Cheng Gee Koh

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi Beta1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane ruffles
    C G Koh
    Glaxo IMCB Group, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    J Cell Sci 114:4239-51. 2001
  2. ncbi The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family
    Cheng Gee Koh
    Institute of Molecular and Cell Biology, 30 Medical Drive, 117609, Singapore, Singapore
    Curr Biol 12:317-21. 2002
  3. doi Actin cytoskeleton dynamics and the cell division cycle
    Yi Wen Heng
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Int J Biochem Cell Biol 42:1622-33. 2010
  4. pmc Functions and regulation of circular dorsal ruffles
    Jing Ling Hoon
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Mol Cell Biol 32:4246-57. 2012
  5. ncbi Rho GTPases and their regulators in neuronal functions and development
    Cheng Gee Koh
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Neurosignals 15:228-37. 2006
  6. ncbi Rac1 GTPase is activated by hepatitis B virus replication--involvement of HBX
    Tuan Lin Tan
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore
    Biochim Biophys Acta 1783:360-74. 2008
  7. doi Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways
    Yi Xie
    School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore
    J Cell Sci 121:514-21. 2008

Collaborators

  • Tuan Lin Tan
  • Jing Ling Hoon
  • Yi Wen Heng
  • Yi Xie
  • Wai Keung Wong
  • Louis Lim
  • E Jean Tan
  • Edward Manser
  • Shimei Wee

Detail Information

Publications7

  1. ncbi Beta1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane ruffles
    C G Koh
    Glaxo IMCB Group, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    J Cell Sci 114:4239-51. 2001
    ..Thus, beta1PIX, like other RhoGEFs, exerts specific morphological functions that are dependent on its intracellular location and are mediated by its C-terminal dimerization domain...
  2. ncbi The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family
    Cheng Gee Koh
    Institute of Molecular and Cell Biology, 30 Medical Drive, 117609, Singapore, Singapore
    Curr Biol 12:317-21. 2002
    ..The association of the POPX phosphatases with PAK complexes may allow PAK to cycle rapidly between active and inactive states; it represents a unique regulatory component of the signaling pathways of the PAK kinase family...
  3. doi Actin cytoskeleton dynamics and the cell division cycle
    Yi Wen Heng
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Int J Biochem Cell Biol 42:1622-33. 2010
    ....
  4. pmc Functions and regulation of circular dorsal ruffles
    Jing Ling Hoon
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Mol Cell Biol 32:4246-57. 2012
    ..We focus specifically on the biochemical pathways leading to CDR formation in order to better define the roles and functions of these enigmatic structures...
  5. ncbi Rho GTPases and their regulators in neuronal functions and development
    Cheng Gee Koh
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Neurosignals 15:228-37. 2006
    ..In general, Rac and Cdc42 promote neurite outgrowth while RhoA stimulates retraction. The balance of these opposing activities of the different Rho GTPases is crucial for the morphology and function of the neurons...
  6. ncbi Rac1 GTPase is activated by hepatitis B virus replication--involvement of HBX
    Tuan Lin Tan
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore
    Biochim Biophys Acta 1783:360-74. 2008
    ..HBV may possibly make use of an activated Rac1 signaling pathway for increased replication and resultant metastatic effects...
  7. doi Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways
    Yi Xie
    School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore
    J Cell Sci 121:514-21. 2008
    ..We propose that the interaction between mDia1 and POPX2 (PPM1F) serves to regulate both the actin cytoskeleton and SRF-mediated transcription, and to link the CDC42/RAC1 pathways with those of RhoA...