Peter Droge

Summary

Affiliation: Nanyang Technological University
Country: Singapore

Publications

  1. doi request reprint Do cells let-7 determine stemness?
    Peter Droge
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551
    Cell Stem Cell 2:8-9. 2008
  2. pmc HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy
    Heike Summer
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 37:4371-84. 2009
  3. ncbi request reprint DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    FEBS Lett 581:3533-7. 2007
  4. pmc Human genomic Z-DNA segments probed by the Z alpha domain of ADAR1
    Heng Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore
    Nucleic Acids Res 37:2737-46. 2009
  5. doi request reprint Alternate rRNA secondary structures as regulators of translation
    Shu Feng
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Nat Struct Mol Biol 18:169-76. 2011
  6. ncbi request reprint Site selectivity of platinum anticancer therapeutics
    Bin Wu
    Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Nat Chem Biol 4:110-2. 2008
  7. ncbi request reprint Comparative analysis of sequence-specific DNA recombination systems in human embryonic stem cells
    Shen Mynn Tan
    Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, 637551, Singapore
    Stem Cells 23:868-73. 2005
  8. pmc A UTF1-based selection system for stable homogeneously pluripotent human embryonic stem cell cultures
    Shen Mynn Tan
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 and ES Cell International Pte Ltd, 11 Biopolis Way, 05 06 Helios, 138667 Singapore
    Nucleic Acids Res 35:e118. 2007
  9. doi request reprint Use of UTF1 Genetic Control Elements as iPSC Reporter
    Amir Morshedi
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, Singapore, 637551
    Stem Cell Rev 9:523-30. 2013
  10. doi request reprint Probing into the Biological Processes Influenced by ESC Factor and Oncoprotein HMGA2 Using iPSCs
    Amir Morshedi
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore
    Stem Cell Rev 9:514-22. 2013

Collaborators

  • Ou Li
  • Heng Li
  • Jing Zhao
  • Bin Wu
  • Le Lu
  • Hannes Hentze
  • Thomas Klonisch
  • Amir Morshedi
  • Shen Mynn Tan
  • Qiuye Bao
  • Shu Feng
  • Heike Summer
  • Zhonglu Ren
  • Jinming Li
  • Monireh Soroush Noghabi
  • Thomas U Schwartz
  • Ky Lowenhaupt
  • Konstantin Pervushin
  • Steven D Goodman
  • Padmapriya Sathiyanathan
  • Lihong Zhan
  • Dana Henderson
  • Sabrina Peter
  • Curt A Davey
  • Yingjie Liu
  • Jie Yan
  • Siew Tein Wang
  • Hu Chen

Detail Information

Publications12

  1. doi request reprint Do cells let-7 determine stemness?
    Peter Droge
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551
    Cell Stem Cell 2:8-9. 2008
    ..In a recent issue of Cell, Yu et al. (2007) now provide evidence that the let-7/HMGA2 linkage could be a signature of cancer stem cells in vivo, with broader implications for stem cell research...
  2. pmc HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy
    Heike Summer
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 37:4371-84. 2009
    ..Our study thus identifies an unexpected role for HMGA2 in DNA repair in cancer cells which has important clinical implications for disease diagnosis and therapy...
  3. ncbi request reprint DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    FEBS Lett 581:3533-7. 2007
    ..Our results establish HMGA2 as a regulator of human genes linked to mesenchymal cell differentiation, adipogenesis, and hES cell growth...
  4. pmc Human genomic Z-DNA segments probed by the Z alpha domain of ADAR1
    Heng Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore
    Nucleic Acids Res 37:2737-46. 2009
    ..Contrary to in silico predictions, however, we found that only two of the 186 hotspots were located in promoter regions...
  5. doi request reprint Alternate rRNA secondary structures as regulators of translation
    Shu Feng
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Nat Struct Mol Biol 18:169-76. 2011
    ..Our study shows that ribosomes can be targeted by a protein that specifically recognizes an alternate rRNA secondary structure, and suggests a new mechanism of translational regulation on the ribosome...
  6. ncbi request reprint Site selectivity of platinum anticancer therapeutics
    Bin Wu
    Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Nat Chem Biol 4:110-2. 2008
    ..Our findings suggest that the nucleosome center may provide a favorable target for the design of improved platinum anticancer drugs...
  7. ncbi request reprint Comparative analysis of sequence-specific DNA recombination systems in human embryonic stem cells
    Shen Mynn Tan
    Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, 637551, Singapore
    Stem Cells 23:868-73. 2005
    ..We also report an improved, easy-to-use plasmid transfection system that employs silica microspheres and, in combination with SSR, could be applied to hESC genome engineering...
  8. pmc A UTF1-based selection system for stable homogeneously pluripotent human embryonic stem cell cultures
    Shen Mynn Tan
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 and ES Cell International Pte Ltd, 11 Biopolis Way, 05 06 Helios, 138667 Singapore
    Nucleic Acids Res 35:e118. 2007
    ..Together with its small size of only 2.4 kb for the entire cassette, these features render our selection system a powerful novel tool for many stem cell applications and human somatic cell reprogramming strategies...
  9. doi request reprint Use of UTF1 Genetic Control Elements as iPSC Reporter
    Amir Morshedi
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, Singapore, 637551
    Stem Cell Rev 9:523-30. 2013
    ..The fact that the human UTF1 genetic control elements work in a mouse background and the demonstrated functionality of the reporter in an epigenetic state further qualifies this system as a versatile new tool for iPSC research. ..
  10. doi request reprint Probing into the Biological Processes Influenced by ESC Factor and Oncoprotein HMGA2 Using iPSCs
    Amir Morshedi
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore
    Stem Cell Rev 9:514-22. 2013
    ..Finally, our data support a model in which tight regulation of intracellular HMGA2 levels is important both to maintain a pluripotent ESC state and to induce differentiation into certain cell lineages during later developmental stages. ..
  11. ncbi request reprint A divalent metal-mediated switch controlling protein-induced DNA bending
    Qiuye Bao
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
    J Mol Biol 367:731-40. 2007
    ..Introduction of acidic residues at the protein-DNA interface holds potential for the design of metal-mediated switches for the investigation of functional relationships...
  12. ncbi request reprint High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Genesis 44:523-9. 2006
    ....