Khek Yu Ho

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi request reprint Symptomatic gastro-oesophageal reflux in pregnancy: a prospective study among Singaporean women
    K Y Ho
    Department of Medicine, National University of Singapore, Singapore
    J Gastroenterol Hepatol 13:1020-6. 1998
  2. ncbi request reprint Primary malignant melanoma of the esophagus with multiple esophageal lesions
    Khek Yu Ho
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
    Nat Clin Pract Gastroenterol Hepatol 4:171-4. 2007
  3. ncbi request reprint Gastroesophageal reflux disease in Asian countries: disorder of nature or nurture?
    Khek Yu Ho
    Department of Medicine, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Gastroenterol Hepatol 21:1362-5. 2006
  4. ncbi request reprint Survey of endoscopic ultrasonographic practice and training in the Asia-Pacific region
    Khek Yu Ho
    Department of Medicine, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Gastroenterol Hepatol 21:1231-5. 2006
  5. doi request reprint Randomized, parallel, double-blind comparison of the ulcer-healing effects of ilaprazole and omeprazole in the treatment of gastric and duodenal ulcers
    Khek Yu Ho
    Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, National University of Singapore, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore
    J Gastroenterol 44:697-707. 2009
  6. doi request reprint Gastroesophageal reflux disease in Asia: a condition in evolution
    Khek Yu Ho
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Gastroenterol Hepatol 23:716-22. 2008
  7. ncbi request reprint Empirical treatment for the management of patients presenting with uninvestigated reflux symptoms: a prospective study in an Asian primary care population
    K Y Ho
    Department of Medicine, National University Hospital, Singapore
    Aliment Pharmacol Ther 21:1313-20. 2005
  8. pmc Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study
    G H Song
    Department of Medicine, National University of Singapore
    Gut 54:1402-7. 2005
  9. ncbi request reprint Patterns of consultation and treatment for heartburn: findings from a Singaporean community survey
    K Y Ho
    Department of Medicine, National University of Singapore, Singapore
    Aliment Pharmacol Ther 13:1029-33. 1999
  10. ncbi request reprint A prospective study of the clinical features, manometric findings, incidence and prevalence of achalasia in Singapore
    K Y Ho
    Department of Medicine, National University of Singapore
    J Gastroenterol Hepatol 14:791-5. 1999

Detail Information

Publications45

  1. ncbi request reprint Symptomatic gastro-oesophageal reflux in pregnancy: a prospective study among Singaporean women
    K Y Ho
    Department of Medicine, National University of Singapore, Singapore
    J Gastroenterol Hepatol 13:1020-6. 1998
    ..Reflux-type symptoms were related to nausea and vomiting, both in frequency and time pattern of onset and disappearance of symptoms. The association suggested either a common mechanism or a cause and effect relationship...
  2. ncbi request reprint Primary malignant melanoma of the esophagus with multiple esophageal lesions
    Khek Yu Ho
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
    Nat Clin Pract Gastroenterol Hepatol 4:171-4. 2007
    ..A 48-year-old Chinese woman presented with a 2-month history of progressive dysphagia for solids, and (less frequently) liquids. She had minimal weight loss and no family history of cancer...
  3. ncbi request reprint Gastroesophageal reflux disease in Asian countries: disorder of nature or nurture?
    Khek Yu Ho
    Department of Medicine, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Gastroenterol Hepatol 21:1362-5. 2006
    ..However, with the recent globalization of economies, the associated lifestyle changes in many developing Asian countries may have tipped the balance in favor of the development of GERD...
  4. ncbi request reprint Survey of endoscopic ultrasonographic practice and training in the Asia-Pacific region
    Khek Yu Ho
    Department of Medicine, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Gastroenterol Hepatol 21:1231-5. 2006
    ..The aim of the present study was to assess EUS practice and training in the Asia-Pacific region and seek to identify areas where the development of EUS expertise could be further enhanced...
  5. doi request reprint Randomized, parallel, double-blind comparison of the ulcer-healing effects of ilaprazole and omeprazole in the treatment of gastric and duodenal ulcers
    Khek Yu Ho
    Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital, National University of Singapore, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore
    J Gastroenterol 44:697-707. 2009
    ..Ilaprazole (IY-81149) is a new proton-pump inhibitor (PPI) not previously studied in human patients with ulcer disease. This study evaluated and compared it with a reference PPI, omeprazole, in the treatment of gastric and duodenal ulcers...
  6. doi request reprint Gastroesophageal reflux disease in Asia: a condition in evolution
    Khek Yu Ho
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Gastroenterol Hepatol 23:716-22. 2008
    ..We will draw on findings from across Asia, take an in-depth look at prevailing trends and patterns and examine some of the most plausible explanations behind the dynamics of this epidemiological transition...
  7. ncbi request reprint Empirical treatment for the management of patients presenting with uninvestigated reflux symptoms: a prospective study in an Asian primary care population
    K Y Ho
    Department of Medicine, National University Hospital, Singapore
    Aliment Pharmacol Ther 21:1313-20. 2005
    ..Data on Asian patients who present with reflux symptoms to their primary care physicians are limited...
  8. pmc Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study
    G H Song
    Department of Medicine, National University of Singapore
    Gut 54:1402-7. 2005
    ..We aimed to determine if melatonin was effective in improving bowel symptoms and sleep disturbances in irritable bowel syndrome (IBS) patients with sleep disturbance...
  9. ncbi request reprint Patterns of consultation and treatment for heartburn: findings from a Singaporean community survey
    K Y Ho
    Department of Medicine, National University of Singapore, Singapore
    Aliment Pharmacol Ther 13:1029-33. 1999
    ..The prevalence of reflux-type symptoms among community individuals in Singapore is low...
  10. ncbi request reprint A prospective study of the clinical features, manometric findings, incidence and prevalence of achalasia in Singapore
    K Y Ho
    Department of Medicine, National University of Singapore
    J Gastroenterol Hepatol 14:791-5. 1999
    ..This study aimed to describe the clinical features, manometric findings, prevalence and incidence of achalasia in Singapore...
  11. doi request reprint Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy
    Mads Sylvest Bergholt
    Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore
    J Biophotonics 6:49-59. 2013
    ....
  12. doi request reprint Combining near-infrared-excited autofluorescence and Raman spectroscopy improves in vivo diagnosis of gastric cancer
    Mads Sylvest Bergholt
    Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore
    Biosens Bioelectron 26:4104-10. 2011
    ..This work demonstrates that the complementary Raman and NIR AF spectroscopy techniques can be integrated together for improving the in vivo diagnosis and detection of gastric cancer at endoscopy...
  13. doi request reprint The response of Asian patients with functional dyspepsia to eradication of Helicobacter pylori infection
    Kok Ann Gwee
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Eur J Gastroenterol Hepatol 21:417-24. 2009
    ..Several randomized controlled trials involving populations in the West, observed no statistically significant advantage over placebo. However, none of these studies involved Asian populations which have high infection rates...
  14. ncbi request reprint Increasing trend of reflux esophagitis and decreasing trend of Helicobacter pylori infection in patients from a multiethnic Asian country
    Khek Yu Ho
    Department of Medicine, National University of Singapore, Singapore
    Am J Gastroenterol 100:1923-8. 2005
    ..This study aimed to determine time trends in the frequency of endoscopic esophagitis, and Helicobacter pylori (H. pylori) infection in a large Singaporean teaching hospital over a 10-yr period...
  15. doi request reprint Activating endogenous visceral pain modulation: a comparison of heterotopic stimulation methods in healthy controls
    Clive H Wilder-Smith
    Department of Medicine, National University of Singapore, Singapore
    Eur J Pain 13:836-42. 2009
    ..Pain facilitation, as shown earlier in IBS patients, was not evident in healthy controls...
  16. doi request reprint In vivo detection of epithelial neoplasia in the stomach using image-guided Raman endoscopy
    Zhiwei Huang
    Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, and National University Hospital System, 9, Engineering Drive 1, Singapore 117576, Singapore
    Biosens Bioelectron 26:383-9. 2010
    ..This work demonstrates for the first time that image-guided Raman endoscopy technique has promising potential for the non-invasive, in vivo diagnosis and detection of gastric cancer at the molecular level...
  17. doi request reprint In vivo diagnosis of gastric cancer using Raman endoscopy and ant colony optimization techniques
    Mads Sylvest Bergholt
    Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore
    Int J Cancer 128:2673-80. 2011
    ....
  18. doi request reprint In-practice predictors of response to proton pump inhibitor therapy in primary care patients with dyspepsia in an Asian population
    Kok Ann Gwee
    Department of Medicine, National University of Singapore, Singapore
    J Clin Gastroenterol 42:134-8. 2008
    ..Data on Asian patients who present to primary care physicians with dyspepsia are limited...
  19. doi request reprint Characterizing variability in in vivo Raman spectra of different anatomical locations in the upper gastrointestinal tract toward cancer detection
    Mads Sylvest Bergholt
    National University of Singapore, Department of Bioengineering, Faculty of Engineering, Singapore
    J Biomed Opt 16:037003. 2011
    ..This work demonstrates that Raman endoscopy technique has promising clinical potential for real-time, in vivo diagnosis and detection of malignancies in the upper GI at the molecular level...
  20. ncbi request reprint Effect of biopsies on sensitivity and specificity of ultra-rapid urease test for detection of Helicobacter pylori infection: a prospective evaluation
    Li Lin Lim
    Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, 119074 Singapore
    World J Gastroenterol 10:1907-10. 2004
    ..To prospectively assess the sensitivity, specificity and time to positivity of theUltra-rapid urease test (URUT) for Helicobacter pylori (H pylori), and compare the results of one with those of two biopsies...
  21. doi request reprint From GERD to Barrett's esophagus: is the pattern in Asia mirroring that in the West?
    Khek Yu Ho
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Gastroenterol Hepatol 26:816-24. 2011
    ....
  22. ncbi request reprint Opposing trends in incidence of esophageal squamous cell carcinoma and adenocarcinoma in a multi-ethnic Asian country
    Mark L Fernandes
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Am J Gastroenterol 101:1430-6. 2006
    ..To describe the incidence trends in esophageal squamous cell carcinoma (SCC) and adenocarcinoma among the three major ethnic groups in Singapore from 1968 to 2002...
  23. doi request reprint Validation of structured scoring using the LA classification for esophagitis and endoscopically suspected Barrett's esophagus in a tertiary Asian endoscopy center
    Reuben K M Wong
    Department of Gastroenterology and Hepatology, National University Hospital, Singapore
    J Gastroenterol Hepatol 24:103-6. 2009
    ..To determine the inter-observer agreement and validity of the LA Classification in scoring the severity of esophagitis in Asian patients...
  24. ncbi request reprint Changing prevalence of gastroesophageal reflux with changing time: longitudinal study in an Asian population
    Shen L Lim
    Department of Medicine, National University of Singapore, Singapore
    J Gastroenterol Hepatol 20:995-1001. 2005
    ..This sample was re-investigated 5 years later to determine changes in the prevalence of reflux symptoms...
  25. doi request reprint The effects of melatonin on colonic transit time in normal controls and IBS patients
    Wei Zhen Lu
    Department of Pharmacology, National University of Singapore, Singapore, Singapore
    Dig Dis Sci 54:1087-93. 2009
    ..The aim of this study was to investigate the effects of exogenous melatonin on colonic transit time (CTT) in healthy subjects and in patients with irritable bowel syndrome (IBS)...
  26. doi request reprint Closure of gastrotomy in natural orifice transluminal endoscopic surgery: a feasibility study using an ex vivo model comparing endoloop with endoclip
    Asim Shabbir
    Department of Surgery University Surgical Centre, National University Hospital, Singapore
    Dig Endosc 23:130-4. 2011
    ..Our study was designed to compare the effectiveness of gastrotomy closure using endoloop and endoclip with hand-sewn closure as a control...
  27. doi request reprint The Asia-Pacific Colorectal Screening score: a validated tool that stratifies risk for colorectal advanced neoplasia in asymptomatic Asian subjects
    Khay Guan Yeoh
    Department of Medicine, National University of Singapore
    Gut 60:1236-41. 2011
    ..To develop and validate a clinical risk score predictive of risk for colorectal advanced neoplasia for Asia...
  28. doi request reprint Comparison of probe-based confocal endomicroscopy with virtual chromoendoscopy and white-light endoscopy for diagnosis of gastric intestinal metaplasia
    Lee Guan Lim
    Department of Gastroenterology and Hepatology, National University Health System, 10 Kent Ridge Crescent, Singapore, 119260, Singapore
    Surg Endosc 27:4649-55. 2013
    ....
  29. ncbi request reprint Cortical effects of anticipation and endogenous modulation of visceral pain assessed by functional brain MRI in irritable bowel syndrome patients and healthy controls
    Guang Hui Song
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Pain 126:79-90. 2006
    ..The aberrant activation of endogenous pain inhibition appears to involve circuitry relating to anticipation as well as pain processing itself...
  30. doi request reprint Validation of a graded response questionnaire for the diagnosis of gastroesophageal reflux disease in an Asian primary care population
    Khek Yu Ho
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Clin Gastroenterol 42:680-6. 2008
    ..Diagnosis of gastroesophageal reflux disease (GERD) based on subjective evaluation of symptoms alone is challenging...
  31. doi request reprint In vivo early diagnosis of gastric dysplasia using narrow-band image-guided Raman endoscopy
    Zhiwei Huang
    National University of Singapore, Department of Bioengineering, Faculty of Engineering, Optical Bioimaging Laboratory, Singapore 117576
    J Biomed Opt 15:037017. 2010
    ....
  32. ncbi request reprint Gastroesophageal reflux disease at the turn of millennium
    Lee Guan Lim
    Department of Medicine, National University Hospital, Singapore
    World J Gastroenterol 9:2135-6. 2003
    ..The second part summarized published studies on the relationship between GERD and Helicobacter pylori, relevant to the Asia-Pacific region. The last part discussed some of the recent advances in the treatment of GERD...
  33. doi request reprint Factors determining diagnostic yield of endoscopic ultrasound guided fine-needle aspiration for pancreatic cystic lesions: a multicentre Asian study
    Lee Guan Lim
    Department of Gastroenterology and Hepatology, National University Health System, 10 Kent Ridge Crescent, Singapore, 119260, Singapore
    Dig Dis Sci 58:1751-7. 2013
    ....
  34. doi request reprint Curry induces acid reflux and symptoms in gastroesophageal reflux disease
    Lee Guan Lim
    Department of Gastroenterology and Hepatology, National University Health System, Singapore, Singapore
    Dig Dis Sci 56:3546-50. 2011
    ..There are limited data on the effect of curry on gastroesophageal reflux disease (GERD). Our objective was to study the effects of curry on GERD...
  35. ncbi request reprint Diagnostic yield of upper endoscopy in Asian patients presenting with dyspepsia
    Chun Tao Wai
    Division of Gastroenterology, Department of Medicine, National University Hospital, Singapore
    Gastrointest Endosc 56:548-51. 2002
    ..The aim of this study was to determine the frequency of diagnosis of significant disease by EGD in Asian patients of various ages with simple dyspepsia...
  36. ncbi request reprint Esophageal intubation with duodenoscope in the presence of pharyngeal pouch by a guidewire and catheter-guided technique
    Chun Tao Wai
    Division of Gastroenterology, Department of Medicine, National University Hospital, Singapore, Republic of Singapore
    Surg Laparosc Endosc Percutan Tech 12:362-3. 2002
    ..Our technique minimizes patient discomfort and is rapid and easy to perform. In addition, no extra device such as an overtube is required...
  37. doi request reprint Endoscopic submucosal dissection of gastric lesions by using a Master and Slave Transluminal Endoscopic Robot (MASTER)
    Khek Yu Ho
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
    Gastrointest Endosc 72:593-9. 2010
    ..Performing endoscopic submucosal dissection (ESD) by using standard endoscopy platforms is technically challenging because of the equipment's lack of dexterity...
  38. doi request reprint Is Barrett's esophagus an over-hyped disease in the West, and an underdiagnosed disease in the East?
    Khek Yu Ho
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Dig Endosc 25:157-61. 2013
    ..Raman spectroscopy, a novel biomolecular probe-based technology that does not rely upon operator's interpretation of images, could potentially enhance the detection of Barrett's esophagus and associated neoplasia...
  39. ncbi request reprint EUS-guided FNA immediately after unrevealing transbronchial needle aspiration in the evaluation of mediastinal lymphadenopathy: a prospective study
    Kay Leong Khoo
    Division of Respiratory Medicine, Department of Medicine, National University Hospital, Singapore
    Gastrointest Endosc 63:215-20. 2006
    ..The aim of this study was to determine the utility of TBNA with ROSE, combined with the option for immediate EUS-FNA in a single-session approach to mediastinal lymphadenopathy...
  40. doi request reprint Asia-Pacific consensus on the management of gastroesophageal reflux disease: update
    Kwong Ming Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    J Gastroenterol Hepatol 23:8-22. 2008
    ..Since the publication of the Asia-Pacific GERD consensus in 2004, more data concerning the epidemiology and management of gastroesophageal reflux disease (GERD) have emerged. An evidence based review and update was needed...
  41. pmc Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study
    Feng Zhu
    Department of Medicine, National University of Singapore, Singapore, Singapore
    BMC Gastroenterol 9:76. 2009
    ..A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC...
  42. ncbi request reprint Post-metallic stent placement bleeding caused by stent-induced ulcers
    Chun Tao Wai
    Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
    World J Gastroenterol 11:5739-41. 2005
    ..We report three cases of gastrointestinal bleeding post-SEMS placement and suggest that bleeding is caused by direct mucosal infringement by the sharp edges of the ends of the stents...
  43. ncbi request reprint Integrated Raman spectroscopy and trimodal wide-field imaging techniques for real-time in vivo tissue Raman measurements at endoscopy
    Zhiwei Huang
    Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, and National University Hospital, Singapore
    Opt Lett 34:758-60. 2009
    ....
  44. ncbi request reprint Preoperative diagnosis of a paraesophageal bronchogenic cyst using endosonography
    Li Lin Lim
    Department of Medicine, National University Hospital, Singapore
    Ann Thorac Surg 73:633-5. 2002
    ..Surgical treatment was achieved by cyst excision using a needlescopic technique. Endoscopic ultrasound seems to be the preoperative diagnostic test of choice for paraesophageal bronchogenic cysts...
  45. ncbi request reprint Colorectal neoplasia in Asia: a multicenter colonoscopy survey in symptomatic patients
    Wai K Leung
    Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Gastrointest Endosc 64:751-9. 2006
    ..The incidence of colorectal cancer is rising rapidly in some Asian countries...