Research Topics
Genomes and Genes
| Philip W InghamSummaryCountry: Singapore Publications
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Detail Information
Publications
Retinoic acid signaling restricts the cardiac progenitor poolBrian R Keegan
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Science 307:247-9. 2005..Thus, retinoic acid signaling creates a balance between cardiac and noncardiac identities, thereby refining the dimensions of the cardiac progenitor pool...
Drugging Hedgehog: signaling the pathway to translationTom J Carney
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673
BMC Biol 11:37. 2013..Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies...
Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafishHyejeong Rosemary Kim
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, UK
BMC Biol 8:65. 2010....- Hedgehog signallingPhilip W Ingham
Institute of Molecular and Cell Biology, Proteos, Singapore
Curr Biol 18:R238-41. 2008 - Orchestrating ontogenesis: variations on a theme by sonic hedgehogPhilip W Ingham
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673, Singapore
Nat Rev Genet 7:841-50. 2006..These examples of SHH function provide paradigms for inductive interactions that should help to inform attempts to recapitulate cellular programming and organogenesis in vitro... - The power of the zebrafish for disease analysisPhilip W Ingham
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore
Hum Mol Genet 18:R107-12. 2009..It also discusses some of its current limitations and how these are being addressed through the transfer of technologies from other systems... - Hedgehog signalling: Kif7 is not that fishy after allPhilip W Ingham
Institute of Molecular and Cellular Biology, 61, Biopolis Drive, Proteos, Singapore
Curr Biol 19:R729-31. 2009..Mammalian Kif7 action centres at the primary cilium, an organelle absent from Drosophila. These studies raise interesting questions about the coupling of microtubule trafficking to the Hedgehog pathway... - Mechanisms and functions of Hedgehog signalling across the metazoaPhilip W Ingham
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore
Nat Rev Genet 12:393-406. 2011.... - Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryoJonas Von Hofsten
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
EMBO Rep 9:683-9. 2008..Thus, Prdm1 promotes slow-twitch fibre differentiation by acting as a global repressor of fast-fibre-specific genes, as well as by abrogating the repression of slow-fibre-specific genes... - iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryoChristian Wolff
Center for Developmental Genetics, School of Medicine and Biomedical Sciences, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
Genes Dev 18:1565-76. 2004.... - Hedgehog signalling is required for cloacal development in the zebrafish embryoCaroline A Parkin
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield, U K
Int J Dev Biol 53:45-57. 2009..These studies establish the zebrafish as a model for ARMs, and for the elucidation of other pathways involved in hindgut developmental processes... - Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activityStone Elworthy
MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
Development 135:2115-26. 2008..The adult trunk slow fibres express smyhc2 and smyhc3, but lack smyhc1 expression. The different slow fibres in the craniofacial muscles variously express smyhc1, smyhc2 and smyhc3, and all differentiate independently of Prdm1... - Expression of patched, prdm1 and engrailed in the lamprey somite reveals conserved responses to Hedgehog signalingKatherine L Hammond
Department of Biomedical Science, MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, UK
Evol Dev 11:27-40. 2009..These data suggest the presence of conserved responses to Hh signaling in lamprey somites, although the full range of effects elicited by Hh in the zebrafish somite is not recapitulated... - Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation modelPhilip M Elks
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom
Blood 118:712-22. 2011..Our data demonstrate that Hif-1α regulates neutrophil function in complex ways during inflammation resolution in vivo... - Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafishCatherine A Loynes
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom
J Leukoc Biol 87:203-12. 2010..This model has several advantages over mammalian models and lends itself to the study of pharmaceutical agents modulating inflammation... - Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryoChristian Wolff
MRC Intercellular Signalling Group, Centre for Developmental Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
Curr Biol 13:1169-81. 2003..Exactly how Hh signaling contributes to the generation of the correct pattern of cells within the zebrafish myotome, however, has remained obscure... - Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury, and models of diseaseClaudia Seger
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom
Dev Dyn 240:2440-51. 2011..We also analyzed Pax7(+ve) cells in animals with dystrophic phenotypes and found an increased number compared with wild-type... - Expression screening and annotation of a zebrafish myoblast cDNA librarySarah Baxendale
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, UK
Gene Expr Patterns 9:73-82. 2009.... - Modeling inflammation in the zebrafish: how a fish can help us understand lung diseaseStephen A Renshaw
Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Western Bank, Sheffield, UK
Exp Lung Res 33:549-54. 2007..The authors hope that these tools will permit detailed study of the genetic controls of the resolution of inflammation, and provide insights with potential clinical utility... - Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebratesJin Ben
Developmental and Biomedical Genetics Group, Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
Development 138:4969-78. 2011..Our findings underline the importance of the primary cilium for Hh signaling in zebrafish and reveal the conservation of Ta3 function during vertebrate evolution... - A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryoShang Yew Tay
Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673
Development 132:625-34. 2005.... - A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusionCatherine A Moore
MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
Development 134:3145-53. 2007..In addition, we show that the adaptor proteins Crk and Crk-like (Crkl), with which Dock proteins are known to interact physically, are also required for myoblast fusion... - Hedgehog signaling in the Drosophila eye and head: an analysis of the effects of different patched trans-heterozygotesChloe Thomas
MRC Intercellular Signalling Group, Centre for Developmental Genetics, University of Sheffield, Sheffield S10 2TN, United Kingdom
Genetics 165:1915-28. 2003.... - The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signalingSarah Baxendale
MRC Intercellular Signaling Group, Center for Developmental Genetics, School of Medicine and Biomedical Sciences, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
Nat Genet 36:88-93. 2004..Our data provide the first molecular insight into the mechanism by which a specific group of muscle precursors is driven along a distinct pathway of fiber-type differentiation in response to positional cues in the vertebrate embryo... - The extracellular matrix protein TGFBI promotes myofibril bundling and muscle fibre growth in the zebrafish embryoH Rosemary Kim
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom
Dev Dyn 238:56-65. 2009.... - Regulation of stem cell maintenance and transit amplifying cell proliferation by tgf-beta signaling in Drosophila spermatogenesisAnish A Shivdasani
MRC Intercellular Signalling Group, Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
Curr Biol 13:2065-72. 2003.... - Prdm1a and miR-499 act sequentially to restrict Sox6 activity to the fast-twitch muscle lineage in the zebrafish embryoXingang Wang
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore
Development 138:4399-404. 2011..We find that translational repression of sox6 is mediated by miR-499, the slow-twitch-specific expression of which is in turn controlled by Prdm1a, forming a regulatory loop that initiates and maintains the slow-twitch muscle lineage... - A transgenic zebrafish model of neutrophilic inflammationStephen A Renshaw
MRC Centre for Developmental and Biomedical Genetics, Acadamic Unit of Respiratory Medicine, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
Blood 108:3976-8. 2006..fmk, demonstrating that experimental manipulation of the resolution of inflammation is possible in this model... - Drosophila melanogaster as a model host for Staphylococcus aureus infectionAndrew J Needham
Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
Microbiology 150:2347-55. 2004..The disease model also allowed the effect of antibiotic treatment on the flies to be determined. D. melanogaster is a genetically tractable model host for high-throughput analysis of S. aureus virulence determinants... - Ischemia is not required for arteriogenesis in zebrafish embryosCaroline Gray
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, UK
Arterioscler Thromb Vasc Biol 27:2135-41. 2007..To investigate this, we developed models of arteriogenesis using the zebrafish embryo, which gains sufficient oxygenation via diffusion to prevent ischemia in response to arterial occlusion... - Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotomeAshish K Maurya
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
Development 138:755-65. 2011.... - Zebrafish models of the immune response: taking it on the ChInStephen A Renshaw
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
BMC Biol 8:148. 2010..A new chemically induced inflammation assay ('ChIn' assay) published in BMC Biology obviates this requirement and seems set to accelerate progress in the field... - The adventures of Sonic Hedgehog in development and repair. I. Hedgehog signaling in gastrointestinal development and diseaseCaroline A Parkin
Institute of Molecular and Cell Biology, 61 Biopolis Dr, Proteos, Singapore 138673
Am J Physiol Gastrointest Liver Physiol 294:G363-7. 2008..Here we focus on the Hh signaling pathway and its role in GI tract development and maintenance and consider the diseases resulting from aberrant Hh activity... - Hedgehogs tryst with the cell cycleSudipto Roy
Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
J Cell Sci 115:4393-7. 2002..These new findings have profound implications in the context of clinical conditions - especially cancers - that arise from de-regulated cell proliferation in response to aberrant Hedgehog signalling activity... - The transformation of the model organism: a decade of developmental geneticsKathryn V Anderson
Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
Nat Genet 33:285-93. 2003..Vertebrate developmental genetics is now flourishing, with forward and reverse genetics in both zebrafish and the mouse providing new dimensions to our understanding of development... - Developmental roles and clinical significance of hedgehog signalingAndrew P McMahon
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Curr Top Dev Biol 53:1-114. 2003..This review focuses on the developing systems themselves, providing a comprehensive survey of the role of Hedgehog signaling in each of these. We also discuss the increasing significance of Hedgehog signaling in the clinical setting... - Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutantsValentina Svetic
Centre for Regenerative Medicine and Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
Development 134:1011-22. 2007..We thus identify Sdf1 as a key molecule in pigment pattern formation, adding to the growing inventory of its roles in embryonic development... - Microcephalin coordinates mitosis in the syncytial Drosophila embryoKathrin Brunk
Institute of Integrative and Comparative Biology, University of Leeds, LS2 9JT, UK
J Cell Sci 120:3578-88. 2007.... - Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wingBruno Glise
MRC Intercellular Signalling Group, Centre for Developmental Genetics, University School of Medicine and Biomedical Science, Sheffield, United Kingdom
Dev Biol 248:93-106. 2002..Our findings suggest a paradigm of repression of the Hh response by N and/or Wnt signalling that may be applicable to signal integration in vertebrate appendages...