Brian Burke

Summary

Country: Singapore

Publications

  1. pmc A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton
    Henning F Horn
    Laborotory of Nuclear Dynamics and Architecture, 2 Laboratory of Developmental and Regenerative Biology, and 3 IMB Microscopy Unit, Institute of Medical Biology, 8A Biomedical Grove, Immunos, Singapore 138648
    J Cell Biol 202:1023-39. 2013
  2. doi request reprint PREEParing for mitosis
    Brian Burke
    Institute of Medical Biology, 8A Biomedical Grove, Immunos, Singapore
    Dev Cell 26:221-2. 2013
  3. doi request reprint Nuclei take a position: managing nuclear location
    Brian Burke
    Department of Anatomy and Cell Biology, The University of Florida, Gainesville, FL 32610 0235, USA
    Dev Cell 17:587-97. 2009
  4. pmc Functional association of Sun1 with nuclear pore complexes
    Qian Liu
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
    J Cell Biol 178:785-98. 2007
  5. pmc Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization
    Kyle J Roux
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 106:2194-9. 2009
  6. pmc The LINC complex is essential for hearing
    Henning F Horn
    Institute of Medical Biology, A STAR, Singapore
    J Clin Invest 123:740-50. 2013
  7. pmc Coupling of the nucleus and cytoplasm: role of the LINC complex
    Melissa Crisp
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610
    J Cell Biol 172:41-53. 2006
  8. ncbi request reprint Blurring the boundary: the nuclear envelope extends its reach
    Colin L Stewart
    Institute of Medical Biology, 61 Biopolis Drive, Proteos, Singapore 138668, Singapore
    Science 318:1408-12. 2007
  9. doi request reprint The nuclear envelope as an integrator of nuclear and cytoplasmic architecture
    Melissa Crisp
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, United States
    FEBS Lett 582:2023-32. 2008
  10. doi request reprint The nuclear lamins: flexibility in function
    Brian Burke
    Institute of Medical Biology, 8A Biomedical Grove, Immunos 06 06, Singapore 138648 Brian Burke imb a star edu sg
    Nat Rev Mol Cell Biol 14:13-24. 2013

Collaborators

  • Colin L Stewart
  • Kyle J Roux
  • Kuan Teh Jeang
  • Nelly Pante
  • Henning F Horn
  • Melissa Crisp
  • Qian Liu
  • Didier Hodzic
  • J B Rattner
  • Davide Salina
  • Graham D Wright
  • Dae In Kim
  • Karen B Avraham
  • Serguei Kozlov
  • Lilach M Friedman
  • Orit Dagan-Rosenfeld
  • Zippora Brownstein
  • Moshe Frydman
  • Esther Sook Miin Wong
  • Shaked Shivatzki
  • Amiel A Dror
  • Danielle R Lenz
  • Mohamed Elsagga
  • Tom Misteli
  • Catherine Shanahan
  • Phillip D Stahl
  • Paul Enarson

Detail Information

Publications19

  1. pmc A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton
    Henning F Horn
    Laborotory of Nuclear Dynamics and Architecture, 2 Laboratory of Developmental and Regenerative Biology, and 3 IMB Microscopy Unit, Institute of Medical Biology, 8A Biomedical Grove, Immunos, Singapore 138648
    J Cell Biol 202:1023-39. 2013
    ..These findings demonstrate that telomere attachment to the NE is insufficient to promote pairing and that telomere attachment sites must be coupled to cytoplasmic dynein and the microtubule system to ensure meiotic progression. ..
  2. doi request reprint PREEParing for mitosis
    Brian Burke
    Institute of Medical Biology, 8A Biomedical Grove, Immunos, Singapore
    Dev Cell 26:221-2. 2013
    ..REEP protein depletion results in ER membrane retention on the spindle and chromosomes, leading to defects in chromosome segregation and nuclear envelope assembly...
  3. doi request reprint Nuclei take a position: managing nuclear location
    Brian Burke
    Department of Anatomy and Cell Biology, The University of Florida, Gainesville, FL 32610 0235, USA
    Dev Cell 17:587-97. 2009
    ..Recent studies have provided insight into how nuclear components can be mechanically coupled to the cytoskeleton, providing a more complete understanding of the role of nuclear positioning in both health and disease...
  4. pmc Functional association of Sun1 with nuclear pore complexes
    Qian Liu
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
    J Cell Biol 178:785-98. 2007
    ..The implication is that Sun1 represents an important determinant of NPC distribution across the nuclear surface...
  5. pmc Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization
    Kyle J Roux
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 106:2194-9. 2009
    ..These effects can be accounted for entirely by Nesp4's kinesin-binding function. The implication is that Nesp4 may contribute to microtubule-dependent nuclear positioning...
  6. pmc The LINC complex is essential for hearing
    Henning F Horn
    Institute of Medical Biology, A STAR, Singapore
    J Clin Invest 123:740-50. 2013
    ..These results demonstrate that the LINC complex is essential for viability and normal morphology of OHCs and suggest that the position of the nucleus in sensory epithelial cells is critical for maintenance of normal hearing...
  7. pmc Coupling of the nucleus and cytoplasm: role of the LINC complex
    Melissa Crisp
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610
    J Cell Biol 172:41-53. 2006
    ..2005), support a model in which Sun proteins tether nesprins in the ONM via interactions spanning the PNS. In this way, Sun proteins and nesprins form a complex that links the nucleoskeleton and cytoskeleton (the LINC complex)...
  8. ncbi request reprint Blurring the boundary: the nuclear envelope extends its reach
    Colin L Stewart
    Institute of Medical Biology, 61 Biopolis Drive, Proteos, Singapore 138668, Singapore
    Science 318:1408-12. 2007
    ..It is becoming apparent that the nuclear envelope defines not only nuclear organization but also that of the cytoskeleton and, in this way, integrates both nuclear and cytoplasmic architecture...
  9. doi request reprint The nuclear envelope as an integrator of nuclear and cytoplasmic architecture
    Melissa Crisp
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, United States
    FEBS Lett 582:2023-32. 2008
    ..The identification of cytoskeletal binding complexes that localize to the NE now reveals a molecular framework that can seamlessly integrate nuclear and cytoplasmic architecture...
  10. doi request reprint The nuclear lamins: flexibility in function
    Brian Burke
    Institute of Medical Biology, 8A Biomedical Grove, Immunos 06 06, Singapore 138648 Brian Burke imb a star edu sg
    Nat Rev Mol Cell Biol 14:13-24. 2013
    ..The picture that is beginning to emerge is of a complex network of interactions at the nuclear periphery that may be defined by cell- and tissue-specific functions...
  11. ncbi request reprint From pore to kinetochore and back: regulating envelope assembly
    Kyle J Roux
    Department of Anatomy and Cell Biology, The University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, 32606, USA
    Dev Cell 11:276-8. 2006
    ..Two recent reports by and in the September 5 issue of Current Biology identify a novel protein, MEL-28, that shuttles between the nuclear pore complex and kinetochore and is essential for envelope assembly in C. elegans early embryos...
  12. ncbi request reprint Remodelling the walls of the nucleus
    Brian Burke
    Department of Anatomy and Cell Biology, The University of Florida, Gainesville, Florida 32610, USA
    Nat Rev Mol Cell Biol 3:487-97. 2002
  13. ncbi request reprint Cell biology. Nuclear pore complex models gel
    Brian Burke
    Department of Anatomy and Cell Biology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32606, USA
    Science 314:766-7. 2006
  14. ncbi request reprint Aspects of nuclear envelope dynamics in mitotic cells
    Brian Burke
    Department of Anatomy and Cell Biology, University of Florida, 1600 SW Archer Rd, Gainesville FL, FL 32610 0235, USA
    Novartis Found Symp 264:22-30; discussion 30-4, 227-30. 2005
    ..Our results suggest that interactions between NE membrane components are far more extensive and complex than current models suggest...
  15. pmc Nup358 integrates nuclear envelope breakdown with kinetochore assembly
    Davide Salina
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610 0235, USA
    J Cell Biol 162:991-1001. 2003
    ..Mitotic arrest associated with Nup358 depletion further suggests that mitotic checkpoint complexes may remain active at nonkinetochore sites...
  16. ncbi request reprint Life at the edge: the nuclear envelope and human disease
    Brian Burke
    Department of Anatomy and Cell Biology, University of Florida, 1600 SW Archer Road, Gainesville, Florida 32610 0235, USA
    Nat Rev Mol Cell Biol 3:575-85. 2002
    ....
  17. ncbi request reprint Nuclear envelope defects in muscular dystrophy
    Kyle J Roux
    Department of Anatomy and Cell Biology, The University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32606, USA
    Biochim Biophys Acta 1772:118-27. 2007
    ..Both emerin and lamin A/C may play an important role in the response of cells to mechanical stress and in this way may help to maintain muscle cell integrity...
  18. ncbi request reprint The laminopathies: the functional architecture of the nucleus and its contribution to disease
    Brian Burke
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida 32610
    Annu Rev Genomics Hum Genet 7:369-405. 2006
    ....
  19. ncbi request reprint Functional Architecture of the Cell's Nucleus in Development, Aging, and Disease
    Brian Burke
    Nuclear Dynamics and Architecture Group, Institute of Medical Biology, Immunos, Singapore, Singapore
    Curr Top Dev Biol 109:1-52. 2014
    ..Here, we review the contributions that mouse mutants have made to our current understanding of the NE/lamina, their respective roles in disease and the use of mice in developing potential therapies for treating the diseases. ..