore
    Ann Acad Med Singapore 38:45-3. 2009
    ..Obesity is a global pandemic and a major health concern. Obesity is a common but complex, multifactorial disorder with high heritability, where as much as 80% of the variance in the body mass index (BMI) is attributable to genetic factors...
  4. ncbi request reprint The role of leptin-melanocortin system and human weight regulation: lessons from experiments of nature
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, and The Children s Medical Institute, National University Hospital, Singapore
    Ann Acad Med Singapore 38:34-11. 2009
    ..There have been major advances in the past decade in our understanding of the human weight regulation mechanism and pathogenesis of obesity, abetted by discoveries of genetic defects which lead to human obesity...
  5. doi request reprint Association of raised liver transaminases with physical inactivity, increased waist-hip ratio, and other metabolic morbidities in severely obese children
    Yung Seng Lee
    Departments of Paediatrics, National University Hospital, Singapore
    J Pediatr Gastroenterol Nutr 47:172-8. 2008
    ..To identify factors associated with raised alanine transaminase, aspartate transaminase, and gamma-glutaryl transferase in severely obese children..
  6. ncbi request reprint Novel melanocortin 4 receptor gene mutations in severely obese children
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, and The Children s Medical Institute, National University Hospital, Singapore
    Clin Endocrinol (Oxf) 68:529-35. 2008
    ..The significance of MC4R mutations in Asian obese populations has not been adequately examined. The objective of this study was to determine the role of MC4R mutations in severely obese Asian children...
  7. ncbi request reprint The role of melanocortin 3 receptor gene in childhood obesity
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, and The Children s Medical Institute, National University Hospital, Singapore
    Diabetes 56:2622-30. 2007
    ..The objective of this study was to identify genetic variants of the MC3R gene and determine its association with childhood obesity...
  8. ncbi request reprint Prevalence of ICA and GAD antibodies at initial presentation of type 1 diabetes mellitus in Singapore children
    Y S Lee
    Department of Paediatrics, National University of Singapore
    J Pediatr Endocrinol Metab 14:767-72. 2001
    ..To determine the prevalence of islet cell antibodies (ICA) and antibodies to glutamic acid decarboxylase (GAD) in Asian children with diabetes mellitus (DM) at the time of diagnosis...
  9. ncbi request reprint A distinctive type of metaphyseal chondrodysplasia with characteristic thickening of the distal ulna and radius: possible metaphyseal chondrodysplasia-Rosenberg
    Yung Seng Lee
    Paediatric Endocrine Section, Department of Paediatrics, National University of Singapore, Singapore
    Am J Med Genet A 119:50-6. 2003
    ..Although many of the radiographic features of this patient are those of MCD-Rosenberg, the skeletal features of our patient do not appear to represent any known classified forms of MCD...
  10. ncbi request reprint Maternal thyrotoxicosis causing central hypothyroidism in infants
    Y S Lee
    Department of Paediatrics, National University Hospital, Singapore
    J Paediatr Child Health 38:206-8. 2002
    ..Suppression of the fetal pituitary-thyroid axis may be due to placental transfer of thyroxine from the hyperthyroid mother. This may persist for months postnatally, necessitating treatment to optimise neurodevelopmental outcome...
  11. ncbi request reprint An activating mutation of the thyrotropin receptor gene in hereditary non-autoimmune hyperthyroidism
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore
    J Pediatr Endocrinol Metab 15:211-5. 2002
    ..The significance of diagnosing activating TSHR mutations lies in therapeutic management and genetic counseling; thyroid ablation is advocated as first line treatment...
  12. ncbi request reprint Cyclic pamidronate infusion improves bone mineralisation and reduces fracture incidence in osteogenesis imperfecta
    Y S Lee
    Department of Paediatrics, National University of Singapore, National University Hospital, Singapore
    Eur J Pediatr 160:641-4. 2001
    ..This may represent a net reduction in bone resorption and provides a biochemical explanation for the increase in bone mineralisation. Height standard deviation scores were not affected and there were no significant adverse effects...
  13. ncbi request reprint Mitochondrial tubulopathy: the many faces of mitochondrial disorders
    Y S Lee
    Department of Pediatrics, National University of Singapore, Singapore
    Pediatr Nephrol 16:710-2. 2001
    ..The case illustrates the spectrum and diversity of mitochondrial presentations, arising because of heteroplasmy of mutations and the type of organs affected...
  14. ncbi request reprint A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
    Yung Seng Lee
    Paediatric Endocrine Section, Department of Paediatrics, National University of Singapore, Singapore
    J Clin Endocrinol Metab 87:1423-6. 2002
    ..The melanocortin 3 receptor (MC3R) plays a critical role in weight regulation as demonstrated in mouse models. We describe a novel mutation Ile183Asn (T548A) found in heterozygosity in a 13-year-old obese girl and her father...
  15. ncbi request reprint Phenotypic variability in 17beta-hydroxysteroid dehydrogenase-3 deficiency and diagnostic pitfalls
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, Singapore
    Clin Endocrinol (Oxf) 67:20-8. 2007
    ..We report the phenotypes of 14 subjects with 17betaHSD3 deficiency in relation to sex of rearing, androgen production, and HSD17B3 mutations...
  16. ncbi request reprint Evidence of autoantibodies to glutamic acid decarboxylase in oral fluid of type 1 diabetic patients
    Alan Leslie Todd
    Department of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Diabetes Res Clin Pract 57:171-7. 2002
    ..Improved antibody recovery and assay re-optimisation could provide a basis for more extensive studies that may lead to an alternative non-invasive screening method for pre-clinical autoimmune diabetes...
  17. doi request reprint Chikungunya mimicking atypical Kawasaki disease in an infant
    Yung Seng Lee
    Department of Paediatrics, National University of Singapore, Singapore
    Pediatr Infect Dis J 29:275-7. 2010
    ....
  18. ncbi request reprint A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance
    Yung Seng Lee
    University Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, CB2 2XY, United Kingdom
    Cell Metab 3:135-40. 2006
    ..Obese children carrying the Tyr221Cys variant were hyperphagic and showed increased linear growth, both of which are features of MC4R deficiency. These studies support a role for beta-MSH in the control of human energy homeostasis...
  19. ncbi request reprint Detection through screening of maternal thyrotoxicosis induced central hypothyroidism in newborns
    Roy Joseph
    Department of Pediatrics, National University of Singapore
    Southeast Asian J Trop Med Public Health 34:150-1. 2003
    ..The use of a supplemental free thyroxine improved testing specificity. The hypothyroidism observed is believed to be secondary to suppression of the hypothalamic-pituitary-thyroid axis by placentally transferred maternal thyroxine...