Cheng Gee Koh

Summary

Affiliation: Nanyang Technological University
Country: Singapore

Publications

  1. ncbi request reprint Rho GTPases and their regulators in neuronal functions and development
    Cheng Gee Koh
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Neurosignals 15:228-37. 2006
  2. pmc In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase
    Yoke Peng Lee
    Division of Molecular and Cell Biology, School of Biological Sciences, College of Science, Nanyang Technological University, Singapore
    PLoS ONE 7:e45836. 2012
  3. doi request reprint Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis
    Pritpal Singh
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore
    Proteomics 11:2891-900. 2011
  4. ncbi request reprint Rac1 GTPase is activated by hepatitis B virus replication--involvement of HBX
    Tuan Lin Tan
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore
    Biochim Biophys Acta 1783:360-74. 2008
  5. doi request reprint Integrative transcriptome and proteome study to identify the signaling network regulated by POPX2 phosphatase
    Songjing Zhang
    School of Biological Sciences, Nanyang Technological University, Singapore 6387551
    J Proteome Res 12:2525-36. 2013
  6. doi request reprint Elucidating the temporal dynamics of chromatin-associated protein release upon DNA digestion by quantitative proteomic approach
    Bamaprasad Dutta
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    J Proteomics 75:5493-506. 2012
  7. doi request reprint TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation
    Yi Wen Heng
    Division of Molecular Genetics and Cell Biology, School of Biological Sciences, College of Science, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore
    J Cell Sci 125:1579-90. 2012
  8. doi request reprint Actin cytoskeleton dynamics and the cell division cycle
    Yi Wen Heng
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Int J Biochem Cell Biol 42:1622-33. 2010
  9. ncbi request reprint The POPX2 phosphatase regulates cancer cell motility and invasiveness
    Agatha Susila
    School of Biological Sciences, Nanyang Technological University, Singapore
    Cell Cycle 9:179-87. 2010
  10. pmc Functions and regulation of circular dorsal ruffles
    Jing Ling Hoon
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Mol Cell Biol 32:4246-57. 2012

Collaborators

  • Sunil S Adav
  • Vinay Tergaonkar
  • Tuan Lin Tan
  • S G Lim
  • Yi Wen Heng
  • Siu Kwan Sze
  • Hei Chan
  • Chi Hang Wong
  • Songjing Zhang
  • Bamaprasad Dutta
  • Jing Ling Hoon
  • Tiannan Guo
  • Yoke Peng Lee
  • Pritpal Singh
  • Hui Qun Phang
  • Soak Kuan Lai
  • Hoi Yeung Li
  • Kheng Sze Chan
  • Agatha Susila
  • Yi Xie
  • Theresia Mina
  • Chwee Teck Lim
  • Prayudi Utomo
  • Eran Meshorer
  • Shaoping Zhong
  • Wai Keung Wong
  • Hong Hwa Lim
  • Chee Sian Gan
  • Andrew Xiong Wen Loh
  • Ee Tsin Wong
  • Chin Yee Ho
  • Louis Lim
  • Shimei Wee
  • E Jean Tan
  • Edward Manser

Detail Information

Publications13

  1. ncbi request reprint Rho GTPases and their regulators in neuronal functions and development
    Cheng Gee Koh
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Neurosignals 15:228-37. 2006
    ..In general, Rac and Cdc42 promote neurite outgrowth while RhoA stimulates retraction. The balance of these opposing activities of the different Rho GTPases is crucial for the morphology and function of the neurons...
  2. pmc In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase
    Yoke Peng Lee
    Division of Molecular and Cell Biology, School of Biological Sciences, College of Science, Nanyang Technological University, Singapore
    PLoS ONE 7:e45836. 2012
    ..Our findings suggest an additional role of RanGTP beyond its known function in mitotic spindle assembly during the prometaphase-metaphase transition...
  3. doi request reprint Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis
    Pritpal Singh
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore
    Proteomics 11:2891-900. 2011
    ....
  4. ncbi request reprint Rac1 GTPase is activated by hepatitis B virus replication--involvement of HBX
    Tuan Lin Tan
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore
    Biochim Biophys Acta 1783:360-74. 2008
    ..HBV may possibly make use of an activated Rac1 signaling pathway for increased replication and resultant metastatic effects...
  5. doi request reprint Integrative transcriptome and proteome study to identify the signaling network regulated by POPX2 phosphatase
    Songjing Zhang
    School of Biological Sciences, Nanyang Technological University, Singapore 6387551
    J Proteome Res 12:2525-36. 2013
    ..Taken together, our data suggest that POPX2 might regulate cell motility through its regulation of the MAPK1/3, leading to changes in the cytoskeleton and cell motility...
  6. doi request reprint Elucidating the temporal dynamics of chromatin-associated protein release upon DNA digestion by quantitative proteomic approach
    Bamaprasad Dutta
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    J Proteomics 75:5493-506. 2012
    ..The comprehensive differential chromatin bound proteome might expand our knowledge of the proteins that were associated with different chromatin regions, which could be very useful in elucidating chromatin biology...
  7. doi request reprint TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation
    Yi Wen Heng
    Division of Molecular Genetics and Cell Biology, School of Biological Sciences, College of Science, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore
    J Cell Sci 125:1579-90. 2012
    ..Both phenotypes are tightly coupled to spindle orientation in the mitotic cells. Thus, our results reveal a new regulatory link between the actin cytoskeleton and the mitotic spindle during the early stages of mitosis...
  8. doi request reprint Actin cytoskeleton dynamics and the cell division cycle
    Yi Wen Heng
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Int J Biochem Cell Biol 42:1622-33. 2010
    ....
  9. ncbi request reprint The POPX2 phosphatase regulates cancer cell motility and invasiveness
    Agatha Susila
    School of Biological Sciences, Nanyang Technological University, Singapore
    Cell Cycle 9:179-87. 2010
    ..Based on these results, we propose a mechanism by which POP X2 regulates the invasive behavior of the cells...
  10. pmc Functions and regulation of circular dorsal ruffles
    Jing Ling Hoon
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Mol Cell Biol 32:4246-57. 2012
    ..We focus specifically on the biochemical pathways leading to CDR formation in order to better define the roles and functions of these enigmatic structures...
  11. ncbi request reprint The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family
    Cheng Gee Koh
    Institute of Molecular and Cell Biology, 30 Medical Drive, 117609, Singapore, Singapore
    Curr Biol 12:317-21. 2002
    ..The association of the POPX phosphatases with PAK complexes may allow PAK to cycle rapidly between active and inactive states; it represents a unique regulatory component of the signaling pathways of the PAK kinase family...
  12. doi request reprint Apoptotic histone modification inhibits nuclear transport by regulating RCC1
    Chi Hang Wong
    Division of Molecular and Cell Biology, School of Biological Sciences, College of Science, Nanyang Technological University, Singapore 637551
    Nat Cell Biol 11:36-45. 2009
    ..Therefore, we propose that RCC1 reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus...
  13. doi request reprint Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways
    Yi Xie
    School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore
    J Cell Sci 121:514-21. 2008
    ..We propose that the interaction between mDia1 and POPX2 (PPM1F) serves to regulate both the actin cytoskeleton and SRF-mediated transcription, and to link the CDC42/RAC1 pathways with those of RhoA...