Scott Sinclair

Summary

Publications

  1. pmc Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice
    Patrudu S Makena
    Department of Medicine, University of Tennessee Health Science Center, Memphis, USA
    Am J Respir Cell Mol Biol 46:461-9. 2012
  2. pmc Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion
    Scott E Sinclair
    Department of Medicine, University of Tennessee Health Sciences Center, 956 Court Ave E222, Memphis, TN 38163 USA
    BMC Pulm Med 10:25. 2010
  3. pmc Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation
    Patrudu S Makena
    Dept of Medicine, Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Appl Physiol 111:1467-76. 2011

Research Grants

Collaborators

Detail Information

Publications3

  1. pmc Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice
    Patrudu S Makena
    Department of Medicine, University of Tennessee Health Science Center, Memphis, USA
    Am J Respir Cell Mol Biol 46:461-9. 2012
    ..ASK-1 is an important regulator of lung injury and apoptosis in this model. Further study is needed to determine the mechanism of lung injury and apoptosis by ASK-1 and its downstream mediators in the lung...
  2. pmc Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion
    Scott E Sinclair
    Department of Medicine, University of Tennessee Health Sciences Center, 956 Court Ave E222, Memphis, TN 38163 USA
    BMC Pulm Med 10:25. 2010
    ..This regional injury heterogeneity was abolished by the application of PEEP = 8 cm H2O. We hypothesized that the spatial distribution of lung injury correlates with areas in which cyclical airway collapse and recruitment occurs...
  3. pmc Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation
    Patrudu S Makena
    Dept of Medicine, Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Appl Physiol 111:1467-76. 2011
    ..NAC protects lung injury and apoptosis by inhibiting ROS-mediated activation of JNK and downstream proapoptotic signaling...

Research Grants6

  1. Stretch and Hyperoxia in Ventilator-induced Lung Injury
    Scott Sinclair; Fiscal Year: 2009
    ....
  2. Stretch and Hyperoxia in Ventilator-induced Lung Injury
    Scott E Sinclair; Fiscal Year: 2010
    ....