K Sim

Summary

Affiliation: Institute of Mental Health
Country: Singapore

Publications

  1. pmc GRIN2B gene and associated brain cortical white matter changes in bipolar disorder: a preliminary combined platform investigation
    Carissa Nadia Kuswanto
    Research Division, Institute of Mental Health, 10 Buangkok View, Singapore 539747
    Biomed Res Int 2013:635131. 2013
  2. pmc Diffusion tensor imaging findings of white matter changes in first episode schizophrenia: a systematic review
    Carissa Nadia Kuswanto
    Institute of Mental Health Woodbridge Hospital, Singapore
    Clin Psychopharmacol Neurosci 10:13-24. 2012
  3. pmc Prolonged Delirium Secondary to Hypoxic-ischemic Encephalopathy Following Cardiac Arrest
    Jegan Yogaratnam
    Institute of Mental Health Woodbridge Hospital, Singapore
    Clin Psychopharmacol Neurosci 11:39-42. 2013
  4. doi request reprint ARVCF genetic influences on neurocognitive and neuroanatomical intermediate phenotypes in Chinese patients with schizophrenia
    Kang Sim
    Department of General Psychiatry, Woodbridge Hospital Institute of Mental Health, Singapore
    J Clin Psychiatry 73:320-6. 2012
  5. ncbi request reprint Physical comorbidity, insight, quality of life and global functioning in first episode schizophrenia: a 24-month, longitudinal outcome study
    Kang Sim
    Department of Adult Psychiatry, Woodbridge Hospital Institute of Mental Health, and Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Schizophr Res 88:82-9. 2006
  6. pmc Newer antidepressant drug use in East Asian psychiatric treatment settings: REAP (Research on East Asia Psychotropic Prescriptions) Study
    Kang Sim
    Institute of Mental Health Woodbridge Hospital, Singapore
    Br J Clin Pharmacol 63:431-7. 2007
  7. ncbi request reprint A 24-month prospective outcome study of first-episode schizophrenia and schizoaffective disorder within an early psychosis intervention program
    Kang Sim
    Department of Adult Psychiatry, Institute of Mental Health Woodbridge Hospital, Singapore
    J Clin Psychiatry 68:1368-76. 2007
  8. doi request reprint Low doses of antipsychotic drugs for hospitalized schizophrenia patients in East Asia: 2004 vs. 2001
    Kang Sim
    Institute of Mental Health Woodbridge Hospital, Singapore
    Int J Neuropsychopharmacol 12:117-23. 2009
  9. ncbi request reprint Depot antipsychotic use in schizophrenia: an East Asian perspective
    Kang Sim
    Institute of Mental Health Woodbridge Hospital, Singapore
    Hum Psychopharmacol 19:103-9. 2004
  10. pmc High-dose antipsychotic use in schizophrenia: a comparison between the 2001 and 2004 Research on East Asia Psychotropic Prescription (REAP) studies
    Kang Sim
    Institute of Mental Health Woodbridge Hospital, Singapore
    Br J Clin Pharmacol 67:110-7. 2009

Collaborators

Detail Information

Publications51

  1. pmc GRIN2B gene and associated brain cortical white matter changes in bipolar disorder: a preliminary combined platform investigation
    Carissa Nadia Kuswanto
    Research Division, Institute of Mental Health, 10 Buangkok View, Singapore 539747
    Biomed Res Int 2013:635131. 2013
    ....
  2. pmc Diffusion tensor imaging findings of white matter changes in first episode schizophrenia: a systematic review
    Carissa Nadia Kuswanto
    Institute of Mental Health Woodbridge Hospital, Singapore
    Clin Psychopharmacol Neurosci 10:13-24. 2012
    ....
  3. pmc Prolonged Delirium Secondary to Hypoxic-ischemic Encephalopathy Following Cardiac Arrest
    Jegan Yogaratnam
    Institute of Mental Health Woodbridge Hospital, Singapore
    Clin Psychopharmacol Neurosci 11:39-42. 2013
    ....
  4. doi request reprint ARVCF genetic influences on neurocognitive and neuroanatomical intermediate phenotypes in Chinese patients with schizophrenia
    Kang Sim
    Department of General Psychiatry, Woodbridge Hospital Institute of Mental Health, Singapore
    J Clin Psychiatry 73:320-6. 2012
    ..We hypothesized that ARVCF gene haplotypes influence caudate nucleus volume, fractional anisotropy, and neurocognitive functioning in schizophrenia...
  5. ncbi request reprint Physical comorbidity, insight, quality of life and global functioning in first episode schizophrenia: a 24-month, longitudinal outcome study
    Kang Sim
    Department of Adult Psychiatry, Woodbridge Hospital Institute of Mental Health, and Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Schizophr Res 88:82-9. 2006
    ....
  6. pmc Newer antidepressant drug use in East Asian psychiatric treatment settings: REAP (Research on East Asia Psychotropic Prescriptions) Study
    Kang Sim
    Institute of Mental Health Woodbridge Hospital, Singapore
    Br J Clin Pharmacol 63:431-7. 2007
    ..We compared patients given newer and older antidepressants to test the hypothesis, suggested in the literature, that use of newer antidepressants is associated with treatment settings rather than specific diagnostic categories...
  7. ncbi request reprint A 24-month prospective outcome study of first-episode schizophrenia and schizoaffective disorder within an early psychosis intervention program
    Kang Sim
    Department of Adult Psychiatry, Institute of Mental Health Woodbridge Hospital, Singapore
    J Clin Psychiatry 68:1368-76. 2007
    ..We tested the hypothesis that patients with first-episode schizoaffective disorder had better clinical and functional outcomes compared to patients with first-episode schizophrenia...
  8. doi request reprint Low doses of antipsychotic drugs for hospitalized schizophrenia patients in East Asia: 2004 vs. 2001
    Kang Sim
    Institute of Mental Health Woodbridge Hospital, Singapore
    Int J Neuropsychopharmacol 12:117-23. 2009
    ..001) and depot antipsychotics (p=0.009). Conservative dosing of APDs was increasingly prevalent in East Asia. Our findings suggest characteristics of patients who may be particularly likely to require low antipsychotic doses...
  9. ncbi request reprint Depot antipsychotic use in schizophrenia: an East Asian perspective
    Kang Sim
    Institute of Mental Health Woodbridge Hospital, Singapore
    Hum Psychopharmacol 19:103-9. 2004
    ..Few studies have examined the use of depot antipsychotics in East Asian patients with schizophrenia. This study examined the prevalence of depot antipsychotic use and its clinical correlates...
  10. pmc High-dose antipsychotic use in schizophrenia: a comparison between the 2001 and 2004 Research on East Asia Psychotropic Prescription (REAP) studies
    Kang Sim
    Institute of Mental Health Woodbridge Hospital, Singapore
    Br J Clin Pharmacol 67:110-7. 2009
    ....
  11. doi request reprint White matter abnormalities and neurocognitive deficits associated with the passivity phenomenon in schizophrenia: a diffusion tensor imaging study
    Kang Sim
    Department of General Psychiatry, Woodbridge Hospital, Institute of Mental Health, 10, Buangkok View, 539747 Singapore
    Psychiatry Res 172:121-7. 2009
    ..The findings suggest distributed involvement of cortical and subcortical regions underlying passivity and support the notion of neural network models underlying specific psychiatric symptoms such as passivity...
  12. doi request reprint Psychosocial and coping responses within the community health care setting towards a national outbreak of an infectious disease
    Kang Sim
    Department of Adult Psychiatry, Woodbridge Hospital Institute of Mental Health, Singapore, Singapore
    J Psychosom Res 68:195-202. 2010
    ....
  13. doi request reprint Integrated genetic and genomic approach in the SingaporeTranslational and Clinical Research in Psychosis Study: an overview
    Kang Sim
    Department of General Psychiatry, Woodbridge Hospital Institute of Mental Health Research Division, Singapore
    Early Interv Psychiatry 5:91-9. 2011
    ..This article seeks to provide an overview on what our group has embarked on--to elucidate genetic risk factors for schizophrenia within the Chinese ethnic group...
  14. doi request reprint Adjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescription study (2001-2008)
    Kang Sim
    Institute of Mental Health Woodbridge Hospital, Singapore
    Int J Neuropsychopharmacol 14:1157-64. 2011
    ..This practice parallels findings in other countries and illustrates ongoing tension between evidence-based practice vs. individualized, empirical treatment of psychotic disorders...
  15. ncbi request reprint Psychiatric comorbidity in first episode schizophrenia: a 2 year, longitudinal outcome study
    Kang Sim
    Department of Adult Psychiatry, Woodbridge Hospital Institute of Mental Health, 10, Buangkok View, Singapore 539747, Singapore
    J Psychiatr Res 40:656-63. 2006
    ....
  16. ncbi request reprint Clinical correlates of antipsychotic polytherapy in patients with schizophrenia in Singapore
    Kang Sim
    Woodbridge Hospital Institute of Mental Health, Singapore
    Psychiatry Clin Neurosci 58:324-9. 2004
    ..The high rate of antipsychotic polytherapy that appeared to be unrelated to current illness severity suggests that this practice may not consistently be based on rational therapeutic principles...
  17. pmc Antipsychotic polypharmacy in patients with schizophrenia: a multicentre comparative study in East Asia
    Kang Sim
    Institute of Mental Health Woodbridge Hospital, Singapore
    Br J Clin Pharmacol 58:178-83. 2004
    ..This study seeks to examine the prevalence of antipsychotic polypharmacy in patients with schizophrenia and compare the differences between patients receiving one vs. those receiving more than one antipsychotic...
  18. ncbi request reprint Severe acute respiratory syndrome-related psychiatric and posttraumatic morbidities and coping responses in medical staff within a primary health care setting in Singapore
    Kang Sim
    Department of Adult Psychiatry, Woodbridge Hospital Institute of Mental Health, Singapore
    J Clin Psychiatry 65:1120-7. 2004
    ..We aimed to determine the level of psychological impact and coping styles among the medical staff in a primary health care setting...
  19. pmc The psychological impact of SARS: a matter of heart and mind
    Kang Sim
    Department of Adult Psychiatry III, Institute of Mental Health Woodbridge Hospital, 10 Buangkok View, Singapore 539747
    CMAJ 170:811-2. 2004
  20. ncbi request reprint High dose antipsychotic use in schizophrenia: findings of the REAP (research on east Asia psychotropic prescriptions) study
    K Sim
    Woodbridge Hospital Institute of Mental Health 10 Buangkok View, Singapore
    Pharmacopsychiatry 37:175-9. 2004
    ..Recent functional neuroimaging studies have found that the previous notion concerning the use of antipsychotic medication, especially in high doses, was unsupported and untenable...
  21. ncbi request reprint Subjective quality of life in first episode schizophrenia spectrum disorders with comorbid depression
    Kang Sim
    Department of Early Psychosis Intervention, Woodbridge Hospital Institute of Mental Health, 10, Buangkok View, Singapore 539747, Singapore
    Psychiatry Res 129:141-7. 2004
    ..Alternative explanations are also possible, providing possible foci for psychological support and intervention...
  22. ncbi request reprint Psychiatric comorbidity in first episode psychosis: the Early Psychosis Intervention Program (EPIP) experience
    K Sim
    Department of Early Psychosis Intervention, Woodbridge Hospital and Institute of Mental Health, Singapore
    Acta Psychiatr Scand 109:23-9. 2004
    ..To determine the prevalence rates of psychiatric comorbidity in a hospitalized Asian patient group with first episode psychosis and examine its clinical correlates...
  23. ncbi request reprint Case formulation in psychotherapy: revitalizing its usefulness as a clinical tool
    Kang Sim
    McLean Hospital Harvard Medical School, Belmont, MA 02467, USA
    Acad Psychiatry 29:289-92. 2005
    ....
  24. ncbi request reprint Thyroid dysfunction in chronic schizophrenia within a state psychiatric hospital
    K Sim
    Woodbridge Hospital and Institute of Mental Health, 10 Buangkok View, Singapore 539747
    Ann Acad Med Singapore 31:641-4. 2002
    ..We also hypothesize that raised thyroid hormones are associated with more severe psychopathology...
  25. ncbi request reprint High prevalence of psychiatric morbidity in a medical intensive care unit
    K Sim
    Department of General Psychiatry, Woodbridge Hospital and Institute of Mental Health, Singapore
    Singapore Med J 42:522-5. 2001
    ..Nevertheless, it is hoped that the index of suspicion for psychiatric morbidity can be raised in order to optimise the clinical management of patients within this setting...
  26. ncbi request reprint Testing models of thalamic dysfunction in schizophrenia using neuroimaging
    K Sim
    Schizophrenia and Bipolar Disorder Program, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    J Neural Transm 113:907-28. 2006
    ....
  27. doi request reprint Neurocognitive, clinical and functional correlates of subjective quality of life in Asian outpatients with schizophrenia
    Puay San Woon
    Research Division, Institute of Mental Health Woodbridge Hospital, Singapore
    Prog Neuropsychopharmacol Biol Psychiatry 34:463-8. 2010
    ....
  28. ncbi request reprint Health-related quality of life and psychiatric comorbidity in first episode psychosis
    Kang Sim
    Department of Early Psychosis Intervention, Woodbridge Hospital Institute of Mental Health, Singapore
    Compr Psychiatry 46:278-83. 2005
    ..This study seeks to evaluate the health-related QOL in patients with first episode psychosis and comparing those with psychiatric comorbidity to those without in an Early Psychosis Intervention Program...
  29. ncbi request reprint Ministry of Health clinical practice guidelines: schizophrenia
    S Verma
    Ang Mo Kio Polyclinic, Singapore
    Singapore Med J 52:521-5; quiz 526. 2011
    ..moh.gov. sg/mohcorp/publications.aspx?id=26138. The recommendations should be used with reference to the full text of the guidelines. Following this article are multiple choice questions based on the full text of the guidelines...
  30. doi request reprint Safety and efficacy of long-acting injectable risperidone in patients with schizophrenia spectrum disorders: a 6-month open-label trial in Asian patients
    Swapna Verma
    Early Psychosis Intervention Programme, Institute of Mental Health Woodbridge Hospital, Singapore
    Hum Psychopharmacol 25:230-5. 2010
    ..LAR was effective in improving symptom severity within the first month of starting treatment. However, significant increases in weight and plasma levels of fasting glucose and cholesterol raise concern about metabolic side effects...
  31. ncbi request reprint Duration of illness, regional brain morphology and neurocognitive correlates in schizophrenia
    Wai Yen Chan
    Research Division, Institute of Mental Health, Singapore
    Ann Acad Med Singapore 38:388-8. 2009
    ....
  32. doi request reprint Hippocampal volumes in first-episode psychosis
    Swapna Verma
    Department of Early Psychosis Intervention, Institute of Mental Health Woodbridge Hospital, Singapore
    J Neuropsychiatry Clin Neurosci 21:24-9. 2009
    ..Our results suggest that smaller hippocampal volumes are present even in early stages of the illness...
  33. ncbi request reprint Amygdala-hippocampal shape and cortical thickness abnormalities in first-episode schizophrenia and mania
    A Qiu
    Department of Bioengineering, National University of Singapore, Singapore
    Psychol Med 43:1353-63. 2013
    ..Method Structural magnetic resonance imaging (MRI) was performed on 28 FES patients, 28 FEM patients and 28 healthy control subjects who were matched for age, gender and handedness...
  34. doi request reprint White matter abnormalities in first-episode schizophrenia: a combined structural MRI and DTI study
    Wai Yen Chan
    Research Division, Institute of Mental Health, Singapore
    Schizophr Res 119:52-60. 2010
    ..Further research is needed to better understand the nature of these white matter changes and its progression in schizophrenia over time...
  35. pmc Hippocampal and parahippocampal volumes in schizophrenia: a structural MRI study
    Kang Sim
    Schizophrenia and Bipolar Disorders Program, McLean Hospital Harvard Medical School, Mill Street, Belmont, MA, 02478, USA
    Schizophr Bull 32:332-40. 2006
    ..The finding of smaller medial temporal lobe volumes in the absence of regional specificity has important implications for studying the functional role of the hippocampus and surrounding cortical regions in schizophrenia...
  36. ncbi request reprint Hippocampal-cortical structural connectivity disruptions in schizophrenia: an integrated perspective from hippocampal shape, cortical thickness, and integrity of white matter bundles
    Anqi Qiu
    Division of Bioengineering, National University of Singapore, Singapore
    Neuroimage 52:1181-9. 2010
    ..Our findings suggested that aberrant structural hippocampal-cortical connectivities may serve as a marker of the illness and provide further structural evidence to support the notion of schizophrenia as a disorder of brain connectivity...
  37. doi request reprint Asymmetry of lexico-semantic processing in schizophrenia changes with disease progression
    M Lam
    Research Division, Institute of Mental Health, Singapore
    Schizophr Res 134:125-30. 2012
    ....
  38. doi request reprint Psychotropic prescription practices in east Asia: looking back and peering ahead
    Chay Hoon Tan
    Department of Pharmacology, National University of Singapore, Singapore
    Curr Opin Psychiatry 21:645-50. 2008
    ..Pharmacogenetic studies in different ethnic groups are also reviewed...
  39. doi request reprint Cortical and subcortical white matter abnormalities in adults with remitted first-episode mania revealed by Tract-Based Spatial Statistics
    Wai Yen Chan
    Research Division, Institute of Mental Health, Singapore
    Bipolar Disord 12:383-9. 2010
    ....
  40. doi request reprint Neurobiological evidence for thalamic, hippocampal and related glutamatergic abnormalities in bipolar disorder: a review and synthesis
    Wan Xiu Dorcas Ng
    Institute of Mental Health Woodbridge Hospital, 10, Buangkok View, Singapore 539747, Singapore
    Neurosci Biobehav Rev 33:336-54. 2009
    ..Overall, the emerging trends from these findings highlight the need for further research to unravel underlying neurobiological changes and clinical correlates of thalamic and hippocampal dysfunction in bipolar disorder...
  41. doi request reprint Increased ratio of 2nd to 4th digit (2D:4D) in schizophrenia
    Simon Lowes Collinson
    Department of Psychology, National University of Singapore, 117570, Singapore
    Psychiatry Res 176:8-12. 2010
    ..The effect was primarily seen in males consistent with a 'less masculinised' pattern and hypotheses suggesting that schizophrenia may be associated with an abnormality in prenatal circulating testosterone...
  42. ncbi request reprint Combined analyses of thalamic volume, shape and white matter integrity in first-episode schizophrenia
    Anqi Qiu
    Division of Bioengineering, National University of Singapore, Singapore
    Neuroimage 47:1163-71. 2009
    ....
  43. ncbi request reprint Individual and familial characteristics of youths involved in street corner gangs in Singapore
    C Kee
    Institute of Mental Health, Singapore
    J Adolesc 26:401-12. 2003
    ..These findings diverge from anticipated familial correlates of antisocial activity in youths and were discussed with reference to cultural factors and their implications on prevention and intervention...
  44. doi request reprint White matter abnormalities in bipolar disorder: insights from diffusion tensor imaging studies
    Serene Heng
    Institute of Mental Health, Woodbridge Hospital, 10 Buangkok View, Singapore
    J Neural Transm 117:639-54. 2010
    ..The emerging trends from these DTI findings underscore the importance of further research to unravel the underlying neural mechanisms and clinico-anatomical correlations involving white matter in BD...
  45. doi request reprint Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: a decade of advance
    Suat Ying Tan Cherlyn
    Institute of Mental Health Woodbridge Hospital, 10 Buangkok View, Singapore 539747, Singapore
    Neurosci Biobehav Rev 34:958-77. 2010
    ....
  46. ncbi request reprint Antipsychotic drug prescription for schizophrenia in East Asia: rationale for change
    Mian Yoon Chong
    Chang Guan Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Psychiatry Clin Neurosci 58:61-7. 2004
    ..The pattern of antipsychotic medication use varied from country to country and is likely to be influenced by the prevailing health-care system, the availability and cost of the drugs...
  47. ncbi request reprint International study on antidepressant prescription pattern at 20 teaching hospitals and major psychiatric institutions in East Asia: Analysis of 1898 cases from China, Japan, Korea, Singapore and Taiwan
    Naoki Uchida
    Fukuoka University College of Medicine, Fukuoka, Japan
    Psychiatry Clin Neurosci 61:522-8. 2007
    ..0% of all cases. At the time of the survey, only two SSRI medications were available in Japan. However, five types of SSRI were available and were often prescribed in Korea...
  48. ncbi request reprint Reversible delayed onset olanzapine-associated leukopenia and neutropenia in a clozapine-naive patient on concomitant depot antipsychotic
    San San Thinn
    J Clin Psychopharmacol 27:394-5. 2007
  49. ncbi request reprint Epidemiology of completed suicides in Singapore for 2001 and 2002
    Marie Loh
    Bioinformatics Institute, National University of Singapore
    Crisis 28:148-55. 2007
    ..Although the overall rate of elderly suicides had gone down since the 1990s, prevention strategy should focus on the elderly as this rate is still about 3-4 times the national average...
  50. ncbi request reprint Clozapine-associated pseudomembranous colitis: a case report and review of the literature
    Kang Sim
    J Clin Psychopharmacol 26:89. 2006