Scott Sinclair

Summary

Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice
Patrudu S Makena
Department of Medicine, University of Tennessee Health Science Center, Memphis, USA
Am J Respir Cell Mol Biol 46:461-9. 2012
Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion
Scott E Sinclair
Department of Medicine, University of Tennessee Health Sciences Center, 956 Court Ave E222, Memphis, TN 38163 USA
BMC Pulm Med 10:25. 2010
Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation
Patrudu S Makena
Dept of Medicine, Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
J Appl Physiol 111:1467-76. 2011

Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice
Patrudu S Makena
Department of Medicine, University of Tennessee Health Science Center, Memphis, USA
Am J Respir Cell Mol Biol 46:461-9. 2012
..ASK-1 is an important regulator of lung injury and apoptosis in this model. Further study is needed to determine the mechanism of lung injury and apoptosis by ASK-1 and its downstream mediators in the lung...
Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion
Scott E Sinclair
Department of Medicine, University of Tennessee Health Sciences Center, 956 Court Ave E222, Memphis, TN 38163 USA
BMC Pulm Med 10:25. 2010
..This regional injury heterogeneity was abolished by the application of PEEP = 8 cm H2O. We hypothesized that the spatial distribution of lung injury correlates with areas in which cyclical airway collapse and recruitment occurs...
Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation
Patrudu S Makena
Dept of Medicine, Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
J Appl Physiol 111:1467-76. 2011
..NAC protects lung injury and apoptosis by inhibiting ROS-mediated activation of JNK and downstream proapoptotic signaling...