Alison P Lee

Summary

Country: Singapore

Publications

  1. pmc TFCONES: a database of vertebrate transcription factor-encoding genes and their associated conserved noncoding elements
    Alison P Lee
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    BMC Genomics 8:441. 2007
  2. pmc Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome
    Byrappa Venkatesh
    Institute of Molecular and Cell Biology, Singapore
    PLoS Biol 5:e101. 2007
  3. pmc Mouse transgenesis identifies conserved functional enhancers and cis-regulatory motif in the vertebrate LIM homeobox gene Lhx2 locus
    Alison P Lee
    Comparative Genomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore
    PLoS ONE 6:e20088. 2011
  4. pmc Basal vertebrates clarify the evolutionary history of ciliopathy-associated genes Tmem138 and Tmem216
    Byrappa Venkatesh
    Comparative Genomics Lab, Institute of Molecular and Cell Biology, A STAR, Biopolis, Singapore
    Mol Biol Evol 30:62-5. 2013
  5. doi Ancient vertebrate conserved noncoding elements have been evolving rapidly in teleost fishes
    Alison P Lee
    Comparative Genomics Laboratory, Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, Biopolis, Singapore
    Mol Biol Evol 28:1205-15. 2011
  6. ncbi Ancient noncoding elements conserved in the human genome
    Byrappa Venkatesh
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    Science 314:1892. 2006
  7. pmc Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters
    Alison P Lee
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    Proc Natl Acad Sci U S A 103:6994-9. 2006

Detail Information

Publications7

  1. pmc TFCONES: a database of vertebrate transcription factor-encoding genes and their associated conserved noncoding elements
    Alison P Lee
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    BMC Genomics 8:441. 2007
    ..To this end, we have used a comparative genomics approach to identify putative cis-regulatory elements associated with TF-encoding genes in vertebrates...
  2. pmc Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome
    Byrappa Venkatesh
    Institute of Molecular and Cell Biology, Singapore
    PLoS Biol 5:e101. 2007
    ..This study also demonstrates that a survey-sequencing approach can be applied productively for comparative analysis of distantly related vertebrate genomes...
  3. pmc Mouse transgenesis identifies conserved functional enhancers and cis-regulatory motif in the vertebrate LIM homeobox gene Lhx2 locus
    Alison P Lee
    Comparative Genomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore
    PLoS ONE 6:e20088. 2011
    ..Other approaches such as sequence comparison between multiple mammals are required to identify and characterize such enhancers...
  4. pmc Basal vertebrates clarify the evolutionary history of ciliopathy-associated genes Tmem138 and Tmem216
    Byrappa Venkatesh
    Comparative Genomics Lab, Institute of Molecular and Cell Biology, A STAR, Biopolis, Singapore
    Mol Biol Evol 30:62-5. 2013
    ..Analyses of the coelacanth and lamprey genomes support this hypothesis. Our study highlights the importance of basal vertebrates as critical reference genomes...
  5. doi Ancient vertebrate conserved noncoding elements have been evolving rapidly in teleost fishes
    Alison P Lee
    Comparative Genomics Laboratory, Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, Biopolis, Singapore
    Mol Biol Evol 28:1205-15. 2011
    ..Transgenic zebrafish assay of some human CNE enhancers that have been lost in teleosts has indicated instances of conservation or changes in trans-acting factors between mammals and fishes...
  6. ncbi Ancient noncoding elements conserved in the human genome
    Byrappa Venkatesh
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    Science 314:1892. 2006
    ..The ancient vertebrate-specific CNEs in the elephant shark and human genomes are likely to play key regulatory roles in vertebrate gene expression...
  7. pmc Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters
    Alison P Lee
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    Proc Natl Acad Sci U S A 103:6994-9. 2006
    ..We propose that the regulatory elements spread across large regions on either side of Hox clusters are a major evolutionary constraint that has maintained the exceptionally long syntenic blocks at the HoxA and HoxD loci...