Si Shen Feng

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi request reprint New-concept chemotherapy by nanoparticles of biodegradable polymers: where are we now?
    Si Shen Feng
    Nanoscience and Nanoengineering Initiative NUSNNI, Department of Chemical and Biomolecular Engineering and Division of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore
    Nanomedicine (Lond) 1:297-309. 2006
  2. ncbi request reprint Nanospheres of biodegradable polymers: a system for clinical administration of an anticancer drug paclitaxel (Taxol)
    S S Feng
    Department of Chemical and Environmental Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    Ann Acad Med Singapore 29:633-9. 2000
  3. ncbi request reprint Effects of material hydrophobicity on physical properties of polymeric microspheres formed by double emulsion process
    Gang Ruan
    Department of Chemical and Environmental Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    J Control Release 84:151-60. 2002
  4. ncbi request reprint d-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS) modified poly(l-lactide) (PLLA) films for localized delivery of paclitaxel
    Yuancai Dong
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576, Singapore
    Int J Pharm 350:166-71. 2008
  5. ncbi request reprint Vitamin E TPGS-emulsified poly(lactic-co-glycolic acid) nanoparticles for cardiovascular restenosis treatment
    Si Shen Feng
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore
    Nanomedicine (Lond) 2:333-44. 2007
  6. ncbi request reprint Nanoparticles of biodegradable polymers for new-concept chemotherapy
    Si Shen Feng
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    Expert Rev Med Devices 1:115-25. 2004
  7. ncbi request reprint Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM)
    Si Shen Feng
    Department of Chemical and Environmental Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biomaterials 25:5181-9. 2004
  8. ncbi request reprint Nanoparticles of biodegradable polymers for clinical administration of paclitaxel
    Si Shen Feng
    Division of Bioengineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    Curr Med Chem 11:413-24. 2004
  9. ncbi request reprint Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers
    S Feng
    Institute of Materials Research and Engineering IMRE, 3 Research Link, 117602, Singapore
    J Control Release 71:53-69. 2001
  10. ncbi request reprint Poly(d,l-lactide-co-glycolide)/montmorillonite nanoparticles for oral delivery of anticancer drugs
    Yuancai Dong
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biomaterials 26:6068-76. 2005

Collaborators

Detail Information

Publications67

  1. ncbi request reprint New-concept chemotherapy by nanoparticles of biodegradable polymers: where are we now?
    Si Shen Feng
    Nanoscience and Nanoengineering Initiative NUSNNI, Department of Chemical and Biomolecular Engineering and Division of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore
    Nanomedicine (Lond) 1:297-309. 2006
    ..High efficacy and low side effects can be achieved, since high drug concentrations can be delivered selectively to the cancer cells, leaving healthy cells untouched. Thus, the required amount of the drug can be minimized...
  2. ncbi request reprint Nanospheres of biodegradable polymers: a system for clinical administration of an anticancer drug paclitaxel (Taxol)
    S S Feng
    Department of Chemical and Environmental Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    Ann Acad Med Singapore 29:633-9. 2000
    ..This study was intended to investigate the feasibility to apply nanospheres of biodegradable polymers as an alternative system to achieve best results with least side effects...
  3. ncbi request reprint Effects of material hydrophobicity on physical properties of polymeric microspheres formed by double emulsion process
    Gang Ruan
    Department of Chemical and Environmental Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    J Control Release 84:151-60. 2002
    ..Our results suggest that these materials could have interesting potential applications in preparation of polymeric microspheres for controlled protein release...
  4. ncbi request reprint d-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS) modified poly(l-lactide) (PLLA) films for localized delivery of paclitaxel
    Yuancai Dong
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576, Singapore
    Int J Pharm 350:166-71. 2008
    ..8, 8.9 and 19.4 times of that for the PLLA film, respectively. In vitro drug release studies found that incorporation of TPGS considerably facilitated paclitaxel release...
  5. ncbi request reprint Vitamin E TPGS-emulsified poly(lactic-co-glycolic acid) nanoparticles for cardiovascular restenosis treatment
    Si Shen Feng
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore
    Nanomedicine (Lond) 2:333-44. 2007
    ..We have synthesized nanoparticles of biodegradable polymers for the effective and sustainable delivery of paclitaxel and other antiproliferative agents for restenosis treatment...
  6. ncbi request reprint Nanoparticles of biodegradable polymers for new-concept chemotherapy
    Si Shen Feng
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    Expert Rev Med Devices 1:115-25. 2004
    ....
  7. ncbi request reprint Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM)
    Si Shen Feng
    Department of Chemical and Environmental Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biomaterials 25:5181-9. 2004
    ..Such a novel controlled release system may have potential to be applied for drug delivery and gene therapy...
  8. ncbi request reprint Nanoparticles of biodegradable polymers for clinical administration of paclitaxel
    Si Shen Feng
    Division of Bioengineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    Curr Med Chem 11:413-24. 2004
    ....
  9. ncbi request reprint Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers
    S Feng
    Institute of Materials Research and Engineering IMRE, 3 Research Link, 117602, Singapore
    J Control Release 71:53-69. 2001
    ..Our result shows that the chain length and unsaturation of the lipids have a significant influence on the emulsifying efficiency. Phospholipids with short and saturated chains have excellent emulsifying effects...
  10. ncbi request reprint Poly(d,l-lactide-co-glycolide)/montmorillonite nanoparticles for oral delivery of anticancer drugs
    Yuancai Dong
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biomaterials 26:6068-76. 2005
    ..Such a novel formulation is expected to possess extended residence time in the gastrointestinal (GI) tract, which promotes oral delivery of paclitaxel...
  11. doi request reprint Nanoparticles of lipid monolayer shell and biodegradable polymer core for controlled release of paclitaxel: effects of surfactants on particles size, characteristics and in vitro performance
    Yutao Liu
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore
    Int J Pharm 395:243-50. 2010
    ..88-, 5.72-, 7.27-fold effective than the commercial formulation Taxol after 24, 48, 72h treatment, respectively...
  12. doi request reprint Enhanced oral bioavailability of paclitaxel formulated in vitamin E-TPGS emulsified nanoparticles of biodegradable polymers: in vitro and in vivo studies
    Lingyun Zhao
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore
    J Pharm Sci 99:3552-60. 2010
    ..The present proof-of-concept experimental data proved that the formulation of vitamin E TPGS emulsified PLGA NPs is a promising approach for paclitaxel oral administration. Oral chemotherapy by NPs formulation is feasible...
  13. doi request reprint Targeted delivery of paclitaxel using folate-decorated poly(lactide)-vitamin E TPGS nanoparticles
    Jie Pan
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 29:2663-72. 2008
    ..7% TPGS-COOH component and 31.1% for the NP formulation of 33.3% TPGS-COOH component after 24h treatment at the same 25 microg/ml paclitaxel concentration. The experiments on C6 glioma cells further confirmed these advantages...
  14. ncbi request reprint Folate-decorated poly(lactide-co-glycolide)-vitamin E TPGS nanoparticles for targeted drug delivery
    Zhiping Zhang
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 28:1889-99. 2007
    ..The latter NPs also exhibited much lower IC(50) value than the DOX after 24h incubation, i.e., 19.4 vs. 43.7micror MCF-7 cells and 3.3 vs. >100micror C6 cells...
  15. ncbi request reprint Novel powder formulations for controlled delivery of poorly soluble anticancer drug: application and investigation of TPGS and PEG in spray-dried particulate system
    Li Mu
    Division of Bioengineering, National University of Singapore, 9 Engineering Drive 1, 117576, Singapore
    J Control Release 103:565-75. 2005
    ..The combination of PLGA/TPGS/PEG as safe pharmaceutical excipient to formulate particulate delivery system is beneficial in improving the pharmaceutical properties for further powder dosage application...
  16. ncbi request reprint Poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles prepared by high pressure homogenization for paclitaxel chemotherapy
    Yuancai Dong
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Int J Pharm 342:208-14. 2007
    ..The freeze-dried nanoparticles were found to possess excellent water redispersability. The high pressure homogenization could be applied for large industrial scale production of nanoparticles for drug delivery...
  17. ncbi request reprint Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release
    Zhiping Zhang
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biomaterials 27:262-70. 2006
    ..The drug release from PLA-TPGS nanoparticles was found to be biphasic with an initial burst of 17% in the first day, followed by a sustained pattern with 51% release after 31 days...
  18. ncbi request reprint Self-assembled nanoparticles of poly(lactide)--Vitamin E TPGS copolymers for oral chemotherapy
    Zhiping Zhang
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Int J Pharm 324:191-8. 2006
    ..The results obtained in this research demonstrated feasibility for the PLA-TPGS NPs to be applied for oral delivery of paclitaxel as well as other anticancer drugs...
  19. doi request reprint In vitro and in vivo investigation on PLA-TPGS nanoparticles for controlled and sustained small molecule chemotherapy
    Zhiping Zhang
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Kent Ridge, 117576, Singapore
    Pharm Res 25:1925-35. 2008
    ..The aim of this work was to evaluate in vivo poly(lactide)-D: -alpha-tocopheryl polyethylene glycol 1,000 succinate nanoparticles (PLA-TPGS NPs) for controlled and sustained small molecule drug chemotherapy...
  20. doi request reprint Multimodality treatment of cancer with herceptin conjugated, thermomagnetic iron oxides and docetaxel loaded nanoparticles of biodegradable polymers
    Yu Mi
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore
    Biomaterials 33:7519-29. 2012
    ..0011 mg/mL for the MMNPs for 24 h, which is 2130 fold more efficient than the physical mixture of the corresponding single modality treatments...
  21. doi request reprint Quantitative control of targeting effect of anticancer drugs formulated by ligand-conjugated nanoparticles of biodegradable copolymer blend
    Jing Zhao
    Department of Bioengineering, National University of Singapore, Singapore 117576, Singapore
    Biomaterials 33:1948-58. 2012
    ....
  22. doi request reprint Multifunctional nanoparticles of biodegradable copolymer blend for cancer diagnosis and treatment
    Jie Pan
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, Engineering Drive 4, 117576, Singapore
    Nanomedicine (Lond) 5:347-60. 2010
    ....
  23. ncbi request reprint Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    Khin Yin Win
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biomaterials 26:2713-22. 2005
    ..It is highly feasible for nanoparticles of biodegradable polymers to be applied to promote oral chemotherapy...
  24. ncbi request reprint In vitro investigation on poly(lactide)-Tween 80 copolymer nanoparticles fabricated by dialysis method for chemotherapy
    Zhiping Zhang
    Department of Chemical and Biomolecular Engineering and Division of Bioengineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    Biomacromolecules 7:1139-46. 2006
    ..8 +/- 4.2% for PLA-Tween 80-10 and 12.0 +/- 5.4% for PLA-Tween 80-20 copolymer nanoparticles, which was comparable with that for Taxol at the same 50 microg/mL drug concentration...
  25. ncbi request reprint In vitro and in vivo studies on vitamin E TPGS-emulsified poly(D,L-lactic-co-glycolic acid) nanoparticles for paclitaxel formulation
    Khin Yin Win
    Faculty of Engineering, Department of Chemical and Biomolecular Engineering, National University of Singapore
    Biomaterials 27:2285-91. 2006
    ..The sustainable therapeutic time, at which the drug concentration drops below the minimum effective value, for the NP formulation could be 1.67 times longer than that for the Taxol formulation...
  26. ncbi request reprint The drug encapsulation efficiency, in vitro drug release, cellular uptake and cytotoxicity of paclitaxel-loaded poly(lactide)-tocopheryl polyethylene glycol succinate nanoparticles
    Zhiping Zhang
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biomaterials 27:4025-33. 2006
    ..This research was also carried out in close comparison with the drug-loaded PLGA NPs...
  27. doi request reprint Trastuzumab-conjugated vitamin E TPGS liposomes for sustained and targeted delivery of docetaxel
    Anandhkumar Raju
    National University of Singapore, Department of Chemical and Biomolecular Engineering, Block E5 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Expert Opin Drug Deliv 10:747-60. 2013
    ....
  28. doi request reprint Multifunctional silica nanoparticles for targeted delivery of hydrophobic imaging and therapeutic agents
    Yutao Liu
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Int J Pharm 421:370-8. 2011
    ..Fluorescent confocal microscopy is used to monitor the cellular uptake by specific cancer cells. Cytotoxicity studies are conducted by using MTT assay...
  29. doi request reprint Transferrin-conjugated nanoparticles of poly(lactide)-D-alpha-tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood-brain barrier
    Chee Wee Gan
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore
    Biomaterials 31:7748-57. 2010
    ..Moreover, our preliminary ex vivo biodistribution investigation demonstrated that although not as satisfactory, the Tf-conjugated PLA-TPGS NPs formulation could be able to deliver imaging/therapeutic agents across the BBB...
  30. doi request reprint Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of Docetaxel
    Yutao Liu
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 31:330-8. 2010
    ....
  31. ncbi request reprint In vitro and in vivo evaluation of methoxy polyethylene glycol-polylactide (MPEG-PLA) nanoparticles for small-molecule drug chemotherapy
    Yuancai Dong
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 28:4154-60. 2007
    ..Our proof-of-concept in vitro and in vivo valuation shows that our MPEG-PLA NP formulation could have great advantages versus the original drug in small-molecule drug chemotherapy as well as in various applications in nanomedicine...
  32. doi request reprint Targeted co-delivery of docetaxel, cisplatin and herceptin by vitamin E TPGS-cisplatin prodrug nanoparticles for multimodality treatment of cancer
    Yu Mi
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, Block E5 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    J Control Release 169:185-92. 2013
    ..225+0.0875+1.827μg/mL for NIH3T3 cells, which are of low HER2 overexpression, after 24h incubation. The same design of TPGS prodrug nanoparticles can also be applied for targeted co-delivery of other hydrophilic and hydrophobic drugs...
  33. ncbi request reprint Multifunctional poly(D,L-lactide-co-glycolide)/montmorillonite (PLGA/MMT) nanoparticles decorated by Trastuzumab for targeted chemotherapy of breast cancer
    Bingfeng Sun
    Division of Bioengineering, National University of Singapore, Block E3A, 04 15, 7 Engineering Drive 1, Singapore 117574, Singapore
    Biomaterials 29:475-86. 2008
    ..Judged by IC50 after 24h culture, the therapeutic effects of the drug formulated in the NPs with surface decoration could be 12.74 times higher than that of the bare NPs and 13.11 times higher than Taxol...
  34. ncbi request reprint Nanoparticles of poly(D,L-lactide)/methoxy poly(ethylene glycol)-poly(D,L-lactide) blends for controlled release of paclitaxel
    Yuancai Dong
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    J Biomed Mater Res A 78:12-9. 2006
    ..3% encapsulated drug released from the nanoparticles for 14 days while the MPEG-PLA nanoparticles (0/100) achieved the fastest drug release with 95.9% drug release in the same period...
  35. doi request reprint Vitamin E TPGS coated liposomes enhanced cellular uptake and cytotoxicity of docetaxel in brain cancer cells
    Madaswamy S Muthu
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore
    Int J Pharm 421:332-40. 2011
    ..93±0.57μg/ml for the commercial Taxotere(®), the nude, PEG coated and TPGS coated liposomes, respectively after 24h culture with C6 glioma cells. The TPGS coated liposomes showed great advantages in vitro than the PEG coated liposomes...
  36. ncbi request reprint Targeted co-delivery of docetaxel and siPlk1 by herceptin-conjugated vitamin E TPGS based immunomicelles
    Jing Zhao
    Department of Bioengineering, Faculty of Engineering, National University of Singapore, Block EA, 03 12, 9 Engineering Drive 1, Singapore 117576, Singapore
    Biomaterials 34:3411-21. 2013
    ..042, 0.0032 and 0.000671 μg/mL for SK-BR-3 cells after 24 h treatment by Taxotere(®), and docetaxel formulated in the TPGS micelles, the TPGS-siPlk1/TPGS micelles and the herceptin-conjugated TPGS-siPlk1/TPGS micelles, respectively...
  37. doi request reprint Development of docetaxel-loaded vitamin E TPGS micelles: formulation optimization, effects on brain cancer cells and biodistribution in rats
    Madaswamy S Muthu
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore
    Nanomedicine (Lond) 7:353-64. 2012
    ....
  38. doi request reprint Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery
    Sneha A Kulkarni
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11 4 Engineering Drive 4, Singapore, 117576, Singapore
    Pharm Res 30:2512-22. 2013
    ....
  39. ncbi request reprint Preparation and characterization of poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) microspheres for controlled release of paclitaxel
    Gang Ruan
    Department of Chemical and Environmental Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore
    Biomaterials 24:5037-44. 2003
    ..PLA-PEG-PLA microspheres could thus be promising for the clinical administration of highly hydrophobic antineoplastic drugs such as paclitaxel...
  40. doi request reprint A strategy for precision engineering of nanoparticles of biodegradable copolymers for quantitative control of targeted drug delivery
    Yutao Liu
    Department of Chemical and Biomolecular Engineering National University of Singapore, 4 Engineering Drive 4, Singapore
    Biomaterials 31:9145-55. 2010
    ....
  41. doi request reprint Herceptin functionalized polyhedral oligomeric silsesquioxane - conjugated oligomers - silica/iron oxide nanoparticles for tumor cell sorting and detection
    Yu Mi
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore
    Biomaterials 32:8226-33. 2011
    ..Such a multiply-engineered structure can be used for either traditional immunomagnetic methods or microfluidic devices for CTC sorting and detection...
  42. doi request reprint Vitamin E (D-alpha-tocopheryl-co-poly(ethylene glycol) 1000 succinate) micelles-superparamagnetic iron oxide nanoparticles for enhanced thermotherapy and MRI
    Prashant Chandrasekharan
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 32:5663-72. 2011
    ..T2 mapped images of xenograft grown on SCID mice showed that the TPGS micelle formulation of IOs had ∼1.7 times and ∼1.05 times T2 decrease at the tumor site compared to Resovist and the F127 micelle formulation, respectively...
  43. doi request reprint Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel
    Si Shen Feng
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 30:3297-306. 2009
    ..59% for Taxotere((R)) to 78% for the PLA-TPGS/MMT NP formulation and 91% for the PLA-TPGS NP formulation respectively. Oral chemotherapy by nanoparticles of biodegradable polymers is feasible...
  44. doi request reprint Multimodal tumor imaging by iron oxides and quantum dots formulated in poly (lactic acid)-D-alpha-tocopheryl polyethylene glycol 1000 succinate nanoparticles
    Yang Fei Tan
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 32:2969-78. 2011
    ..With therapeutics co-encapsulation and ligand conjugation, such nanoparticles system can realize a multi-functional system for medical diagnosis and treatment...
  45. doi request reprint Doxorubicin conjugated to D-alpha-tocopheryl polyethylene glycol succinate and folic acid as a prodrug for targeted chemotherapy
    Vanangamudi Anbharasi
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore
    J Biomed Mater Res A 94:730-43. 2010
    ..Furthermore, TPGS-DOX can limit, and TPGS-DOX-FOL can further deduce, the gastrointestinal side effect of the drug...
  46. ncbi request reprint Nanoparticles of poly(lactide)-tocopheryl polyethylene glycol succinate (PLA-TPGS) copolymers for protein drug delivery
    Sie Huey Lee
    NUS Nanoscience and Nanotechnology Initiative NUSNNI, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 28:2041-50. 2007
    ..This research suggests that PLA-TPGS NPs could be of great potential for clinical formulation of proteins and peptides...
  47. doi request reprint Theranostic liposomes of TPGS coating for targeted co-delivery of docetaxel and quantum dots
    Madaswamy S Muthu
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576, Singapore
    Biomaterials 33:3494-501. 2012
    ..The targeting multi-functional liposomes showed greater efficacy than the non-targeting liposomes and thus great potential to improve the cancer imaging and therapy...
  48. doi request reprint Vitamin E TPGS prodrug micelles for hydrophilic drug delivery with neuroprotective effects
    Yu Mi
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, Block E5 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Int J Pharm 438:98-106. 2012
    ..The TPGS prodrug micelles can also be generalized to become a new strategy for codelivery of hydrophilic and hydrophobic drugs and/or imaging agents...
  49. doi request reprint Formulation of Docetaxel by folic acid-conjugated d-α-tocopheryl polyethylene glycol succinate 2000 (Vitamin E TPGS(2k)) micelles for targeted and synergistic chemotherapy
    Yu Mi
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 32:4058-66. 2011
    ....
  50. ncbi request reprint Effects of lipid chain length on molecular interactions between paclitaxel and phospholipid within model biomembranes
    Lingyun Zhao
    Department of Chemical and Environmental Engineering, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore
    J Colloid Interface Sci 274:55-68. 2004
    ....
  51. doi request reprint Folic acid-functionalized two-photon absorbing nanoparticles for targeted MCF-7 cancer cell imaging
    Kai Li
    Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, Singapore, 117576, Singapore
    Chem Commun (Camb) 47:7323-5. 2011
    ..We report a facile strategy to synthesize folic acid-functionalized two-photon absorbing (TPA) nanoparticles with aggregation-induced emission for targeted cancer cell imaging using a two-photon fluorescence microscope...
  52. doi request reprint Effects of surface modification on delivery efficiency of biodegradable nanoparticles across the blood-brain barrier
    Sneha Avinash Kulkarni
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore
    Nanomedicine (Lond) 6:377-94. 2011
    ....
  53. doi request reprint Targeting and imaging cancer cells by folate-decorated, quantum dots (QDs)- loaded nanoparticles of biodegradable polymers
    Jie Pan
    Division of Bioengineering, National University of Singapore, Block E3A, 04 15, 7 Engineering Drive 1, Singapore 117574, Singapore
    Biomaterials 30:1176-83. 2009
    ..Targeted imaging by QDs formulated in folate-decorated PLA-TPGS/TPGS-COOH nanoparticles with better effects and less side effects is feasible...
  54. ncbi request reprint Superparamagnetic iron oxide--loaded poly(lactic acid)-D-alpha-tocopherol polyethylene glycol 1000 succinate copolymer nanoparticles as MRI contrast agent
    Chandrasekharan Prashant
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore
    Biomaterials 31:5588-97. 2010
    ..Xenograft tumor model MRI confirmed the advantages of the IOs-PNPs formulation versus Resovist through the enhanced permeation and retention (EPR) effect of the tumor vasculature...
  55. ncbi request reprint Effects of lipid chain unsaturation and headgroup type on molecular interactions between paclitaxel and phospholipid within model biomembrane
    Lingyun Zhao
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescents, 119260 Singapore
    J Colloid Interface Sci 285:326-35. 2005
    ..However, it may penetrate into the deeper hydrophobic zone of the DEPC bilayers. These findings provide useful information for liposomal formulation of anticancer drugs as well as for understanding drug-cell membrane interactions...
  56. ncbi request reprint Effects of cholesterol component on molecular interactions between paclitaxel and phospholipid within the lipid monolayer at the air-water interface
    Lingyun Zhao
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescents, 119260 Singapore
    J Colloid Interface Sci 300:314-26. 2006
    ..FTIR and AFM investigation on the mixed monolayer deposited on solid surface confirmed the obtained results...
  57. doi request reprint Conjugated polymer loaded nanospheres with surface functionalization for simultaneous discrimination of different live cancer cells under single wavelength excitation
    Kai Li
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore
    Anal Chem 83:2125-32. 2011
    ..The conjugated polymer loaded nanospheres with high quantum yield, low cytotoxicity, and multiple color emission upon single laser excitation are ideal for simultaneous multiple-target imaging and detection...
  58. doi request reprint Formulation, characterization, and in vitro evaluation of quantum dots loaded in poly(lactide)-vitamin E TPGS nanoparticles for cellular and molecular imaging
    Jie Pan
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biotechnol Bioeng 101:622-33. 2008
    ..It was found that the QDs formulated in the PLA-TPGS NPs can result in higher fluorescence intensity and higher photostability than the bare QDs as well as lower cytotoxicity than the MAA-coated QDs...
  59. ncbi request reprint DSC and EPR investigations on effects of cholesterol component on molecular interactions between paclitaxel and phospholipid within lipid bilayer membrane
    Lingyun Zhao
    Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Int J Pharm 338:258-66. 2007
    ..Cholesterol can remarkably increase the reduction reaction speed. This research may provide useful information for optimizing liposomal formulation of the drug as well as for understanding the pharmacology of paclitaxel...
  60. ncbi request reprint Cetuximab conjugated vitamin E TPGS micelles for targeted delivery of docetaxel for treatment of triple negative breast cancers
    Rajaletchumy Veloo Kutty
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 34:10160-71. 2013
    ..6 and 223.8 fold higher efficiency than Taxotere(®) for the MDA MB 468 and MDA MB 231 cell lines respectively...
  61. ncbi request reprint Investigation of molecular interactions between paclitaxel and DPPC by Langmuir film balance and differential scanning calorimetry
    Lingyun Zhao
    Department of Chemical and Environmental Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260
    J Pharm Sci 93:86-98. 2004
    ..There was no significant change in the peak melting temperature of the DPPC bilayers, which demonstrated that paclitaxel was localized in the outer hydrophobic cooperative zone of the bilayer...
  62. doi request reprint Doxorubicin conjugated to D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS): conjugation chemistry, characterization, in vitro and in vivo evaluation
    Na Cao
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, Singapore
    Biomaterials 29:3856-65. 2008
    ..Our TPGS-DOX conjugate showed great potential to be a prodrug of higher therapeutic effects and fewer side effects than DOX itself...
  63. doi request reprint Trastuzumab-functionalized nanoparticles of biodegradable copolymers for targeted delivery of docetaxel
    Bingfeng Sun
    Division of Bioengineering, National University of Singapore, Singapore
    Nanomedicine (Lond) 4:431-45. 2009
    ..We synthesized a novel system of docetaxel-loaded, trastuzumab-functionalized nanoparticles (NPs) of biodegradable copolymers for targeted and synergistic chemotherapy...
  64. ncbi request reprint Nanomedicine: enhancement of chemotherapeutical efficacy of docetaxel by using a biodegradable nanoparticle formulation
    Chee Wee Gan
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117576, Singapore
    Curr Pharm Des 16:2308-20. 2010
    ..44-fold higher therapeutic effect and 4.42- fold lower side effect than that of Taxotere at the same dose of 10 mg/kg, as indicated by the larger area-under-the-curve and better biodistribution...
  65. doi request reprint Facile synthesis of water-stable magnetite nanoparticles for clinical MRI and magnetic hyperthermia applications
    Dipak Maity
    Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, Singapore
    Nanomedicine (Lond) 5:1571-84. 2010
    ..However, it is still a challenge to synthesize high-quality water-stable magnetite nanoparticles for better magnetic performance and less side effects in medical MRI and nanothermotherapy...
  66. ncbi request reprint Nanoparticles of biodegradable polymers for cancer treatment
    Si Shen Feng
    Chemotherapeutic Engineering Laboratory, Division of Bioengineering and Department of Chemical Enginering, National University of Singapore
    Biomaterials 29:4146-7. 2008
  67. ncbi request reprint PLGA/TPGS nanoparticles for controlled release of paclitaxel: effects of the emulsifier and drug loading ratio
    Li Mu
    Division of Bioengineering, The National University of Singapore, 9 Engineering Drive 1, Singapore 117576
    Pharm Res 20:1864-72. 2003
    ..Among various controlling parameters in the process, the present work is to elucidate the effects of the surfactant stabilizer and the drug loading ratio...