Boon Chin Heng

Summary

Affiliation: Nanyang Technological University
Country: Singapore

Publications

  1. doi Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress
    Boon Chin Heng
    School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore
    Food Chem Toxicol 48:1762-6. 2010
  2. doi Cytotoxicity of zinc oxide (ZnO) nanoparticles is influenced by cell density and culture format
    Boon Chin Heng
    Division of Materials Science, School of Materials Science and Engineering, Nanyang Technological University, N3 B4 W310, Nanyang Avenue, 639798, Singapore, Singapore
    Arch Toxicol 85:695-704. 2011
  3. doi Effect of cell-seeding density on the proliferation and gene expression profile of human umbilical vein endothelial cells within ex vivo culture
    Boon Chin Heng
    School of Materials Science and Engineering, Nanyang Technological University, Singapore
    Cytotherapy 13:606-17. 2011
  4. doi Cytotoxicity of hydroxyapatite nanoparticles is shape and cell dependent
    Xinxin Zhao
    School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Arch Toxicol 87:1037-52. 2013
  5. doi Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles
    Boon Chin Heng
    School of Materials Science and Engineering, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Arch Toxicol 85:1517-28. 2011
  6. doi Seeding density matters: extensive intercellular contact masks the surface dependence of endothelial cell-biomaterial interactions
    Yun Xia
    School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Nanyang, 639798, Singapore
    J Mater Sci Mater Med 22:389-96. 2011
  7. doi In vitro assessment of cellular responses to rod-shaped hydroxyapatite nanoparticles of varying lengths and surface areas
    Xinxin Zhao
    School of Materials Science and Engineering, Nanyang Technological University, Singapore
    Nanotoxicology 5:182-94. 2011
  8. doi Adhesion, proliferation, and gene expression profile of human umbilical vein endothelial cells cultured on bilayered polyelectrolyte coatings composed of glycosaminoglycans
    Boon Chin Heng
    School of Materials Science and Engineering, Nanyang Technological University, Block N4 1, 50 Nanyang Avenue, Singapore 639798, Singapore
    Biointerphases 5:FA53-62. 2010
  9. doi Cellular uptake of Poly-(D,L-lactide-co-glycolide) (PLGA) nanoparticles synthesized through solvent emulsion evaporation and nanoprecipitation method
    Sijing Xiong
    School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore
    Biotechnol J 6:501-8. 2011
  10. doi The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles
    Kee Woei Ng
    School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore
    Biomaterials 32:8218-25. 2011

Collaborators

Detail Information

Publications12

  1. doi Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress
    Boon Chin Heng
    School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore
    Food Chem Toxicol 48:1762-6. 2010
    ..1% obtained for initial exposure to 5 microM H(2)O(2) and the negative control, respectively. Hence, initial exposure of BEAS-2B cells to oxidative stress sensitized their subsequent response to cytotoxic challenge with ZnO nanoparticles...
  2. doi Cytotoxicity of zinc oxide (ZnO) nanoparticles is influenced by cell density and culture format
    Boon Chin Heng
    Division of Materials Science, School of Materials Science and Engineering, Nanyang Technological University, N3 B4 W310, Nanyang Avenue, 639798, Singapore, Singapore
    Arch Toxicol 85:695-704. 2011
    ....
  3. doi Effect of cell-seeding density on the proliferation and gene expression profile of human umbilical vein endothelial cells within ex vivo culture
    Boon Chin Heng
    School of Materials Science and Engineering, Nanyang Technological University, Singapore
    Cytotherapy 13:606-17. 2011
    ..Characterization of endothelial cell-biomaterial interaction is crucial for the development of blood-contacting biomedical devices and implants. However, a crucial parameter that has largely been overlooked is the cell-seeding density...
  4. doi Cytotoxicity of hydroxyapatite nanoparticles is shape and cell dependent
    Xinxin Zhao
    School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Arch Toxicol 87:1037-52. 2013
    ..Taken collectively, we demonstrated the shape-dependent effects of nHA on cytotoxicity, inflammatory cytokine expression and particle-cell association...
  5. doi Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles
    Boon Chin Heng
    School of Materials Science and Engineering, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Arch Toxicol 85:1517-28. 2011
    ..Hence, our study indicated that ZnO nanoparticles can have potential detrimental effects on cells even at dosages where there are little or no observable cytotoxic effects...
  6. doi Seeding density matters: extensive intercellular contact masks the surface dependence of endothelial cell-biomaterial interactions
    Yun Xia
    School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Nanyang, 639798, Singapore
    J Mater Sci Mater Med 22:389-96. 2011
    ..It is recommended that low seeding density should be utilized for evaluating biomaterial applications where EC density is likely to be low, such as in situ endothelialization of blood-contacting devices...
  7. doi In vitro assessment of cellular responses to rod-shaped hydroxyapatite nanoparticles of varying lengths and surface areas
    Xinxin Zhao
    School of Materials Science and Engineering, Nanyang Technological University, Singapore
    Nanotoxicology 5:182-94. 2011
    ..The results thus suggest that high surface area may increase cell-particle interaction, which in turn influenced ROS generation. The combined results from all the cell lines thus indicated high biocompatibility of rod-shaped nHA...
  8. doi Adhesion, proliferation, and gene expression profile of human umbilical vein endothelial cells cultured on bilayered polyelectrolyte coatings composed of glycosaminoglycans
    Boon Chin Heng
    School of Materials Science and Engineering, Nanyang Technological University, Block N4 1, 50 Nanyang Avenue, Singapore 639798, Singapore
    Biointerphases 5:FA53-62. 2010
    ..CT-HA displayed the highest level of expression of VWF, whereas expression levels of VEGFR were almost similar among the three glycosaminoglycans...
  9. doi Cellular uptake of Poly-(D,L-lactide-co-glycolide) (PLGA) nanoparticles synthesized through solvent emulsion evaporation and nanoprecipitation method
    Sijing Xiong
    School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore
    Biotechnol J 6:501-8. 2011
    ..7 cells show increased uptake compared to BEAS-2B cells. The information drawn from this study would provide important clues on how nanomaterials interact with cells and how these interactions can influence biocompatibility or toxicity...
  10. doi The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles
    Kee Woei Ng
    School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore
    Biomaterials 32:8218-25. 2011
    ....
  11. doi Comparative cytotoxicity evaluation of lanthanide nanomaterials on mouse and human cell lines with metabolic and DNA-quantification assays
    Boon Chin Heng
    School of Materials Science and Engineering, Nanyang Technological University, Block N4 1, 50 Nanyang Avenue, Singapore 639798, Singapore
    Biointerphases 5:FA88-97. 2010
    ..Hence, the Pico-Green assay could have an advantage over the WST-8 assay because it is not skewed by the differential effects of nanomaterials on cellular metabolism...
  12. doi Translating human embryonic stem cells from 2-dimensional to 3-dimensional cultures in a defined medium on laminin- and vitronectin-coated surfaces
    Boon Chin Heng
    Bioprocessing Technology Institute, Agency for Science, Technology and Research A STAR, Singapore, Singapore
    Stem Cells Dev 21:1701-15. 2012
    ....