Yoshiaki Ito

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi request reprint Oncogenic potential of the RUNX gene family: 'overview'
    Yoshiaki Ito
    Institute of Molecular and Cell Biology and Oncology Research Institute, National University of Singapore, 30 Medical Drive, Singapore 117609, Singapore
    Oncogene 23:4198-208. 2004
  2. ncbi request reprint RUNX transcription factors as key targets of TGF-beta superfamily signaling
    Yoshiaki Ito
    Institute of Molecular and Cell Biology and Oncology Research Institute, National University of Singapore, Singapore
    Curr Opin Genet Dev 13:43-7. 2003
  3. ncbi request reprint Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer
    Qing Lin Li
    Department of Biochemistry, School of Medicine and Institute for Tumor Research, Chungbuk National University, Cheongju, Republic of Korea
    Biochem Biophys Res Commun 314:223-8. 2004
  4. pmc Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
    Sayyed K Zaidi
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655 0106, USA
    EMBO J 23:790-9. 2004
  5. ncbi request reprint Contribution of reactivated RUNX3 to inhibition of gastric cancer cell growth following suberoylanilide hydroxamic acid (vorinostat) treatment
    Canhua Huang
    Oncology Research Institute, National University of Singapore, Singapore
    Biochem Pharmacol 73:990-1000. 2007
  6. doi request reprint Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells
    Ti Ling Chang
    Cancer Science Institute of Singapore, National University of Singapore, Singapore
    Gastroenterology 138:255-65.e1-3. 2010
  7. pmc Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study
    Feng Zhu
    Department of Medicine, National University of Singapore, Singapore, Singapore
    BMC Gastroenterol 9:76. 2009
  8. doi request reprint Role of RUNX3 in bone morphogenetic protein signaling in colorectal cancer
    Cecilia Wei Lin Lee
    Cancer Science Institute of Singapore and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
    Cancer Res 70:4243-52. 2010
  9. doi request reprint Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity
    Dominic Chih Cheng Voon
    The Cancer Biology Program, Cancer Science Institute of Singapore, National University of Singapore, Singapore
    Stem Cells 30:2088-99. 2012
  10. doi request reprint Role of TAp73alpha in induction of apoptosis by transforming growth factor-beta in gastric cancer cells
    Yasuko Yamamura
    Oncology Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    FEBS Lett 582:2663-7. 2008

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Oncogenic potential of the RUNX gene family: 'overview'
    Yoshiaki Ito
    Institute of Molecular and Cell Biology and Oncology Research Institute, National University of Singapore, 30 Medical Drive, Singapore 117609, Singapore
    Oncogene 23:4198-208. 2004
    ..In this Overview, I will summarize how this growing field has been formed and what are the challenging new frontiers for better understanding of the oncogenic potential of this gene family...
  2. ncbi request reprint RUNX transcription factors as key targets of TGF-beta superfamily signaling
    Yoshiaki Ito
    Institute of Molecular and Cell Biology and Oncology Research Institute, National University of Singapore, Singapore
    Curr Opin Genet Dev 13:43-7. 2003
    ..A possible relationship between the TGF-beta-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined...
  3. ncbi request reprint Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer
    Qing Lin Li
    Department of Biochemistry, School of Medicine and Institute for Tumor Research, Chungbuk National University, Cheongju, Republic of Korea
    Biochem Biophys Res Commun 314:223-8. 2004
    ..RUNX3 methylation is tumor-specific, since it is not observed in surrounding normal lung tissues. Our results suggest that loss of RUNX3 expression by DNA hypermethylation is frequently associated with the evolution of lung cancer...
  4. pmc Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
    Sayyed K Zaidi
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655 0106, USA
    EMBO J 23:790-9. 2004
    ..Our results suggest that Src/Yes signals are integrated through organization of Runx2-YAP transcriptional complexes at subnuclear sites to attenuate skeletal gene expression...
  5. ncbi request reprint Contribution of reactivated RUNX3 to inhibition of gastric cancer cell growth following suberoylanilide hydroxamic acid (vorinostat) treatment
    Canhua Huang
    Oncology Research Institute, National University of Singapore, Singapore
    Biochem Pharmacol 73:990-1000. 2007
    ....
  6. doi request reprint Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells
    Ti Ling Chang
    Cancer Science Institute of Singapore, National University of Singapore, Singapore
    Gastroenterology 138:255-65.e1-3. 2010
    ..We aimed to identify RUNX3 target genes that promote cell-cell contact to improve our understanding of RUNX3's role in suppressing gastric carcinogenesis...
  7. pmc Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study
    Feng Zhu
    Department of Medicine, National University of Singapore, Singapore, Singapore
    BMC Gastroenterol 9:76. 2009
    ..A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC...
  8. doi request reprint Role of RUNX3 in bone morphogenetic protein signaling in colorectal cancer
    Cecilia Wei Lin Lee
    Cancer Science Institute of Singapore and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
    Cancer Res 70:4243-52. 2010
    ..Evidence is presented suggesting that RUNX3 downregulates c-Myc expression by two parallel pathways-directly at the transcriptional level and through attenuation of beta-catenin/TCFs, downstream of BMPs in colorectal cancer cells...
  9. doi request reprint Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity
    Dominic Chih Cheng Voon
    The Cancer Biology Program, Cancer Science Institute of Singapore, National University of Singapore, Singapore
    Stem Cells 30:2088-99. 2012
    ..These data demonstrate a protective role for RUNX3 in safeguarding gastric epithelial cells against aberrant growth factor signaling and the resultant cellular plasticity and stemness...
  10. doi request reprint Role of TAp73alpha in induction of apoptosis by transforming growth factor-beta in gastric cancer cells
    Yasuko Yamamura
    Oncology Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    FEBS Lett 582:2663-7. 2008
    ..Our findings reveal a novel role of TAp73alpha in the induction of apoptosis by TGF-beta in cancer cells...
  11. ncbi request reprint RUNX3 downregulation in human lung adenocarcinoma is independent of p53, EGFR or KRAS status
    Mohd Feroz Mohd Omar
    Cancer Science Institute of Singapore, Centre for Translational Medicine, National University of Singapore, 12 01, 14 Medical Drive, Singapore, 117599, Singapore
    Pathol Oncol Res 18:783-92. 2012
    ..Our results suggest a central role of RUNX3 downregulation in pulmonary adenocarcinoma, which may not be dependent of other established cancer-causing pathways and may have important diagnostic and screening implications...
  12. doi request reprint MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer
    Kin Wai Lai
    Cancer Science Institute of Singapore, Centre for Life Sciences 02 15, 28 Medical Drive, National University of Singapore, Singapore 117456, Singapore
    Eur J Cancer 46:1456-63. 2010
    ..Accumulating evidence indicates that RUNX3 is an important tumour suppressor that is inactivated in many cancer types. This study aimed to assess the role of microRNA (miRNA) in the regulation of RUNX3...
  13. pmc EMT-Induced Stemness and Tumorigenicity Are Fueled by the EGFR/Ras Pathway
    Dominic Chih Cheng Voon
    The Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
    PLoS ONE 8:e70427. 2013
    ..These data show that the EGFR/Ras pathway requisite for the sustenance of gastric stem cells in vivo and in vitro is involved in the genesis and promotion of EMT-induced tumor-initiating cells. ..
  14. doi request reprint RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression
    Manish Mani Subramaniam
    Oncology Research Institute, National University of Singapore, Singapore, Republic of Singapore
    Breast Cancer Res Treat 113:113-21. 2009
    ..Here, we hypothesize that inactivation of RUNX3 occurring in ductal carcinoma in situ (DCIS) represent early event in breast carcinogenesis...
  15. pmc Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility
    David T Leong
    Cancer Science Institute of Singapore, National University of Singapore, Singapore
    Breast Cancer Res 12:R89. 2010
    ..RUNX2 expression is inversely regulated with respect to cell growth in osteoblasts and deregulated in osteosarcoma cells...
  16. doi request reprint RUNX3 functions as an oncogene in ovarian cancer
    Cecilia Wei Lin Lee
    Cancer Science Institute of Singapore, National University of Singapore, Singapore
    Gynecol Oncol 122:410-7. 2011
    ..Interestingly, an oncogenic role for RUNX3 has also been suggested in basal cell carcinoma and head and neck cancer. Here, we explore the role of RUNX3 in ovarian cancer...
  17. doi request reprint RUNX family: Regulation and diversification of roles through interacting proteins
    Linda Shyue Huey Chuang
    Cancer Science Institute of Singapore, National University of Singapore, Singapore
    Int J Cancer 132:1260-71. 2013
    ..This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses...
  18. doi request reprint RUNX3 inactivation in colorectal polyps arising through different pathways of colonic carcinogenesis
    Manish M Subramaniam
    Faculty of Medicine, Oncology Research Institute, National University of Singapore, Singapore
    Am J Gastroenterol 104:426-36. 2009
    ..We hypothesized that RUNX3 inactivation by promoter hypermethylation in colorectal polyps is an early molecular event in colorectal carcinogenesis...
  19. ncbi request reprint CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer
    Qiang Liu
    Oncology Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore
    Mod Pathol 20:1286-97. 2007
    ..Intestinal metaplasia or dysplasia with low expression of CDX2 may serve as predictive markers for gastric cancer...
  20. ncbi request reprint RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells
    Yasuko Yamamura
    Oncology Research Institute, National University Medical Institutes, Institute of Molecular and Cell Biology, Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117592, Singapore
    J Biol Chem 281:5267-76. 2006
    ..These findings show that RUNX3 cooperates with FoxO3a/FKHRL1 to participate in the induction of apoptosis by activating Bim and may play an important role in tumor suppression in gastric cancer...
  21. ncbi request reprint Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer
    Chouhei Sakakura
    Graduate School of Medical Science, Surgery and Regenerative Medicine, Surgery and Physiology of Digestive System, Kyoto Prefectural University of Medicine, Kamigyo ku, Kawaramachi dori, Kyoto 602, Japan
    Int J Cancer 113:221-8. 2005
    ..These findings suggest that RUNX1 and CBFBeta in addition to RUNX3 play some roles in gastric cancers and that roles of RUNX gene family in gastric cancer are more widespread and complex than previously realized...
  22. ncbi request reprint Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription
    Faiza Afzal
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 204:63-72. 2005
    ..Our findings suggest that TGFbeta/ BMP2 signaling, MAPK dependent phosphorylation, and Runx2 subnuclear targeting converge to induce the osteogenic phenotype...
  23. ncbi request reprint Runx1 promotes angiogenesis by downregulation of insulin-like growth factor-binding protein-3
    Ken Iwatsuki
    Department of Tumor Biochemistry, The Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    Oncogene 24:1129-37. 2005
    ..These results demonstrate that Runx1 is directly involved in angiogenesis by repression of IGFBP-3 mRNA expression...
  24. ncbi request reprint Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice
    Masatoshi Yanagida
    Institute of Molecular and Cell Biology, Singapore
    Oncogene 24:4477-85. 2005
    ....
  25. pmc RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD
    Xin Zi Chi
    Department of Biochemistry, School of Medicine, and Institute for Tumor Research, Chungbuk National University, Cheongju 361 763, South Korea
    Mol Cell Biol 25:8097-107. 2005
    ..Our results suggest that at least part of the tumor suppressor activity of RUNX3 is associated with its ability to induce p21 expression...
  26. pmc The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis
    Takashi Yano
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Singapore
    Mol Cell Biol 26:4474-88. 2006
    ..These results demonstrate that RUNX3 is responsible for transcriptional up-regulation of Bim in TGF-beta-induced apoptosis...
  27. ncbi request reprint Runx3 is essential for the target-specific axon pathfinding of trkc-expressing dorsal root ganglion neurons
    Ken ichi Inoue
    Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Blood Cells Mol Dis 30:157-60. 2003
    ..Our results suggest that Runx3 controls the target-specific axon pathfinding of trkC-expressing DRG neurons in the spinal cord...
  28. ncbi request reprint Runx3-/- gastric epithelial cells differentiate into intestinal type cells
    Hiroshi Fukamachi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 321:58-64. 2004
    ..The relationship between loss of function of Runx3, formation of intestinal metaplasia, and gastric cancer was discussed...
  29. ncbi request reprint Nomenclature for Runt-related (RUNX) proteins
    Andre J Van Wijnen
    Molecular and Cell Biology and Oncology Research Institute, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
    Oncogene 23:4209-10. 2004
  30. ncbi request reprint Heterozygous PU.1 mutations are associated with acute myeloid leukemia
    Beatrice U Mueller
    Blood 101:2074. 2003
  31. pmc Comment on Levanon et al., "Runx3 knockouts and stomach cancer", in EMBO reports (June 2003)
    Suk Chul Bae
    EMBO Rep 4:538-9. 2003
  32. ncbi request reprint Putative intermediate precursor between hematogenic endothelial cells and blood cells in the developing embryo
    Stuart T Fraser
    Department of Molecular Genetics, Faculty of Medicine and Graduate School of Medicine, Kyoto University, Shogoin Kawaharacho 53, Sakyo ku, Japan
    Dev Growth Differ 45:63-75. 2003
    ..Collectively, these results introduce a novel VE-cadherin+ population within the developing embryo, which may represent an intermediate cell type in the transition of hemogenic endothelial cells into blood...
  33. ncbi request reprint Causal relationship between the loss of RUNX3 expression and gastric cancer
    Qing Lin Li
    Department of Biochemistry, College of Medicine, Institute of Medical Research, Chungbuk National University, 361 763, Cheongju, South Korea
    Cell 109:113-24. 2002
    ....
  34. pmc The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1
    Yoichi Imai
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Cell Biol 24:1033-43. 2004
    ..This study provides a novel regulatory mechanism for the function of transcription factors mediated by protein modification and interaction with cofactors...
  35. ncbi request reprint In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis
    Joelle Michaud
    Division of Medical Genetics, Geneva University Medical School, Switzerland
    Blood 99:1364-72. 2002
    ....
  36. ncbi request reprint Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines
    Manabu Wada
    Department of Gastroenterology and Hepatology, Graduate School of Internal Medicine, Kyoto University, Kyoto 606 8507, Japan
    Oncogene 23:2401-7. 2004
    ..These data suggest that the inactivation of RUNX3 plays an important role in bile duct and pancreatic carcinogenesis, and that methylation is a common mechanism by which the gene is inactivated...
  37. pmc Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegans
    Seunghee Nam
    Department of Biology, Yonsei University, Seoul 120 749, South Korea
    Mol Cell Biol 22:547-54. 2002
    ..elegans. The highly conserved role of the Runt domain transcription factor in gut development during evolution from nematodes to mammals is discussed...
  38. pmc Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
    Carolina A Yoshida
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Genes Dev 18:952-63. 2004
    ..These findings demonstrate that Runx2 and Runx3 are essential for chondrocyte maturation and that Runx2 regulates limb growth by organizing chondrocyte maturation and proliferation through the induction of Ihh expression...
  39. ncbi request reprint Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera
    Gang Huang
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Blood 103:3200-7. 2004
    ....
  40. pmc K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development
    Takaaki Matsui
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    EMBO J 21:1021-30. 2002
    ..These results indicate that K-Ras specifically mediates cytokine signaling for formation of AJs during liver development...
  41. doi request reprint RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis
    Kosei Ito
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673
    Cancer Cell 14:226-37. 2008
    ..Taken together, these data demonstrate that RUNX3 functions as a tumor suppressor by attenuating Wnt signaling...
  42. ncbi request reprint Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 111:621-33. 2002
    ..Runx3-deficient cytotoxic T cells, but not helper cells, have defective responses to antigen, suggesting that Runx proteins have critical functions in lineage specification and homeostasis of CD8-lineage T lymphocytes...
  43. ncbi request reprint Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor
    Wei hui Guo
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo ku Kyoto 606 8507, Japan
    Oncogene 21:8351-5. 2002
    ..These observations suggest that the mouse system described here may be useful as a model for the study of human gastric carcinogenesis...
  44. ncbi request reprint SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis
    Tomomi Watanabe
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, 113 0033, Japan
    Dev Biol 250:332-47. 2002
    ..Thus, SEK1 appears to play a crucial role in hepatoblast proliferation and survival in a manner apparently different from NF-kappaB or c-Jun...
  45. pmc Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms
    Hee Jun Wee
    Department of Viral Oncology, Kyoto University, Japan
    EMBO Rep 3:967-74. 2002
    ..One CCD mutation, S104R of RUNX2, appears to mimic the phosphorylation-dependent inhibition of heterodimerization, thereby rendering RUNX2 metabolically unstable...
  46. pmc Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations
    Taketoshi Yoshida
    Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Am J Hum Genet 71:724-38. 2002
    ..Overall, these results suggest that CCD could result from much smaller losses in the RUNX2 function than has been envisioned on the basis of the conventional haploinsufficiency model...
  47. ncbi request reprint Heterozygous PU.1 mutations are associated with acute myeloid leukemia
    Beatrice U Mueller
    Harvard Institutes of Medicine, Harvard Medical School, Boston, MA, USA
    Blood 100:998-1007. 2002
    ..1 target genes. This is the first report of mutations in the PU.1 gene in human neoplasia and suggests that disruption of PU.1 function contributes to the block in differentiation found in AML patients...
  48. pmc Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation
    Satoshi Fujii
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center at Kashiwa, 6 5 1, Kashiwanoha, Kashiwa, Chiba 277 857 7 Japan
    J Biol Chem 283:17324-32. 2008
    ..The results showed that RUNX3 is a target for repression by EZH2 and indicated an underlying mechanism of the functional role of EZH2 overexpression on cancer cell proliferation...
  49. doi request reprint Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice
    Atsuko Sakuma
    The Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama, Japan
    Mol Reprod Dev 75:1653-61. 2008
    ..These results suggest that Runx3 takes part in the regulation of reproductive functions...
  50. ncbi request reprint Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma
    Yasuhiro Oshimo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 71:137-43. 2004
    ..Our results overall suggest that transcriptional inactivation of RUNX3 by promoter hypermethylation may participate in the stomach carcinogenesis...
  51. ncbi request reprint RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization
    Kosei Ito
    Institute of Molecular and Cell Biology, Proteos, Singapore
    Cancer Res 65:7743-50. 2005
    ..In addition to the deregulation of mechanisms controlling gene expression, there would also seem to be at least one other mechanism controlling nuclear translocation of RUNX3 that is impaired frequently in gastric cancer...
  52. ncbi request reprint Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice
    Namiko Yamashita
    Institute of Molecular and Cell Biology, Singapore
    Br J Haematol 131:495-507. 2005
    ..In conclusion, the BXH2-Runx1+/- system is a promising mouse model to investigate the mechanism of leukaemogenesis in FPD/AML...
  53. ncbi request reprint Increased dosage of the RUNX1/AML1 gene: a third mode of RUNX leukemia?
    Motomi Osato
    Institute of Molecular and Cell Biology, Oncology Research Institute, National University of Singapore
    Crit Rev Eukaryot Gene Expr 15:217-28. 2005
    ..The possibility that this mode might underlie Down syndrome-related leukemias caused by trisomy of chromosome 21 is discussed...
  54. ncbi request reprint Runx3 expression during mouse tongue and palate development
    Hiromitsu Yamamoto
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Anat Rec A Discov Mol Cell Evol Biol 288:695-9. 2006
    ..5 to 16.5. The functional relationship between Runx3 and TGF-beta/BMPs signaling in tongue and palate development is discussed...
  55. ncbi request reprint Transcription factor Runx1 recruits the polyomavirus replication origin to replication factories
    Yota Murakami
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Cell Biochem 100:1313-23. 2007
    ..These observations together suggest that Runx1 recruits the polyomavirus replication origin to the replication factory on the nuclear matrix, and that this requires the nuclear matrix-binding activity of Runx1...
  56. ncbi request reprint Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia
    Norio Asou
    Department of Hematology, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Blood 109:4023-7. 2007
    ....
  57. ncbi request reprint Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult
    Lena Motoda
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore
    Stem Cells 25:2976-86. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  58. ncbi request reprint Functional analysis of RUNX2 mutations in cleidocranial dysplasia: novel insights into genotype-phenotype correlations
    Taketoshi Yoshida
    Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Blood Cells Mol Dis 30:184-93. 2003
    ..This makes an interesting contrast to the case of familial and sporadic leukemias mediated by RUNX1 mutations, in which mutants acting in a dominant negative manner have been suggested to confer a higher propensity to develop leukemia...
  59. ncbi request reprint Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons
    Ken ichi Inoue
    Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 5:946-54. 2002
    ..Our data demonstrate that Runx3 is critical in regulating the axonal projections of a specific subpopulation of DRG neurons...
  60. doi request reprint Dynamic regulation of the expression of neurotrophin receptors by Runx3
    Souichiro Nakamura
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
    Development 135:1703-11. 2008
    ..Moreover, we show that the number of TrkA-positive DRG neurons is reduced in Runx3(-/-) mice, as compared with the wild type. These results suggest that Runx3 positively regulates the expression of TrkC and TrkA in DRG neurons...