Kwong Ming Fock

Summary

Affiliation: Changi General Hospital
Country: Singapore

Publications

  1. ncbi request reprint Proton pump inhibitors: do differences in pharmacokinetics translate into differences in clinical outcomes?
    Kwong Ming Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    Clin Pharmacokinet 47:1-6. 2008
  2. ncbi request reprint A randomized, placebo-controlled trial of thymosin-alpha1 and lymphoblastoid interferon for HBeAg-positive chronic hepatitis B
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, National University Hospital, Singapore
    Antivir Ther 11:245-53. 2006
  3. doi request reprint Helicobacter pylori research: historical insights and future directions
    Kwong Ming Fock
    Changi General Hospital, 2 Semei Street 3, Singapore 529889
    Nat Rev Gastroenterol Hepatol 10:495-500. 2013
  4. pmc The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: a case-control study
    Heather Marie A Schmidt
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW, Sydney, Australia
    Gut Pathog 1:5. 2009
  5. doi request reprint Gastroesophageal reflux disease
    Kwong Ming Fock
    Department of Gastroenterology, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore
    J Gastroenterol 45:808-15. 2010
  6. doi request reprint Epidemiology of Helicobacter pylori infection and gastric cancer in Asia
    Kwong Ming Fock
    Division of Gastroenterology, Changi General Hospital, Singapore
    J Gastroenterol Hepatol 25:479-86. 2010
  7. doi request reprint Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection
    K Ming Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore 529889
    J Gastroenterol Hepatol 24:1587-600. 2009
  8. ncbi request reprint Dexlansoprazole, a modified release formulation of an enantiomer of lansoprazole, for the treatment of reflux esophagitis
    Kwong Ming Fock
    Changi General Hospital, Department of Medicine, Division of Gastroenterology, 2 Simei Street 3, 529889, Singapore
    Curr Opin Investig Drugs 9:1108-15. 2008
  9. doi request reprint Asia-Pacific consensus on the management of gastroesophageal reflux disease: update
    Kwong Ming Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    J Gastroenterol Hepatol 23:8-22. 2008
  10. doi request reprint The utility of narrow band imaging in improving the endoscopic diagnosis of gastroesophageal reflux disease
    Kwong Ming Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    Clin Gastroenterol Hepatol 7:54-9. 2009

Detail Information

Publications44

  1. ncbi request reprint Proton pump inhibitors: do differences in pharmacokinetics translate into differences in clinical outcomes?
    Kwong Ming Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    Clin Pharmacokinet 47:1-6. 2008
    ..Tenatoprazole is a new PPI that has a 5- to 7-fold longer elimination half-life than current PPIs. It could be potentially more useful for the treatment of gastro-esophageal reflux disease and nocturnal acid breakthrough than other PPIs...
  2. ncbi request reprint A randomized, placebo-controlled trial of thymosin-alpha1 and lymphoblastoid interferon for HBeAg-positive chronic hepatitis B
    Seng Gee Lim
    Department of Gastroenterology and Hepatology, National University Hospital, Singapore
    Antivir Ther 11:245-53. 2006
    ..8% improvement in HBeAg loss rates using combination therapy over interferon monotherapy. This could clinically indicate a potential important difference that would need confirmation in subsequent trials...
  3. doi request reprint Helicobacter pylori research: historical insights and future directions
    Kwong Ming Fock
    Changi General Hospital, 2 Semei Street 3, Singapore 529889
    Nat Rev Gastroenterol Hepatol 10:495-500. 2013
    ..pylori research over the past 30 years and where research should be focused in the future...
  4. pmc The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: a case-control study
    Heather Marie A Schmidt
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW, Sydney, Australia
    Gut Pathog 1:5. 2009
    ..Our results would suggest that in the clinical isolates investigated dupA is not associated with IL-8 induction in vitro...
  5. doi request reprint Gastroesophageal reflux disease
    Kwong Ming Fock
    Department of Gastroenterology, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore
    J Gastroenterol 45:808-15. 2010
    ..PPI remains the mainstay of treatment for GERD. In a subset of patients who wish to discontinue maintenance treatment, anti-reflux surgery is a therapeutic option...
  6. doi request reprint Epidemiology of Helicobacter pylori infection and gastric cancer in Asia
    Kwong Ming Fock
    Division of Gastroenterology, Changi General Hospital, Singapore
    J Gastroenterol Hepatol 25:479-86. 2010
    ..This review summarizes the current epidemiology of H. pylori infection in Asia and analyzes these data in the context of gastric cancer epidemiology...
  7. doi request reprint Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection
    K Ming Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore 529889
    J Gastroenterol Hepatol 24:1587-600. 2009
    ..Both CYP2C19 genetic polymorphisms and cigarette smoking can influence future H. pylori eradication rates...
  8. ncbi request reprint Dexlansoprazole, a modified release formulation of an enantiomer of lansoprazole, for the treatment of reflux esophagitis
    Kwong Ming Fock
    Changi General Hospital, Department of Medicine, Division of Gastroenterology, 2 Simei Street 3, 529889, Singapore
    Curr Opin Investig Drugs 9:1108-15. 2008
    ..By January 2008, an NDA for gastric acid-related diseases had been filed with the FDA, and the drug was undergoing phase II trials in Japan for gastroesophageal reflux disease...
  9. doi request reprint Asia-Pacific consensus on the management of gastroesophageal reflux disease: update
    Kwong Ming Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    J Gastroenterol Hepatol 23:8-22. 2008
    ..Since the publication of the Asia-Pacific GERD consensus in 2004, more data concerning the epidemiology and management of gastroesophageal reflux disease (GERD) have emerged. An evidence based review and update was needed...
  10. doi request reprint The utility of narrow band imaging in improving the endoscopic diagnosis of gastroesophageal reflux disease
    Kwong Ming Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    Clin Gastroenterol Hepatol 7:54-9. 2009
    ..We investigated the utility of NBI in improving the endoscopic diagnosis of GERD when compared with conventional endoscopy...
  11. doi request reprint Asia-Pacific consensus guidelines on gastric cancer prevention
    Kwong Ming Fock
    Changi General Hospital, Singapore
    J Gastroenterol Hepatol 23:351-65. 2008
    ..Gastric cancer is a major health burden in the Asia-Pacific region but consensus on prevention strategies has been lacking. We aimed to critically evaluate strategies for preventing gastric cancer...
  12. doi request reprint Global epidemiology of Barrett's esophagus
    Kwong Ming Fock
    Department of Gastroenterology, Changi General Hospital, 2 Simei Street 3, 529889 Singapore
    Expert Rev Gastroenterol Hepatol 5:123-30. 2011
    ..However, a truly cost-effective surveillance strategy remains to be determined...
  13. doi request reprint Functional dyspepsia, H. pylori and post infectious FD
    Kwong Ming Fock
    Department of Gastroenterology, Changi General Hospital, Singapore
    J Gastroenterol Hepatol 26:39-41. 2011
    ..This suggests impaired ability of the immune system to terminate the inflammatory response after acute insult...
  14. ncbi request reprint Report of the Asia-Pacific consensus on the management of gastroesophageal reflux disease
    Kwong Ming Fock
    Changi General Hospital, Singapore
    J Gastroenterol Hepatol 19:357-67. 2004
    ..Treatment of patients with typical GERD symptoms without alarm features in primary care could begin with PPI for 2 weeks followed by a further 4 weeks before going to on-demand therapy...
  15. ncbi request reprint Have Cox2 inhibitors lived up to expectations?
    Ming Fock Kwong
    Changi General Hosptial, Singapore, Singapore
    Best Pract Res Clin Gastroenterol 18:13-6. 2004
    ..Cox2 inhibitors have reduced the GI risk of patients needing anti-inflammatory drugs, but there are still unmet needs...
  16. ncbi request reprint Rabeprazole vs esomeprazole in non-erosive gastro-esophageal reflux disease: a randomized, double-blind study in urban Asia
    K M Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, 2 Simei Street 3, 529889 Singapore
    World J Gastroenterol 11:3091-8. 2005
    ..This double-blind study compared the efficacy and safety of rabeprazole with esomeprazole in relief of symptoms in patients with NERD...
  17. doi request reprint The diagnostic utility of narrow band imaging magnifying endoscopy in clinical practice in a population with intermediate gastric cancer risk
    Tiing Leong Ang
    Department of Gastroenterology, Changi General Hospital, Singapore, Singapore
    Eur J Gastroenterol Hepatol 24:362-7. 2012
    ....
  18. ncbi request reprint Helicobacter pylori eradication versus prokinetics in the treatment of functional dyspepsia: a randomized, double-blind study
    Tiing Leong Ang
    Department of Gastroenterology, Changi General Hospital, 2 Simei Street 3, Singapore, 529889, Singapore
    J Gastroenterol 41:647-53. 2006
    ..This randomized, double-blind study compared the efficacy of Helicobacter pylori eradication against prokinetics in H. pylori-infected functional dyspepsia patients...
  19. doi request reprint Is there still a role for empiric first-line triple therapy using proton pump inhibitor, amoxicillin and clarithromycin for Helicobacter pylori infection in Singapore? Results of a time trend analysis
    Tiing Leong Ang
    Department of Gastroenterology, Changi General Hospital, Singapore
    J Dig Dis 14:100-4. 2013
    ..pylori) infection in Singapore has decreased over the duration from 2005 to 2010...
  20. doi request reprint Wireless oesophageal pH monitoring: establishing values in a multiracial cohort of asymptomatic Asian subjects
    Daphne Ang
    Department of Gastroenterology, Changi General Hospital, Singapore
    Dig Liver Dis 45:371-6. 2013
    ..Wireless oesophageal (Bravo) readings in healthy European and American subjects show varied results. Values in Asians remain unstudied...
  21. ncbi request reprint Racial differences in Helicobacter pylori, serum pepsinogen and gastric cancer incidence in an urban Asian population
    Tiing Leong Ang
    Division of Gastroenterology, Changi General Hospital, Singapore
    J Gastroenterol Hepatol 20:1603-9. 2005
    ..The purpose of the present paper was to examine whether racial differences in the prevalence of Helicobacter pylori and serum pepsinogen (PG) could account for this difference...
  22. ncbi request reprint Seroreactivity to 19.5-kDa antigen in combination with absence of seroreactivity to 35-kDa antigen is associated with an increased risk of gastric adenocarcinoma
    Tju Siang Chua
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    Helicobacter 7:257-64. 2002
    ..We studied the anti-H. pylori antibody profile in Asian patients with gastric adenocarcinoma to identify any H. pylori antigen that may be associated with an increased or decreased risk of gastric carcinoma...
  23. doi request reprint Is impedance pH monitoring superior to the conventional 24-h pH meter in the evaluation of patients with laryngorespiratory symptoms suspected to be due to gastroesophageal reflux disease?
    Daphne Ang
    Department of Gastroenterology, Changi General Hospital, Singapore
    J Dig Dis 12:341-8. 2011
    ....
  24. ncbi request reprint Direct endoscopic necrosectomy: a minimally invasive endoscopic technique for the treatment of infected walled-off pancreatic necrosis and infected pseudocysts with solid debris
    Tiing Leong Ang
    Department of Gastroenterology, Changi General Hospital, 2 Simei Street 3, Singapore
    Singapore Med J 54:206-11. 2013
    ..This study examined the efficacy and safety of DEN for the treatment of infected walled-off pancreatic necrosis and infected pseudocysts with solid debris...
  25. ncbi request reprint Epinephrine injection therapy versus a combination of epinephrine injection and endoscopic hemoclip in the treatment of bleeding ulcers
    Tju Siang Chua
    Changi General Hospital, 2 Simei Street 3, Singapore 529889, Republic of Singapore
    World J Gastroenterol 11:1044-7. 2005
    ....
  26. ncbi request reprint A comparison of the clinical, demographic and psychiatric profiles among patients with erosive and non-erosive reflux disease in a multi-ethnic Asian country
    Tiing Leong Ang
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, 2 Simei Street 3, 529889, Singapore
    World J Gastroenterol 11:3558-61. 2005
    ..To examine the clinical spectrum of gastroesophageal reflux disease (GERD) and compare erosive (ERD) with non-erosive (NERD) in terms of clinical, demographic and psychiatric profiles...
  27. doi request reprint A comparison of surgery versus transcatheter angiographic embolization in the treatment of nonvariceal upper gastrointestinal bleeding uncontrolled by endoscopy
    Daphne Ang
    Department of Gastroenterology, Changi General Hospital, Singapore
    Eur J Gastroenterol Hepatol 24:929-38. 2012
    ..Percutaneous transcatheter angiographic embolization (TAE) is an alternative to surgery but remains controversial. This study compares the treatment outcomes in patients with recurrent nonvariceal upper gastrointestinal bleeding...
  28. doi request reprint EUS-guided drainage of infected pancreatic pseudocyst: use of a 10F Soehendra dilator to facilitate a double-wire technique for initial transgastric access (with videos)
    Tiing Leong Ang
    Division of Gastroenterology, Changi General Hospital, Singapore
    Gastrointest Endosc 68:192-4. 2008
  29. ncbi request reprint EUS-FNA of the left adrenal gland is safe and useful
    Tiing Leong Ang
    Division of Gastroenterology, Changi General Hospital, Singapore
    Ann Acad Med Singapore 36:954-7. 2007
    ..There are limited data on the use of endosonography-guided fine-needle aspiration (EUS-FNA) to determine the nature of left adrenal lesions. We described our experience in performing EUS-FNA of left adrenal lesions...
  30. doi request reprint To Bravo or not? A comparison of wireless esophageal pH monitoring and conventional pH catheter to evaluate non-erosive gastroesophageal reflux disease in a multiracial Asian cohort
    Daphne Ang
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    J Dig Dis 11:19-27. 2010
    ....
  31. ncbi request reprint Clinical utility, safety and tolerability of capsule endoscopy in urban Southeast Asian population
    Tiing Leong Ang
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    World J Gastroenterol 9:2313-6. 2003
    ..In this prospective study, we aimed to determine the clinical utility, safety and tolerability of capsule endoscopy in the evaluation of suspected small bowel disease in an urban Southeast Asian population...
  32. doi request reprint Variation in human genetic polymorphisms, their association with Helicobacter pylori acquisition and gastric cancer in a multi-ethnic country
    Heather Marie A Schmidt
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
    J Gastroenterol Hepatol 26:1725-32. 2011
    ..pylori infection among the major ethnicities, Chinese, Malay and Indian, resident in Singapore and Malaysia as well as the association between these polymorphisms and GC development in ethnic Chinese patients...
  33. ncbi request reprint Accuracy of endoscopic ultrasound staging of gastric cancer in routine clinical practice in Singapore
    Tiing Leong Ang
    Division of Gastroenterology, Changi General Hospital, Singapore
    Chin J Dig Dis 7:191-6. 2006
    ..Endoscopic ultrasound has emerged as the leading modality to assess the T and N stage in gastric cancer. This study aimed to assess the accuracy of TN staging by endoscopic ultrasound in routine clinical practice in Singapore...
  34. ncbi request reprint EUS-guided transduodenal biliary drainage in unresectable pancreatic cancer with obstructive jaundice
    Tiing Leong Ang
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore, Singapore
    JOP 8:438-43. 2007
    ..We herein describe our experience with two cases of unresectable pancreatic cancer associated with obstructive jaundice treated by EUS-guided biliary drainage...
  35. ncbi request reprint An audit of the outcome of long-term biliary stenting in the treatment of common bile duct stones in a general hospital
    Tiing Leong Ang
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore 529889, Singapore
    J Gastroenterol 41:765-71. 2006
    ..This study audited the clinical outcome of a cohort of patients with choledocholithiasis treated with long-term biliary stenting in order to determine the feasibility of this practice...
  36. pmc Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study
    Feng Zhu
    Department of Medicine, National University of Singapore, Singapore, Singapore
    BMC Gastroenterol 9:76. 2009
    ..A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC...
  37. doi request reprint Endoscopic drainage and endoscopic necrosectomy in the management of symptomatic pancreatic collections
    Tiing Leong Ang
    Division of Gastroenterology, Changi General Hospital, Singapore
    J Dig Dis 10:213-24. 2009
    ..To evaluate the role of endoscopic drainage and endoscopic necrosectomy in the management of symptomatic pancreatic fluid collection...
  38. ncbi request reprint Diagnosis of a metastatic phyllodes tumor of the pancreas using EUS-FNA
    Tiing Leong Ang
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore, Singapore
    JOP 8:35-8. 2007
    ..Until now, there have been no published reports on the use of EUS-FNA to diagnose recurrent phyllodes tumors metastatic to the pancreas...
  39. doi request reprint Are there roles for intraductal US and saline solution irrigation in ensuring complete clearance of common bile duct stones?
    Tiing Leong Ang
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    Gastrointest Endosc 69:1276-81. 2009
    ..CBD saline solution irrigation may flush out residual stones...
  40. ncbi request reprint Clinical profile of primary sclerosing cholangitis in Singapore
    Tiing Leong Ang
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    J Gastroenterol Hepatol 17:908-13. 2002
    ..The present study aimed to define the demographic and clinical profile of patients with PSC in Singapore...
  41. ncbi request reprint A rare case of upper GI bleeding: esophageal rupture associated with thoracic aortic aneurysm
    Tiing Leong Ang
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore, Singapore
    Gastrointest Endosc 67:151-2; commentary 152. 2008
  42. doi request reprint An analysis of the efficacy and safety of a strategy of early precut for biliary access during difficult endoscopic retrograde cholangiopancreatography in a general hospital
    Tiing Leong Ang
    Department of Gastroenterology, Changi General Hospital, Singapore
    J Dig Dis 11:306-12. 2010
    ..This study examined the efficacy and safety of a strategy of early precut for biliary access during difficult ERCP in a general hospital...
  43. ncbi request reprint Whistler summary: "the slow rate of rapid progress"
    Richard H Hunt
    J Clin Gastroenterol 41:539-45. 2007
  44. doi request reprint Gastric Cancer Consensus conference recommends Helicobacter pylori screening and treatment in asymptomatic persons from high-risk populations to prevent gastric cancer
    Nicholas J Talley
    Department of Internal Medicine and Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA
    Am J Gastroenterol 103:510-4. 2008
    ..pylori in particularly high-risk population settings. The evidence for these recommendations is summarized in this report, and the global and U.S. implications are considered...