Lawrence Lee

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi Unexpected drug-drug interactions in human immunodeficiency virus (HIV) therapy: induction of UGT1A1 and bile efflux transporters by Efavirenz
    Lawrence S U Lee
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Ann Acad Med Singapore 41:559-62. 2012
  2. ncbi Darunavir/ritonavir and efavirenz exert differential effects on MRP1 transporter expression and function in healthy volunteers
    Lawrence S Lee
    National Healthcare Group, Singapore, Singapore
    Antivir Ther 15:275-9. 2010
  3. ncbi Pharmacokinetics of darunavir at 900 milligrams and ritonavir at 100 milligrams once daily when coadministered with efavirenz at 600 milligrams once daily in healthy volunteers
    Gaik H Soon
    National Healthcare Group, 6 Commonwealth Lane, Singapore 149547, Singapore
    Antimicrob Agents Chemother 54:2775-80. 2010
  4. ncbi Pharmacokinetic modeling of plasma and intracellular concentrations of raltegravir in healthy volunteers
    Lingzhi Wang
    Cancer Science Institute of Singapore, National University of Singapore, 28 Medical Drive, Singapore 117456
    Antimicrob Agents Chemother 55:4090-5. 2011

Collaborators

  • Charles Flexner
  • Lingzhi Wang
  • Eu Leong Yong
  • Gaik H Soon
  • Boon Cher Goh
  • Jun Li
  • Kok Yong Seng
  • Edmund Lee
  • Gaik Hong Soon
  • Paul Pham
  • Ping Shen

Detail Information

Publications4

  1. ncbi Unexpected drug-drug interactions in human immunodeficiency virus (HIV) therapy: induction of UGT1A1 and bile efflux transporters by Efavirenz
    Lawrence S U Lee
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Ann Acad Med Singapore 41:559-62. 2012
    ..Efavirenz is an inducer of drug metabolism enzymes. We studied the effect of efavirenz and ritonavir-boosted darunavir on serum unconjugated and conjugated bilirubin, as probes for UGT1A1 and bile transporters...
  2. ncbi Darunavir/ritonavir and efavirenz exert differential effects on MRP1 transporter expression and function in healthy volunteers
    Lawrence S Lee
    National Healthcare Group, Singapore, Singapore
    Antivir Ther 15:275-9. 2010
    ..We studied MRP1 expression and function in healthy volunteers treated with darunavir/ritonavir and efavirenz...
  3. ncbi Pharmacokinetics of darunavir at 900 milligrams and ritonavir at 100 milligrams once daily when coadministered with efavirenz at 600 milligrams once daily in healthy volunteers
    Gaik H Soon
    National Healthcare Group, 6 Commonwealth Lane, Singapore 149547, Singapore
    Antimicrob Agents Chemother 54:2775-80. 2010
    ..This regimen should be evaluated with treatment-naïve patients with no preexisting resistance...
  4. ncbi Pharmacokinetic modeling of plasma and intracellular concentrations of raltegravir in healthy volunteers
    Lingzhi Wang
    Cancer Science Institute of Singapore, National University of Singapore, 28 Medical Drive, Singapore 117456
    Antimicrob Agents Chemother 55:4090-5. 2011
    ..2% with a relative standard error of 35%. The results suggest that there is no intracellular accumulation or persistence of raltegravir in PBMCs...