Lance D Miller

Summary

Country: Singapore

Publications

  1. pmc Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells
    Chin Yo Lin
    Genome Institute of Singapore, Singapore 117528
    Genome Biol 5:R66. 2004
  2. pmc Optimization and clinical validation of a pathogen detection microarray
    Christopher W Wong
    Genomic Technologies, Genome Institute of Singapore, Republic of Singapore
    Genome Biol 8:R93. 2007
  3. pmc Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort study
    Per Hall
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    BMC Med 4:16. 2006
  4. pmc Correlation test to assess low-level processing of high-density oligonucleotide microarray data
    Alexander Ploner
    Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    BMC Bioinformatics 6:80. 2005
  5. pmc LOMA: a fast method to generate efficient tagged-random primers despite amplification bias of random PCR on pathogens
    Wah Heng Lee
    Genome Institute of Singapore, Genome, Singapore
    BMC Bioinformatics 9:368. 2008
  6. pmc An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
    Lance D Miller
    Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672
    Proc Natl Acad Sci U S A 102:13550-5. 2005
  7. pmc Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer
    Chin Yo Lin
    Genome Institute of Singapore, Singapore 138672, Republic of Singapore
    Breast Cancer Res 9:R25. 2007
  8. pmc Identification of cell cycle-regulated genes in fission yeast
    Xu Peng
    Genome Institute of Singapore, Singapore 138672, Singapore
    Mol Biol Cell 16:1026-42. 2005
  9. pmc BEARR: Batch Extraction and Analysis of cis-Regulatory Regions
    Vinsensius B Vega
    Genome Institute of Singapore, 60 Biopolis Street, 02 01, Singapore 138672
    Nucleic Acids Res 32:W257-60. 2004
  10. ncbi request reprint A global map of p53 transcription-factor binding sites in the human genome
    Chia Lin Wei
    Genome Institute of Singapore, Singapore 138672
    Cell 124:207-19. 2006

Detail Information

Publications31

  1. pmc Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells
    Chin Yo Lin
    Genome Institute of Singapore, Singapore 117528
    Genome Biol 5:R66. 2004
    ..In this study, we utilized an integrated genome-wide molecular and computational approach to characterize the interaction between the activated estrogen receptor (ER) and the regulatory elements of candidate target genes...
  2. pmc Optimization and clinical validation of a pathogen detection microarray
    Christopher W Wong
    Genomic Technologies, Genome Institute of Singapore, Republic of Singapore
    Genome Biol 8:R93. 2007
    ..Our findings show that microarrays can be used for the robust and accurate diagnosis of pathogens, and further substantiate the use of microarray technology in clinical diagnostics...
  3. pmc Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort study
    Per Hall
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    BMC Med 4:16. 2006
    ..Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well understood...
  4. pmc Correlation test to assess low-level processing of high-density oligonucleotide microarray data
    Alexander Ploner
    Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    BMC Bioinformatics 6:80. 2005
    ..The choice of technique has a profound effect on subsequent statistical analyses, but there is no method to assess whether a particular technique is appropriate for a specific data set, without reference to external data...
  5. pmc LOMA: a fast method to generate efficient tagged-random primers despite amplification bias of random PCR on pathogens
    Wah Heng Lee
    Genome Institute of Singapore, Genome, Singapore
    BMC Bioinformatics 9:368. 2008
    ....
  6. pmc An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
    Lance D Miller
    Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672
    Proc Natl Acad Sci U S A 102:13550-5. 2005
    ..Our results show the primary importance of p53 functional status in predicting clinical breast cancer behavior...
  7. pmc Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer
    Chin Yo Lin
    Genome Institute of Singapore, Singapore 138672, Republic of Singapore
    Breast Cancer Res 9:R25. 2007
    ..The goal of this study was to examine transcriptomic alterations in cancer cells co-expressing both receptors and the association of gene expression signatures with disease outcome...
  8. pmc Identification of cell cycle-regulated genes in fission yeast
    Xu Peng
    Genome Institute of Singapore, Singapore 138672, Singapore
    Mol Biol Cell 16:1026-42. 2005
    ..Our complete data sets are available at http://giscompute.gis.a-star.edu.sg/~gisljh/CDC...
  9. pmc BEARR: Batch Extraction and Analysis of cis-Regulatory Regions
    Vinsensius B Vega
    Genome Institute of Singapore, 60 Biopolis Street, 02 01, Singapore 138672
    Nucleic Acids Res 32:W257-60. 2004
    ..The software is publicly available at http://giscompute.gis.a-star.edu.sg/~vega/BEARR1.0/...
  10. ncbi request reprint A global map of p53 transcription-factor binding sites in the human genome
    Chia Lin Wei
    Genome Institute of Singapore, Singapore 138672
    Cell 124:207-19. 2006
    ....
  11. doi request reprint Genomic profiles specific to patient ethnicity in lung adenocarcinoma
    Philippe Broet
    Genome Institute of Singapore, Genome, Singapore
    Clin Cancer Res 17:3542-50. 2011
    ..We sought to identify novel molecular differences between NSCLCs from EA and Western European (WE) patients...
  12. ncbi request reprint In the pursuit of complexity: systems medicine in cancer biology
    Edison T Liu
    Genome Institute of Singapore, Singapore 138672
    Cancer Cell 9:245-7. 2006
    ..This work shows that the intersect analysis of gene amplification and transcriptional expression on a genome-wide scale can uncover complex conditional interactions embedded in the systems map of transcriptional regulation...
  13. pmc Tracking the evolution of the SARS coronavirus using high-throughput, high-density resequencing arrays
    Christopher W Wong
    Genome Institute of Singapore, Singapore 138672, Republic of Singapore
    Genome Res 14:398-405. 2004
    ....
  14. ncbi request reprint Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma
    Xiu Qin Xu
    Microarray and Expression Genomics, Genome Institute of Singapore, Republic of Singapore
    J Biol Chem 280:23987-4003. 2005
    ..Further functional characterization of the identified subset of specifically autocrine hGH regulated genes will delineate additional novel oncogenes for the human mammary epithelial cell...
  15. pmc Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness
    Ena Wang
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 62:3581-6. 2002
    ..001). Analysis of their annotations denoted that approximately half of them were related to T-cell regulation, suggesting that immune responsiveness might be predetermined by a tumor microenvironment conducive to immune recognition...
  16. doi request reprint Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma
    Josephine M Y Ko
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    Mol Cancer Res 6:592-603. 2008
    ..Transfection of wild-type THSD1 into SLMT-1 resulted in significant reduction of colony-forming ability, hence providing functional evidence for its growth-suppressive activity. These findings suggest that THSD1 is a good candidate TSG...
  17. pmc Whole-genome cartography of estrogen receptor alpha binding sites
    Chin Yo Lin
    Genome Institute of Singapore, Singapore, Republic of Singapore
    PLoS Genet 3:e87. 2007
    ..Taken together, this genome-scale analysis suggests complex but definable rules governing ERalpha binding and gene regulation...
  18. ncbi request reprint Optimal gene expression analysis by microarrays
    Lance D Miller
    Genome Institute of Singapore, Singapore 117528
    Cancer Cell 2:353-61. 2002
    ....
  19. pmc Expression genomics in breast cancer research: microarrays at the crossroads of biology and medicine
    Lance D Miller
    Genome Institute of Singapore, Singapore
    Breast Cancer Res 9:206. 2007
    ....
  20. ncbi request reprint Transcriptome kinetics of arsenic-induced adaptive response in zebrafish liver
    Siew Hong Lam
    Department of Biological Sciences, National University of Singapore
    Physiol Genomics 27:351-61. 2006
    ....
  21. ncbi request reprint Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome
    Jonna Frasor
    Department of Molecular and Integrative Physiology and Cell and Developmental Biology, University of Illinois and College of Medicine, Urbana, Illinois 61801 3704, USA
    Cancer Res 66:7334-40. 2006
    ..This may have a potential effect on the choice of tamoxifen versus aromatase inhibitors as adjuvant endocrine therapy...
  22. ncbi request reprint A modular analysis of breast cancer reveals a novel low-grade molecular signature in estrogen receptor-positive tumors
    Kun Yu
    National Cancer Centre, Singapore, Republic of Singapore
    Clin Cancer Res 12:3288-96. 2006
    ....
  23. ncbi request reprint Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling
    Suk Woo Nam
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seocho Gu, Seoul, South Korea
    Hepatology 42:809-18. 2005
    ..The progression from grade 1 through grade 3 HCC is associated with changes in gene expression consistent with plausible functional consequences...
  24. ncbi request reprint Laboratory-acquired severe acute respiratory syndrome
    Poh Lian Lim
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    N Engl J Med 350:1740-5. 2004
  25. ncbi request reprint Identifying gene expression changes in breast cancer that distinguish early and late relapse among uncured patients
    Philippe Broet
    Faculté de Médecine Université Paris XI, IFR69, 16 Avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France
    Bioinformatics 22:1477-85. 2006
    ..In this context, we propose a simple and an efficient method for identifying gene expression changes that characterize early and late recurrence for uncured patients...
  26. ncbi request reprint Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effects
    Yi Zhou
    Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 62:1688-95. 2002
    ....
  27. pmc Identification of white spot syndrome virus latency-related genes in specific-pathogen-free shrimps by use of a microarray
    Siti Khadijah
    Animal Health Biotechnology, Temasek Life Sciences Laboratory, 1 Research Link, The National University of Singapore, Singapore 117604
    J Virol 77:10162-7. 2003
    ..Viral sequences could be PCR amplified from genomic DNA of SPF shrimp, further supporting the suggestion that these shrimps are asymptomatic carriers...
  28. ncbi request reprint A gene signature in breast cancer
    Kristian Wennmalm
    N Engl J Med 356:1887-8; author reply 1887-8. 2007
  29. ncbi request reprint Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression
    Siew Hong Lam
    Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, Singapore 117543
    Nat Biotechnol 24:73-5. 2006
    ..This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype...
  30. ncbi request reprint Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer
    Anna V Ivshina
    Genome Institute of Singapore, Singapore
    Cancer Res 66:10292-301. 2006
    ....
  31. pmc Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance
    Lance D Miller
    1Genome Institute of Singapore, Agency for Science, Technology and Research, 60 Biopolis Street, Singapore, 138672
    Genome Biol 5:R31. 2004
    ..To understand the transcriptional program underlying TRbeta mutant-induced phenotypic expression of RTH, cDNA microarrays were used to profile the expression of 11,500 genes in a mouse model of human RTH...