Duncan Sinclair

Summary

Publications

  1. pmc Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder
    Duncan Sinclair
    Schizophrenia Research Institute, Liverpool St, Darlinghurst, NSW, 2011, Australia
    BMC Psychiatry 12:84. 2012
  2. pmc Glucocorticoid receptor 1B and 1C mRNA transcript alterations in schizophrenia and bipolar disorder, and their possible regulation by GR gene variants
    Duncan Sinclair
    Schizophrenia Research Institute, Sydney, New South Wales, Australia
    PLoS ONE 7:e31720. 2012
  3. pmc Abnormal glucocorticoid receptor mRNA and protein isoform expression in the prefrontal cortex in psychiatric illness
    Duncan Sinclair
    Schizophrenia Research Institute, Sydney, NSW, Australia
    Neuropsychopharmacology 36:2698-709. 2011
  4. pmc Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness
    Duncan Sinclair
    1 Schizophrenia Research Institute, Sydney, New South Wales, Australia 2 Neuroscience Research Australia, Sydney, New South Wales, Australia 3 School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia 4 Neuropsychiatric Signaling Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania
    Sci Rep 3:3539. 2013

Detail Information

Publications4

  1. pmc Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder
    Duncan Sinclair
    Schizophrenia Research Institute, Liverpool St, Darlinghurst, NSW, 2011, Australia
    BMC Psychiatry 12:84. 2012
    ..A critical component of the HPA axis which mediates cellular stress responses in the OFC, and has been implicated in psychiatric illness, is the glucocorticoid receptor (GR)...
  2. pmc Glucocorticoid receptor 1B and 1C mRNA transcript alterations in schizophrenia and bipolar disorder, and their possible regulation by GR gene variants
    Duncan Sinclair
    Schizophrenia Research Institute, Sydney, New South Wales, Australia
    PLoS ONE 7:e31720. 2012
    ....
  3. pmc Abnormal glucocorticoid receptor mRNA and protein isoform expression in the prefrontal cortex in psychiatric illness
    Duncan Sinclair
    Schizophrenia Research Institute, Sydney, NSW, Australia
    Neuropsychopharmacology 36:2698-709. 2011
    ..These findings confirm total GR mRNA reductions in schizophrenia and provide the first evidence of GR protein isoform abnormalities in schizophrenia and bipolar disorder...
  4. pmc Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness
    Duncan Sinclair
    1 Schizophrenia Research Institute, Sydney, New South Wales, Australia 2 Neuroscience Research Australia, Sydney, New South Wales, Australia 3 School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia 4 Neuropsychiatric Signaling Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania
    Sci Rep 3:3539. 2013
    ..GR, co-factor and chaperone mRNA levels were strongly correlated. These results reveal coordinated cortical dysregulation of FKBP5, PTGES3, BAG1 and GR genes within the glucocorticoid signaling pathway in psychotic illness. ..