Chiea C Khor

Summary

Country: Singapore

Publications

  1. pmc Revealing the molecular signatures of host-pathogen interactions
    Chiea Chuen Khor
    Infectious Diseases, Genome Institute of Singapore, 60 Biopolis Street, 02 01 Genome Building, Singapore 138672
    Genome Biol 12:229. 2011
  2. pmc Shared pathways to infectious disease susceptibility?
    Chiea C Khor
    Infectious Diseases, Genome Institute of Singapore, 60 Biopolis Street, 02 01 Genome, 138672 Singapore
    Genome Med 2:52. 2010
  3. pmc CISH and susceptibility to infectious diseases
    Chiea C Khor
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    N Engl J Med 362:2092-101. 2010
  4. doi request reprint Hepatocyte growth factor and retinal arteriolar diameter in Singapore Chinese
    Chiea C Khor
    Section for Genetic Medicine, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Republic of Singapore
    Ophthalmology 117:939-45. 2010
  5. pmc Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    BMC Med Genet 11:5. 2010
  6. pmc Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Crit Care 14:R227. 2010
  7. pmc A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
    Chiea C Khor
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Nat Genet 39:523-8. 2007
  8. ncbi request reprint IkappaB genetic polymorphisms and invasive pneumococcal disease
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, and Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Roosevelt Drive, Oxford, OX3 7BN, UK
    Am J Respir Crit Care Med 176:181-7. 2007
  9. pmc Leprosy and the adaptation of human toll-like receptor 1
    Sunny H Wong
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 6:e1000979. 2010
  10. pmc CD209 genetic polymorphism and tuberculosis disease
    Fredrik O Vannberg
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 3:e1388. 2008

Collaborators

Detail Information

Publications12

  1. pmc Revealing the molecular signatures of host-pathogen interactions
    Chiea Chuen Khor
    Infectious Diseases, Genome Institute of Singapore, 60 Biopolis Street, 02 01 Genome Building, Singapore 138672
    Genome Biol 12:229. 2011
    ..Advances in sequencing technology and genome-wide association studies are now revealing the complex interactions between hosts and pathogen through genomic variation signatures, which arise from evolutionary co-existence...
  2. pmc Shared pathways to infectious disease susceptibility?
    Chiea C Khor
    Infectious Diseases, Genome Institute of Singapore, 60 Biopolis Street, 02 01 Genome, 138672 Singapore
    Genome Med 2:52. 2010
    ..Intriguingly, these still preliminary findings suggest that pathogen innate detection mechanisms may not be as shared among diseases as immune response mechanisms...
  3. pmc CISH and susceptibility to infectious diseases
    Chiea C Khor
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    N Engl J Med 362:2092-101. 2010
    ..The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling...
  4. doi request reprint Hepatocyte growth factor and retinal arteriolar diameter in Singapore Chinese
    Chiea C Khor
    Section for Genetic Medicine, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Republic of Singapore
    Ophthalmology 117:939-45. 2010
    ..To assess if natural genetic variation in hepatocyte growth factor (HGF) is associated with altered retinal vessel diameter...
  5. pmc Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    BMC Med Genet 11:5. 2010
    ..The possible role of MBL genotypic deficiency in susceptibility to thoracic empyema has not previously been reported...
  6. pmc Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Crit Care 14:R227. 2010
    ..The possible role of genetic variation in the atypical NF-κB inhibitor IκB-R, encoded by NFKBIL2, in susceptibility to invasive pneumococcal disease has not, to our knowledge, previously been reported upon...
  7. pmc A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
    Chiea C Khor
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Nat Genet 39:523-8. 2007
    ..6 x 10(-8)). We found that the Mal S180L variant attenuated TLR2 signal transduction...
  8. ncbi request reprint IkappaB genetic polymorphisms and invasive pneumococcal disease
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, and Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Roosevelt Drive, Oxford, OX3 7BN, UK
    Am J Respir Crit Care Med 176:181-7. 2007
    ..Rare NFKBIA mutations cause immunodeficiency with severe bacterial infection, raising the possibility that common IkappaB gene polymorphisms confer susceptibility to common bacterial disease...
  9. pmc Leprosy and the adaptation of human toll-like receptor 1
    Sunny H Wong
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 6:e1000979. 2010
    ..These observations provide insight into the long standing host-pathogen relationship between human and mycobacteria and highlight the key role of the TLR pathway in infectious diseases...
  10. pmc CD209 genetic polymorphism and tuberculosis disease
    Fredrik O Vannberg
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 3:e1388. 2008
    ..The present study investigates the role of the CD209 -336A/G variant in susceptibility to tuberculosis in a large sample of individuals from sub-Saharan Africa...
  11. ncbi request reprint Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Mol Immunol 44:3267-70. 2007
    ..Although we are unable to exclude small effects of FCN2 genetic variation on susceptibility to IPD, the result suggests that L-ficolin may not be critical for host defence against pneumococcal infection...
  12. doi request reprint cMET and refractive error progression in children
    Chiea C Khor
    Genetic Medicine Group, Singapore Institute for Clinical Sciences, Singapore
    Ophthalmology 116:1469-74, 1474.e1. 2009
    ..To assess whether genetic variation in cMET is associated with refractive error or change in refractive error over time...