Rory Johnson

Summary

Country: Singapore

Publications

  1. ncbi request reprint A microRNA-based gene dysregulation pathway in Huntington's disease
    Rory Johnson
    Genome Institute of Singapore, 60 Biopolis Street, 02 01 Genome, Singapore 138672, Singapore
    Neurobiol Dis 29:438-45. 2008
  2. pmc Regulation of neural macroRNAs by the transcriptional repressor REST
    Rory Johnson
    Genome Institute of Singapore, Singapore 138672
    RNA 15:85-96. 2009
  3. doi request reprint Evolution of the vertebrate gene regulatory network controlled by the transcriptional repressor REST
    Rory Johnson
    Stem Cell and Developmental Biology Group, Genome Institute of Singapore, Singapore
    Mol Biol Evol 26:1491-507. 2009
  4. doi request reprint Gene dysregulation in Huntington's disease: REST, microRNAs and beyond
    Rory Johnson
    Stem Cell and Developmental Biology Group, Genome Institute of Singapore, 60 Biopolis Street, Singapore, 138672, Singapore
    Neuromolecular Med 11:183-99. 2009
  5. pmc A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes
    Rory Johnson
    Stem Cell and Developmental Biology Group, Genome Institute of Singapore, Singapore, Singapore
    PLoS Genet 8:e1002624. 2012
  6. pmc Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors
    Shi Yan Ng
    Stem Cell and Developmental Biology Group, Genome Institute of Singapore, Singapore
    EMBO J 31:522-33. 2012
  7. pmc REST regulates distinct transcriptional networks in embryonic and neural stem cells
    Rory Johnson
    Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore
    PLoS Biol 6:e256. 2008
  8. pmc Distinct profiles of REST interactions with its target genes at different stages of neuronal development
    Yuh Man Sun
    School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom
    Mol Biol Cell 16:5630-8. 2005
  9. pmc Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication
    Rory Johnson
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK
    Nucleic Acids Res 34:3862-77. 2006

Detail Information

Publications9

  1. ncbi request reprint A microRNA-based gene dysregulation pathway in Huntington's disease
    Rory Johnson
    Genome Institute of Singapore, 60 Biopolis Street, 02 01 Genome, Singapore 138672, Singapore
    Neurobiol Dis 29:438-45. 2008
    ....
  2. pmc Regulation of neural macroRNAs by the transcriptional repressor REST
    Rory Johnson
    Genome Institute of Singapore, Singapore 138672
    RNA 15:85-96. 2009
    ..Therefore neural macroRNAs represent an additional component of the REST regulatory network. These macroRNAs are new candidates for understanding the role of REST in neuronal development, neurodegeneration, and cancer...
  3. doi request reprint Evolution of the vertebrate gene regulatory network controlled by the transcriptional repressor REST
    Rory Johnson
    Stem Cell and Developmental Biology Group, Genome Institute of Singapore, Singapore
    Mol Biol Evol 26:1491-507. 2009
    ....
  4. doi request reprint Gene dysregulation in Huntington's disease: REST, microRNAs and beyond
    Rory Johnson
    Stem Cell and Developmental Biology Group, Genome Institute of Singapore, 60 Biopolis Street, Singapore, 138672, Singapore
    Neuromolecular Med 11:183-99. 2009
    ..Thus, we propose that a combination of REST, microRNAs and possibly other non-coding RNAs profoundly affect the neuronal transcriptome in HD...
  5. pmc A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes
    Rory Johnson
    Stem Cell and Developmental Biology Group, Genome Institute of Singapore, Singapore, Singapore
    PLoS Genet 8:e1002624. 2012
    ..Recently available ChIP-seq data allow the annotation of human genetic polymorphisms with regulatory information to generate prior hypotheses about their disease-causing mechanism...
  6. pmc Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors
    Shi Yan Ng
    Stem Cell and Developmental Biology Group, Genome Institute of Singapore, Singapore
    EMBO J 31:522-33. 2012
    ..This study indicates that lncRNAs are important regulators of pluripotency and neurogenesis, and represents important evidence for an indispensable role of lncRNAs in human brain development...
  7. pmc REST regulates distinct transcriptional networks in embryonic and neural stem cells
    Rory Johnson
    Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore
    PLoS Biol 6:e256. 2008
    ..We propose that an extensive, pluripotency-specific recruitment profile lends REST a key role in the maintenance of the ESC phenotype...
  8. pmc Distinct profiles of REST interactions with its target genes at different stages of neuronal development
    Yuh Man Sun
    School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom
    Mol Biol Cell 16:5630-8. 2005
    ..These data indicate that the REST regulon is specific to each developmental stage and support the notion that REST plays distinct roles in regulating gene expression in pluripotent ES cells, multipotent NS cells, and mature neurons...
  9. pmc Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication
    Rory Johnson
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK
    Nucleic Acids Res 34:3862-77. 2006
    ..Most of these sequences are associated with transposable elements, leading us to propose that transposon-mediated duplication and insertion of RE1s has led to the acquisition of novel target genes by REST during evolution...