Kandiah Jeyaseelan

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi request reprint Six isoforms of cardiotoxin in malayan spitting cobra (Naja naja sputatrix) venom: cloning and characterization of cDNAs
    K Jeyaseelan
    Department of Biochemistry and Bioscience Centre, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biochim Biophys Acta 1380:209-22. 1998
  2. ncbi request reprint Structure and phylogeny of the venom group I phospholipase A(2) gene
    K Jeyaseelan
    Department of Biochemistry, Faculty of Medicine and Bioscience Center, Faculty of Science, National University of Singapore, Singapore
    Mol Biol Evol 17:1010-21. 2000
  3. pmc MicroRNAs in Neurotoxicity
    Prameet Kaur
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, Singapore 117597
    J Toxicol 2012:870150. 2012
  4. pmc Expression profile of MicroRNAs in young stroke patients
    Kay Sin Tan
    Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 4:e7689. 2009
  5. pmc Blood microRNAs in Low or No Risk Ischemic Stroke Patients
    Jun Rong Tan
    Department of Biochemistry and Neuroscience Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597, Singapore
    Int J Mol Sci 14:2072-84. 2013
  6. doi request reprint Neuroprotectants in stroke therapy
    K Jeyaseelan
    Department of Biochemistry, National University of Singapore, Yong Loo Lin School of Medicine, Singapore
    Expert Opin Pharmacother 9:887-900. 2008
  7. ncbi request reprint MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion
    Kandiah Jeyaseelan
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Dr, Singapore 117597, Singapore
    Stroke 39:959-66. 2008
  8. ncbi request reprint Aquaporins: a promising target for drug development
    Kandiah Jeyaseelan
    Yong Loo Lin School of Medicine, National University of Singapore, Department of Biochemistry, 8 Medical Drive, 117597, Singapore
    Expert Opin Ther Targets 10:889-909. 2006
  9. ncbi request reprint Structurally conserved alpha-neurotoxin genes encode functionally diverse proteins in the venom of Naja sputatrix
    Kandiah Jeyaseelan
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Drive, 117597 Singapore
    FEBS Lett 553:333-41. 2003
  10. pmc Real-time detection of gene promoter activity: quantitation of toxin gene transcription
    K Jeyaseelan
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 10 Medical Drive, 119260, Singapore
    Nucleic Acids Res 29:E58-8. 2001

Collaborators

  • Arunmozhiarasi Armugam
  • Fung Lin Yong
  • E M Wintour
  • Yi Li
  • Mahesh Choolani
  • Ariff Bongso
  • Arijit Biswas
  • Kalamegam Gauthaman
  • Subramaniam Tavintharan
  • Judice L Y Koh
  • Vladimir Brusic
  • Asif M Khan
  • Paul T J Tan
  • P Ganesan Adaikan
  • D Ma
  • Alirio J Melendez
  • Sugunavathi Sepramaniam
  • Dwi Setyowati Karolina
  • Prameet Kaur
  • Guofei Sun
  • Jun Rong Tan
  • Kay Sin Tan
  • Tai Shung Chung
  • Chee Woon Wang
  • Kai Ying Lim
  • Wudayagiri Rajendra
  • Minghui Jessica Chen
  • Chui Yee Fong
  • Paul A Tambyah
  • Honglei Wang
  • Karthikeyan Chandrasekaran
  • Chee Fang Sum
  • Su Chi Lim
  • Michael T K Wong
  • Lang Chu Lau
  • Jia Hui Chua
  • Siaw Ching Chai
  • Tan Boon Toh
  • Nam Sang Cheung
  • Joyce Phui Yee Siew
  • Joyce Siew Phui Yee
  • Charmian D N Cher
  • Suganya Cheyyatraivendran
  • Deidre Ann Desilva
  • Shu Uin Gan
  • Fu jia Liu
  • Kimberley Tam
  • Fung Peng Woon
  • Jaminah Mohamed Ali
  • Yu Xuan Koo
  • Priyadharshini Swaminathan
  • Lim Kai Ying
  • Hui Zhing Tan
  • Jian Chye Sam Tan
  • Kun Song Yeo
  • Zaichun Chen
  • Peter N Strong
  • Minghui Hong
  • John F Bertram
  • Wolfgang Meier
  • Vibha Ghariwala
  • Dwi S Karolina
  • Yen Wah Tong
  • Hu Zhou
  • Sharon Li Ting Pek
  • Priyadharshni Swaminathan
  • John Bertram
  • Karolina Dwi Setyowati
  • Qiu Tian Li
  • Jayapal Manikandan
  • Zhao Feng Peng
  • Meng Shyan Choy
  • Chuay Yeng Koo
  • Fatemah Afifiyan
  • Gong Nanling
  • Poh Siew Lay
  • Seng Hong Seah
  • Ma Donghui
  • Ramkumar Lachumanan
  • Marelyn Wintour Coghlan

Detail Information

Publications41

  1. ncbi request reprint Six isoforms of cardiotoxin in malayan spitting cobra (Naja naja sputatrix) venom: cloning and characterization of cDNAs
    K Jeyaseelan
    Department of Biochemistry and Bioscience Centre, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biochim Biophys Acta 1380:209-22. 1998
    ..We also speculate that Asiatic cobras could be the modern descendants of the African and Egyptian counterparts...
  2. ncbi request reprint Structure and phylogeny of the venom group I phospholipase A(2) gene
    K Jeyaseelan
    Department of Biochemistry, Faculty of Medicine and Bioscience Center, Faculty of Science, National University of Singapore, Singapore
    Mol Biol Evol 17:1010-21. 2000
    ....
  3. pmc MicroRNAs in Neurotoxicity
    Prameet Kaur
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, Singapore 117597
    J Toxicol 2012:870150. 2012
    ..It is therefore vital to understand the expression of these microRNAs and their impact on neuronal activities. In this paper, we discuss some of the neuronal pathophysiological conditions that could be caused by dysregulated microRNAs...
  4. pmc Expression profile of MicroRNAs in young stroke patients
    Kay Sin Tan
    Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 4:e7689. 2009
    ..We therefore carried out microRNA (miRNA) profiling from peripheral blood to detect and identify characteristic patterns in ischaemic stroke...
  5. pmc Blood microRNAs in Low or No Risk Ischemic Stroke Patients
    Jun Rong Tan
    Department of Biochemistry and Neuroscience Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597, Singapore
    Int J Mol Sci 14:2072-84. 2013
    ..The findings from our study suggest that molecular mechanisms in stroke pathogenesis involving low or no risk ischemic stroke patients could differ substantially from those with pre-existing risk factors...
  6. doi request reprint Neuroprotectants in stroke therapy
    K Jeyaseelan
    Department of Biochemistry, National University of Singapore, Yong Loo Lin School of Medicine, Singapore
    Expert Opin Pharmacother 9:887-900. 2008
    ..Identifying novel neuroprotectants that can reverse the effects of stroke is becoming a challenge to both clinicians and scientists...
  7. ncbi request reprint MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion
    Kandiah Jeyaseelan
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Dr, Singapore 117597, Singapore
    Stroke 39:959-66. 2008
    ..In this report, we present data on the miRNAs expressed under ischemic conditions in both the brain and blood of rats subjected to middle cerebral artery occlusion (MCAo)...
  8. ncbi request reprint Aquaporins: a promising target for drug development
    Kandiah Jeyaseelan
    Yong Loo Lin School of Medicine, National University of Singapore, Department of Biochemistry, 8 Medical Drive, 117597, Singapore
    Expert Opin Ther Targets 10:889-909. 2006
    ..Hence, in this review, the authors look at each AQP and its association with various pathological conditions in humans and demonstrate that they form potential targets for the treatment of such diseases...
  9. ncbi request reprint Structurally conserved alpha-neurotoxin genes encode functionally diverse proteins in the venom of Naja sputatrix
    Kandiah Jeyaseelan
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Drive, 117597 Singapore
    FEBS Lett 553:333-41. 2003
    ..This forms the first report where the molecular basis of evolution of postsynaptic neurotoxins from an ancestral gene can be demonstrated using the same species of snake...
  10. pmc Real-time detection of gene promoter activity: quantitation of toxin gene transcription
    K Jeyaseelan
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 10 Medical Drive, 119260, Singapore
    Nucleic Acids Res 29:E58-8. 2001
    ....
  11. ncbi request reprint Group IB phospholipase A2 from Pseudonaja textilis
    Arunmozhiarasi Armugam
    Department of Biochemistry, Faculty of Medicine, National University of Singapore 8 Medical Drive, Singapore 117597, Singapore
    Arch Biochem Biophys 421:10-20. 2004
    ..In the present study, we report that the Pt-PLA2 gene could be responsible for the production of PL1, 2, and 3 possibly via RNA editing process...
  12. ncbi request reprint Alpha-neurotoxin gene expression in Naja sputatrix: identification of a silencer element in the promoter region
    Donghui Ma
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore
    Arch Biochem Biophys 404:98-105. 2002
    ..This element has been found to play a major role in the down-regulation of NTX-2 gene expression. A point mutation on this silencer appears to attenuate its repressive property in CTX-2 gene...
  13. pmc MicroRNA 320a functions as a novel endogenous modulator of aquaporins 1 and 4 as well as a potential therapeutic target in cerebral ischemia
    Sugunavathi Sepramaniam
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore
    J Biol Chem 285:29223-30. 2010
    ..We have also shown that anti-miR-320a could bring about a reduction of infarct volume in cerebral ischemia with a concomitant increase in aquaporins 1 and 4 mRNA and protein expression...
  14. doi request reprint Circulating miRNA profiles in patients with metabolic syndrome
    Dwi Setyowati Karolina
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, Singapore 117597
    J Clin Endocrinol Metab 97:E2271-6. 2012
    ..Coordinated interplay of dysregulated microRNAs in isolated metabolic disorder is implicated in the pathogenesis of metabolic syndrome...
  15. pmc Cytotoxic potency of cardiotoxin from Naja sputatrix: development of a new cytolytic assay
    Donghui Ma
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 10 Medical Drive, Singapore 119260
    Biochem J 366:35-43. 2002
    ..cDNAs encoding cardiotoxin and the chimaeric toxins, when expressed in transfected cultured Chinese hamster ovary cells, resulted in cell lysis, indicating that these cDNAs can be developed as useful cytolytic agents...
  16. pmc A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis
    Arunmozhiarasi Armugam
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    BMC Neurosci 10:120. 2009
    ..The neuroprotective effect of neutral phospholipase from snake venom has been investigated...
  17. pmc microRNAs in circulation are altered in response to influenza A virus infection in humans
    Paul A Tambyah
    Department of Medicine, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore
    PLoS ONE 8:e76811. 2013
    ..Consequences of their altered expression were extrapolated to changes in the host proteome expression. These highly dysregulated microRNAs may have crucial roles in influenza pathogenesis and are potential biomarkers of influenza. ..
  18. pmc MicroRNA-130a represses transcriptional activity of aquaporin 4 M1 promoter
    Sugunavathi Sepramaniam
    Department of Biochemistry and Neuroscience Research Centre, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    J Biol Chem 287:12006-15. 2012
    ..In vivo studies revealed that LNA(TM) anti-miR-130a could up-regulate the AQP4 M1 transcript and its protein to bring about a reduction in cerebral infarct and promote recovery...
  19. ncbi request reprint Snake postsynaptic neurotoxins: gene structure, phylogeny and applications in research and therapy
    Joyce Siew Phui Yee
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochimie 86:137-49. 2004
    ..The importance of alpha-neurotoxins in therapy and research has also been discussed to highlight their potential applications especially in the area of drug discovery...
  20. pmc Circulating MicroRNAs as Biomarkers of Acute Stroke
    Sugunavathi Sepramaniam
    Department of Biochemistry and Neuroscience Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore
    Int J Mol Sci 15:1418-32. 2014
    ..Hence, their specificity to the stroke pathology emphasizes the possibility of developing these microRNAs into accurate and useful tools for diagnosis of stroke. ..
  21. doi request reprint Role of microRNAs in kidney homeostasis and disease
    Karthikeyan Chandrasekaran
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore
    Kidney Int 81:617-27. 2012
    ..In addition, we highlight the need for further investigations on miRNA-based studies in the development of diagnostic, prognostic, and therapeutic tools for renal diseases...
  22. ncbi request reprint Systematic analysis of snake neurotoxins' functional classification using a data warehousing approach
    Joyce Phui Yee Siew
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597
    Bioinformatics 20:3466-80. 2004
    ..There is a need for a specialized svNTXs database that contains NTX entries, which are organized, well annotated and classified in a systematic manner...
  23. pmc MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus
    Dwi Setyowati Karolina
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore
    PLoS ONE 6:e22839. 2011
    ..In parallel, we have examined the expression profiles of miRNAs in blood samples from Impaired Fasting Glucose (IFG) and T2D male patients...
  24. doi request reprint Stabilization and immobilization of aquaporin reconstituted lipid vesicles for water purification
    Guofei Sun
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Colloids Surf B Biointerfaces 102:466-71. 2013
    ..2% and 88.1%, respectively. With AqpZ incorporation, the vesicle immobilized membrane exhibits a promising strategy for high productivity water purification...
  25. ncbi request reprint Pro-domain in precursor nerve growth factor mediates cell death
    Arunmozhiarasi Armugam
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Neurochem Int 60:852-63. 2012
    ..The pro-domain, has been found to mediate apoptosis possibly by promoting the formation of a signaling complex comprising of endogenous p75(NTR) receptor, Bim/Bcl2 group of proteins and JNK and MEK1/2 signaling pathways...
  26. ncbi request reprint Biochemistry of envenomation
    Prameet Kaur
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore
    Adv Clin Chem 57:187-252. 2012
    ..Because of their use in folk and traditional medicine, the biochemistry behind venom therapy and possible implications on conventional medicine will also be addressed...
  27. ncbi request reprint Pulmonary inflammation and edema induced by phospholipase A2: global gene analysis and effects on aquaporins and Na+/K+-ATPase
    Charmian D N Cher
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, S117597, Singapore
    J Biol Chem 278:31352-60. 2003
    ....
  28. ncbi request reprint Neuroprotection and peptide toxins
    Wudayagiri Rajendra
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Brain Res Brain Res Rev 45:125-41. 2004
    ....
  29. ncbi request reprint Antioxidants: promising neuroprotection against cardiotoxin-4b-induced cell death which triggers oxidative stress with early calpain activation
    Tan Boon Toh
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Toxicon 51:964-73. 2008
    ..Most importantly, antioxidants have proved to be a promising therapeutic avenue against CTX-4b-induced neuronal death...
  30. ncbi request reprint Human Wharton's jelly stem cells and its conditioned medium enhance healing of excisional and diabetic wounds
    Chui Yee Fong
    Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, 119228, Singapore
    J Cell Biochem 115:290-302. 2014
    ..Our studies demonstrated that hWJSCs enhance healing of excisional and diabetic wounds via differentiation into keratinocytes and release of important molecules...
  31. ncbi request reprint Expression Profiling of RNA Transcripts during Neuronal Maturation and Ischemic Injury
    Prameet Kaur
    Department of Biochemistry and Neuroscience Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    PLoS ONE 9:e103525. 2014
    ..Furthermore, we propose that expression of the cell adhesion molecules, Ncam1 and Negr1 might be tightly regulated by both long non-coding RNAs and microRNAs. ..
  32. ncbi request reprint Toxins in anti-nociception and anti-inflammation
    Wudayagiri Rajendra
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8, Medical Drive, Singapore, Singapore 117597
    Toxicon 44:1-17. 2004
    ..The possible mechanisms of these potential therapeutic agents and possible clinical applications in the treatment of pain and inflammation are also summarized...
  33. ncbi request reprint MicroRNAs: biogenesis, function and applications
    Jia Hui Chua
    National University of Singapore, Yong Loo Lin School of Medicine, Department of Biochemistry, 10 Medical Drive, Singapore
    Curr Opin Mol Ther 11:189-99. 2009
    ..This review focuses on the developments in miRNAs and their potential therapeutic applications...
  34. ncbi request reprint Riboregulators and metabolic disorders: getting closer towards understanding the pathogenesis of diabetes mellitus?
    Subramaniam Tavintharan
    Department of Medicine, Alexandra Hospital, Singapore
    Curr Mol Med 9:281-6. 2009
    ..In this review, we will be discussing about the role/function of miRNAs in insulin secretion and regulation, lipid metabolism and conditions like hypertension and cardiovascular diseases and the potential use of miRNA in therapy...
  35. ncbi request reprint Highly permeable and selective pore-spanning biomimetic membrane embedded with aquaporin Z
    Honglei Wang
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 Singapore
    Small 8:1185-90, 1125. 2012
    ..This approach represents a significant breakthrough in the architecture of biomimetic membranes embedded with aquaporin in a planar form...
  36. ncbi request reprint MicroRNAs as therapeutic targets in human diseases
    Kandiah Jeyaseelan
    National University of Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, Singapore
    Expert Opin Ther Targets 11:1119-29. 2007
    ..The commercial potential of miRNA and related drugs is expected to exponentially increase within the next few years, yet there are several areas in miRNA biology and delivery that need to be extensively investigated...
  37. pmc Water and ion channels: crucial in the initiation and progression of apoptosis in central nervous system?
    Minghui Jessica Chen
    Departments of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Curr Neuropharmacol 6:102-16. 2008
    ....
  38. doi request reprint A novel method of AquaporinZ incorporation via binary-lipid Langmuir monolayers
    Guofei Sun
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore
    Colloids Surf B Biointerfaces 89:283-8. 2012
    ..The new approach of AqpZ reconstitution revealed in this work could potentially be applied in biomimetic membrane formation for water purification applications...
  39. doi request reprint Riboregulators in kidney development and function
    Dwi Setyowati Karolina
    Department of Biochemistry, YLL School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Biochimie 92:217-25. 2010
    ..Further progress in the understanding of microRNA activity, identification of microRNA signatures in different states as well as advancement of microRNA manipulation techniques will be valuable for kidney research...
  40. doi request reprint Characterizing behavior of corpus cavernosum in chloride-free condition
    Lang Chu Lau
    Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Urology 77:1265.e17-22. 2011
    ..To elucidate the role of chloride currents in erectile function through characterizing the behavior of corpus cavernosum (CC) in chloride-free (Cf) medium, which has not been evaluated before...