Peter Droge

Summary

Affiliation: Nanyang Technological University
Country: Singapore

Publications

  1. pmc Human genomic Z-DNA segments probed by the Z alpha domain of ADAR1
    Heng Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore
    Nucleic Acids Res 37:2737-46. 2009
  2. pmc A UTF1-based selection system for stable homogeneously pluripotent human embryonic stem cell cultures
    Shen Mynn Tan
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 and ES Cell International Pte Ltd, 11 Biopolis Way, 05 06 Helios, 138667 Singapore
    Nucleic Acids Res 35:e118. 2007
  3. pmc Physical organization of DNA by multiple non-specific DNA-binding modes of integration host factor (IHF)
    Jie Lin
    Department of Physics, National University of Singapore, Singapore, Singapore
    PLoS ONE 7:e49885. 2012
  4. doi request reprint Do cells let-7 determine stemness?
    Peter Droge
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551
    Cell Stem Cell 2:8-9. 2008
  5. pmc HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy
    Heike Summer
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 37:4371-84. 2009
  6. ncbi request reprint DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    FEBS Lett 581:3533-7. 2007
  7. ncbi request reprint A divalent metal-mediated switch controlling protein-induced DNA bending
    Qiuye Bao
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
    J Mol Biol 367:731-40. 2007
  8. doi request reprint Probing into the biological processes influenced by ESC factor and oncoprotein HMGA2 using iPSCs
    Amir Morshedi
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Stem Cell Rev 9:514-22. 2013
  9. doi request reprint Alternate rRNA secondary structures as regulators of translation
    Shu Feng
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Nat Struct Mol Biol 18:169-76. 2011
  10. ncbi request reprint Comparative analysis of sequence-specific DNA recombination systems in human embryonic stem cells
    Shen Mynn Tan
    Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, 637551, Singapore
    Stem Cells 23:868-73. 2005

Collaborators

  • Ou Li
  • Le Lu
  • Thomas Klonisch
  • Heng Li
  • Bin Wu
  • Jinming Li
  • Jing Zhao
  • Paul J Dyson
  • Michael Groessl
  • Hannes Hentze
  • Haojie Yu
  • Amir Morshedi
  • Qiuye Bao
  • Jie Lin
  • Shen Mynn Tan
  • Jie Yan
  • Hu Chen
  • Zenita Adhireksan
  • Shimin Le
  • Steven D Goodman
  • Padmapriya Sathiyanathan
  • Shu Feng
  • Curt A Davey
  • Heike Summer
  • Gabriela E Davey
  • Tian Wei Chew
  • Suchitra Natarajan
  • Alexey A Nazarov
  • Ursula Rothlisberger
  • Natalia O Tjokro
  • Uttam Surana
  • Catherine M Clavel
  • Pablo Campomanes
  • Wee Han Ang
  • Hong Hwa Lim
  • Charmian Hui Fang Yeo
  • Zhonglu Ren
  • Monireh Soroush Noghabi
  • Peiwen Cong
  • Thomas U Schwartz
  • Ky Lowenhaupt
  • Konstantin Pervushin
  • Lihong Zhan
  • Dana Henderson
  • Sabrina Peter
  • Yingjie Liu
  • Siew Tein Wang
  • Nicole Christ

Detail Information

Publications19

  1. pmc Human genomic Z-DNA segments probed by the Z alpha domain of ADAR1
    Heng Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore
    Nucleic Acids Res 37:2737-46. 2009
    ..Contrary to in silico predictions, however, we found that only two of the 186 hotspots were located in promoter regions...
  2. pmc A UTF1-based selection system for stable homogeneously pluripotent human embryonic stem cell cultures
    Shen Mynn Tan
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 and ES Cell International Pte Ltd, 11 Biopolis Way, 05 06 Helios, 138667 Singapore
    Nucleic Acids Res 35:e118. 2007
    ..Together with its small size of only 2.4 kb for the entire cassette, these features render our selection system a powerful novel tool for many stem cell applications and human somatic cell reprogramming strategies...
  3. pmc Physical organization of DNA by multiple non-specific DNA-binding modes of integration host factor (IHF)
    Jie Lin
    Department of Physics, National University of Singapore, Singapore, Singapore
    PLoS ONE 7:e49885. 2012
    ..Our findings provide important insights into how IHF contributes to bacterial chromatin organization, gene regulation, and biofilm formation...
  4. doi request reprint Do cells let-7 determine stemness?
    Peter Droge
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551
    Cell Stem Cell 2:8-9. 2008
    ..In a recent issue of Cell, Yu et al. (2007) now provide evidence that the let-7/HMGA2 linkage could be a signature of cancer stem cells in vivo, with broader implications for stem cell research...
  5. pmc HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy
    Heike Summer
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 37:4371-84. 2009
    ..Our study thus identifies an unexpected role for HMGA2 in DNA repair in cancer cells which has important clinical implications for disease diagnosis and therapy...
  6. ncbi request reprint DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    FEBS Lett 581:3533-7. 2007
    ..Our results establish HMGA2 as a regulator of human genes linked to mesenchymal cell differentiation, adipogenesis, and hES cell growth...
  7. ncbi request reprint A divalent metal-mediated switch controlling protein-induced DNA bending
    Qiuye Bao
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
    J Mol Biol 367:731-40. 2007
    ..Introduction of acidic residues at the protein-DNA interface holds potential for the design of metal-mediated switches for the investigation of functional relationships...
  8. doi request reprint Probing into the biological processes influenced by ESC factor and oncoprotein HMGA2 using iPSCs
    Amir Morshedi
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Stem Cell Rev 9:514-22. 2013
    ..Finally, our data support a model in which tight regulation of intracellular HMGA2 levels is important both to maintain a pluripotent ESC state and to induce differentiation into certain cell lineages during later developmental stages. ..
  9. doi request reprint Alternate rRNA secondary structures as regulators of translation
    Shu Feng
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    Nat Struct Mol Biol 18:169-76. 2011
    ..Our study shows that ribosomes can be targeted by a protein that specifically recognizes an alternate rRNA secondary structure, and suggests a new mechanism of translational regulation on the ribosome...
  10. ncbi request reprint Comparative analysis of sequence-specific DNA recombination systems in human embryonic stem cells
    Shen Mynn Tan
    Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, 637551, Singapore
    Stem Cells 23:868-73. 2005
    ..We also report an improved, easy-to-use plasmid transfection system that employs silica microspheres and, in combination with SSR, could be applied to hESC genome engineering...
  11. doi request reprint Use of UTF1 genetic control elements as iPSC reporter
    Amir Morshedi
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, Singapore 637551
    Stem Cell Rev 9:523-30. 2013
    ..The fact that the human UTF1 genetic control elements work in a mouse background and the demonstrated functionality of the reporter in an epigenetic state further qualifies this system as a versatile new tool for iPSC research...
  12. ncbi request reprint The human genome-wide distribution of DNA palindromes
    Le Lu
    Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Funct Integr Genomics 7:221-7. 2007
    ..It contains 12,556,994 entries covering all palindromes in the human genome longer than 6 bp. Queries can be performed in different ways. Each entry in the database is linked to its location on NCBI's human chromosome Map Viewer...
  13. ncbi request reprint High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Genesis 44:523-9. 2006
    ....
  14. ncbi request reprint Site selectivity of platinum anticancer therapeutics
    Bin Wu
    Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Nat Chem Biol 4:110-2. 2008
    ..Our findings suggest that the nucleosome center may provide a favorable target for the design of improved platinum anticancer drugs...
  15. pmc Mechanosensing of DNA bending in a single specific protein-DNA complex
    Shimin Le
    1 Mechanobiology Institute, National University of Singapore, Singapore, 117411 2 Centre for Bioimaging Sciences, National University of Singapore, Singapore, 117546
    Sci Rep 3:3508. 2013
    ..These findings have broad implications with regard to general mechanosensitivity of site-specific DNA bending proteins. ..
  16. doi request reprint Chaperoning HMGA2 protein protects stalled replication forks in stem and cancer cells
    Haojie Yu
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Cell Rep 6:684-97. 2014
    ..This fork chaperone function seemingly evolved to preserve ESC genome integrity. It is hijacked by tumor (stem) cells to also guard their genomes against DNA-damaging agents widely used to treat cancer patients. ..
  17. ncbi request reprint Replication-induced supercoiling: a neglected DNA transaction regulator?
    Haojie Yu
    School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
    Trends Biochem Sci 39:219-20. 2014
    ..Here, we argue that this unrecognized supercoiling is causally involved in the regulation of key DNA transactions and deserves further consideration. ..
  18. ncbi request reprint Single-chain integration host factors as probes for high-precision nucleoprotein complex formation
    Qiuye Bao
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore
    Gene 343:99-106. 2004
    ..coli require different types of high-precision DNA architectural activities. The scIHF variants described here will help to explore further how flexible these requirements are...
  19. pmc Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity
    Zenita Adhireksan
    1 Division of Structural Biology and Biochemistry, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore 2
    Nat Commun 5:3462. 2014
    ..Our study shows promise for developing new ruthenium drugs, via ligand-based modulation of DNA versus protein binding and thus cytotoxic potential, to target distinguishing epigenetic features of cancer cells. ..