Chenjie Xu


Affiliation: Nanyang Technological University
Country: Singapore


  1. Wiraja C, Zhu Y, Lio D, Yeo D, Xie M, Fang W, et al. Framework nucleic acids as programmable carrier for transdermal drug delivery. Nat Commun. 2019;10:1147 pubmed publisher
    ..Programmable penetration with minimal systemic biodistribution underlines FNA potential as localized transdermal drug delivery carriers. ..
  2. Yeo D, Wiraja C, Paller A, Mirkin C, Xu C. Abnormal scar identification with spherical-nucleic-acid technology. Nat Biomed Eng. 2018;2:227-238 pubmed publisher
    ..Our proof-of-concept studies of topically applied NanoFlare technology as a means of biopsy-free scar diagnosis may eventually inform therapeutic decisions on the basis of the mRNA-expression patterns of skin disorders. ..
  3. Than A, Liu C, Chang H, Duong P, Cheung C, Xu C, et al. Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nat Commun. 2018;9:4433 pubmed publisher
    ..The eye patch application is easy and minimally invasive to ensure good patient compliance. Such intraocular drug delivery strategy promises effective home-based treatment of many eye diseases. ..
  4. Wang M, Wiraja C, Wee M, Yeo D, Hu L, Xu C. Hairpin-structured probe conjugated nano-graphene oxide for the cellular detection of connective tissue growth factor mRNA. Anal Chim Acta. 2018;1038:140-147 pubmed publisher
    ..Utilizing this probe, we can distinguish abnormal fibroblasts derived from abnormal scars and assess the effectiveness of anti-scarring drugs like Repsox and transforming growth factor-beta type I receptor (TGF-βRI) siRNA. ..
  5. Mathiyazhakan M, Yang Y, Liu Y, Zhu C, Liu Q, Ohl C, et al. Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation. Colloids Surf B Biointerfaces. 2015;126:569-74 pubmed publisher
    ..Furthermore, we characterized their size, morphology, phase transition temperature and stability. Finally, we demonstrated that this photo-triggered release might be due to the membrane disruption caused by microbubble cavitation. ..
  6. Movahedi F, Hu R, Becker D, Xu C. Stimuli-responsive liposomes for the delivery of nucleic acid therapeutics. Nanomedicine. 2015;11:1575-84 pubmed publisher
    ..In this review article the authors describe and discuss the potentials of various trigger-responsive "smart" liposomes, with a view to help other researchers to design better liposomal nucleic acid delivery systems. ..
  7. Lio D, Yeo D, Xu C. Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles. Nanoscale Res Lett. 2016;11:9 pubmed publisher
    ..Specifically, taking calcein as a model drug, microparticles containing the smallest alginate core (10 μm) show the slowest release over a period of 26 days with burst release less than 1 %. ..
  8. Gao Y, Lim J, Han Y, Wang L, Chong M, Teoh S, et al. Cryomilling for the fabrication of doxorubicin-containing silica-nanoparticle/polycaprolactone nanocomposite films. Nanoscale. 2016;8:2568-74 pubmed publisher
    ..When human cervical cancer cells were seeded directly on these films, uptake of Dox was observed as early as day 1 and significant inhibition of cell growth was recorded on day 5. ..
  9. Kumar N, Wiraja C, Palanisamy K, Marsili E, Xu C. Heat shock mediated labelling of Pseudomonas aeruginosa with quantum dots. Colloids Surf B Biointerfaces. 2016;142:259-265 pubmed publisher
    ..Through the assay of the respiration rate of bacteria together with morphology analysis, the heat shock process does not show any negative effect over the cells activity even at sub-toxic concentrations. ..

More Information


  1. Mathiyazhakan M, Chan W, Ohl C, Xu C. Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation. J Vis Exp. 2016;:53619 pubmed publisher
    ..Finally, we show that this photo-triggered release is due to the membrane disruption caused by microbubble cavitation, which can be measured with hydrophone. ..
  2. Liang K, Xu K, Bessarab D, Obaje J, Xu C. Arbutin encapsulated micelles improved transdermal delivery and suppression of cellular melanin production. BMC Res Notes. 2016;9:254 pubmed publisher
    ..Graphical abstract Transdermal delivery of arbutin with micelles for melanin production suppression. ..
  3. Tay H, Yeo D, Wiraja C, Xu C, Hou H. Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering. J Vis Exp. 2016;: pubmed publisher
  4. Fu J, Wiraja C, Chong R, Xu C, Wang D. Real-time and non-invasive monitoring of embryonic stem cell survival during the development of embryoid bodies with smart nanosensor. Acta Biomater. 2017;49:358-367 pubmed publisher
    ..Noninvasive and real-time monitoring of viable ESC distribution in EBs would allow researchers to optimize the culturing condition in time during the EB development and to select the suitable EBs for subsequent applications. ..
  5. Yeo D, Balmayor E, Schantz J, Xu C. Microneedle physical contact as a therapeutic for abnormal scars. Eur J Med Res. 2017;22:28 pubmed publisher
    ..Larger cohort clinical studies need to be performed to validate its efficacy on abnormal scars. ..