Florent Ginhoux

Summary

Country: Singapore

Publications

  1. pmc Origin and differentiation of microglia
    Florent Ginhoux
    Singapore Immunology Network, Agency for Science, Technology, and Research Singapore
    Front Cell Neurosci 7:45. 2013
  2. doi request reprint Understanding the murine cutaneous dendritic cell network to improve intradermal vaccination strategies
    F Ginhoux
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, 8A Biomedical Grove, Immunos, Biopolis, Singapore 138648, Singapore
    Curr Top Microbiol Immunol 351:1-24. 2012
  3. pmc Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    Florent Ginhoux
    Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Science 330:841-5. 2010
  4. doi request reprint Ontogeny and homeostasis of Langerhans cells
    Florent Ginhoux
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, Immunos, Biopolis, Singapore
    Immunol Cell Biol 88:387-92. 2010
  5. doi request reprint [Microglia arise from extra-embryonic yolk sac primitive progenitors]
    Florent Ginhoux
    Singapore Immunology Network, Agency for Science, Technology and Research, Immunos, Biopolis, Singapour
    Med Sci (Paris) 27:719-24. 2011
  6. pmc Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells
    Muzlifah Haniffa
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Immunity 37:60-73. 2012
  7. pmc Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages
    Guillaume Hoeffel
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Immunos Building 3 4, Biopolis, 138648, Singapore
    J Exp Med 209:1167-81. 2012
  8. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009
  9. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
  10. ncbi request reprint Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:3019-27. 2008

Collaborators

Detail Information

Publications34

  1. pmc Origin and differentiation of microglia
    Florent Ginhoux
    Singapore Immunology Network, Agency for Science, Technology, and Research Singapore
    Front Cell Neurosci 7:45. 2013
    ..Here, we review the history of microglial cells and discuss the latest advances in our understanding of their origin, differentiation, and homeostasis, which provides new insights into their roles in health and disease...
  2. doi request reprint Understanding the murine cutaneous dendritic cell network to improve intradermal vaccination strategies
    F Ginhoux
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, 8A Biomedical Grove, Immunos, Biopolis, Singapore 138648, Singapore
    Curr Top Microbiol Immunol 351:1-24. 2012
    ..We will also review recent evidence underlining the functional specialization of dermal DC subsets and its relevance in the design of novel vaccine approaches...
  3. pmc Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    Florent Ginhoux
    Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Science 330:841-5. 2010
    ..These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders...
  4. doi request reprint Ontogeny and homeostasis of Langerhans cells
    Florent Ginhoux
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, Immunos, Biopolis, Singapore
    Immunol Cell Biol 88:387-92. 2010
    ..We will also discuss recent evidence that suggests that LCs arise from dedicated precursors during early embryonic development...
  5. doi request reprint [Microglia arise from extra-embryonic yolk sac primitive progenitors]
    Florent Ginhoux
    Singapore Immunology Network, Agency for Science, Technology and Research, Immunos, Biopolis, Singapour
    Med Sci (Paris) 27:719-24. 2011
    ..These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically-derived microglial progenitors for the treatment of various brain disorders...
  6. pmc Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells
    Muzlifah Haniffa
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Immunity 37:60-73. 2012
    ..These studies inform the rational design of targeted immunotherapies and facilitate translation of mouse functional DC biology to the human setting...
  7. pmc Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages
    Guillaume Hoeffel
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Immunos Building 3 4, Biopolis, 138648, Singapore
    J Exp Med 209:1167-81. 2012
    ..Altogether, we establish that adult LCs have a dual origin, bridging early embryonic and late fetal myeloid development...
  8. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009
    ..Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system...
  9. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
    ..Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program...
  10. ncbi request reprint Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:3019-27. 2008
    ..Overall, these data demonstrate that the two circulating subsets of monocytes give rise to distinct tissue DC populations...
  11. pmc IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses
    Andreas Schlitzer
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, 138648 Singapore
    Immunity 38:970-83. 2013
    ....
  12. pmc Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
    Daigo Hashimoto
    Department of Oncological Sciences and Tisch Cancer Institute, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 38:792-804. 2013
    ..Collectively, these results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state...
  13. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  14. pmc Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery
    Frank Tacke
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 203:583-97. 2006
    ..These data reveal that immature monocytes unexpectedly sample antigen from the bone marrow environment and that they can present these antigens after they leave the bone marrow...
  15. doi request reprint Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice
    Julie Helft
    Department of Gene and Cell Medicine and Mount Sinai School of Medicine, New York, NY, USA
    Immunol Rev 234:55-75. 2010
    ..We also review recent results underlining the functional specialization of tissue DCs and discuss the potential implications of these findings in tissue immunity and in the development of novel vaccine strategies...
  16. pmc Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection
    Pierre Guermonprez
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA
    Nat Med 19:730-8. 2013
    ..Our findings highlight a new mechanism that regulates dendritic cell homeostasis and T cell responses to infection...
  17. pmc Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes
    Claudia Jakubzick
    Department of Pediatrics at National Jewish Health, Denver, CO 80206, USA Integrated Department of Immunology, University of Colorado, Denver, CO 80206, USA Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 39:599-610. 2013
    ..Thus, monocytes can enter steady-state nonlymphoid organs and recirculate to LNs without differentiation to macrophages or DCs, revising a long-held view that monocytes become tissue-resident macrophages by default...
  18. ncbi request reprint The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics
    Levi G Ledgerwood
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 9:42-53. 2008
    ..Thus, the increased sphingosine 1-phosphate present in inflamed peripheral tissues may induce T cell retention and suppress T cell egress...
  19. pmc Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 203:2627-38. 2006
    ..Given the role of residual host tissue DCs in transplant immune reactions, these results suggest that dermal DC homeostasis may contribute to the development of cutaneous graft-versus-host disease in clinical transplantation...
  20. doi request reprint Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
    ..In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity...
  21. pmc Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow
    Sapna Devi
    Singapore Immunology Network SIgN, A STAR Agency for Science, Technology and Research, Biopolis, 138648 Singapore
    J Exp Med 210:2321-36. 2013
    ..Collectively, our data provides valuable insights into the fundamental regulation of neutrophil homeostasis, which may lead to the development of improved treatment regimens for neutropenic patients. ..
  22. ncbi request reprint B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization
    Veronique Angeli
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Immunity 24:203-15. 2006
    ..Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination...
  23. ncbi request reprint Langerhans cells arise from monocytes in vivo
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 7:265-73. 2006
    ..These results identify Gr-1(hi) monocytes as the direct precursors for LCs in vivo and establish the importance of the CSF-1 receptor in this process...
  24. pmc Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation
    Daigo Hashimoto
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 208:1069-82. 2011
    ..This study establishes the unexpected key role of host macrophages in inhibiting GVHD and identifies CSF-1 as a potential prophylactic therapy to limit acute GVHD after allo-HCT in the clinic...
  25. pmc Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria
    Shanshan W Howland
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Singapore, Singapore
    EMBO Mol Med 5:916-31. 2013
    ..Thus our data suggest that combined therapies targeting both the parasite and host antigen-presenting cells may improve the outcome of CM patients. ..
  26. pmc Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection
    Matheswaran Kandasamy
    Infection and Immunity Programme, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research ASTAR, Singapore
    PLoS Pathog 9:e1003115. 2013
    ..Collectively, our findings show that complement has a profound impact on immune regulation by controlling tissue DC trafficking and highlights a potential utility for complement as an adjuvant in novel vaccine strategies...
  27. pmc Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression
    Jingjing Jiao
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 55:244-55. 2012
    ..In contrast, transfer of DCs from MMP-9-deficient mice failed to improve fibrosis regression...
  28. ncbi request reprint CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections
    Nadja Bakocevic
    Singapore Immunology Network SIgN, Agency for Science Technology and Research A STAR, Biopolis, Singapore
    Eur J Immunol 44:1823-34. 2014
    ..In conclusion, we provide evidence that CD41 can be used as both an identification and activation marker for basophils during homeostasis and immune challenge. ..
  29. pmc The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
    Claudia Waskow
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Nat Immunol 9:676-83. 2008
    ..In contrast, Flt3 was essential to the regulation of homeostatic DC development in the spleen, where it was needed to maintain normal numbers of DCs by controlling their division in the periphery...
  30. doi request reprint Dendritic cells and the malaria pre-erythrocytic stage
    Marjorie Mauduit
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Immunos, 8A Biomedical Grove, Biopolis, Singapore
    Immunol Res 53:115-26. 2012
    ....
  31. doi request reprint Organization of the mouse and human DC network
    Andreas Schlitzer
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, 138648 Singapore
    Curr Opin Immunol 26:90-9. 2014
    ..Understanding the inter-relationships between DC populations in both man and mouse will ultimately allow us to exploit our knowledge of DC biology for effective therapeutic strategies. ..
  32. doi request reprint CD11b+ DCs rediscovered: implications for vaccination
    Florent Ginhoux
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, Biopolis, 138648, Singapore
    Expert Rev Vaccines 13:445-7. 2014
    ..Therefore, a deeper understanding of DC subset biology is fundamental for the development and implementation of innovative vaccination strategies. ..
  33. pmc CD8+ T cells and IFN-╬│ mediate the time-dependent accumulation of infected red blood cells in deep organs during experimental cerebral malaria
    Carla Claser
    Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis, Singapore, Singapore
    PLoS ONE 6:e18720. 2011
    ..Red blood cells infected with PbA parasites have been shown to accumulate in the brain and other tissues during infection. This accumulation is thought to be involved in PbA-induced pathologies, which mechanisms are poorly understood...