Yonggui Robin Chi


Affiliation: Nanyang Technological University
Country: Singapore


  1. request reprint
    Zhang Y, Wong Z, Wu X, Lauw S, Huang X, Webster R, et al. Sulfoxidation of alkenes and alkynes with NFSI as a radical initiator and selective oxidant. Chem Commun (Camb). 2016;53:184-187 pubmed
    ..Over-oxidation of the sulfoxides to sulfones is avoided in our approach. ..
  2. Chen Q, Zhu T, Majhi P, Mou C, Chai H, Zhang J, et al. Carbene-catalyzed enantioselective oxidative coupling of enals and di(hetero)arylmethanes. Chem Sci. 2018;9:8711-8715 pubmed publisher
    ..Our method allows for highly enantioselective transformation of diaryl methanes and quick access to benzimidazole fused lactams. ..
  3. Li B, Wang Y, Jin Z, Chi Y. Cycloaddition of cyclobutenone and azomethine imine enabled by chiral isothiourea organic catalysts. Chem Sci. 2015;6:6008-6012 pubmed publisher
    ..In addition, the present study with isothioureas as the organocatalysts expands the potential in using organocatalysts for C-C bond breaking and selective reactions. ..
  4. Mou C, Wu J, Huang Z, Sun J, Jin Z, Chi Y. Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines. Chem Commun (Camb). 2017;: pubmed publisher
    ..A previously unexplored unsaturated alkyne acyl azolium intermediate is involved in the key step of the reaction...
  5. Liu Y, Chen Q, Mou C, Pan L, Duan X, Chen X, et al. Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs. Nat Commun. 2019;10:1675 pubmed publisher
    ..Our catalytic strategy of asymmetric acetalizations of carboxylic acids shall benefit future development of chiral phthalidyl ester prodrugs and related molecules. ..
  6. Jin Z, Jiang K, Fu Z, Torres J, Zheng P, Yang S, et al. Nucleophilic β-Carbon Activation of Propionic Acid as a 3-Carbon Synthon by Carbene Organocatalysis. Chemistry. 2015;21:9360-3 pubmed publisher
    ..This approach provides a much better solution to azolium homoenolate synthesis than the previously established use of acrolein (enal without any substituent), which is expensive, unstable, and toxic. ..
  7. Zheng P, Cheng J, Su S, Jin Z, Wang Y, Yang S, et al. Oxidative N-Heterocyclic Carbene-Catalyzed γ-Carbon Addition of Enals to Imines: Mechanistic Studies and Access to Antimicrobial Compounds. Chemistry. 2015;21:9984-7 pubmed publisher
    ..The results of our study also provide highly enantioselective access to tricyclic sulfonyl amides that exhibit interesting antimicrobial activities against X. oryzae, a bacterium that causes bacterial disease in rice growing. ..
  8. Li B, Wang Y, Proctor R, Jin Z, Chi Y. Carbene-catalyzed desymmetrization of 1,3-diols: access to optically enriched tertiary alkyl chlorides. Chem Commun (Camb). 2016;52:8313-6 pubmed publisher
    ..Instead of forming a new C-Cl bond, our approach involves carbene-catalyzed desymmetrization of 2-chloro-1,3-diols as the key step to set up the chiral carbon center with excellent enantiomeric excess. ..
  9. Wu X, Liu B, Zhang Y, Jeret M, Wang H, Zheng P, et al. Enantioselective Nucleophilic ?-Carbon-Atom Amination of Enals: Carbene-Catalyzed Formal [3+2] Reactions. Angew Chem Int Ed Engl. 2016;55:12280-4 pubmed publisher
    ..The pyrazolidinone products from our catalytic reactions are common scaffolds in bioactive molecules, and can be easily transformed into useful compounds such as ?(3) -amino-acid derivatives. ..

More Information


  1. Wang Y, Wu X, Robin Chi Y. Synthesis of indanes via carbene-catalyzed single-electron-transfer processes and cascade reactions. Chem Commun (Camb). 2017;53:11952-11955 pubmed publisher
    ..This work demonstrates the synthetic potentials of NHC-mediated single-electron-transfer processes for efficient reactions and rapid synthesis. ..