Vincent T Chow

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi request reprint The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22
    V T Chow
    Department of Microbiology, Faculty of Medicine, National University of Singapore, Kent Ridge, Republic of Singapore
    Genome 41:543-52. 1998
  2. ncbi request reprint Combination therapy with hepatocyte growth factor and oseltamivir confers enhanced protection against influenza viral pneumonia
    T Narasaraju
    Host And Pathogen Interactivity Laboratory, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 5 Science Drive 2, Kent Ridge 117545, Singapore
    Curr Mol Med 14:690-702. 2014
  3. pmc In vivo and in vitro studies on the roles of neutrophil extracellular traps during secondary pneumococcal pneumonia after primary pulmonary influenza infection
    Anandi Narayana Moorthy
    Department of Microbiology, Infectious Diseases Program, National University of Singapore Kent Ridge, Singapore
    Front Immunol 4:56. 2013
  4. pmc Human genomic diversity, viral genomics and proteomics, as exemplified by human papillomaviruses and H5N1 influenza viruses
    Meena K Sakharkar
    Biomedical Engineering Research Centre, Nanyang Technological University, Singapore
    Hum Genomics 3:320-31. 2009
  5. pmc Characterization and specificity of the linear epitope of the enterovirus 71 VP2 protein
    Tanja K Kiener
    Animal Health Biotechnology, Temasek Life Sciences Laboratory, National University of Singapore, 117604 Singapore, Singapore
    Virol J 9:55. 2012
  6. pmc MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis
    T Narasaraju
    Infectious Diseases Program, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Kent Ridge 117597, Singapore
    Am J Respir Cell Mol Biol 42:732-43. 2010
  7. ncbi request reprint Measurement of serum leptin concentrations in university undergraduates by competitive ELISA reveals correlations with body mass index and sex
    Vincent T K Chow
    Human Genome Laboratory, Department of Microbiology, Faculty of Medicine, National University of Singapore, Kent Ridge 117597, Singapore
    Adv Physiol Educ 27:70-7. 2003
  8. ncbi request reprint Phylogenetic relationships of the seven coat protein subunits of the coatomer complex, and comparative sequence analysis of murine xenin and proxenin
    V T Chow
    Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore
    Biochem Genet 39:201-11. 2001
  9. ncbi request reprint Diagnosis of nipah virus encephalitis by electron microscopy of cerebrospinal fluid
    V T Chow
    Departments of Microbiology and Medicine, Faculty of Medicine, National University of Singapore, 117597, Kent Ridge, Singapore
    J Clin Virol 19:143-7. 2000
  10. ncbi request reprint Identification of multiple genital HPV types and sequence variants by consensus and nested type-specific PCR coupled with cycle sequencing
    V T Chow
    Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore
    Pathology 32:204-8. 2000

Collaborators

  • Meng Kwoon Sim
  • K S Tan
  • Hyungwon Choi
  • Shi Wang
  • Bevin Engelward
  • Kishore R Sakharkar
  • Lu Yin
  • Nico Van Rooijen
  • Yan Wu
  • E Loh
  • Graham A Tipples
  • T Narasaraju
  • Meng Chee Phoon
  • Rui Li
  • M C Phoon
  • H H Ng
  • Sylvie Alonso
  • Teluguakula Narasaraju
  • Anandi Narayana Moorthy
  • Tanja K Kiener
  • Fransiskus X Ivan
  • Lay Teng Ang
  • Wei Xin Khong
  • Jowin K W Ng
  • Li Wei Ang
  • Camille Locht
  • Wee Peng Poh
  • Annabelle Lim
  • Meena K Sakharkar
  • E Yang
  • A N Moorthy
  • R P Samy
  • N van Rooijen
  • R Perumalsamy
  • Prashant Rai
  • Jagath C Rajapakse
  • Fang He
  • Steve G Rozen
  • Qiang Jia
  • Roy E Welsch
  • Xiao Fang Lim
  • Ling Yin Tan
  • Gordon M Xiong
  • Jia Jun Lee
  • Tao Meng
  • J E Seet
  • Huimin Yeo
  • Jimmy Kwang
  • Benedict Yan
  • Eng Lee Tan
  • Jeffery Cutter
  • Lyn James
  • Audrey Ann Liew
  • Edwin Yang
  • Huey Hian Ng
  • Ramar Perumal Samy
  • Stephanie T L Ow

Detail Information

Publications21

  1. ncbi request reprint The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22
    V T Chow
    Department of Microbiology, Faculty of Medicine, National University of Singapore, Kent Ridge, Republic of Singapore
    Genome 41:543-52. 1998
    ....
  2. ncbi request reprint Combination therapy with hepatocyte growth factor and oseltamivir confers enhanced protection against influenza viral pneumonia
    T Narasaraju
    Host And Pathogen Interactivity Laboratory, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 5 Science Drive 2, Kent Ridge 117545, Singapore
    Curr Mol Med 14:690-702. 2014
    ..Thus, the combination of rhHGF and oseltamivir may represent a promising therapeutic option against influenza pneumonia to improve existing antiviral treatment regimens. ..
  3. pmc In vivo and in vitro studies on the roles of neutrophil extracellular traps during secondary pneumococcal pneumonia after primary pulmonary influenza infection
    Anandi Narayana Moorthy
    Department of Microbiology, Infectious Diseases Program, National University of Singapore Kent Ridge, Singapore
    Front Immunol 4:56. 2013
    ..These results substantiate that the NETs released by primary influenza infection do not protect against secondary bacterial infection, but may compromise lung function...
  4. pmc Human genomic diversity, viral genomics and proteomics, as exemplified by human papillomaviruses and H5N1 influenza viruses
    Meena K Sakharkar
    Biomedical Engineering Research Centre, Nanyang Technological University, Singapore
    Hum Genomics 3:320-31. 2009
    ..We also review the influence of diverse host-pathogen interactions that determine the pathophysiology of infections, and their responses to drugs or vaccines...
  5. pmc Characterization and specificity of the linear epitope of the enterovirus 71 VP2 protein
    Tanja K Kiener
    Animal Health Biotechnology, Temasek Life Sciences Laboratory, National University of Singapore, 117604 Singapore, Singapore
    Virol J 9:55. 2012
    ..Furthermore, the elucidation of viral epitopes will contribute to the development of targeted therapeutics and vaccines...
  6. pmc MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis
    T Narasaraju
    Infectious Diseases Program, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Kent Ridge 117597, Singapore
    Am J Respir Cell Mol Biol 42:732-43. 2010
    ....
  7. ncbi request reprint Measurement of serum leptin concentrations in university undergraduates by competitive ELISA reveals correlations with body mass index and sex
    Vincent T K Chow
    Human Genome Laboratory, Department of Microbiology, Faculty of Medicine, National University of Singapore, Kent Ridge 117597, Singapore
    Adv Physiol Educ 27:70-7. 2003
    ..This practical study also exemplifies the principles and applications of the competitive ELISA technique and integrates certain key concepts of physiology, molecular biology, immunology, and medicine...
  8. ncbi request reprint Phylogenetic relationships of the seven coat protein subunits of the coatomer complex, and comparative sequence analysis of murine xenin and proxenin
    V T Chow
    Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore
    Biochem Genet 39:201-11. 2001
    ..Interestingly, although 6 out of 7 epsilon-COP genes appeared to be grouped and related to the beta-COP genes, 4 out of 7 epsilon..
  9. ncbi request reprint Diagnosis of nipah virus encephalitis by electron microscopy of cerebrospinal fluid
    V T Chow
    Departments of Microbiology and Medicine, Faculty of Medicine, National University of Singapore, 117597, Kent Ridge, Singapore
    J Clin Virol 19:143-7. 2000
    ..Although Japanese encephalitis virus was initially suspected, the predominant aetiologic agent was subsequently confirmed to be Nipah virus, a novel paramyxovirus related to but distinct from Hendra virus...
  10. ncbi request reprint Identification of multiple genital HPV types and sequence variants by consensus and nested type-specific PCR coupled with cycle sequencing
    V T Chow
    Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore
    Pathology 32:204-8. 2000
    ..This study also emphasises the need for educational, interventional and behavioral modification to minimise HPV transmission, such as through consistent condom usage among sex workers...
  11. ncbi request reprint Complete nucleotide sequence, genomic organization and phylogenetic analysis of a novel genital human papillomavirus type, HLT7474-S
    V T Chow
    Programme in Infectious Diseases, Department of Microbiology, Faculty of Medicine, National University of Singapore, Kent Ridge, Singapore 117597, Republic of Singapore
    J Gen Virol 80:2923-9. 1999
    ..These features clearly suggest that HLT7474-S is a high-risk genital HPV isolate, closely related to HPV-18 and other members of the A7 group of genital HPVs...
  12. pmc The changing seroepidemiology of enterovirus 71 infection among children and adolescents in Singapore
    Li Wei Ang
    Epidemiology and Disease Control Division, Ministry of Health, CollegeRoad, 169854, Singapore
    BMC Infect Dis 11:270. 2011
    ..We compared our EV71 seroepidemiologic findings with a previous study conducted in 1996-1997...
  13. doi request reprint Doxycycline treatment attenuates acute lung injury in mice infected with virulent influenza H3N2 virus: involvement of matrix metalloproteinases
    H H Ng
    Infectious Diseases Program, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    Exp Mol Pathol 92:287-95. 2012
    ..Further studies are warranted to determine whether DOX can be used in combination with anti-viral agents to alleviate severe influenza pneumonia...
  14. pmc Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis
    Teluguakula Narasaraju
    Infectious Diseases Program, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    Am J Pathol 179:199-210. 2011
    ..These findings support the pathogenic effects of excessive neutrophils in acute lung injury of influenza pneumonia by instigating alveolar-capillary damage...
  15. doi request reprint Development of live attenuated Bordetella pertussis strains expressing the universal influenza vaccine candidate M2e
    Rui Li
    Department of Microbiology, National University of Singapore, CeLS building 03 05, 28 Medical Drive, 115597 Singapore, Singapore
    Vaccine 29:5502-11. 2011
    ..Despite improving significantly the secretion efficacy of the FHA-(M2e)(3) chimera, the dsbA deletion did not result in higher anti-M2e antibody titers in mice, due to impaired bacterial fitness and colonization ability...
  16. doi request reprint Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines
    Fransiskus X Ivan
    Computational and Systems Biology Program, Singapore MIT Alliance, Singapore, Singapore
    Funct Integr Genomics 12:105-17. 2012
    ..Overall, our comparative transcriptomic study provided insights into key host factors that influence the dynamics, pathogenesis, and outcome of severe influenza...
  17. doi request reprint Des-aspartate-angiotensin I exerts antiviral effects and attenuates ICAM-1 formation in rhinovirus-infected epithelial cells
    Lay Teng Ang
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Eur J Pharmacol 683:310-5. 2012
    ..Indeed the angiotensin AT₁ receptor has been reported to be obligatory for the development of virus-induced myocardial injury through the proinflammatory action of angiotensin II via the NF-κB/cytokine pathway...
  18. pmc A non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infection
    Wei Xin Khong
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Virol 86:2121-31. 2012
    ....
  19. ncbi request reprint Micro-RNAs in regenerating lungs: an integrative systems biology analysis of murine influenza pneumonia
    Kai Sen Tan
    Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 5 Science Drive 2, Kent Ridge 117545, Singapore
    BMC Genomics 15:587. 2014
    ..In this study, we explored the role of microRNAs, short non-coding RNAs involved in post-transcriptional regulation, during pulmonary regeneration after influenza infection...
  20. pmc Bioinformatics of varicella-zoster virus: single nucleotide polymorphisms define clades and attenuated vaccine genotypes
    Vincent T Chow
    Department of Microbiology, National University of Singapore, Singapore
    Infect Genet Evol 18:351-6. 2013
    ..Taken together, these VZV bioinformatics analyses have provided enormous insights into VZV phylogenetics as well as VZV SNPs associated with attenuation. ..
  21. pmc Attenuated Bordetella pertussis protects against highly pathogenic influenza A viruses by dampening the cytokine storm
    Rui Li
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, CeLS Building no 03 05, 28 Medical Drive, Singapore 117597, Singapore
    J Virol 84:7105-13. 2010
    ..Furthermore, nasal treatment with live attenuated B. pertussis offers a potential alternative to conventional approaches in the fight against one of the most frightening current global public health threats...