Affiliation: Nanyang Technological University
Wiraja C, Zhu Y, Lio D, Yeo D, Xie M, Fang W, et al
. Framework nucleic acids as programmable carrier for transdermal drug delivery. Nat Commun. 2019;10:1147 pubmed publisher
..Programmable penetration with minimal systemic biodistribution underlines FNA potential as localized transdermal drug delivery carriers. ..
Yeo D, Wiraja C, Paller A, Mirkin C, Xu C. Abnormal scar identification with spherical-nucleic-acid technology. Nat Biomed Eng. 2018;2:227-238 pubmed publisher
..Our proof-of-concept studies of topically applied NanoFlare technology as a means of biopsy-free scar diagnosis may eventually inform therapeutic decisions on the basis of the mRNA-expression patterns of skin disorders. ..
Than A, Liu C, Chang H, Duong P, Cheung C, Xu C, et al
. Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nat Commun. 2018;9:4433 pubmed publisher
..The eye patch application is easy and minimally invasive to ensure good patient compliance. Such intraocular drug delivery strategy promises effective home-based treatment of many eye diseases. ..
Wang M, Wiraja C, Wee M, Yeo D, Hu L, Xu C. Hairpin-structured probe conjugated nano-graphene oxide for the cellular detection of connective tissue growth factor mRNA. Anal Chim Acta. 2018;1038:140-147 pubmed publisher
..Utilizing this probe, we can distinguish abnormal fibroblasts derived from abnormal scars and assess the effectiveness of anti-scarring drugs like Repsox and transforming growth factor-beta type I receptor (TGF-βRI) siRNA. ..
Mathiyazhakan M, Yang Y, Liu Y, Zhu C, Liu Q, Ohl C, et al
. Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation. Colloids Surf B Biointerfaces. 2015;126:569-74 pubmed publisher
..Furthermore, we characterized their size, morphology, phase transition temperature and stability. Finally, we demonstrated that this photo-triggered release might be due to the membrane disruption caused by microbubble cavitation. ..
Movahedi F, Hu R, Becker D, Xu C. Stimuli-responsive liposomes for the delivery of nucleic acid therapeutics. Nanomedicine. 2015;11:1575-84 pubmed publisher
..In this review article the authors describe and discuss the potentials of various trigger-responsive "smart" liposomes, with a view to help other researchers to design better liposomal nucleic acid delivery systems. ..
Lio D, Yeo D, Xu C. Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles. Nanoscale Res Lett. 2016;11:9 pubmed publisher
..Specifically, taking calcein as a model drug, microparticles containing the smallest alginate core (10Â Î¼m) show the slowest release over a period of 26Â days with burst releaseÂ less than 1 %. ..
Gao Y, Lim J, Han Y, Wang L, Chong M, Teoh S, et al
. Cryomilling for the fabrication of doxorubicin-containing silica-nanoparticle/polycaprolactone nanocomposite films. Nanoscale. 2016;8:2568-74 pubmed publisher
..When human cervical cancer cells were seeded directly on these films, uptake of Dox was observed as early as day 1 and significant inhibition of cell growth was recorded on day 5. ..
Kumar N, Wiraja C, Palanisamy K, Marsili E, Xu C. Heat shock mediated labelling of Pseudomonas aeruginosa with quantum dots. Colloids Surf B Biointerfaces. 2016;142:259-265 pubmed publisher
..Through the assay of the respiration rate of bacteria together with morphology analysis, the heat shock process does not show any negative effect over the cells activity even at sub-toxic concentrations. ..