Alan Colman

Summary

Country: Singapore

Publications

  1. doi request reprint Induced pluripotent stem cells and human disease
    Alan Colman
    Wolfson Centre for Age Related Disease, King s College London, Guy s Campus, London, UK
    Cell Stem Cell 3:236-7. 2008
  2. pmc Induced pluripotent stem cells and the stability of the differentiated state
    Alan Colman
    Institute of Medical Biology, Immunos, Singapore
    EMBO Rep 10:714-21. 2009
  3. pmc Lamin B1 fluctuations have differential effects on cellular proliferation and senescence
    Oliver Dreesen
    Stem Cell Disease Models, Institute of Medical Biology, 138648 Singapore
    J Cell Biol 200:605-17. 2013
  4. doi request reprint Pluripotent stem cells and disease modeling
    Alan Colman
    Institute of Medical Biology, Singapore, Singapore
    Cell Stem Cell 5:244-7. 2009
  5. doi request reprint Stem cell research in Singapore
    Alan Colman
    Singapore Stem Cell Consortium, A STAR Institute of Medical Biology, Singapore 138648
    Cell 132:519-21. 2008
  6. doi request reprint Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells
    Xiu Qin Xu
    ES Cell International Pte Ltd, 60 Biopolis St 01 03 Genome, Singapore 138672, Republic of Singapore
    Differentiation 76:958-70. 2008
  7. pmc Survival and maturation of human embryonic stem cell-derived cardiomyocytes in rat hearts
    Wangde Dai
    The Heart Institute, Good Samaritan Hospital, University of Southern California, 1225 Wilshire Boulevard, Los Angeles, CA 90017 2395, USA
    J Mol Cell Cardiol 43:504-16. 2007
  8. ncbi request reprint The generation of six clinical-grade human embryonic stem cell lines
    Jeremy Micah Crook
    Cell Stem Cell 1:490-4. 2007
  9. ncbi request reprint ES Cell International & regenerative medicine
    Alan Colman
    ES Cell International, Helios, Singapore
    Regen Med 1:287-91. 2006
  10. ncbi request reprint Cell therapy and the safety of embryonic stem cell-derived grafts
    Hannes Hentze
    ES Cell International, 11 Biopolis Way, 05 06 Helios Building, 138667 Singapore, Republic of Singapore
    Trends Biotechnol 25:24-32. 2007

Collaborators

  • Christine Mummery
  • Robert Zweigerdt
  • Xiu Qin Xu
  • Hannes Hentze
  • Oliver Dreesen
  • Wangde Dai
  • Jeremy Micah Crook
  • Jeremy M Crook
  • Leah A Vardy
  • Colin L Stewart
  • E Birgitte Lane
  • Shu Jin Lee
  • Tian Yun Zhao
  • Peh Fern Ong
  • John E Common
  • Alexandre Chojnowski
  • Declan Lunny
  • Alexis Gina Bosman
  • Rachel Horne
  • Teija Tuulikki Peura
  • Ralph Graichen
  • Sharon L Hale
  • Michael Rubart
  • Martin Pera
  • Gregory L Kay
  • Loren J Field
  • Robert A Kloner
  • Lucy Kravets
  • Florence Chua
  • Bruce P Davidson
  • Aarne J Jyrala
  • Norris Ray Dunn
  • Ralph E Graichen
  • Jeremy James Buzzard
  • Sean Reuter
  • Alan Upshall
  • N Ray Dunn

Detail Information

Publications11

  1. doi request reprint Induced pluripotent stem cells and human disease
    Alan Colman
    Wolfson Centre for Age Related Disease, King s College London, Guy s Campus, London, UK
    Cell Stem Cell 3:236-7. 2008
  2. pmc Induced pluripotent stem cells and the stability of the differentiated state
    Alan Colman
    Institute of Medical Biology, Immunos, Singapore
    EMBO Rep 10:714-21. 2009
    ..Here, we highlight the recent progress, and the implications of this work for our understanding of the relationship between the pluripotent and more differentiated cell states...
  3. pmc Lamin B1 fluctuations have differential effects on cellular proliferation and senescence
    Oliver Dreesen
    Stem Cell Disease Models, Institute of Medical Biology, 138648 Singapore
    J Cell Biol 200:605-17. 2013
    ..This phenotype was exacerbated by a simultaneous reduction of LMNA/C. Our results demonstrate that altering LMNB1 levels inhibits proliferation and are relevant to understanding the molecular pathology of ADLD...
  4. doi request reprint Pluripotent stem cells and disease modeling
    Alan Colman
    Institute of Medical Biology, Singapore, Singapore
    Cell Stem Cell 5:244-7. 2009
    ..hESCs and hiPSCs carrying genetic defects can now be produced to model diseases in vitro. We suggest several guiding principles to help ensure an optimal fit between technology and disease...
  5. doi request reprint Stem cell research in Singapore
    Alan Colman
    Singapore Stem Cell Consortium, A STAR Institute of Medical Biology, Singapore 138648
    Cell 132:519-21. 2008
    ..Singapore is investing heavily in stem cell research. This investment is part of an ambitious biomedical science initiative designed to enhance its thriving economy...
  6. doi request reprint Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells
    Xiu Qin Xu
    ES Cell International Pte Ltd, 60 Biopolis St 01 03 Genome, Singapore 138672, Republic of Singapore
    Differentiation 76:958-70. 2008
    ..This study represents a significant step toward developing scalable production for cardiomyocytes from hESC using clinically compliant reagents compatible with Good Manufacturing Practice...
  7. pmc Survival and maturation of human embryonic stem cell-derived cardiomyocytes in rat hearts
    Wangde Dai
    The Heart Institute, Good Samaritan Hospital, University of Southern California, 1225 Wilshire Boulevard, Los Angeles, CA 90017 2395, USA
    J Mol Cell Cardiol 43:504-16. 2007
    ..However, hESC-derived cells did not escape immune surveillance in the xenograft setting in that they elicited a rejection phenomenon in immune competent rats...
  8. ncbi request reprint The generation of six clinical-grade human embryonic stem cell lines
    Jeremy Micah Crook
    Cell Stem Cell 1:490-4. 2007
  9. ncbi request reprint ES Cell International & regenerative medicine
    Alan Colman
    ES Cell International, Helios, Singapore
    Regen Med 1:287-91. 2006
    ..However with demographic changes towards an aging population in the richer countries, leading to growing demands of ways to combat degenerative disease, science would be remiss not to explore every potential medical solution...
  10. ncbi request reprint Cell therapy and the safety of embryonic stem cell-derived grafts
    Hannes Hentze
    ES Cell International, 11 Biopolis Way, 05 06 Helios Building, 138667 Singapore, Republic of Singapore
    Trends Biotechnol 25:24-32. 2007
    ..It is this final safety issue that will form the focus of this review...
  11. ncbi request reprint Repressed by a NuRD
    Jeremy M Crook
    Nat Cell Biol 8:212-4. 2006