Research Topics
Species | Lance D MillerSummaryCountry: Singapore Publications
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Detail Information
Publications
Discovery of estrogen receptor alpha target genes and response elements in breast tumor cellsChin Yo Lin
Genome Institute of Singapore, Singapore 117528
Genome Biol 5:R66. 2004..In this study, we utilized an integrated genome-wide molecular and computational approach to characterize the interaction between the activated estrogen receptor (ER) and the regulatory elements of candidate target genes...- Optimization and clinical validation of a pathogen detection microarrayChristopher W Wong
Genomic Technologies, Genome Institute of Singapore, Republic of Singapore
Genome Biol 8:R93. 2007..Our findings show that microarrays can be used for the robust and accurate diagnosis of pathogens, and further substantiate the use of microarray technology in clinical diagnostics... - Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort studyPer Hall
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
BMC Med 4:16. 2006..Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well understood... - Correlation test to assess low-level processing of high-density oligonucleotide microarray dataAlexander Ploner
Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
BMC Bioinformatics 6:80. 2005..The choice of technique has a profound effect on subsequent statistical analyses, but there is no method to assess whether a particular technique is appropriate for a specific data set, without reference to external data... - LOMA: a fast method to generate efficient tagged-random primers despite amplification bias of random PCR on pathogensWah Heng Lee
Genome Institute of Singapore, Genome, Singapore
BMC Bioinformatics 9:368. 2008.... - An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survivalLance D Miller
Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672
Proc Natl Acad Sci U S A 102:13550-5. 2005..Our results show the primary importance of p53 functional status in predicting clinical breast cancer behavior... - Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancerChin Yo Lin
Genome Institute of Singapore, Singapore 138672, Republic of Singapore
Breast Cancer Res 9:R25. 2007..The goal of this study was to examine transcriptomic alterations in cancer cells co-expressing both receptors and the association of gene expression signatures with disease outcome... - Identification of cell cycle-regulated genes in fission yeastXu Peng
Genome Institute of Singapore, Singapore 138672, Singapore
Mol Biol Cell 16:1026-42. 2005..Our complete data sets are available at http://giscompute.gis.a-star.edu.sg/~gisljh/CDC... - BEARR: Batch Extraction and Analysis of cis-Regulatory RegionsVinsensius B Vega
Genome Institute of Singapore, 60 Biopolis Street, 02 01, Singapore 138672
Nucleic Acids Res 32:W257-60. 2004..The software is publicly available at http://giscompute.gis.a-star.edu.sg/~vega/BEARR1.0/... 
A global map of p53 transcription-factor binding sites in the human genomeChia-Lin Wei
Genome Institute of Singapore, Singapore 138672
Cell 124:207-19. 2006....
Genomic profiles specific to patient ethnicity in lung adenocarcinomaPhilippe Broet
Genome Institute of Singapore, Genome, Singapore
Clin Cancer Res 17:3542-50. 2011..We sought to identify novel molecular differences between NSCLCs from EA and Western European (WE) patients...- In the pursuit of complexity: systems medicine in cancer biologyEdison T Liu
Genome Institute of Singapore, Singapore 138672
Cancer Cell 9:245-7. 2006..This work shows that the intersect analysis of gene amplification and transcriptional expression on a genome-wide scale can uncover complex conditional interactions embedded in the systems map of transcriptional regulation... - Tracking the evolution of the SARS coronavirus using high-throughput, high-density resequencing arraysChristopher W Wong
Genome Institute of Singapore, Singapore 138672, Republic of Singapore
Genome Res 14:398-405. 2004.... - Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinomaXiu Qin Xu
Microarray and Expression Genomics, Genome Institute of Singapore, Republic of Singapore
J Biol Chem 280:23987-4003. 2005..Further functional characterization of the identified subset of specifically autocrine hGH regulated genes will delineate additional novel oncogenes for the human mammary epithelial cell... - Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsivenessEna Wang
Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, Maryland 20892, USA
Cancer Res 62:3581-6. 2002..001). Analysis of their annotations denoted that approximately half of them were related to T-cell regulation, suggesting that immune responsiveness might be predetermined by a tumor microenvironment conducive to immune recognition... - Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinomaJosephine M Y Ko
Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
Mol Cancer Res 6:592-603. 2008..Transfection of wild-type THSD1 into SLMT-1 resulted in significant reduction of colony-forming ability, hence providing functional evidence for its growth-suppressive activity. These findings suggest that THSD1 is a good candidate TSG... - Whole-genome cartography of estrogen receptor alpha binding sitesChin Yo Lin
Genome Institute of Singapore, Singapore, Republic of Singapore
PLoS Genet 3:e87. 2007..Taken together, this genome-scale analysis suggests complex but definable rules governing ERalpha binding and gene regulation... - Optimal gene expression analysis by microarraysLance D Miller
Genome Institute of Singapore, Singapore 117528
Cancer Cell 2:353-61. 2002.... - Expression genomics in breast cancer research: microarrays at the crossroads of biology and medicineLance D Miller
Genome Institute of Singapore, Singapore
Breast Cancer Res 9:206. 2007.... - Transcriptome kinetics of arsenic-induced adaptive response in zebrafish liverSiew Hong Lam
Department of Biological Sciences, National University of Singapore
Physiol Genomics 27:351-61. 2006.... - Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcomeJonna Frasor
Department of Molecular and Integrative Physiology and Cell and Developmental Biology, University of Illinois and College of Medicine, Urbana, Illinois 61801-3704, USA
Cancer Res 66:7334-40. 2006..This may have a potential effect on the choice of tamoxifen versus aromatase inhibitors as adjuvant endocrine therapy... - A modular analysis of breast cancer reveals a novel low-grade molecular signature in estrogen receptor-positive tumorsKun Yu
National Cancer Centre, Singapore, Republic of Singapore
Clin Cancer Res 12:3288-96. 2006.... - Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profilingSuk Woo Nam
Department of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, South Korea
Hepatology 42:809-18. 2005..The progression from grade 1 through grade 3 HCC is associated with changes in gene expression consistent with plausible functional consequences... - Laboratory-acquired severe acute respiratory syndromePoh Lian Lim
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
N Engl J Med 350:1740-5. 2004 - Identifying gene expression changes in breast cancer that distinguish early and late relapse among uncured patientsPhilippe Broet
Faculté de Médecine Université Paris XI, IFR69, 16 Avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France
Bioinformatics 22:1477-85. 2006..From a biological perspective, many of the genes identified here as associated with the speed of disease recurrence have known roles in tumorigenesis... - Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effectsYi Zhou
Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 62:1688-95. 2002.... - Identification of white spot syndrome virus latency-related genes in specific-pathogen-free shrimps by use of a microarraySiti Khadijah
Animal Health Biotechnology, Temasek Life Sciences Laboratory, 1 Research Link, The National University of Singapore, Singapore 117604
J Virol 77:10162-7. 2003..Viral sequences could be PCR amplified from genomic DNA of SPF shrimp, further supporting the suggestion that these shrimps are asymptomatic carriers... - A gene signature in breast cancerKristian Wennmalm
N Engl J Med 356:1887-8; author reply 1887-8. 2007 - Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progressionSiew Hong Lam
Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, Singapore 117543
Nat Biotechnol 24:73-5. 2006..This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype... - Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancerAnna V Ivshina
Genome Institute of Singapore, Singapore
Cancer Res 66:10292-301. 2006.... - Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistanceLance D Miller
1Genome Institute of Singapore, Agency for Science, Technology and Research, 60 Biopolis Street, Singapore, 138672
Genome Biol 5:R31. 2004..Thus, the molecular actions of TRbeta mutants are more complex than previously envisioned...