Christopher Chen

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. doi request reprint Brief screening tests during acute admission in patients with mild stroke are predictive of vascular cognitive impairment 3-6 months after stroke
    Yanhong Dong
    Department of Pharmacology, National University Health System, Singapore
    J Neurol Neurosurg Psychiatry 83:580-5. 2012
  2. pmc Novel pathophysiological markers are revealed by iTRAQ-based quantitative clinical proteomics approach in vascular dementia
    Arnab Datta
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Proteomics 99:54-67. 2014
  3. pmc The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial
    John Gommans
    Department of Medicine, Hawke s Bay Hospital, Hastings, New Zealand
    BMC Geriatr 13:88. 2013
  4. doi request reprint Chinese medicine neuroaid efficacy on stroke recovery: a double-blind, placebo-controlled, randomized study
    Christopher L H Chen
    Department of Pharmacology, National University of Singapore, Clinical Research Centre, Singapore, Singapore
    Stroke 44:2093-100. 2013
  5. doi request reprint The interaction between neuropsychological and motor deficits in patients after stroke
    Christopher Chen
    National University of Singapore, Singapore
    Neurology 80:S27-34. 2013
  6. ncbi request reprint Ethnicity does not affect the homocysteine-lowering effect of B-vitamin therapy in singaporean stroke patients
    Katherine Kasiman
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Clinical Research Centre, MD11 Level 5 05 09, 10 Medical Drive, Singapore 117597
    Stroke 40:2209-11. 2009
  7. doi request reprint Danqi Piantang Jiaonang (DJ), a traditional Chinese medicine, in poststroke recovery
    Christopher Chen
    Department of Pharmacology, National University of Singapore, Singapore
    Stroke 40:859-63. 2009
  8. doi request reprint Retinal neurodegeneration on optical coherence tomography and cerebral atrophy
    Yi Ting Ong
    Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Neurosci Lett 584:12-6. 2015
  9. doi request reprint Safety profile of MLC601 (Neuroaid) in acute ischemic stroke patients: A Singaporean substudy of the Chinese medicine neuroaid efficacy on stroke recovery study
    Sherry H Y Young
    Changi General Hospital, Singapore, Singapore
    Cerebrovasc Dis 30:1-6. 2010
  10. doi request reprint Prevalence and Risk Factors of Acute Incidental Infarcts
    Monica Saini
    From the Department of Pharmacology, National University of Singapore, Singapore, Singapore M S, M S P S, S H, Y H D, C C Department of Medicine, Changi General Hospital, Singapore, Singapore M S Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore M S P S, S H, Y H D, N V, M K I, C C Raffles Neuroscience Centre, Department of Neurology, Raffles Hospital, Singapore, Singapore N V Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore M K I and Department of Pharmacology, Duke NUS Graduate Medical School, National University of Singapore, Singapore, Singapore M K I
    Stroke 46:2722-7. 2015

Collaborators

Detail Information

Publications35

  1. doi request reprint Brief screening tests during acute admission in patients with mild stroke are predictive of vascular cognitive impairment 3-6 months after stroke
    Yanhong Dong
    Department of Pharmacology, National University Health System, Singapore
    J Neurol Neurosurg Psychiatry 83:580-5. 2012
    ....
  2. pmc Novel pathophysiological markers are revealed by iTRAQ-based quantitative clinical proteomics approach in vascular dementia
    Arnab Datta
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Proteomics 99:54-67. 2014
    ..The synaptic proteins did not exhibit a generalized decrease in abundance (e.g. syntaxin) in the VaD subjects. This reported proteome offers a reference data set for future basic or translational studies on VaD...
  3. pmc The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial
    John Gommans
    Department of Medicine, Hawke s Bay Hospital, Hastings, New Zealand
    BMC Geriatr 13:88. 2013
    ..We evaluated whether homocysteine-lowering therapy with B-vitamins in patients with symptomatic cerebrovascular disease reduced the incidence of osteoporotic fractures...
  4. doi request reprint Chinese medicine neuroaid efficacy on stroke recovery: a double-blind, placebo-controlled, randomized study
    Christopher L H Chen
    Department of Pharmacology, National University of Singapore, Clinical Research Centre, Singapore, Singapore
    Stroke 44:2093-100. 2013
    ..The Chinese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES) study tested the hypothesis that MLC601 is superior to placebo in acute, moderately severe ischemic stroke within a 72-hour time window...
  5. doi request reprint The interaction between neuropsychological and motor deficits in patients after stroke
    Christopher Chen
    National University of Singapore, Singapore
    Neurology 80:S27-34. 2013
    ..These insights, among others, contribute to a growing, if embryonic, body of knowledge about poststroke motor/cognitive interaction that will ultimately inform developments in treatment and rehabilitation...
  6. ncbi request reprint Ethnicity does not affect the homocysteine-lowering effect of B-vitamin therapy in singaporean stroke patients
    Katherine Kasiman
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Clinical Research Centre, MD11 Level 5 05 09, 10 Medical Drive, Singapore 117597
    Stroke 40:2209-11. 2009
    ..This suggests that the effect of B-vitamins in lowering tHcy is generalizable across Asian populations. However, due to relatively small numbers of non-Chinese studied, confirmation in other populations is required...
  7. doi request reprint Danqi Piantang Jiaonang (DJ), a traditional Chinese medicine, in poststroke recovery
    Christopher Chen
    Department of Pharmacology, National University of Singapore, Singapore
    Stroke 40:859-63. 2009
    ..The results of these studies were pooled and reanalyzed to assess efficacy and safety...
  8. doi request reprint Retinal neurodegeneration on optical coherence tomography and cerebral atrophy
    Yi Ting Ong
    Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Neurosci Lett 584:12-6. 2015
    ....
  9. doi request reprint Safety profile of MLC601 (Neuroaid) in acute ischemic stroke patients: A Singaporean substudy of the Chinese medicine neuroaid efficacy on stroke recovery study
    Sherry H Y Young
    Changi General Hospital, Singapore, Singapore
    Cerebrovasc Dis 30:1-6. 2010
    ..We assessed the safety of Neuroaid in patients with acute stroke treated for 3 months in a substudy of an ongoing randomized placebo-controlled trial...
  10. doi request reprint Prevalence and Risk Factors of Acute Incidental Infarcts
    Monica Saini
    From the Department of Pharmacology, National University of Singapore, Singapore, Singapore M S, M S P S, S H, Y H D, C C Department of Medicine, Changi General Hospital, Singapore, Singapore M S Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore M S P S, S H, Y H D, N V, M K I, C C Raffles Neuroscience Centre, Department of Neurology, Raffles Hospital, Singapore, Singapore N V Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore M K I and Department of Pharmacology, Duke NUS Graduate Medical School, National University of Singapore, Singapore, Singapore M K I
    Stroke 46:2722-7. 2015
    ..This study aims to describe prevalence and risk factors of AII in a community and a clinic-based population...
  11. doi request reprint Microvascular network alterations in retina of subjects with cerebral small vessel disease
    Saima Hilal
    Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore Department of Pharmacology, National University of Singapore, Singapore, Singapore
    Neurosci Lett 577:95-100. 2014
    ..In conclusion, subjects with early structural changes in retinal microvasculature were more likely to have CMBs, supporting hypothesis that CMB may be an early manifestation of cerebral small vessel disease...
  12. doi request reprint Abnormalities of cortical thickness, subcortical shapes, and white matter integrity in subcortical vascular cognitive impairment
    Jamie Yu Jin Thong
    Department of Bioengineering, National University of Singapore, Singapore
    Hum Brain Mapp 35:2320-32. 2014
    ....
  13. doi request reprint Inflammatory markers and their association with post stroke cognitive decline
    Kaavya Narasimhalu
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore
    Int J Stroke 10:513-8. 2015
    ..Population-based studies have demonstrated the association of inflammation and cognitive impairment. However, few studies to date have examined this association in ischemic stroke patients...
  14. doi request reprint Computer tomography for prediction of cognitive outcomes after ischemic cerebrovascular events
    Monica Saini
    Department of Pharmacology, National University of Singapore, Singapore, Singapore Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University Health System, Singapore, Singapore
    J Stroke Cerebrovasc Dis 23:1921-7. 2014
    ....
  15. doi request reprint Association of silent lacunar infarct with brain atrophy and cognitive impairment
    Jamie Yu Jin Thong
    Department of Bioengineering, National University of Singapore, Singapore, Singapore
    J Neurol Neurosurg Psychiatry 84:1219-25. 2013
    ..We examined the association of SLI with MRI measures of cortical thickness, subcortical and lateral ventricular shapes and cognition in 285 ethnic Chinese elderly...
  16. doi request reprint Danqi Piantan Jiaonang does not modify hemostasis, hematology, and biochemistry in normal subjects and stroke patients
    Robert Gan
    Department of Neurology, National Neuroscience Institute, Singapore, Singapore
    Cerebrovasc Dis 25:450-6. 2008
    ....
  17. doi request reprint Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study
    Raymond C S Seet
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Atherosclerosis 209:215-9. 2010
    ..No significant relationship was observed between urate and vascular outcomes. Depending on its level, serum urate may exhibit protective and deleterious effects on stroke outcomes...
  18. pmc A pilot study to examine the correlation between cognition and blood biomarkers in a Singapore Chinese male cohort with type 2 diabetes mellitus
    Deborah Amanda Goh
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    PLoS ONE 9:e96874. 2014
    ..The purpose of this study is to examine (a) clinical correlation between cognitive function and the biochemical perturbations in T2DM, and (b) the impact of statin treatment on cognitive function in diabetic subjects...
  19. doi request reprint Ankle-brachial index, cognitive impairment and cerebrovascular disease in a Chinese population
    Saima Hilal
    Department of Pharmacology, National University of Singapore, Singapore, Singapore
    Neuroepidemiology 42:131-8. 2014
    ..We investigated whether ABI was associated with cognition independent of neuroimaging markers of cerebrovascular disease...
  20. doi request reprint Patterns of neuropsychological impairment in Alzheimer's disease and mixed dementia
    Yanhong Dong
    Memory Aging and Cognition Centre, Department of Pharmacology, National University Health System, Singapore Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, The University of New South Wales, Australia
    J Neurol Sci 333:5-8. 2013
    ..We aimed to establish the neuropsychological profile of mild-moderate MD in relation to mild-moderate AD...
  21. doi request reprint Changes in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: a pilot study
    Yanhong Dong
    Department of Pharmacology, National University Health System, Singapore
    J Neurol Sci 322:112-6. 2012
    ..In this pilot study, we evaluated changes in cerebral hemodynamic and cognition in these patients...
  22. doi request reprint Multi-stage segmentation of white matter hyperintensity, cortical and lacunar infarcts
    Yanbo Wang
    Department of Pharmacology, National University of Singapore, Singapore
    Neuroimage 60:2379-88. 2012
    ..The evaluations against the manual labeling and ARWMC visual grading suggest that our algorithm provides reasonable segmentation accuracy for the WMH, CI, and LI...
  23. ncbi request reprint Concomitant coronary artery disease among Asian ischaemic stroke patients
    Deidre Anne De Silva
    Singapore General Hospital Campus, National University of Singapore, Singapore
    Ann Acad Med Singapore 37:573-5. 2008
    ..Coronary artery disease (CAD) is the leading cause of death following ischaemic stroke. We aimed to study the prevalence and associations of concomitant CAD among ischaemic stroke patients in Singapore...
  24. ncbi request reprint Deep vein thrombosis following ischemic stroke among Asians
    Deidre Anne De Silva
    National Neuroscience Institute, Singapore General Hospital Campus, Singapore, Singapore
    Cerebrovasc Dis 22:245-50. 2006
    ..However, there is a paucity of published data, and thus, we studied the frequency, characteristics and prognosis of DVT following ischemic stroke in Asian patients with lower limb paresis...
  25. doi request reprint Elevated platelet-derived growth factor AB/BB is associated with a lower risk of recurrent vascular events in stroke patients
    Kaavya Narasimhalu
    Department of Pharmacology, National University of Singapore, Singapore Saw Swee Hock School of Public Health, National University of Singapore, Singapore
    Int J Stroke 10:85-9. 2015
    ..Therefore, in this sudy, we investigated the association between PDGFand both vascular and cognitive outcomes in a cohort of patients with recent nondisabling ischemic stroke...
  26. doi request reprint Retinal microvasculature in Alzheimer's disease
    Carol Yim Lui Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Duke NUS Graduate Medical School, Singapore Memory Aging and Cognition Centre, National University Health System, Singapore
    J Alzheimers Dis 42:S339-52. 2014
    ....
  27. pmc Markers of cardiac dysfunction in cognitive impairment and dementia
    Saima Hilal
    From the Memory, Ageing and Cognition Centre MACC, National University Health System, Singapore SH, YLC, MKi, SE, XX, JYC, NV, MKPL, CC Department of Pharmacology, National University of Singapore, Singapore SH, YLC, XX, JYC, MKPL, CC Singapore Eye Research Institute, Singapore National Eye Center, Singapore MKI Department of Ophthalmology, National University of Singapore, Singapore MKI St Luke s Hospital, Singapore TBY, NV Neuroscience Clinic, Raffles Hospital, Singapore NV and Cardiovascular Research Institute, National University Heart Centre, Singapore AMR, JPCC
    Medicine (Baltimore) 94:e297. 2015
    ..74; 95%CI: 1.23-48.58). These associations were independent of other vascular risk factors.In this study, we showed that plasma NTproBNP and hs-cTnT are associated with dementia and CIND, only when accompanied by presence of CeVD. ..
  28. doi request reprint Efficacy and safety of MLC601 (NeuroAiD®), a traditional Chinese medicine, in poststroke recovery: a systematic review
    Fahad Javaid Siddiqui
    Duke NUS Graduate Medical School, Singapore, Singapore
    Cerebrovasc Dis 35:8-17. 2013
    ..Therefore, we conducted a systematic review of the efficacy of MLC601 in improving the recovery of stroke patients...
  29. doi request reprint Chinese medicine NeuroAiD efficacy stroke recovery-extension study (CHIMES-E study): an observational multicenter study to investigate the longer-term efficacy of NeuroAiD in stroke recovery
    N Venketasubramanian
    Division of Neurology, University Medicine Cluster, National University of Singapore, Singapore, Singapore drnvramani gmail com
    Cerebrovasc Dis 35:18-22. 2013
    ....
  30. doi request reprint Silent stroke: not listened to rather than silent
    Monica Saini
    Department of Pharmacology, Clinical Imaging Research Centre, National University of Singapore, Building MD11 Level 5, Medical Drive, NUH, Singapore 117597
    Stroke 43:3102-4. 2012
    ..Our aim is to report a series of patients with incidentally detected acute and subacute strokes and examine whether they were truly asymptomatic...
  31. pmc Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice
    Elizabeth S Chan
    Departments of Physiology Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Sci Rep 5:13842. 2015
    ..However, in the presence of Aβ42, insulin failed to elicit a downstream response only in ApoE4 hippocampal neurons. Taken together, our data show that ApoE genotypes can modulate this Aβ-mediated insulin signaling impairment. ..
  32. doi request reprint Allantoin in human plasma, serum, and nasal-lining fluids as a biomarker of oxidative stress: avoiding artifacts and establishing real in vivo concentrations
    Jan Gruber
    Centre for Life Sciences, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Antioxid Redox Signal 11:1767-76. 2009
    ..We were able to demonstrate an ozone-induced increase in allantoin, in the absence of increases in either ascorbate or glutathione oxidation products...
  33. ncbi request reprint High plasma cyst(e)ine level may indicate poor clinical outcome in patients with acute stroke: possible involvement of hydrogen sulfide
    Peter T H Wong
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Neuropathol Exp Neurol 65:109-15. 2006
    ..Inhibition of H2S formation may therefore be a novel approach in acute stroke therapy...
  34. ncbi request reprint Efficacy of dual antiplatelet therapy in cerebrovascular disease as demonstrated by a decline in microembolic signals. A report of eight cases
    Romulo Urgel Esagunde
    Neurovascular Laboratory, BRAIN Center, National Neuroscience Institute, Singapore General Hospital Campus, Singapore, Singapore
    Cerebrovasc Dis 21:242-6. 2006
    ..We report the effect of clopidogrel in addition to aspirin on the number of MES in a series of patients with ischemic stroke and transient ischemic attack (TIA) due to large-vessel disease...