NanGuang Chen

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. doi request reprint Multi-contrast focal modulation microscopy for in vivo imaging of thick biological tissues
    NanGuang Chen
    Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore
    Opt Express 20:12166-70. 2012
  2. ncbi request reprint Focal modulation microscopy
    NanGuang Chen
    Division of Bioengineering, National University of Singapore, Singapore
    Opt Express 16:18764-9. 2008
  3. ncbi request reprint Controlled Monte Carlo method for light propagation in tissue of semi-infinite geometry
    NanGuang Chen
    Division of Bioengineering and the Department of Electrical and Computer Engineering, National University of Singapore, Singapore
    Appl Opt 46:1597-603. 2007
  4. doi request reprint Edge enhancement for in-phase focal modulation microscope
    Ke Si
    Graduate School for Integrative Sciences and Engineering, National University of Singapore, 10 Medical Drive, Singapore 117597, Singapore
    Appl Opt 48:6290-5. 2009
  5. ncbi request reprint Focal modulation microscopy: a theoretical study
    Shau Poh Chong
    Division of Bioengineering, National University of Singapore, 9 Engineering Drive 1, EA 03 12, Singapore 129789
    Opt Lett 35:1804-6. 2010
  6. ncbi request reprint Fast time-domain diffuse optical tomography using pseudorandom bit sequences
    Weirong Mo
    Division of Bioengineering, National University of Singapore, Singapore
    Opt Express 16:13643-50. 2008
  7. doi request reprint Focal modulation microscopy with annular apertures: a numerical study
    Wei Gong
    Division of Bioengineering, National University of Singapore, Singapore, Singapore
    J Biophotonics 3:476-84. 2010
  8. doi request reprint Considerations of aperture configuration in focal modulation microscopy from the standpoint of modulation depth
    Guangjun Gao
    Division of Bioengineering, National University of Singapore, Singapore 117576
    J Opt Soc Am A Opt Image Sci Vis 28:496-501. 2011
  9. ncbi request reprint Simple spatial phase modulator for focal modulation microscopy
    Chee Howe Wong
    Department of Electrical and Computer Engineering, National University of Singapore, Singapore
    Appl Opt 48:3237-42. 2009
  10. doi request reprint Multistage inversion algorithm for biological tissue imaging
    Krishna Agarwal
    National University of Singapore, Department of Electrical and Computer Engineering, Singapore
    J Biomed Opt 15:016007. 2010

Collaborators

Detail Information

Publications21

  1. doi request reprint Multi-contrast focal modulation microscopy for in vivo imaging of thick biological tissues
    NanGuang Chen
    Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore
    Opt Express 20:12166-70. 2012
    ....
  2. ncbi request reprint Focal modulation microscopy
    NanGuang Chen
    Division of Bioengineering, National University of Singapore, Singapore
    Opt Express 16:18764-9. 2008
    ..Our method has been validated with animal tissue and an imaging depth around 600 microns has been demonstrated...
  3. ncbi request reprint Controlled Monte Carlo method for light propagation in tissue of semi-infinite geometry
    NanGuang Chen
    Division of Bioengineering and the Department of Electrical and Computer Engineering, National University of Singapore, Singapore
    Appl Opt 46:1597-603. 2007
    ..Consequently, path-length resolved photon trajectories can be generated with a significantly improved efficiency. We report a more than 29 times reduction in simulation time for early arriving photons in a typical configuration...
  4. doi request reprint Edge enhancement for in-phase focal modulation microscope
    Ke Si
    Graduate School for Integrative Sciences and Engineering, National University of Singapore, 10 Medical Drive, Singapore 117597, Singapore
    Appl Opt 48:6290-5. 2009
    ..4% and 58.9% for a thick edge and a thin edge, respectively. Signal level is also discussed, and the results show that, to obtain high transverse resolution with IPFMM, the normalized detector pinhole radius should not exceed 2.8...
  5. ncbi request reprint Focal modulation microscopy: a theoretical study
    Shau Poh Chong
    Division of Bioengineering, National University of Singapore, 9 Engineering Drive 1, EA 03 12, Singapore 129789
    Opt Lett 35:1804-6. 2010
    ..The scalar diffraction theory is combined with Monte Carlo simulation to evaluate the signal-to-background ratio at various depths. The performance of confocal microscopy with a similar optical setup is also evaluated for comparison...
  6. ncbi request reprint Fast time-domain diffuse optical tomography using pseudorandom bit sequences
    Weirong Mo
    Division of Bioengineering, National University of Singapore, Singapore
    Opt Express 16:13643-50. 2008
    ..The high signal-to-noise ratio and the environmental illumination insensitivity warrant a great potential for applications in clinical noninvasive breast cancer detection...
  7. doi request reprint Focal modulation microscopy with annular apertures: a numerical study
    Wei Gong
    Division of Bioengineering, National University of Singapore, Singapore, Singapore
    J Biophotonics 3:476-84. 2010
    ..The capability of background rejection is also investigated, showing AFMM has the potential to further increase the imaging penetration depth. Finally, an optimal configuration of AFMM is elaborated...
  8. doi request reprint Considerations of aperture configuration in focal modulation microscopy from the standpoint of modulation depth
    Guangjun Gao
    Division of Bioengineering, National University of Singapore, Singapore 117576
    J Opt Soc Am A Opt Image Sci Vis 28:496-501. 2011
    ..In summary, the annular configuration is superior to the fan- and stripe-shaped configurations in modulation depth and spatial resolution...
  9. ncbi request reprint Simple spatial phase modulator for focal modulation microscopy
    Chee Howe Wong
    Department of Electrical and Computer Engineering, National University of Singapore, Singapore
    Appl Opt 48:3237-42. 2009
    ..We have designed a simple spatial phase modulator based on a tilting glass plate that provides superb modulation stability. Image quality has been improved remarkably after integrating such a modulator into a FMM system...
  10. doi request reprint Multistage inversion algorithm for biological tissue imaging
    Krishna Agarwal
    National University of Singapore, Department of Electrical and Computer Engineering, Singapore
    J Biomed Opt 15:016007. 2010
    ..The method reduces the ill-posedness of the image reconstruction problem iteratively such that good imaging results are obtained for multiple heterogeneities having complicated geometries even in the presence of 3% additive white noise...
  11. doi request reprint Improved spatial resolution in fluorescence focal modulation microscopy
    Wei Gong
    Division of Bioengineering, National University of Singapore, Singapore 117576, Singapore
    Opt Lett 34:3508-10. 2009
    ..4%. When applied to saturable fluorescence, the half-width at half-maximum is improved by 33.6%, 50.0%, and 62.9%, at demodulation frequencies 2omega, 4omega, and 8omega, respectively...
  12. doi request reprint Quantitative characterization of optical and physiological parameters in normal breasts using time-resolved spectroscopy: in vivo results of 19 Singapore women
    Weirong Mo
    National University of Singapore, Division of Bioengineering, Faculty of Engineering, Singapore
    J Biomed Opt 14:064004. 2009
    ..These in vivo experiment results will contribute to the breast tissue diagnosis between healthy and diseased breast tissues...
  13. doi request reprint Plasmonic chiral contrast agents for optical coherence tomography: numerical study
    Kalpesh B Mehta
    Optical Bioimaging Lab, Division of Bioengineering, National University of Singapore, 7 Engineering Drive 1, Blk E3A, 04 15, Singapore 117574, Singapore
    Opt Express 19:14903-12. 2011
    ..The proposed contrast agents may extend the applicability of OCT to the problems that require the molecular contrast with enhanced sensitivity...
  14. ncbi request reprint Recent advances in optical microscopy methods for subcellular imaging of thick biological tissues
    NanGuang Chen
    Department of Biomedical Engineering, National University of Singapore, Singapore
    Crit Rev Biomed Eng 41:393-403. 2013
    ..Focal modulation microscopy has demonstrated an imaging depth comparable to those of multiphoton microscopy and optical coherence microscopy, near-real-time image acquisition, and capability with a multiple contrast mechanism. ..
  15. doi request reprint Optimization of source and detector configurations based on Cramer-Rao lower bound analysis
    Ling Chen
    National University of Singapore, Division of Bioengineering, Faculty of Engineering, Singapore, Singapore
    J Biomed Opt 16:035001. 2011
    ..It is demonstrated that the SD sets selected by this method afford better reconstructed images. This methodology can be adapted to other probe surfaces and other imaging geometries...
  16. ncbi request reprint Superresolution along extended depth of focus with binary-phase filters for the Gaussian beam
    Linbo Liu
    Graduate Programme in Bioengineering, National University of Singapore, Singapore
    J Opt Soc Am A Opt Image Sci Vis 25:2095-101. 2008
    ..Optimal filter designs are proposed for either high-resolution or ultra-large-DOF applications followed by experimental verifications...
  17. ncbi request reprint Double-reflection polygon mirror for high-speed optical coherence microscopy
    Linbo Liu
    Graduate Programme in Bioengineering, National University of Singapore 117576, Singapore
    Opt Lett 32:3528-30. 2007
    ..8 degrees scanning range, and 90% duty cycle. A much higher scanning speed and much larger scanning range can be readily achieved by increasing the scanner diameter...
  18. pmc Emission and absorption properties of indocyanine green in Intralipid solution
    Baohong Yuan
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT 06269 1157, USA
    J Biomed Opt 9:497-503. 2004
    ..Also, in the concentration range of 0 to 2 microM, ICG solution always has a higher absorption coefficient at wavelength 830 nm than that at 660 nm, which is quite different from the ICG in water case...
  19. pmc Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound
    Quing Zhu
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269 2157, USA
    Opt Lett 28:337-9. 2003
    ..It is shown that detailed distributions of wavelength-dependent absorption and hemoglobin concentration of breast carcinoma can be obtained with the new reconstruction scheme...