Alan Kumar

Summary

Affiliation: Cancer Science Institute of Singapore, National University of Singapore
Location: Singapore, Singapore
Summary:
Diabetes and cancer are common diseases among adults worldwide. New research shows that both hyperinsulinaemia and hyperglycemia, characteristics of type 2 diabetes, are major risk factors for a number of cancer

Publications

  1. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism
    Alan P Kumar
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Biol Chem 279:8300-15. 2004
  2. doi request reprint Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model
    Muthu K Shanmugam
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Int J Cancer 129:1552-63. 2011
  3. pmc Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
    Radhamani Kannaiyan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Br J Pharmacol 164:1506-21. 2011
  4. doi request reprint Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway
    Chern Chiuh Woo
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Biochem Pharmacol 82:464-75. 2011
  5. doi request reprint PPARγ disease gene network and identification of therapeutic targets for prostate cancer
    Gireedhar Venkatachalam
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Drug Target 19:781-96. 2011
  6. doi request reprint Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
    Radhamani Kannaiyan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore
    Apoptosis 16:1028-41. 2011
  7. doi request reprint Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1
    Peramaiyan Rajendran
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Cell Physiol 227:2184-95. 2012
  8. pmc Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4
    Kanjoormana Aryan Manu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Mol Cancer 10:107. 2011
  9. doi request reprint Multifaceted link between cancer and inflammation
    Gautam Sethi
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Biosci Rep 32:1-15. 2012
  10. doi request reprint Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
    Muthu K Shanmugam
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore
    J Mol Med (Berl) 89:713-27. 2011

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism
    Alan P Kumar
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Biol Chem 279:8300-15. 2004
    ....
  2. doi request reprint Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model
    Muthu K Shanmugam
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Int J Cancer 129:1552-63. 2011
    ..Overall, our experimental findings suggest that UA exerts its antimetastatic effects through the suppression of CXCR4 expression in prostate cancer both in vitro and in vivo...
  3. pmc Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
    Radhamani Kannaiyan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Br J Pharmacol 164:1506-21. 2011
    ..Thus, in the present study, we investigated whether celastrol could suppress the proliferation and induce chemosensitization of MM cells by interfering with NF-κB and STAT3 activation pathways...
  4. doi request reprint Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway
    Chern Chiuh Woo
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Biochem Pharmacol 82:464-75. 2011
    ....
  5. doi request reprint PPARγ disease gene network and identification of therapeutic targets for prostate cancer
    Gireedhar Venkatachalam
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Drug Target 19:781-96. 2011
    ..These investigations would not only aid in understanding the molecular mechanisms by which PPARγ regulates disease targets but would also lead to the identification of novel PPARγ gene targets...
  6. doi request reprint Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
    Radhamani Kannaiyan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore
    Apoptosis 16:1028-41. 2011
    ..Overall, our results indicate that celastrol can inhibit cell proliferation and induce apoptosis through the activation of JNK, suppression of Akt, and down-regulation of anti-apoptotic protein expression...
  7. doi request reprint Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1
    Peramaiyan Rajendran
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Cell Physiol 227:2184-95. 2012
    ..Overall, the results suggest that honokiol is a novel blocker of STAT3 activation and may have a great potential for the treatment of HCC and other cancers...
  8. pmc Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4
    Kanjoormana Aryan Manu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Mol Cancer 10:107. 2011
    ..Thus, novel agents that can downregulate the CXCR4/CXCL12 axis have therapeutic potential in inhibiting cancer metastasis...
  9. doi request reprint Multifaceted link between cancer and inflammation
    Gautam Sethi
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Biosci Rep 32:1-15. 2012
    ..The present review will focus primarily on the role of various inflammatory intermediates responsible for tumour initiation and progression, and discuss in detail the critical link between inflammation and cancer...
  10. doi request reprint Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
    Muthu K Shanmugam
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore
    J Mol Med (Berl) 89:713-27. 2011
    ..Overall, our results from experimental and predictive studies suggest that UA mediates its anti-tumor effects through suppression of NF-κB and STAT3 pathways in prostate cancer...
  11. pmc γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent
    Peramaiyan Rajendran
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Cancer Science Institute of Singapore, National University of Singapore, Singapore
    Br J Pharmacol 163:283-98. 2011
    ..In the present study, we investigated whether the apoptotic, antiproliferative and chemosensitizing effects of γ-tocotrienol are associated with its ability to suppress STAT3 activation in hepatocellular carcinoma (HCC)...
  12. doi request reprint Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo
    Peramaiyan Rajendran
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Clin Cancer Res 17:1425-39. 2011
    ..Thus, the novel agents that can suppress STAT3 activation have potential for both prevention and treatment of HCC...
  13. ncbi request reprint Inducible nitric oxide synthase expression is inhibited by myeloperoxidase
    Alan P Kumar
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Nitric Oxide 13:42-53. 2005
    ..The combined signaling of IFNgamma/LPS overrides the gatekeeper function by suppressing MPO gene expression...
  14. pmc The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands
    Wanda F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Biochem Biophys Res Commun 349:846-54. 2006
    ..These findings identify human MPO as a novel LXR and PPARalpha target gene, consistent with the role of these receptors in regulation of proinflammatory genes in macrophages...
  15. ncbi request reprint Oxidative repression of NHE1 gene expression involves iron-mediated caspase activity
    A P Kumar
    1National University Medical Institutes, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117 597 Singapore
    Cell Death Differ 14:1733-46. 2007
    ..These data show that a mild oxidative stress represses NHE1 promoter activity and expression via an early oxidation phase blocked by reducing agents, and a late phase requiring an iron-dependent increase in caspases 3 and 6 activities...
  16. doi request reprint Deformability study of breast cancer cells using microfluidics
    H W Hou
    NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore
    Biomed Microdevices 11:557-64. 2009
    ..This work lays the foundation for the development of potential microfluidic devices which can subsequently be used in the detection of cancer cells...
  17. doi request reprint Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo
    Alan Prem Kumar
    Departments of Physiology, National University Medical Institutes, Yong Loo Lin School of Medicine, Singapore
    Cancer Res 69:8636-44. 2009
    ....
  18. pmc Computational identification and experimental validation of PPRE motifs in NHE1 and MnSOD genes of human
    Gireedhar Venkatachalam
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    BMC Genomics 10:S5. 2009
    ..Here we computationally identified PPAR binding regions in NHE1 and MnSOD. We further validated the predictions in vitro...
  19. ncbi request reprint Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells
    Sandra Min Li Tan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Pharmacol Exp Ther 334:285-93. 2010
    ..Overall, these results suggest that beta-escin is a novel blocker of STAT3 activation that may have potential in the suppression of proliferation and chemosensitization in HCC...
  20. ncbi request reprint Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells
    Angeline Wei Ling Chua
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Biochem Pharmacol 80:1553-62. 2010
    ..Overall, our results demonstrate for the first time that butein is a novel inhibitor of CXCR4 expression and thus has a potential in suppressing metastasis of cancer...
  21. doi request reprint Thymoquinone: potential cure for inflammatory disorders and cancer
    Chern Chiuh Woo
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Biochem Pharmacol 83:443-51. 2012
    ..In this review, we summarize the anti-oxidant/anti-inflammatory and anticancer effects of thymoquinone with a focus on its molecular targets, and its possible role in the treatment of inflammatory diseases and cancer...