Affiliation: National University of Singapore
- Unexpected drug-drug interactions in human immunodeficiency virus (HIV) therapy: induction of UGT1A1 and bile efflux transporters by EfavirenzLawrence S U Lee
Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Ann Acad Med Singapore 41:559-62. 2012..Efavirenz is an inducer of drug metabolism enzymes. We studied the effect of efavirenz and ritonavir-boosted darunavir on serum unconjugated and conjugated bilirubin, as probes for UGT1A1 and bile transporters...
- Darunavir/ritonavir and efavirenz exert differential effects on MRP1 transporter expression and function in healthy volunteersLawrence S Lee
National Healthcare Group, Singapore, Singapore
Antivir Ther 15:275-9. 2010..We studied MRP1 expression and function in healthy volunteers treated with darunavir/ritonavir and efavirenz...
- Pharmacokinetics of darunavir at 900 milligrams and ritonavir at 100 milligrams once daily when coadministered with efavirenz at 600 milligrams once daily in healthy volunteersGaik H Soon
National Healthcare Group, 6 Commonwealth Lane, Singapore 149547, Singapore
Antimicrob Agents Chemother 54:2775-80. 2010..This regimen should be evaluated with treatment-naïve patients with no preexisting resistance...
- Pharmacokinetic modeling of plasma and intracellular concentrations of raltegravir in healthy volunteersLingzhi Wang
Cancer Science Institute of Singapore, National University of Singapore, 28 Medical Drive, Singapore 117456
Antimicrob Agents Chemother 55:4090-5. 2011..2% with a relative standard error of 35%. The results suggest that there is no intracellular accumulation or persistence of raltegravir in PBMCs...