Research Topics
Species | Anh Tuân PhanSummaryAffiliation: Nanyang Technological University Country: Singapore Publications
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Detail Information
Publications
Engineering of interlocked DNA G-quadruplexes as a robust scaffoldAnh Tuân Phan
School of Physical and Mathematical Sciences and School of Biological Sciences, Nanyang Technological University, Singapore
Nucleic Acids Res 41:2683-8. 2013..Different structural elements can be engineered in these robust scaffolds. We demonstrated the anti-HIV inhibition activity of the newly designed DNA sequences...
2'-F-ANA-guanosine and 2'-F-guanosine as powerful tools for structural manipulation of G-quadruplexesChristopher Jacques Lech
School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore
Chem Commun (Camb) 48:11425-7. 2012..Rational substitutions of either type of 2'-F-modified nucleotide enable conformational switching from a (3+1) hybrid to a parallel folding topology...
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoterAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Am Chem Soc 129:4386-92. 2007..This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to the promoter DNA of c-kit...- Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solutionAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nucleic Acids Res 34:5715-9. 2006..Furthermore, even small changes to flanking sequences can perturb the equilibrium between different coexisting G-quadruplex forms... - Human telomeric G-quadruplex: structures of DNA and RNA sequencesAnh Tuân Phan
Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
FEBS J 277:1107-17. 2010..This minireview describes the structural diversity or conservation of DNA and RNA human telomeric G-quadruplexes, discusses structural views on targeting these G-quadruplexes and presents some future challenges for structural studies... - Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junctionAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Nat Struct Mol Biol 18:796-804. 2011..These findings on FMRP RGG domain recognition by a combination of G-quadruplex and surrounding RNA sequences have implications for the recognition of other genomic G-rich RNAs... - Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solutionAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nucleic Acids Res 35:6517-25. 2007..This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds... - Two-repeat Tetrahymena telomeric d(TGGGGTTGGGGT) Sequence interconverts between asymmetric dimeric G-quadruplexes in solutionAnh Tuân Phan
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Mol Biol 338:93-102. 2004..In contrast to the human telomere counterpart, the proportions of the two forms here are similar for a wide range of temperatures; their unfolding rates are also similar, with an activation enthalpy of 153 kJ/mol... - Structure of long human telomeric RNA (TERRA): G-quadruplexes formed by four and eight UUAGGG repeats are stable building blocksHerry Martadinata
School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
Biochemistry 50:6455-61. 2011.... - Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetradKah Wai Lim
Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
Nucleic Acids Res 37:6239-48. 2009..Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G.C base pair and a G.C.G.C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA... - Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kineticsAnh Tuân Phan
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Am Chem Soc 125:15021-7. 2003.... - An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integraseAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:634-9. 2005..Finally, we propose a model, based on molecular docking approaches, for positioning the 93del dimeric DNA quadruplex within a basic channel/canyon formed between subunits of a dimer of dimers of HIV-1 integrase... - Monomer-dimer equilibrium for the 5'-5' stacking of propeller-type parallel-stranded G-quadruplexes: NMR structural studyNgoc Quang Do
School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
Chemistry 18:14752-9. 2012..We report on the high-definition structure of a simple monomeric G-quadruplex containing three single-residue loops, which could serve as a reference for propeller-type G-quadruplex structures in solution... - NMR spectroscopy of G-quadruplexesMichael Adrian
Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore
Methods 57:11-24. 2012..NMR spectroscopy has played an important role in G-quadruplex research. Here we review on the application of NMR techniques to study structure, dynamics and interaction of G-quadruplexes... - Effects of site-specific guanine C8-modifications on an intramolecular DNA G-quadruplexChristopher Jacques Lech
School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
Biophys J 101:1987-98. 2011..This effect was reproduced by ab initio quantum mechanical computations, which showed that the observed variation in imino proton chemical shift is largely influenced by changes in hydrogen-bond geometry within the guanine tetrad... - Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activityNgoc Quang Do
School of Physical and Mathematical Sciences and School of Biological Sciences, Nanyang Technological University, Singapore
Nucleic Acids Res 39:9448-57. 2011..Our analysis of possible structures at the stacking interface provides a general principle for stacking of G-quadruplexes, which could have implications for the assembly and recognition of higher-order G-quadruplex structures... - Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layersKah Wai Lim
School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
J Am Chem Soc 131:4301-9. 2009..This novel structure highlights the conformational heterogeneity of human telomeric DNA. It establishes a new folding principle for G-quadruplexes and suggests new loop sequences and structures for targeting in human telomeric DNA... - Structure of human telomeric DNA in crowded solutionBrahim Heddi
School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
J Am Chem Soc 133:9824-33. 2011..These results regarding human telomeric DNA can be extended to oncogenic promoters and other genomic G-rich sequences... - Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solutionHerry Martadinata
Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
J Am Chem Soc 131:2570-8. 2009..Based on these findings we proposed how higher-order structures might be formed by long telomeric RNA... - HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulgesVineeth Thachappilly Mukundan
School of Physical and Mathematical Sciences and School of Biological Sciences, Nanyang Technological University, Singapore
Nucleic Acids Res 39:8984-91. 2011..In this work, we also propose a simple analytical approach to stoichiometry determination using concentration-dependent melting curves... - Formation of pearl-necklace monomorphic G-quadruplexes in the human CEB25 minisatelliteSamir Amrane
School of Physical and Mathematical Sciences, Nanyang Technological University, 637371 Singapore
J Am Chem Soc 134:5807-16. 2012..Further, we demonstrate that such a monomorphic structure is formed within longer sequence contexts folding into a pearl-necklace structure... - Coexistence of two distinct G-quadruplex conformations in the hTERT promoterKah Wai Lim
School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
J Am Chem Soc 132:12331-42. 2010.... - Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoterAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Nat Chem Biol 1:167-73. 2005.... - Differentiation between unlabeled and very-low-level fully 15N,13C-labeled nucleotides for resonance assignments in nucleic acidsAnh Tuân Phan
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Biomol NMR 23:257-62. 2002..We expect this approach to be useful for selective monitoring of important functional domains and of their interactions in large nucleic acids... - A novel chair-type G-quadruplex formed by a Bombyx mori telomeric sequenceSamir Amrane
Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
Nucleic Acids Res 37:931-8. 2009..Our result highlights the effect of G-tract length on the folding topology of G-quadruplexes, but also poses the question of whether a similar chair-type G-quadruplex fold exists in the human telomeric sequences... - Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigenMarianna Teplova
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mol Cell 21:75-85. 2006.... - Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoterAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Am Chem Soc 126:8710-6. 2004..The central loop contains two or six residues, while the two other loops contain only one residue... - Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeuticsDinshaw J Patel
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nucleic Acids Res 35:7429-55. 2007.... - Giardia telomeric sequence d(TAGGG)4 forms two intramolecular G-quadruplexes in K+ solution: effect of loop length and sequence on the folding topologyLanying Hu
Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371
J Am Chem Soc 131:16824-31. 2009.... - Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffoldKim Ngoc Luu
Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
J Am Chem Soc 128:9963-70. 2006..The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA... - Guanine base stacking in G-quadruplex nucleic acidsChristopher Jacques Lech
Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
Nucleic Acids Res 41:2034-46. 2013.... - Formation of (3+1) G-quadruplexes with a long loop by human telomeric DNA spanning five or more repeatsDoris Jia En Yue
School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
J Am Chem Soc 133:11462-5. 2011..We report on the formation of a Watson-Crick duplex within the long propeller loop upon addition of the complementary strand, demonstrating that the long loop could serve as a new recognition motif... - DNA architecture: from G to ZAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Curr Opin Struct Biol 16:288-98. 2006..These results will enhance our understanding of the biology of these structures and provide a platform for drug design... - Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoterVitaly Kuryavyi
Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Nucleic Acids Res 38:6757-73. 2010..We propose that strand exchange during recombination events within guanine-rich segments, could potentially be mediated by a synapsis intermediate involving an intergenic parallel-stranded dimeric G-quadruplex... - (3 + 1) Assembly of three human telomeric repeats into an asymmetric dimeric G-quadruplexNa Zhang
Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
J Am Chem Soc 127:17277-85. 2005..We discuss the possible implications of the new folding topology for understanding the structure of telomeric DNA, including t-loop formation, and for targeting G-quadruplexes in the telomeres... - Following G-quadruplex formation by its intrinsic fluorescenceNguyen Thuan Dao
Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
FEBS Lett 585:3969-77. 2011..Thus, the stability and possibly also the structure of G-quadruplexes can be characterized and distinguished by their intrinsic fluorescence spectra... - A site-specific low-enrichment (15)N,(13)C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acidsAnh Tuân Phan
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center New York, New York 10021, USA
J Am Chem Soc 124:1160-1. 2002..This simple and cost-effective methodology is demonstrated on the d(GGGTTCAGG) DNA sequence, which forms a dimeric G-quadruplex containing G.G.G.G tetrads sandwiched between G.(C-A) triads... - Structure of Human Telomeric RNA (TERRA): Stacking of Two G-Quadruplex Blocks in K(+) SolutionHerry Martadinata
School of Physical and Mathematical Sciences and School of Biological Sciences, Nanyang Technological University, Singapore
Biochemistry 52:2176-83. 2013..This stacking conformation is a potential target for drugs that recognize or induce the stacking interface... - Photoelectrochemical studies of DNA-tagged biomolecules on Au and Au/Ni/Au multilayer nanowiresViswanathan Swaminathan
School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore
Nanoscale Res Lett 6:535. 2011..The importance of these PEC and optical studies provides an inexpensive and facile processing platform for Au NWs that may be suitable for biolabeling applications... - Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAsAlexander Serganov
Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Chem Biol 11:1729-41. 2004..Recognition specificity is associated with Watson-Crick pairing of the encapsulated adenine and guanine ligands with uridine and cytosine, respectively... - Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formationAlexander Serganov
Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Nat Struct Mol Biol 12:218-24. 2005..We observe structural parallels in the independently evolved catalytic pocket architectures for ribozyme- and antibody-catalyzed Diels-Alder carbon-carbon bond-forming reactions...