Anh Tuân Phan

Summary

Affiliation: Nanyang Technological University
Country: Singapore

Publications

  1. pmc Engineering of interlocked DNA G-quadruplexes as a robust scaffold
    Anh Tuân Phan
    School of Physical and Mathematical Sciences and School of Biological Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 41:2683-8. 2013
  2. pmc Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 18:796-804. 2011
  3. doi request reprint Human telomeric G-quadruplex: structures of DNA and RNA sequences
    Anh Tuân Phan
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    FEBS J 277:1107-17. 2010
  4. pmc Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucleic Acids Res 34:5715-9. 2006
  5. pmc Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucleic Acids Res 35:6517-25. 2007
  6. ncbi request reprint Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 129:4386-92. 2007
  7. ncbi request reprint Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation
    Alexander Serganov
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Struct Mol Biol 12:218-24. 2005
  8. ncbi request reprint Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs
    Alexander Serganov
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Chem Biol 11:1729-41. 2004
  9. ncbi request reprint Two-repeat Tetrahymena telomeric d(TGGGGTTGGGGT) Sequence interconverts between asymmetric dimeric G-quadruplexes in solution
    Anh Tuân Phan
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Mol Biol 338:93-102. 2004
  10. ncbi request reprint Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold
    Kim Ngoc Luu
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 128:9963-70. 2006

Collaborators

Detail Information

Publications49

  1. pmc Engineering of interlocked DNA G-quadruplexes as a robust scaffold
    Anh Tuân Phan
    School of Physical and Mathematical Sciences and School of Biological Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 41:2683-8. 2013
    ..Different structural elements can be engineered in these robust scaffolds. We demonstrated the anti-HIV inhibition activity of the newly designed DNA sequences...
  2. pmc Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 18:796-804. 2011
    ..These findings on FMRP RGG domain recognition by a combination of G-quadruplex and surrounding RNA sequences have implications for the recognition of other genomic G-rich RNAs...
  3. doi request reprint Human telomeric G-quadruplex: structures of DNA and RNA sequences
    Anh Tuân Phan
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    FEBS J 277:1107-17. 2010
    ..This minireview describes the structural diversity or conservation of DNA and RNA human telomeric G-quadruplexes, discusses structural views on targeting these G-quadruplexes and presents some future challenges for structural studies...
  4. pmc Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucleic Acids Res 34:5715-9. 2006
    ..Furthermore, even small changes to flanking sequences can perturb the equilibrium between different coexisting G-quadruplex forms...
  5. pmc Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucleic Acids Res 35:6517-25. 2007
    ..This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds...
  6. ncbi request reprint Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 129:4386-92. 2007
    ..This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to the promoter DNA of c-kit...
  7. ncbi request reprint Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation
    Alexander Serganov
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Struct Mol Biol 12:218-24. 2005
    ..We observe structural parallels in the independently evolved catalytic pocket architectures for ribozyme- and antibody-catalyzed Diels-Alder carbon-carbon bond-forming reactions...
  8. ncbi request reprint Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs
    Alexander Serganov
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Chem Biol 11:1729-41. 2004
    ..Recognition specificity is associated with Watson-Crick pairing of the encapsulated adenine and guanine ligands with uridine and cytosine, respectively...
  9. ncbi request reprint Two-repeat Tetrahymena telomeric d(TGGGGTTGGGGT) Sequence interconverts between asymmetric dimeric G-quadruplexes in solution
    Anh Tuân Phan
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Mol Biol 338:93-102. 2004
    ..In contrast to the human telomere counterpart, the proportions of the two forms here are similar for a wide range of temperatures; their unfolding rates are also similar, with an activation enthalpy of 153 kJ/mol...
  10. ncbi request reprint Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold
    Kim Ngoc Luu
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 128:9963-70. 2006
    ..The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA...
  11. pmc Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad
    Kah Wai Lim
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 37:6239-48. 2009
    ..Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G.C base pair and a G.C.G.C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA...
  12. doi request reprint Structure of long human telomeric RNA (TERRA): G-quadruplexes formed by four and eight UUAGGG repeats are stable building blocks
    Herry Martadinata
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    Biochemistry 50:6455-61. 2011
    ..On the basis of these results, we propose a "beads-on-a-string"-like arrangement along human TERRA, whereby each bead is made up of either four or eight UUAGGG repeats in a one- or two-block G-quadruplex arrangement, respectively...
  13. ncbi request reprint Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kinetics
    Anh Tuân Phan
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 125:15021-7. 2003
    ....
  14. pmc An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:634-9. 2005
    ..Finally, we propose a model, based on molecular docking approaches, for positioning the 93del dimeric DNA quadruplex within a basic channel/canyon formed between subunits of a dimer of dimers of HIV-1 integrase...
  15. doi request reprint Monomer-dimer equilibrium for the 5'-5' stacking of propeller-type parallel-stranded G-quadruplexes: NMR structural study
    Ngoc Quang Do
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    Chemistry 18:14752-9. 2012
    ..We report on the high-definition structure of a simple monomeric G-quadruplex containing three single-residue loops, which could serve as a reference for propeller-type G-quadruplex structures in solution...
  16. doi request reprint NMR spectroscopy of G-quadruplexes
    Michael Adrian
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore
    Methods 57:11-24. 2012
    ..NMR spectroscopy has played an important role in G-quadruplex research. Here we review on the application of NMR techniques to study structure, dynamics and interaction of G-quadruplexes...
  17. pmc Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity
    Ngoc Quang Do
    School of Physical and Mathematical Sciences and School of Biological Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 39:9448-57. 2011
    ..Our analysis of possible structures at the stacking interface provides a general principle for stacking of G-quadruplexes, which could have implications for the assembly and recognition of higher-order G-quadruplex structures...
  18. pmc Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers
    Kah Wai Lim
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    J Am Chem Soc 131:4301-9. 2009
    ..This novel structure highlights the conformational heterogeneity of human telomeric DNA. It establishes a new folding principle for G-quadruplexes and suggests new loop sequences and structures for targeting in human telomeric DNA...
  19. doi request reprint Coexistence of two distinct G-quadruplex conformations in the hTERT promoter
    Kah Wai Lim
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    J Am Chem Soc 132:12331-42. 2010
    ....
  20. pmc Effects of site-specific guanine C8-modifications on an intramolecular DNA G-quadruplex
    Christopher Jacques Lech
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    Biophys J 101:1987-98. 2011
    ..This effect was reproduced by ab initio quantum mechanical computations, which showed that the observed variation in imino proton chemical shift is largely influenced by changes in hydrogen-bond geometry within the guanine tetrad...
  21. doi request reprint Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution
    Herry Martadinata
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
    J Am Chem Soc 131:2570-8. 2009
    ..Based on these findings we proposed how higher-order structures might be formed by long telomeric RNA...
  22. ncbi request reprint (3 + 1) Assembly of three human telomeric repeats into an asymmetric dimeric G-quadruplex
    Na Zhang
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 127:17277-85. 2005
    ..We discuss the possible implications of the new folding topology for understanding the structure of telomeric DNA, including t-loop formation, and for targeting G-quadruplexes in the telomeres...
  23. doi request reprint Structure of human telomeric DNA in crowded solution
    Brahim Heddi
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    J Am Chem Soc 133:9824-33. 2011
    ..These results regarding human telomeric DNA can be extended to oncogenic promoters and other genomic G-rich sequences...
  24. pmc HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges
    Vineeth Thachappilly Mukundan
    School of Physical and Mathematical Sciences and School of Biological Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 39:8984-91. 2011
    ..In this work, we also propose a simple analytical approach to stoichiometry determination using concentration-dependent melting curves...
  25. doi request reprint Formation of pearl-necklace monomorphic G-quadruplexes in the human CEB25 minisatellite
    Samir Amrane
    School of Physical and Mathematical Sciences, Nanyang Technological University, 637371 Singapore
    J Am Chem Soc 134:5807-16. 2012
    ..Further, we demonstrate that such a monomorphic structure is formed within longer sequence contexts folding into a pearl-necklace structure...
  26. ncbi request reprint Differentiation between unlabeled and very-low-level fully 15N,13C-labeled nucleotides for resonance assignments in nucleic acids
    Anh Tuân Phan
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Biomol NMR 23:257-62. 2002
    ..We expect this approach to be useful for selective monitoring of important functional domains and of their interactions in large nucleic acids...
  27. pmc A novel chair-type G-quadruplex formed by a Bombyx mori telomeric sequence
    Samir Amrane
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
    Nucleic Acids Res 37:931-8. 2009
    ..Our result highlights the effect of G-tract length on the folding topology of G-quadruplexes, but also poses the question of whether a similar chair-type G-quadruplex fold exists in the human telomeric sequences...
  28. ncbi request reprint Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Chem Biol 1:167-73. 2005
    ....
  29. doi request reprint Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity
    Kah Wai Lim
    School of Physical and Mathematical Sciences, Nanyang Technological University, 637371 Singapore, School of Biological Sciences, Nanyang Technological University, 637551 Singapore and Instituto de Química Física Rocasolano, CSIC, 28006 Madrid, Spain
    Nucleic Acids Res 41:10556-62. 2013
    ....
  30. doi request reprint Structure of human telomeric RNA (TERRA): stacking of two G-quadruplex blocks in K(+) solution
    Herry Martadinata
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    Biochemistry 52:2176-83. 2013
    ..This stacking conformation is a potential target for drugs that recognize or induce the stacking interface...
  31. ncbi request reprint Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen
    Marianna Teplova
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell 21:75-85. 2006
    ....
  32. pmc Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics
    Dinshaw J Patel
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucleic Acids Res 35:7429-55. 2007
    ....
  33. ncbi request reprint Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 126:8710-6. 2004
    ..The central loop contains two or six residues, while the two other loops contain only one residue...
  34. doi request reprint Giardia telomeric sequence d(TAGGG)4 forms two intramolecular G-quadruplexes in K+ solution: effect of loop length and sequence on the folding topology
    Lanying Hu
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371
    J Am Chem Soc 131:16824-31. 2009
    ....
  35. pmc Guanine base stacking in G-quadruplex nucleic acids
    Christopher Jacques Lech
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
    Nucleic Acids Res 41:2034-46. 2013
    ....
  36. pmc Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter
    Vitaly Kuryavyi
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Nucleic Acids Res 38:6757-73. 2010
    ..We propose that strand exchange during recombination events within guanine-rich segments, could potentially be mediated by a synapsis intermediate involving an intergenic parallel-stranded dimeric G-quadruplex...
  37. ncbi request reprint DNA architecture: from G to Z
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Opin Struct Biol 16:288-98. 2006
    ..These results will enhance our understanding of the biology of these structures and provide a platform for drug design...
  38. doi request reprint Formation of (3+1) G-quadruplexes with a long loop by human telomeric DNA spanning five or more repeats
    Doris Jia En Yue
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    J Am Chem Soc 133:11462-5. 2011
    ..We report on the formation of a Watson-Crick duplex within the long propeller loop upon addition of the complementary strand, demonstrating that the long loop could serve as a new recognition motif...
  39. doi request reprint Following G-quadruplex formation by its intrinsic fluorescence
    Nguyen Thuan Dao
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    FEBS Lett 585:3969-77. 2011
    ..Thus, the stability and possibly also the structure of G-quadruplexes can be characterized and distinguished by their intrinsic fluorescence spectra...
  40. doi request reprint Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3
    Wan Jun Chung
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 Singapore
    Angew Chem Int Ed Engl 53:999-1002. 2014
    ..On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation. ..
  41. doi request reprint 2'-F-ANA-guanosine and 2'-F-guanosine as powerful tools for structural manipulation of G-quadruplexes
    Christopher Jacques Lech
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    Chem Commun (Camb) 48:11425-7. 2012
    ..Rational substitutions of either type of 2'-F-modified nucleotide enable conformational switching from a (3+1) hybrid to a parallel folding topology...
  42. ncbi request reprint A site-specific low-enrichment (15)N,(13)C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acids
    Anh Tuân Phan
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center New York, New York 10021, USA
    J Am Chem Soc 124:1160-1. 2002
    ..This simple and cost-effective methodology is demonstrated on the d(GGGTTCAGG) DNA sequence, which forms a dimeric G-quadruplex containing G.G.G.G tetrads sandwiched between G.(C-A) triads...
  43. doi request reprint Bulges in g-quadruplexes: broadening the definition of g-quadruplex-forming sequences
    Vineeth Thachappilly Mukundan
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    J Am Chem Soc 135:5017-28. 2013
    ..This study could also open the possibilities of exploiting bulges as recognition elements for interactions between G-quadruplexes and other molecules. ..
  44. doi request reprint Metamaterials-based label-free nanosensor for conformation and affinity biosensing
    Cuong Cao
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
    ACS Nano 7:7583-91. 2013
    ..We further demonstrate the use of the metamaterials for fingerprinting and detection of the arginine-glycine-glycine domain of nucleolin, a cancer biomarker that specifically binds to a G-quadruplex, with the picomolar sensitivity. ..
  45. doi request reprint Thermal stability of DNA quadruplex-duplex hybrids
    Kah Wai Lim
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
    Biochemistry 53:247-57. 2014
    ..Bulges at the junction are largely detrimental to the adoption of the desired G-quadruplex topology for Construct I but not for Construct II. These findings should facilitate future design and prediction of quadruplex-duplex hybrids. ..
  46. doi request reprint Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative
    Wan Jun Chung
    School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    J Am Chem Soc 135:13495-501. 2013
    ..This structural information provides a platform for the design of topology-specific G-quadruplex-targeting compounds and is valuable for the development of new potent anticancer drugs. ..
  47. doi request reprint Electron-hole transfer in G-quadruplexes with different tetrad stacking geometries: a combined QM and MD study
    Christopher J Lech
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    J Phys Chem B 117:9851-6. 2013
    ..The results of this study suggest engineering G-tetrads with continuous 5/6-ring stacking from an assembly of single guanosine analogs or through modification of the backbone in G-rich DNA sequences. ..
  48. doi request reprint Structural basis of DNA quadruplex-duplex junction formation
    Kah Wai Lim
    School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 Singapore School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551 Singapore
    Angew Chem Int Ed Engl 52:8566-9. 2013
    ..The modularity of the approach was validated through the simultaneous attachment of multiple duplex stems onto a G-quadruplex scaffold to generate a G-junction. ..
  49. pmc Photoelectrochemical studies of DNA-tagged biomolecules on Au and Au/Ni/Au multilayer nanowires
    Viswanathan Swaminathan
    School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore
    Nanoscale Res Lett 6:535. 2011
    ..The importance of these PEC and optical studies provides an inexpensive and facile processing platform for Au NWs that may be suitable for biolabeling applications...