Ken Kwok Keung Chan

Summary

Country: Singapore

Publications

  1. doi request reprint Generation of high-level stable transgene expressing human embryonic stem cell lines using Chinese hamster elongation factor-1 alpha promoter system
    Ken Kwok Keung Chan
    Stem Cell Group, Agency for Science, Technology and Research A STAR, Biopolis Way, Centros, Singapore
    Stem Cells Dev 17:825-36. 2008
  2. doi request reprint KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells
    Ken Kwok Keung Chan
    Stem Cell Group, Bioprocessing Technology Institute, A STAR Agency for Science, Technology and Research, Biopolis, Singapore
    Stem Cells 27:2114-25. 2009
  3. doi request reprint Enhanced production of neuroprogenitors, dopaminergic neurons, and identification of target genes by overexpression of sonic hedgehog in human embryonic stem cells
    Selena Meiyun Wu
    Stem Cell Group, Bioprocessing Technology Institute, A STAR Agency for Science, Technology and Research, Biopolis, Singapore, Singapore
    Stem Cells Dev 21:729-41. 2012
  4. ncbi request reprint Excess of O-linked N-acetylglucosamine modifies human pluripotent stem cell differentiation
    Julien Jean Pierre Maury
    Bioprocessing Technology Institute, Agency for Science, Technology and Research A STAR, 20 Biopolis Way, 06 01 Centros, Singapore 138668, Singapore
    Stem Cell Res 11:926-37. 2013
  5. pmc Integrated transcriptome and binding sites analysis implicates E2F in the regulation of self-renewal in human pluripotent stem cells
    Hock Chuan Yeo
    Bioprocessing Technology Institute, Agency for Science, Technology and Research A STAR, Singapore, Singapore
    PLoS ONE 6:e27231. 2011
  6. doi request reprint Role of Sonic hedgehog signaling and the expression of its components in human embryonic stem cells
    Selena Meiyun Wu
    Stem Cell Group, Bioprocessing Technology Institute, ASTAR Agency for Science, Technology and Research, 20 Biopolis Way, No 06 01 Centros, Singapore 138668, Singapore
    Stem Cell Res 4:38-49. 2010
  7. doi request reprint Technical advances to genetically engineering human embryonic stem cells
    Julien Jean Pierre Maury
    Stem Cell Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research A STAR, 20 Biopolis Way, 06 01 Centros, Singapore 138668
    Integr Biol (Camb) 3:717-23. 2011

Collaborators

Detail Information

Publications7

  1. doi request reprint Generation of high-level stable transgene expressing human embryonic stem cell lines using Chinese hamster elongation factor-1 alpha promoter system
    Ken Kwok Keung Chan
    Stem Cell Group, Agency for Science, Technology and Research A STAR, Biopolis Way, Centros, Singapore
    Stem Cells Dev 17:825-36. 2008
    ..It may have signi, cant implication for uses in bioprocess development and future development of gene-modified hESC in tissue regeneration and transplantation applications...
  2. doi request reprint KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells
    Ken Kwok Keung Chan
    Stem Cell Group, Bioprocessing Technology Institute, A STAR Agency for Science, Technology and Research, Biopolis, Singapore
    Stem Cells 27:2114-25. 2009
    ..Our results show two novel upstream transcription activators of NANOG that are functionally important for the self-renewal of hESC and provide new insights into the expanded regulatory circuitry that maintains hESC pluripotency...
  3. doi request reprint Enhanced production of neuroprogenitors, dopaminergic neurons, and identification of target genes by overexpression of sonic hedgehog in human embryonic stem cells
    Selena Meiyun Wu
    Stem Cell Group, Bioprocessing Technology Institute, A STAR Agency for Science, Technology and Research, Biopolis, Singapore, Singapore
    Stem Cells Dev 21:729-41. 2012
    ....
  4. ncbi request reprint Excess of O-linked N-acetylglucosamine modifies human pluripotent stem cell differentiation
    Julien Jean Pierre Maury
    Bioprocessing Technology Institute, Agency for Science, Technology and Research A STAR, 20 Biopolis Way, 06 01 Centros, Singapore 138668, Singapore
    Stem Cell Res 11:926-37. 2013
    ..These data will be useful for developing targeted differentiation protocols and aid in understanding the effects of O-GlcNAc on hPSC differentiation. ..
  5. pmc Integrated transcriptome and binding sites analysis implicates E2F in the regulation of self-renewal in human pluripotent stem cells
    Hock Chuan Yeo
    Bioprocessing Technology Institute, Agency for Science, Technology and Research A STAR, Singapore, Singapore
    PLoS ONE 6:e27231. 2011
    ..In addition, we proposed a core self-renewal module of regulatory interplay between E2F and, WNT and FGF pathways in these cells. Thus, we conclude that E2F plays a significant role in influencing the self-renewal capabilities of hPSCs...
  6. doi request reprint Role of Sonic hedgehog signaling and the expression of its components in human embryonic stem cells
    Selena Meiyun Wu
    Stem Cell Group, Bioprocessing Technology Institute, ASTAR Agency for Science, Technology and Research, 20 Biopolis Way, No 06 01 Centros, Singapore 138668, Singapore
    Stem Cell Res 4:38-49. 2010
    ..Our findings provide a new insight in understanding the SHH signaling in hESC and the further development of hESC differentiation for regenerative medicine...
  7. doi request reprint Technical advances to genetically engineering human embryonic stem cells
    Julien Jean Pierre Maury
    Stem Cell Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research A STAR, 20 Biopolis Way, 06 01 Centros, Singapore 138668
    Integr Biol (Camb) 3:717-23. 2011
    ..We also propose new opportunities for future developments to aid genetic modifications of hESC, and new applications for future basic and therapeutic research in hESC...