Hung Huynh

Summary

Affiliation: National Cancer Centre
Country: Singapore

Publications

  1. ncbi request reprint SarCNU-induced G2/M arrest in hepatoma cells is mediated by a p53-independent phosphorylation of cdc-2 at Tyr15
    Huynh Hung
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore
    J Cell Physiol 204:785-91. 2005
  2. ncbi request reprint Xenografts of human hepatocellular carcinoma: a useful model for testing drugs
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre, Singapore
    Clin Cancer Res 12:4306-14. 2006
  3. ncbi request reprint Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610, Singapore
    Mol Cancer Ther 6:2959-66. 2007
  4. doi request reprint Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore
    J Hepatol 56:595-601. 2012
  5. doi request reprint Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
    Angiogenesis 15:59-70. 2012
  6. doi request reprint RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore
    J Cell Mol Med 13:1371-80. 2009
  7. ncbi request reprint AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore 169610
    Mol Cancer Ther 6:2468-76. 2007
  8. ncbi request reprint Bevacizumab plus 5-fluorouracil induce growth suppression in the CWR-22 and CWR-22R prostate cancer xenografts
    Huynh Hung
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre, Singapore 169610, Singapore
    Mol Cancer Ther 6:2149-57. 2007
  9. ncbi request reprint Dietary quercetin inhibits proliferation of lung carcinoma cells
    Huynh Hung
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore
    Forum Nutr 60:146-57. 2007
  10. ncbi request reprint Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610, Singapore
    Mol Cancer Ther 6:138-46. 2007

Collaborators

Detail Information

Publications58

  1. ncbi request reprint SarCNU-induced G2/M arrest in hepatoma cells is mediated by a p53-independent phosphorylation of cdc-2 at Tyr15
    Huynh Hung
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore
    J Cell Physiol 204:785-91. 2005
    ..These findings indicate that SarCNU-induced G(2)/M growth arrest in hepatoma cells by a p53-independent phosphorylation of cdc-2. Our data suggest the potential use of SarCNU in treatment of HCC...
  2. ncbi request reprint Xenografts of human hepatocellular carcinoma: a useful model for testing drugs
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre, Singapore
    Clin Cancer Res 12:4306-14. 2006
    ..Our aims were to establish and characterize primary human hepatocellular carcinoma xenografts. They were used to screen new drugs and improve our current treatment regimens used in hepatocellular carcinoma...
  3. ncbi request reprint Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610, Singapore
    Mol Cancer Ther 6:2959-66. 2007
    ....
  4. doi request reprint Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore
    J Hepatol 56:595-601. 2012
    ..This study aims at investigating the antitumor, antiangiogenesis and antimetastatic activities of dovitinib in preclinical models of HCC...
  5. doi request reprint Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
    Angiogenesis 15:59-70. 2012
    ..The purpose of this study is to assess the anti-tumor and anti-angiogenic activities of foretinib, a vascular endothelial growth factor receptor 2 (VEGFR-2) and c-Met inhibitor using mouse models of human HCC...
  6. doi request reprint RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore
    J Cell Mol Med 13:1371-80. 2009
    ..Our study provides a strong rationale for clinical investigation of mTOR inhibitor RAD001 in patients with HCC...
  7. ncbi request reprint AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore 169610
    Mol Cancer Ther 6:2468-76. 2007
    ..Our study provides a strong rationale for clinical investigation of combination therapy with the mitogen-activated protein/ERK kinase 1/2 inhibitor AZD6244 and doxorubicin in patients with HCC...
  8. ncbi request reprint Bevacizumab plus 5-fluorouracil induce growth suppression in the CWR-22 and CWR-22R prostate cancer xenografts
    Huynh Hung
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre, Singapore 169610, Singapore
    Mol Cancer Ther 6:2149-57. 2007
    ..Our data indicate that bevacizumab/5-FU effectively inhibits angiogenesis and cell cycle progression and suggest that bevacizumab/5-FU may represent an alternative treatment for patients with prostate cancer...
  9. ncbi request reprint Dietary quercetin inhibits proliferation of lung carcinoma cells
    Huynh Hung
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore
    Forum Nutr 60:146-57. 2007
    ..Inhibition of MEK1/2 but not PI3 kinase, p38 kinase or JNK abolished quercetin-induced apoptosis suggesting MEK-ERK activation was required to trigger apoptosis...
  10. ncbi request reprint Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610, Singapore
    Mol Cancer Ther 6:138-46. 2007
    ..Targeted inhibition of the MEK-ERK pathway with AZD6244 may represent an alternative approach for the treatment of this disease...
  11. ncbi request reprint Treatment modalities for hepatocellular carcinoma
    Huynh Hung
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610
    Curr Cancer Drug Targets 5:131-8. 2005
    ..Future clinical trials and research will help to evaluate and improve both systemic and targeted molecular therapies for this complex disease...
  12. doi request reprint Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, 11 Hospital Drive, Singapore 169610, Singapore
    J Hepatol 49:52-60. 2008
    ..We investigated if combined targeting of vascular endothelial growth factor protein and expression might affect hepatocellular carcinoma growth and angiogenesis...
  13. doi request reprint Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore
    Clin Cancer Res 14:6146-53. 2008
    ..The aim of this study was to determine the antineoplastic activity of brivanib alaninate, a dual inhibitor of VEGF receptor (VEGFR) and FGF receptor (FGFR) signaling pathways...
  14. ncbi request reprint Comparing the efficacy of sunitinib with sorafenib in xenograft models of human hepatocellular carcinoma: mechanistic explanation
    H Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11 Hospital Drive, Singapore
    Curr Cancer Drug Targets 11:944-53. 2011
    ..In conclusion, sunitinib demonstrated an inferior anti-tumor activity compared to sorafenib in ectopic and orthotopic models of human HCC. It remains to be seen whether such observations would be recapitulated in humans...
  15. ncbi request reprint Targeting receptor tyrosine kinase pathways in hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore
    Anticancer Agents Med Chem 11:560-75. 2011
    ..Understanding the mechanisms of action of these therapeutic agents and methods of combining these drugs may help to increase their efficacy, reduce toxicity, and improve overall survival and quality of life in patients with HCC...
  16. doi request reprint Tyrosine kinase inhibitors to treat liver cancer
    Hung Huynh
    National Cancer Centre of Singapore, Humphrey Oei Institute of Cancer Research, Division of Cellular and Molecular Research, Laboratory of Molecular Endocrinology, 11 Hospital Drive, 169610, Singapore
    Expert Opin Emerg Drugs 15:13-26. 2010
    ..Despite the death risk of patients with advanced HCC being reduced with sorafenib therapy, many patients eventually turn out to be refractory to this therapy. Thus, treatment of HCC remains an urgent health concern...
  17. doi request reprint AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma
    Hung Huynh
    Division of Molecular and Cellular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore
    Cancer 116:1315-25. 2010
    ....
  18. doi request reprint AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
    J Hepatol 52:79-87. 2010
    ..Hepatocellular carcinoma (HCC) is a particularly vascularized solid tumor where the Raf/MEK/ERK pathway is activated; suggesting that inhibition of this pathway may have therapeutic potential...
  19. ncbi request reprint Sunitinib (SUTENT, SU11248) suppresses tumor growth and induces apoptosis in xenograft models of human hepatocellular carcinoma
    H Huynh
    Humphrey Oei Institute of Cancer Research, National Cancer Centre of Singapore, Singapore
    Curr Cancer Drug Targets 9:738-47. 2009
    ..This study provides a strong rationale for further clinical investigation of sunitinib in patients with hepatocellular carcinoma...
  20. doi request reprint Molecularly targeted therapy in hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Level 6, Lab 1, 11 Hospital Drive, Singapore 169610, Singapore
    Biochem Pharmacol 80:550-60. 2010
    ..This review describes evolving molecular targeted agents, their common adverse side effects, and its potential use in management of HCC...
  21. doi request reprint Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre 169610, Singapore
    J Cell Mol Med 13:2673-83. 2009
    ..These data also provide a strong rationale for clinical investigation of sorafenib in combination with mTOR inhibitors in patients with HCC...
  22. doi request reprint Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore 169610, Singapore
    Mol Cancer Ther 8:152-9. 2009
    ..Our study provides a strong rationale for the clinical investigation of sorafenib in patients with GIST as well as an established platform for further drug evaluation studies using GIST xenograft models...
  23. ncbi request reprint Suppression of ps20 expression in the rat uterus by tamoxifen and estrogens
    Huynh Hung
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Center of Singapore, Singapore 169610
    Endocrinology 146:2388-96. 2005
    ..The data indicate that ps20 expression is negatively regulated by estrogens and tamoxifen and suggest that ps20 may function as a mediator of local growth...
  24. ncbi request reprint Extracellular signal-regulated kinase induces cyclin D1 and Cdk-2 expression and phosphorylation of retinoblastoma in hepatocellular carcinoma
    H Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, 169610, Singapore
    Int J Oncol 25:1839-47. 2004
    ..Our data indicate that activated ERK plays an important role in cyclin D1 and Cdk-2 expression and phosphorylation of pRB at Ser780 and Ser795 in liver cancer cells...
  25. ncbi request reprint Inhibition of estrogen receptor alpha expression and function in MCF-7 cells by kaempferol
    Huynh Hung
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore
    J Cell Physiol 198:197-208. 2004
    ..These findings suggest that modulation of ER-alpha expression and function by kaempferol may be, in part, responsible for its anti-proliferative effects seen in in vitro...
  26. pmc Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, Singapore General Hospital, Singapore 169610
    BMC Gastroenterol 3:19. 2003
    ..Although activation of the MEK-MAPK is often associated with cellular growth, the role of MEK-MAPK in growth and survival of hepatocarcinoma cells has not been established...
  27. ncbi request reprint Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610, Republic of Singapore
    Int J Oncol 23:821-9. 2003
    ..Since ErbB receptor is important for growth, metastasis and drug resistance, inhibition of ErbB-2 and ErbB-3 by pharmacological doses of quercetin may provide a new approach for treatment of prostate cancers...
  28. ncbi request reprint Induction of apoptosis in rat ventral prostate by finasteride is associated with alteration in MAP kinase pathways and Bcl-2 related family of proteins
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610
    Int J Oncol 20:1297-303. 2002
    ....
  29. ncbi request reprint A possible role for insulin-like growth factor-binding protein-3 autocrine/paracrine loops in controlling hepatocellular carcinoma cell proliferation
    Hung Huynh
    Laboratory of Molecular Endocrinology, National Cancer Centre of Singapore, Singapore
    Cell Growth Differ 13:115-22. 2002
    ..Our data indicate that loss of autocrine/paracrine IGFBP-3 loops may lead to HCC tumor growth and suggest that modulating production of the IGFs, IGFBP-3, and IGF-IR may represent a novel approach in the treatment of HCC...
  30. ncbi request reprint Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate
    H Huynh
    Molecular Endocrinology Laboratory, Division of Cellular and Molecular Research, National Cancer Centre, Singapore 169610
    J Endocrinol 171:109-18. 2001
    ..These observations support a potential use of ICI in conjunction with finasteride in the prevention and/or treatment of prostate cancer...
  31. ncbi request reprint Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland
    H Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research National Cancer Center of Singapore, Singapore 169610
    Endocrinology 142:3607-15. 2001
    ..These observations led to speculation that OKL38 may play a vital role in the growth regulation and differentiation of breast epithelial cells during pregnancy and its implications in tumorigenesis...
  32. ncbi request reprint Post-transcriptional and post-translational regulation of insulin-like growth factor binding protein-3 and -4 by insulin-like growth factor-I in uterine myometrial cells
    H Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, 169610, Singapore
    Growth Horm IGF Res 10:20-7. 2000
    ..By enhancing IGFBP-4 proteolysis, increasing cell-associated IGFBP-3 and stabilizing IGFBP-3, IGF-I may initiate a mitogenic response...
  33. ncbi request reprint Overexpression of tumour suppressor retinoblastoma 2 protein (pRb2/p130) in hepatocellular carcinoma
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610
    Carcinogenesis 25:1485-94. 2004
    ..Overexpression of pRb2/p130 in HCC was, therefore, suggested to be a programmed protective response of the organism to uncontrolled proliferation...
  34. ncbi request reprint 2-Chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU) inhibits prostate carcinoma cell growth via p53-dependent and p53-independent pathways
    Hung Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore, Singapore
    Cancer 101:2881-91. 2004
    ..In the current study, the authors sought to investigate the effects of SarCNU on prostate carcinoma cell growth in vivo and in vitro...
  35. doi request reprint AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer
    Shu Yang
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610
    Mol Cancer Ther 8:2537-45. 2009
    ..Our data show that MAP/ERK kinase inhibition enhances the antitumor activity of sorafenib in vivo, supporting a rationale for multitargeted suppression of the angiogenesis and ERK signaling network in gastric cancer therapy...
  36. ncbi request reprint Reduction of CWR22 prostate tumor xenograft growth by combined tamoxifen-quercetin treatment is associated with inhibition of angiogenesis and cellular proliferation
    Zeng Shuan Ma
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Center of Singapore, Singapore 169610
    Int J Oncol 24:1297-304. 2004
    ..1 and 59.0%, respectively, by the combined treatment. These findings indicate that tamoxifen inhibits CWR22 prostate tumor by modulating the angiogenesis and its antineoplastic effects can be potentiated by combined use with quercetin...
  37. ncbi request reprint Structural characterization of three novel rat OKL38 transcripts, their tissue distributions, and their regulation by human chorionic gonadotropin
    Choon Kiat Ong
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, 11 Hospital Drive, Singapore 169610
    Endocrinology 145:4763-74. 2004
    ....
  38. pmc Effective inhibition of xenografts of hepatocellular carcinoma (HepG2) by rapamycin and bevacizumab in an intrahepatic model
    Lai Chun Ong
    Singapore General Hospital, Outram Road, Singapore, 169608, Singapore
    Mol Imaging Biol 11:334-42. 2009
    ....
  39. ncbi request reprint Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane-associated protein, UO-44
    Caine Tuck Choy Leong
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610, Singapore
    Oncogene 23:5707-18. 2004
    ..These findings suggest the potential role of HuUO-44 in cell motility, cell-cell interactions and/or interactions with the extracellular matrices...
  40. doi request reprint Combination of the ERK inhibitor AZD6244 and low-dose sorafenib in a xenograft model of human renal cell carcinoma
    John Shyi Peng Yuen
    Department of Urology, Singapore General Hospital, Singapore, Republic of Singapore
    Int J Oncol 41:712-20. 2012
    ..This study provides sound evidence for the clinical investigation of low-dose sorafenib in combination with AZD6244 in patients with advanced RCC...
  41. doi request reprint An Epstein-Barr virus positive natural killer lymphoma xenograft derived for drug testing
    Susan Li Er Loong
    Division of Cellular and Molecular Research, Department of Radiation Oncology, National Cancer Centre, Singapore
    Leuk Lymphoma 49:1161-7. 2008
    ..Our data suggest that the NK-S1 xenograft is a useful tool for screening preclinical drugs, and cyclophosphamide may be a useful drug for the treatment of this disease...
  42. ncbi request reprint Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation
    Zengshuan Ma
    Division of Cellular and Molecular Research, National Cancer Center of Singapore, Singapore 169610
    J Endocrinol 181:493-507. 2004
    ..The results suggest that quercetin synergizes with finasteride to reduce the wet prostate weight through a cell cycle-related pathway, which may be androgen independent...
  43. ncbi request reprint Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis
    Choon Kiat Ong
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Center, Singapore 169610
    J Biol Chem 279:743-54. 2004
    ..This study demonstrates the complex genomic structure of the OKL38 gene and its growth inhibitory and cytotoxic properties. Our data suggest the potential use of OKL38 in diagnosis, prognosis, and/or treatment of kidney cancer...
  44. ncbi request reprint Induction of apoptosis in mammary gland by a pure anti-estrogen ICI 182780
    K B Lim
    Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore
    Breast Cancer Res Treat 68:127-38. 2001
    ..These findings suggest that modulation of Bax, Bcl-xL, Bcl-2 and Bad proteins by ICI may be, in part, responsible for the anti-proliferative and apoptotic effect of ICI seen clinically and in animal models...
  45. ncbi request reprint 2-Chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU) exhibits p53-dependent and -independent antiproliferative activity in human nasopharyngeal carcinoma cells in vitro and in vivo
    T H Nguyen
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610
    Int J Oncol 27:1131-40. 2005
    ..Our data suggest a potential use of SarCNU in the treatment of NPC...
  46. ncbi request reprint Inhibition of Akt pathway phosphorylation as a mechanism in the pathogenesis of functional intestinal obstruction in carcinomatosis peritonei
    Donald Poon
    Department of Medical Oncology, Division of Cellular and Molecular Research, National Cancer Centre, Singapore
    Hematol Oncol Stem Cell Ther 1:73-9. 2008
    ....
  47. ncbi request reprint Kaempferol-induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK
    T T T Nguyen
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore
    J Cell Physiol 197:110-21. 2003
    ....
  48. ncbi request reprint Induction of mammary epithelial cell differentiation and inhibition of dimethylbenz(A)anthracene-induced mammary tumour by co-administration of a pure antiestrogen ICI 182,780 and testosterone enanthate
    T W Chan
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610
    Int J Oncol 19:263-9. 2001
    ....
  49. ncbi request reprint Inhibition of insulin-like growth factor signaling pathways in mammary gland by pure antiestrogen ICI 182,780
    T W Chan
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610
    Clin Cancer Res 7:2545-54. 2001
    ..The data indicate that in addition to their classic actions, antiestrogens have major effects on IGF signaling pathways...
  50. ncbi request reprint An efficient and safe herpes simplex virus type 1 amplicon vector for transcriptionally targeted therapy of human hepatocellular carcinomas
    Paula Y P Lam
    Laboratory of Cancer Gene Therapy, Division of Cellular and Molecular Research, National Cancer Centre, Singapore
    Mol Ther 15:1129-36. 2007
    ..Together, these results demonstrated that the new hybrid vectors could provide options for the design of safe and efficient systemic gene therapeutic strategies for human HCC...
  51. ncbi request reprint Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids
    T T Phan
    Department of Plastic Surgery, Singapore General Hospital, Singapore
    Br J Dermatol 148:544-52. 2003
    ..Keloids are characterized by abnormal proliferation of fibroblasts and overproduction of collagen. Insulin-like growth factor (IGF)-I is mitogenic for fibroblasts and a stimulatory factor for collagen synthesis...
  52. doi request reprint Hybrid herpes simplex virus/Epstein-Barr virus amplicon viral vectors confer enhanced transgene expression in primary human tumors and human bone marrow-derived mesenchymal stem cells
    Kian Chuan Sia
    Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humprey Oei Institute of Cancer Research, National Cancer Centre of Singapore, Singapore
    J Gene Med 12:848-58. 2010
    ....
  53. ncbi request reprint The role of 5' untranslated region in translational suppression of OKL38 mRNA in hepatocellular carcinoma
    C K Ong
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore, Singapore
    Oncogene 26:1155-65. 2007
    ..Taken together, the 5'UTRs of OKL38 might play an important role in downregulation of its protein and the absence of OKL38 could lead to the development or progression of HCC...
  54. ncbi request reprint Induction of UO-44 gene expression by tamoxifen in the rat uterus and ovary
    H Huynh
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610
    Endocrinology 142:2985-95. 2001
    ....
  55. doi request reprint Preclinical evaluation of transcriptional targeting strategy for human hepatocellular carcinoma in an orthotopic xenograft mouse model
    Kian Chuan Sia
    Corresponding Author Paula Yeng Po Lam, Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11, Hospital Drive, Singapore 169610
    Mol Cancer Ther 12:1651-64. 2013
    ..Mol Cancer Ther; 12(8); 1651-64. ©2013 AACR. ..
  56. ncbi request reprint Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro
    C T C Leong
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore, Singapore
    Oncogene 26:870-80. 2007
    ....
  57. ncbi request reprint The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells
    T T T Nguyen
    Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre of Singapore, Singapore 169610
    Carcinogenesis 25:647-59. 2004
    ..The results suggest that in addition to inactivation of Akt-1 and alteration in the expression of the Bcl-2 family of proteins, activation of MEK-ERK is required for quercetin-induced apoptosis in A549 lung carcinoma cells...
  58. ncbi request reprint Phyllodes tumors of the breast: the role of pathologic parameters
    Puay Hoon Tan
    Department of Pathology, Singapore General Hospital, Singapore
    Am J Clin Pathol 123:529-40. 2005
    ..3% and 51.7% respectively. The 7 women who died of disease during follow-up had malignant phyllodes tumor at the outset and experienced recurrences, and death was preceded by distant metastases...