Hung Huynh

Summary

Affiliation: National Cancer Centre
Country: Singapore

Publications

  1. request reprint
    Huynh H, Teo C, Soo K. Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer. Mol Cancer Ther. 2007;6:2959-66 pubmed
  2. request reprint
    Huynh H, Soo K, Chow P, Tran E. Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. Mol Cancer Ther. 2007;6:138-46 pubmed
    ..Targeted inhibition of the MEK-ERK pathway with AZD6244 may represent an alternative approach for the treatment of this disease. ..
  3. Huynh H. AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma. Cancer. 2010;116:1315-25 pubmed publisher
    ..Given the urgent need for effective therapies in HCC, clinical evaluating AZD6244/RAPA combination seems warranted. ..
  4. Huynh H, Chow P, Palanisamy N, Salto Tellez M, Goh B, Lee C, et al. Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Hepatol. 2008;49:52-60 pubmed publisher
    ..Bevacizumab and rapamycin, which are both clinically approved drugs, may represent a novel molecularly-targeted combination treatment for hepatocellular carcinoma. ..
  5. Huynh H, Ngo V, Koong H, Poon D, Choo S, Thng C, et al. Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Cell Mol Med. 2009;13:2673-83 pubmed publisher
    ..These data also provide a strong rationale for clinical investigation of sorafenib in combination with mTOR inhibitors in patients with HCC. ..
  6. Huynh H, Chow K, Soo K, Toh H, Choo S, Foo K, et al. RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma. J Cell Mol Med. 2009;13:1371-80 pubmed publisher
    ..Our study provides a strong rationale for clinical investigation of mTOR inhibitor RAD001 in patients with HCC. ..
  7. request reprint
    Huynh H. Induction of apoptosis in rat ventral prostate by finasteride is associated with alteration in MAP kinase pathways and Bcl-2 related family of proteins. Int J Oncol. 2002;20:1297-303 pubmed
  8. Huynh H, Ong R, Zopf D. Antitumor activity of the multikinase inhibitor regorafenib in patient-derived xenograft models of gastric cancer. J Exp Clin Cancer Res. 2015;34:132 pubmed publisher
    ..These findings are consistent with the observed activity of regorafenib in preclinical models of other gastrointestinal tumors, and support further clinical investigation in gastric cancer. ..
  9. Huynh H. Tyrosine kinase inhibitors to treat liver cancer. Expert Opin Emerg Drugs. 2010;15:13-26 pubmed publisher

More Information

Publications19

  1. Huynh H, Ngo V, Fargnoli J, Ayers M, Soo K, Koong H, et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res. 2008;14:6146-53 pubmed publisher
    ..This study provides a strong rationale for clinical investigation of brivanib in patients with HCC. ..
  2. Fong E, Toh T, Lin Q, Liu Z, Hooi L, Mohd Abdul Rashid M, et al. Generation of matched patient-derived xenograft in vitro-in vivo models using 3D macroporous hydrogels for the study of liver cancer. Biomaterials. 2018;159:229-240 pubmed publisher
    ..Furthermore, we demonstrate the feasibility of using these in vitro HCC-PDX models for drug testing, paving the way for more efficient preclinical studies in HCC drug development. ..
  3. Wang W, Iyer N, Tay H, Wu Y, Lim T, Zheng L, et al. Microarray profiling shows distinct differences between primary tumors and commonly used preclinical models in hepatocellular carcinoma. BMC Cancer. 2015;15:828 pubmed publisher
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    Hung H. Inhibition of estrogen receptor alpha expression and function in MCF-7 cells by kaempferol. J Cell Physiol. 2004;198:197-208 pubmed
    ..These findings suggest that modulation of ER-alpha expression and function by kaempferol may be, in part, responsible for its anti-proliferative effects seen in in vitro. ..
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    Hung H. Suppression of ps20 expression in the rat uterus by tamoxifen and estrogens. Endocrinology. 2005;146:2388-96 pubmed
    ..The data indicate that ps20 expression is negatively regulated by estrogens and tamoxifen and suggest that ps20 may function as a mediator of local growth. ..
  6. request reprint
    Huynh H, Ng C, Ong C, Lim K, Chan T. Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland. Endocrinology. 2001;142:3607-15 pubmed
    ..These observations led to speculation that OKL38 may play a vital role in the growth regulation and differentiation of breast epithelial cells during pregnancy and its implications in tumorigenesis. ..
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    Huynh H. Overexpression of tumour suppressor retinoblastoma 2 protein (pRb2/p130) in hepatocellular carcinoma. Carcinogenesis. 2004;25:1485-94 pubmed
    ..Overexpression of pRb2/p130 in HCC was, therefore, suggested to be a programmed protective response of the organism to uncontrolled proliferation. ..
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    Huynh H, Nguyen T, Chan E, Tran E. Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation. Int J Oncol. 2003;23:821-9 pubmed
    ..Since ErbB receptor is important for growth, metastasis and drug resistance, inhibition of ErbB-2 and ErbB-3 by pharmacological doses of quercetin may provide a new approach for treatment of prostate cancers. ..
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    Huynh H, Chow P, Ooi L, Soo K. A possible role for insulin-like growth factor-binding protein-3 autocrine/paracrine loops in controlling hepatocellular carcinoma cell proliferation. Cell Growth Differ. 2002;13:115-22 pubmed
    ..Our data indicate that loss of autocrine/paracrine IGFBP-3 loops may lead to HCC tumor growth and suggest that modulating production of the IGFs, IGFBP-3, and IGF-IR may represent a novel approach in the treatment of HCC. ..
  10. request reprint
    Huynh H, Alpert L, Alaoui Jamali M, Ng C, Chan T. Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate. J Endocrinol. 2001;171:109-18 pubmed
    ..These observations support a potential use of ICI in conjunction with finasteride in the prevention and/or treatment of prostate cancer. ..