Philip W Ingham

Summary

Country: Singapore

Publications

  1. ncbi request reprint Retinoic acid signaling restricts the cardiac progenitor pool
    Brian R Keegan
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Science 307:247-9. 2005
  2. pmc Drugging Hedgehog: signaling the pathway to translation
    Tom J Carney
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673
    BMC Biol 11:37. 2013
  3. pmc Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish
    Hyejeong Rosemary Kim
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, UK
    BMC Biol 8:65. 2010
  4. doi request reprint Hedgehog signalling: Kif7 is not that fishy after all
    Philip W Ingham
    Institute of Molecular and Cellular Biology, 61, Biopolis Drive, Proteos, Singapore
    Curr Biol 19:R729-31. 2009
  5. doi request reprint The power of the zebrafish for disease analysis
    Philip W Ingham
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore
    Hum Mol Genet 18:R107-12. 2009
  6. doi request reprint Mechanisms and functions of Hedgehog signalling across the metazoa
    Philip W Ingham
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore
    Nat Rev Genet 12:393-406. 2011
  7. doi request reprint Hedgehog signalling
    Philip W Ingham
    Institute of Molecular and Cell Biology, Proteos, Singapore
    Curr Biol 18:R238-41. 2008
  8. ncbi request reprint Orchestrating ontogenesis: variations on a theme by sonic hedgehog
    Philip W Ingham
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673, Singapore
    Nat Rev Genet 7:841-50. 2006
  9. pmc Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo
    Jonas Von Hofsten
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    EMBO Rep 9:683-9. 2008
  10. pmc iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
    Christian Wolff
    Center for Developmental Genetics, School of Medicine and Biomedical Sciences, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Genes Dev 18:1565-76. 2004

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Retinoic acid signaling restricts the cardiac progenitor pool
    Brian R Keegan
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Science 307:247-9. 2005
    ..Thus, retinoic acid signaling creates a balance between cardiac and noncardiac identities, thereby refining the dimensions of the cardiac progenitor pool...
  2. pmc Drugging Hedgehog: signaling the pathway to translation
    Tom J Carney
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673
    BMC Biol 11:37. 2013
    ..Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies...
  3. pmc Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish
    Hyejeong Rosemary Kim
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, UK
    BMC Biol 8:65. 2010
    ....
  4. doi request reprint Hedgehog signalling: Kif7 is not that fishy after all
    Philip W Ingham
    Institute of Molecular and Cellular Biology, 61, Biopolis Drive, Proteos, Singapore
    Curr Biol 19:R729-31. 2009
    ..Mammalian Kif7 action centres at the primary cilium, an organelle absent from Drosophila. These studies raise interesting questions about the coupling of microtubule trafficking to the Hedgehog pathway...
  5. doi request reprint The power of the zebrafish for disease analysis
    Philip W Ingham
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore
    Hum Mol Genet 18:R107-12. 2009
    ..It also discusses some of its current limitations and how these are being addressed through the transfer of technologies from other systems...
  6. doi request reprint Mechanisms and functions of Hedgehog signalling across the metazoa
    Philip W Ingham
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore
    Nat Rev Genet 12:393-406. 2011
    ....
  7. doi request reprint Hedgehog signalling
    Philip W Ingham
    Institute of Molecular and Cell Biology, Proteos, Singapore
    Curr Biol 18:R238-41. 2008
  8. ncbi request reprint Orchestrating ontogenesis: variations on a theme by sonic hedgehog
    Philip W Ingham
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673, Singapore
    Nat Rev Genet 7:841-50. 2006
    ..These examples of SHH function provide paradigms for inductive interactions that should help to inform attempts to recapitulate cellular programming and organogenesis in vitro...
  9. pmc Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo
    Jonas Von Hofsten
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    EMBO Rep 9:683-9. 2008
    ..Thus, Prdm1 promotes slow-twitch fibre differentiation by acting as a global repressor of fast-fibre-specific genes, as well as by abrogating the repression of slow-fibre-specific genes...
  10. pmc iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
    Christian Wolff
    Center for Developmental Genetics, School of Medicine and Biomedical Sciences, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Genes Dev 18:1565-76. 2004
    ....
  11. doi request reprint Hedgehog signalling is required for cloacal development in the zebrafish embryo
    Caroline A Parkin
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield, U K
    Int J Dev Biol 53:45-57. 2009
    ..These studies establish the zebrafish as a model for ARMs, and for the elucidation of other pathways involved in hindgut developmental processes...
  12. doi request reprint Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity
    Stone Elworthy
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 135:2115-26. 2008
    ..The adult trunk slow fibres express smyhc2 and smyhc3, but lack smyhc1 expression. The different slow fibres in the craniofacial muscles variously express smyhc1, smyhc2 and smyhc3, and all differentiate independently of Prdm1...
  13. ncbi request reprint Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo
    Christian Wolff
    MRC Intercellular Signalling Group, Centre for Developmental Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
    Curr Biol 13:1169-81. 2003
    ..Exactly how Hh signaling contributes to the generation of the correct pattern of cells within the zebrafish myotome, however, has remained obscure...
  14. doi request reprint Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model
    Philip M Elks
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom
    Blood 118:712-22. 2011
    ..Our data demonstrate that Hif-1α regulates neutrophil function in complex ways during inflammation resolution in vivo...
  15. doi request reprint Expression of patched, prdm1 and engrailed in the lamprey somite reveals conserved responses to Hedgehog signaling
    Katherine L Hammond
    Department of Biomedical Science, MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, UK
    Evol Dev 11:27-40. 2009
    ..These data suggest the presence of conserved responses to Hh signaling in lamprey somites, although the full range of effects elicited by Hh in the zebrafish somite is not recapitulated...
  16. pmc Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish
    Catherine A Loynes
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom
    J Leukoc Biol 87:203-12. 2010
    ..This model has several advantages over mammalian models and lends itself to the study of pharmaceutical agents modulating inflammation...
  17. doi request reprint Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury, and models of disease
    Claudia Seger
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom
    Dev Dyn 240:2440-51. 2011
    ..We also analyzed Pax7(+ve) cells in animals with dystrophic phenotypes and found an increased number compared with wild-type...
  18. doi request reprint Expression screening and annotation of a zebrafish myoblast cDNA library
    Sarah Baxendale
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, UK
    Gene Expr Patterns 9:73-82. 2009
    ....
  19. ncbi request reprint Modeling inflammation in the zebrafish: how a fish can help us understand lung disease
    Stephen A Renshaw
    Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Western Bank, Sheffield, UK
    Exp Lung Res 33:549-54. 2007
    ..The authors hope that these tools will permit detailed study of the genetic controls of the resolution of inflammation, and provide insights with potential clinical utility...
  20. pmc Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates
    Jin Ben
    Developmental and Biomedical Genetics Group, Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
    Development 138:4969-78. 2011
    ..Our findings underline the importance of the primary cilium for Hh signaling in zebrafish and reveal the conservation of Ta3 function during vertebrate evolution...
  21. ncbi request reprint A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
    Shang Yew Tay
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673
    Development 132:625-34. 2005
    ....
  22. ncbi request reprint A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion
    Catherine A Moore
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Development 134:3145-53. 2007
    ..In addition, we show that the adaptor proteins Crk and Crk-like (Crkl), with which Dock proteins are known to interact physically, are also required for myoblast fusion...
  23. ncbi request reprint The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling
    Sarah Baxendale
    MRC Intercellular Signaling Group, Center for Developmental Genetics, School of Medicine and Biomedical Sciences, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Nat Genet 36:88-93. 2004
    ..Our data provide the first molecular insight into the mechanism by which a specific group of muscle precursors is driven along a distinct pathway of fiber-type differentiation in response to positional cues in the vertebrate embryo...
  24. pmc Hedgehog signaling in the Drosophila eye and head: an analysis of the effects of different patched trans-heterozygotes
    Chloe Thomas
    MRC Intercellular Signalling Group, Centre for Developmental Genetics, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Genetics 165:1915-28. 2003
    ....
  25. doi request reprint The extracellular matrix protein TGFBI promotes myofibril bundling and muscle fibre growth in the zebrafish embryo
    H Rosemary Kim
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom
    Dev Dyn 238:56-65. 2009
    ....
  26. ncbi request reprint Regulation of stem cell maintenance and transit amplifying cell proliferation by tgf-beta signaling in Drosophila spermatogenesis
    Anish A Shivdasani
    MRC Intercellular Signalling Group, Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 13:2065-72. 2003
    ....
  27. doi request reprint Prdm1a and miR-499 act sequentially to restrict Sox6 activity to the fast-twitch muscle lineage in the zebrafish embryo
    Xingang Wang
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore
    Development 138:4399-404. 2011
    ..We find that translational repression of sox6 is mediated by miR-499, the slow-twitch-specific expression of which is in turn controlled by Prdm1a, forming a regulatory loop that initiates and maintains the slow-twitch muscle lineage...
  28. ncbi request reprint A transgenic zebrafish model of neutrophilic inflammation
    Stephen A Renshaw
    MRC Centre for Developmental and Biomedical Genetics, Acadamic Unit of Respiratory Medicine, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Blood 108:3976-8. 2006
    ..fmk, demonstrating that experimental manipulation of the resolution of inflammation is possible in this model...
  29. ncbi request reprint Drosophila melanogaster as a model host for Staphylococcus aureus infection
    Andrew J Needham
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Microbiology 150:2347-55. 2004
    ..The disease model also allowed the effect of antibiotic treatment on the flies to be determined. D. melanogaster is a genetically tractable model host for high-throughput analysis of S. aureus virulence determinants...
  30. pmc Ischemia is not required for arteriogenesis in zebrafish embryos
    Caroline Gray
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, UK
    Arterioscler Thromb Vasc Biol 27:2135-41. 2007
    ..To investigate this, we developed models of arteriogenesis using the zebrafish embryo, which gains sufficient oxygenation via diffusion to prevent ischemia in response to arterial occlusion...
  31. doi request reprint Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome
    Ashish K Maurya
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    Development 138:755-65. 2011
    ....
  32. pmc Zebrafish models of the immune response: taking it on the ChIn
    Stephen A Renshaw
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
    BMC Biol 8:148. 2010
    ..A new chemically induced inflammation assay ('ChIn' assay) published in BMC Biology obviates this requirement and seems set to accelerate progress in the field...
  33. pmc Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library
    Xingang Wang
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore
    Dis Model Mech 7:163-9. 2014
    ....
  34. ncbi request reprint The adventures of Sonic Hedgehog in development and repair. I. Hedgehog signaling in gastrointestinal development and disease
    Caroline A Parkin
    Institute of Molecular and Cell Biology, 61 Biopolis Dr, Proteos, Singapore 138673
    Am J Physiol Gastrointest Liver Physiol 294:G363-7. 2008
    ..Here we focus on the Hh signaling pathway and its role in GI tract development and maintenance and consider the diseases resulting from aberrant Hh activity...
  35. ncbi request reprint Hedgehogs tryst with the cell cycle
    Sudipto Roy
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
    J Cell Sci 115:4393-7. 2002
    ..These new findings have profound implications in the context of clinical conditions - especially cancers - that arise from de-regulated cell proliferation in response to aberrant Hedgehog signalling activity...
  36. ncbi request reprint Microcephalin coordinates mitosis in the syncytial Drosophila embryo
    Kathrin Brunk
    Institute of Integrative and Comparative Biology, University of Leeds, LS2 9JT, UK
    J Cell Sci 120:3578-88. 2007
    ....
  37. ncbi request reprint Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants
    Valentina Svetic
    Centre for Regenerative Medicine and Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Development 134:1011-22. 2007
    ..We thus identify Sdf1 as a key molecule in pigment pattern formation, adding to the growing inventory of its roles in embryonic development...
  38. ncbi request reprint The transformation of the model organism: a decade of developmental genetics
    Kathryn V Anderson
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nat Genet 33:285-93. 2003
    ..Vertebrate developmental genetics is now flourishing, with forward and reverse genetics in both zebrafish and the mouse providing new dimensions to our understanding of development...
  39. ncbi request reprint Developmental roles and clinical significance of hedgehog signaling
    Andrew P McMahon
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Top Dev Biol 53:1-114. 2003
    ..This review focuses on the developing systems themselves, providing a comprehensive survey of the role of Hedgehog signaling in each of these. We also discuss the increasing significance of Hedgehog signaling in the clinical setting...
  40. ncbi request reprint Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing
    Bruno Glise
    MRC Intercellular Signalling Group, Centre for Developmental Genetics, University School of Medicine and Biomedical Science, Sheffield, United Kingdom
    Dev Biol 248:93-106. 2002
    ..Our findings suggest a paradigm of repression of the Hh response by N and/or Wnt signalling that may be applicable to signal integration in vertebrate appendages...