Research Topics
| Hon Nian ChuaSummaryCountry: Singapore Publications
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Detail Information
Publications
Using indirect protein interactions for the prediction of Gene Ontology functionsHon Nian Chua
School of Computing, National University of Singapore, Singapore, Singapore
BMC Bioinformatics 8:S8. 2007....
An efficient strategy for extensive integration of diverse biological data for protein function predictionHon Nian Chua
Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
Bioinformatics 23:3364-73. 2007..In the presence of cross-genome information, which is overwhelming for existing approaches, IWA makes even better predictions. We also demonstrate the significance of appropriate weighting strategies in data integration...
A probabilistic graph-theoretic approach to integrate multiple predictions for the protein-protein subnetwork prediction challengeHon Nian Chua
Data Mining Department, Institute for Infocomm Research, Singapore
Ann N Y Acad Sci 1158:224-33. 2009..This technique is then used to produce our entry for the protein-protein subnetwork prediction challenge...- Using indirect protein-protein interactions for protein complex predictionHon Nian Chua
Graduate School of Integrated Sciences, National University of Singapore, Singapore
J Bioinform Comput Biol 6:435-66. 2008..Since no other information except the original PPI network is used, our approach would be very useful for protein complex prediction, especially for prediction of novel protein complexes... - Complex discovery from weighted PPI networksGuimei Liu
School of Computing, National University of Singapore, Singapore and Institute for Infocomm Research, Singapore
Bioinformatics 25:1891-7. 2009..However, protein interaction data produced by high-throughput experiments are often associated with high false positive and false negative rates, which makes it difficult to predict complexes accurately... - Using indirect protein-protein interactions for protein complex predicationHon Nian Chua
Graduate School of Integrated Sciences, National University of Singapore, Singapore
Comput Syst Bioinformatics Conf 6:97-109. 2007..Since no any other information except the original PPI network is used, our approach would be very useful for protein complex prediction, especially for prediction of novel protein complexes... - Increasing the reliability of protein interactomesHon Nian Chua
Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore 119613, Singapore
Drug Discov Today 13:652-8. 2008..We review here computational techniques for assessing and improving the reliability of protein-protein interaction data from these high-throughput experiments... - Exploiting indirect neighbours and topological weight to predict protein function from protein-protein interactionsHon Nian Chua
Graduate School for Integrated Sciences and Engineering, National University of Singapore, Singapore
Bioinformatics 22:1623-30. 2006..Using leave-one-out cross validation, we compare the performance of our method against that of several other existing approaches and show that our method performs relatively well... - Increasing confidence of protein-protein interactomesJin Chen
National University of Singapore, Graduate School of Computing, Singapore
Genome Inform 17:284-97. 2006..We also present indices that are based on explicit motifs associated with true-positive protein interactions--e.g., "new interaction generality" (IG2) and "meso-scale motifs" (NeMoFinder)... - Supervised maximum-likelihood weighting of composite protein networks for complex predictionChern Han Yong
Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
BMC Syst Biol 6:S13. 2012..As a result, predicted complexes often do not match true complexes well, and many true complexes go undetected... - Decomposing PPI networks for complex discoveryGuimei Liu
School of Computing, National University of Singapore, Singapore
Proteome Sci 9:S15. 2011..As a result, predicted complexes often contain many spuriously included proteins, precluding them from matching true complexes...