The effects of long-acting bronchodilators on total mortality in patients with stable chronic obstructive pulmonary diseaseAgnes Kliber
Department of Medicine Respiratory Division, University of British Columbia, 6040 Iona Drive, Vancouver, V6T 2E8, Canada
Respir Res 11:56. 2010
..We performed a comprehensive systematic review and meta-analysis to evaluate the effects of long-acting bronchodilators on total mortality in stable COPD...
- What to do when a smoker's CT scan is "normal"?: Implications for lung cancer screening
Joanna H Zurawska
Department of Medicine, Division of Respiratory Medicine, University of British Columbia, BC, Canada
Chest 141:1147-52. 2012
..In this article, we offer a possible low-cost strategy to risk-stratify smokers on the basis of spirometry measurements and emphysema scoring by radiologists on CT scans...
- Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease
Don D Sin
UBC James Hogg Research Centre, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
Am J Respir Crit Care Med 183:1187-92. 2011
..There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum...
The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary diseaseDon D Sin
Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, Canada
Am J Respir Crit Care Med 177:1207-14. 2008
..Small studies have suggested that inhaled corticosteroids can suppress systemic inflammation in chronic obstructive pulmonary disease (COPD)...
- Marijuana and chronic obstructive lung disease: a population-based study
Wan C Tan
iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital and the University of British Columbia, Vancouver, Canada
CMAJ 180:814-20. 2009
..Our aim was to determine the combined and independent effects of tobacco and marijuana smoking on respiratory symptoms and chronic obstructive pulmonary disease (COPD) in the general population...
- Budesonide and the risk of pneumonia: a meta-analysis of individual patient data
Don D Sin
Providence Heart and Lung Institute, St Paul s Hospital iCAPTURE Centre, and Department of Medicine Division of Respirology, University of British Columbia, Vancouver, BC, Canada
Lancet 374:712-9. 2009
..We aimed to establish the effects of inhaled budesonide on the risk of pneumonia in such patients...
- Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancer
Don D Sin
St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Chest 134:582-8. 2008
..Surfactant dysfunction has been implicated in both lung cancer and COPD. This study evaluated the relationship between surfactant protein D (SP-D) and the progression of bronchial dysplasia in heavy smokers...
- Acute lung injury induces cardiovascular dysfunction: effects of IL-6 and budesonide/formoterol
Koichi Suda
Division of Respiratory Medicine, University of British Columbia, Providence Heart and Lung Institute, St Paul s Hospital, 1081 Burrard St, Vancouver, British Columbia V6Z 1Y6, Canada
Am J Respir Cell Mol Biol 45:510-6. 2011
..ICS/LABA may reduce acute cardiovascular events related to ALI...
- Can inhaled fluticasone alone or in combination with salmeterol reduce systemic inflammation in chronic obstructive pulmonary disease? Study protocol for a randomized controlled trial [NCT00120978]
Don D Sin
Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada
BMC Pulm Med 6:3. 2006
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Do chronic inhaled steroids alone or in combination with a bronchodilator prolong life in chronic obstructive pulmonary disease patients?Don D Sin
The University of British Columbia Respiratory Division, Vancouver, British Columbia, Canada
Curr Opin Pulm Med 13:90-7. 2007
..Whether these medications prolong survival is uncertain...
- Endotoxin-induced translocation of interleukin-6 from lungs to the systemic circulation
Eiji Tamagawa
Division of Respiratory Medicine, The University of British Columbia, the Providence Heart and Lung Institute and The James Hogg iCapture Center for Cardiovascular and Pulmonary Research St Paul s Hospital, Vancouver, BC, Canada
Innate Immun 15:251-8. 2009
..This murine model facilitates the estimation of cytokine translocation across the lungs and evaluation of compounds to modulate this gradient...
- Effect of gene environment interactions on lung function and cardiovascular disease in COPD
Tillie Louise Hackett
University of British Columbia, James Hogg Research Laboratories, St Paul s Hospital, Division of Respirology, Department of Medicine, Vancouver, BC, Canada
Int J Chron Obstruct Pulmon Dis 6:277-87. 2011
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- Corticosteroids and adrenoceptor agonists: the compliments for combination therapy in chronic airways diseases
Don D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, and Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, B C, Canada V6Z 1Y6
Eur J Pharmacol 533:28-35. 2006
..There is a large clinical trial currently underway, which will provide mortality data by the year 2006. On balance, clinical evidence supports the use of combination therapy in moderate to severe asthma and COPD...
- Systemic inflammation and mortality in chronic obstructive pulmonary disease
Don D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul, s Hospital, Vancouver, Canada
Can J Physiol Pharmacol 85:141-7. 2007
..Systemic inflammation may contribute substantially to the overall morbidity and mortality of COPD patients...
- Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality
John Hill
Providence Heart and Lung Institute and The UBC James Hogg Research Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Eur Heart J 32:1918-25. 2011
..Surfactant protein-D (SP-D) is a lung-specific protein that is detectable in human plasma. We determined the relationship of circulating SP-D to cardiovascular disease (CVD) and total mortality in subjects with and without CVD...
- Particulate matter induces translocation of IL-6 from the lung to the systemic circulation
Takashi Kido
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
Am J Respir Cell Mol Biol 44:197-204. 2011
..These results support our hypothesis that exposure to PM(10) increases pulmonary inflammatory mediators that translocate to the circulation, contributing to systemic inflammation, with downstream effects such as vascular dysfunction...
- The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis
David A Ngan
UBC James Hogg Research Centre, Institute for Heart Lung Health at St, Paul s Hospital and Department of Medicine, University of British Columbia, Vancouver, BC, Canada
BMC Pulm Med 12:3. 2012
..The relationship of plasma inflammatory biomarkers to lung function and hospitalization history remains largely unexplored...
- Sex-related differences in serum cotinine concentrations in daily cigarette smokers
Wen Qi Gan
The Heart and Lung Institute and the James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research at St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Nicotine Tob Res 10:1293-300. 2008
..These findings indicate that significant sex-related differences exist in serum cotinine levels among smokers, which suggests that self-reports may overestimate cigarette exposure in women compared with men...
- Recruitment for a provincial asthma study. Participation of network and non-network primary care physicians
Don D Sin
Department of Medicine, University of British Columbia, Vancouver
Can Fam Physician 50:1251-4. 2004
- Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease
Andrew Churg
Department of Pathology and UBC James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
Am J Respir Crit Care Med 185:34-43. 2012
..Myeloperoxidase (MPO), a neutrophil and macrophage product, is important in bacterial killing, but also drives inflammatory reactions and tissue oxidation...
- Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology
James C Hogg
University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
Am J Respir Crit Care Med 176:454-9. 2007
..COPD is associated with reduced life expectancy...
- The relationship between lung inflammation and cardiovascular disease
Stephan van Eeden
Division of Respiratory Medicine, Department of Medicine, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Am J Respir Crit Care Med 186:11-6. 2012
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- Treatment of mild chronic obstructive pulmonary disease
Alex Chee
Department of Medicine, Division of Respirology, The University of British Columbia and Providence Heart and Lung Institute and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
Int J Chron Obstruct Pulmon Dis 3:563-73. 2008
..Influenza and pneumococcal vaccination and pulmonary rehabilitation are other therapies that may be considered for select patients with mild disease. In this paper, we summarize the current standard of care for patients with mild COPD...
- Effects of corticosteroids on systemic inflammation in chronic obstructive pulmonary disease
S F Paul Man
Department of Medicine, University of British Columbia, Canada
Proc Am Thorac Soc 2:78-82. 2005
..We found that withdrawal of inhaled corticosteroids increased serum CRP levels, and that reintroduction of inhaled fluticasone could suppress CRP levels...
- Effects of inhaled corticosteroids on sputum cell counts in stable chronic obstructive pulmonary disease: a systematic review and a meta-analysis
Wen Qi Gan
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital and the Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
BMC Pulm Med 5:3. 2005
..We sought to determine the effects of inhaled corticosteroids on sputum indices of inflammation in stable COPD...
- The effects of inhaled and oral corticosteroids on serum inflammatory biomarkers in COPD: an exploratory study
S F Paul Man
Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Ther Adv Respir Dis 3:73-80. 2009
..Several studies suggest that inhaled and oral corticosteroids repress systemic inflammation in chronic obstructive pulmonary disease (COPD). However, the cytokines that may respond to these medications are unclear...
- The airway epithelium: more than just a structural barrier
Anthony Tam
The UBC James Hogg Research Centre, Providence Heart and Lung Centre and Department of Medicine, University of British Columbia, UBC, Vancouver, BC, Canada
Ther Adv Respir Dis 5:255-73. 2011
..In this paper, we review the current understanding of the airway epithelial response to injury and its interaction with inflammatory cells, in particular the neutrophil...
- The interactions between cigarette smoking and reduced lung function on systemic inflammation
Wen Qi Gan
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Room No. 368A, 1081 Burrard St, Vancouver, BC, V6Z 1Y6 Canada
Chest 127:558-64. 2005
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- Inhaled corticosteroids in chronic obstructive pulmonary disease: is there a clinical benefit?
S F Paul Man
Department of Medicine, Pulmonary Division, St Paul s Hospital, Vancouver, British Columbia
Drugs 65:579-91. 2005
..On balance, for those with moderate-to-severe COPD and those who experience frequent exacerbations, judicious use of inhaled corticosteroids alone or in combination with long-acting beta2-adrenoceptor agonists appears reasonable...
- Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study
Don D Sin
The University of British Columbia Respiratory Division, Vancouver, BC
BMC Pulm Med 7:13. 2007
..The principal aim of this pilot study was to determine whether circulating surfactant protein D (SPD) or Clara Cell protein-16 (CC16) levels are associated with lung function or health status in patients with severe COPD...
- The relationship between telomere length and mortality in chronic obstructive pulmonary disease (COPD)
Jee Lee
The Providence Heart and Lung Institute at St Paul s Hospital, The UBC James Hogg Research Centre and Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada
PLoS ONE 7:e35567. 2012
..In conclusion, COPD patients have short leukocyte telomeres, which are in turn associated increased risk of total and cancer mortality. Accelerated aging is of particular relevance to cancer mortality in COPD...
- Effects of increased primary care access on process of care and health outcomes among patients with asthma who frequent emergency departments
Don D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
Am J Med 117:479-83. 2004
..This study was conducted to determine the effectiveness of a health professional-based intervention in improving process of care and health outcomes among asthmatic patients discharged from emergency departments...
- Impact of cancers and cardiovascular diseases in chronic obstructive pulmonary disease
Don D Sin
Respiratory Division, Department of Medicine, University of British Columbia, Canada
Curr Opin Pulm Med 14:115-21. 2008
..Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in patients with chronic obstructive pulmonary disease. The epidemiological and mechanistic evidence linking these disorders, however, is uncertain...
- Pharmacotherapy for mortality reduction in chronic obstructive pulmonary disease
Don D Sin
The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
Proc Am Thorac Soc 3:624-9. 2006
..This article reviews some of the relevant epidemiologic and pathophysiologic processes that affect mortality in COPD and critically examines the effect of current COPD therapies on mortality...
- Novel properties of statins: suppression of the systemic and bone marrow responses induced by exposure to ambient particulate matter (PM(10)) air pollution
Ryohei Miyata
UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, UK
Am J Physiol Lung Cell Mol Physiol 303:L492-9. 2012
..01). We conclude that lovastatin downregulates the PM(10)-induced overactive bone marrow by attenuating PM(10)-induced systemic inflammatory responses...
- Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction
Eiji Tamagawa
Division of Respiratory Medicine, University of British Columbia and James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia, Canada
Am J Physiol Lung Cell Mol Physiol 295:L79-85. 2008
..This suggests that PM-induced lung and systemic inflammatory responses contribute to the adverse vascular events associated with exposure to air pollution...
- Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis
Wen Qi Gan
James Hogg iCAPTURE Center for Cardiovascular and Respiratory Research, University of British Columbia, Vancouver, BC, Canada
Respir Res 7:52. 2006
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- Understanding the biological differences in susceptibility to chronic obstructive pulmonary disease between men and women
Don D Sin
University of British Columbia, Vancouver, British Columbia, Canada
Proc Am Thorac Soc 4:671-4. 2007
..This article reviews this and other potential mechanisms that may confer increased susceptibility of COPD to female smokers...
- Surfactant protein D: a lung specific biomarker in COPD?
Don D Sin
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
Ther Adv Respir Dis 2:65-74. 2008
..In this paper, we review one promising systemic biomarker that ful"lls some of these criteria, surfactant protein D (SPD)...
- Biomarkers in chronic obstructive pulmonary disease
Don D Sin
Department of Medicine, Division of Respiratory Medicine, the University of British Columbia and The Providence Heart and Lung Institute, James Hogg iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
Proc Am Thorac Soc 6:543-5. 2009
..In this article, we discuss the current barriers of biomarker discovery and propose possible criteria and methods for developing novel biomarkers in COPD...
- New and current clinical imaging techniques to study chronic obstructive pulmonary disease
Harvey O Coxson
Providence Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
Am J Respir Crit Care Med 180:588-97. 2009
..In this article, we provide an overview of these imaging modalities in the context of COPD and discuss their strengths as well as their limitations for providing quantitative COPD phenotypes...
- The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature
Don D Sin
Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
Chest 127:1952-9. 2005
..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking...
- Unifying thoracic biomarkers: surfactant protein-D and beyond
Jen Erh Jaw
UBC James Hogg Research Center, The Institute for Heart and Lung Health, St Paul s Hospital and Department of Medicine Pulmonary Division, University of British Columbia, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
Expert Rev Respir Med 6:147-54. 2012
..In this paper, we discuss surfactant protein-D and other pneumoproteins as promising biomarkers of COPD...
- Improved patient outcome with smoking cessation: when is it too late?
Jane Wu
Department of Medicine Division of Respirology, The University of British Columbia, Vancouver, BC, Canada
Int J Chron Obstruct Pulmon Dis 6:259-67. 2011
..In this paper, we summarize the evidence for tobacco treatment and the methods by which smoking cessation can be promoted in smokers with lung disease...
- Airway wall thickness assessed using computed tomography and optical coherence tomography
Harvey O Coxson
Department of Radiology, Vancouver General Hospital, 855 West 12th Avenue, Room 3350 JPN, Vancouver, BC, Canada
Am J Respir Crit Care Med 177:1201-6. 2008
..Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less...
- Effects of nocturnal noninvasive mechanical ventilation on heart rate variability of patients with advanced COPD
Don D Sin
Pulmonary Division, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada
Chest 131:156-63. 2007
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- The growing burden of chronic obstructive pulmonary disease and lung cancer in women: examining sex differences in cigarette smoke metabolism
Sigal Ben Zaken Cohen
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, and the Department of Medicine, The University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
Am J Respir Crit Care Med 176:113-20. 2007
..In this article, we explore CYP and other related pathways as potential mechanisms and targets of future research and novel discoveries to curb the growing epidemic of COPD and lung cancer in women...
- The relationship between stage 1 and 2 non-small cell lung cancer and lung function in men and women
Samir Malhotra
Respiratory Division, Department of Medicine, University of British Columbia, British Columbia, Canada
BMC Pulm Med 6:2. 2006
..Using a large tissue registry, we sought to determine the relationship between FEV1 and subtypes of NSCLC and determine whether this relationship is modified by gender...
- Everything prevents emphysema: are animal models of cigarette smoke-induced chronic obstructive pulmonary disease any use?
Andrew Churg
Department of Pathology, University of British Columbia, Vancouver, Canada
Am J Respir Cell Mol Biol 45:1111-5. 2011
..This approach, combined with the realization that human COPD probably needs early rather than late treatment, may make development of treatments based on animal models more relevant...
- The influence of gender on the effects of aspirin in preventing myocardial infarction
Todd Yerman
Department of Medicine Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital, Vancouver, British Columbia, Canada
BMC Med 5:29. 2007
..We conducted a systematic review and meta-analysis to determine whether gender mix might play a role in explaining the large variation of aspirin efficacy across primary and secondary MI prevention trials...
- Is the aging process accelerated in chronic obstructive pulmonary disease?
Jee Lee
Department of Medicine and the Providence Heart and Lung Institute at St Paul s Hospital, The University of British Columbia James Hogg Research Centre, Vancouver, British Columbia, Canada
Curr Opin Pulm Med 17:90-7. 2011
..The purpose of this review is to provide a comprehensive overview of the senescence hypothesis of COPD and summarize methods that are used to assess cellular aging...
- Quantification of lung surface area using computed tomography
Ren Yuan
University of British Columbia James Hogg Research Centre and the Heart and Lung Institute, St Paul s Hospital, Burrard Street, Vancouver, Canada
Respir Res 11:153. 2010
..To incorporate both regional lung density measured by CT and cluster analysis of low attenuation areas for comparison with histological measurement of surface area per unit lung volume...
- Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality
Don D Sin
Department of Medicine, University of British Columbia, Canada
Proc Am Thorac Soc 2:8-11. 2005
..These data indicate that chronic obstructive pulmonary disease is a powerful, independent risk factor for cardiovascular morbidity and mortality...
- Commentary: fuelling the fire--systemic inflammation and development of lung disease in the general community
Don D Sin
The James Hogg Icapture Center For Cardiovascular, Pulmonary Research, St Paul's Hospital, Vancouver, BC, Canada
Int J Epidemiol 35:1008-10. 2006
- Acute exacerbation of chronic obstructive pulmonary disease: influence of social factors in determining length of hospital stay and readmission rates
Alyson W M Wong
The James iCAPTURE Centre for Cardiovascular and pulmonary Research, Heart and Lung Institute, St Paul s Hospital, Providence Healthcare, University of British Columbia, Vancouver, British Columbia, Canada
Can Respir J 15:361-4. 2008
..Identifying factors that influence the time a patient spends in the hospital and readmission rates will allow for better use of scarce hospital resources...
- Small-airway obstruction and emphysema in chronic obstructive pulmonary disease
John E McDonough
University of British Columbia James Hogg Research Centre, St Paul s Hospital, Vancouver, BC, Canada
N Engl J Med 365:1567-75. 2011
..We wanted to determine whether there was a relationship between small-airway obstruction and emphysematous destruction in COPD...
- The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
Jeremy A Hirota
St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
J Allergy Clin Immunol 129:1116-25.e6. 2012
..The airway epithelium is the first line of defense against inhaled insults and therefore must be capable of coordinating appropriate inflammatory and immune responses...
- Combination therapy of inhaled corticosteroids and long-acting beta2-adrenergics in management of patients with chronic obstructive pulmonary disease
Don D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
Curr Pharm Des 10:3547-60. 2004
..This article will present a comprehensive overview of the currently available clinical evidence for the use of combination therapy as well as the potential mechanisms of their actions in COPD...
- Phenotyping airway disease with optical coherence tomography
Harvey O Coxson
Providence Heart and Lung Institute and The UBC James Hogg Research Center, St Paul s Hospital, Vancouver, British Columbia, Canada
Respirology 16:34-43. 2011
..In this paper, we review the current state of knowledge of OCT and its possible application in airway diseases...
- Pharmacotherapy in pulmonary arterial hypertension: a systematic review and meta-analysis
Christopher J Ryerson
Department of Medicine, University of British Columbia, Vancouver, Canada
Respir Res 11:12. 2010
..Previous meta-analyses of treatments for pulmonary arterial hypertension (PAH) have not shown mortality benefit from any individual class of medication...
- Pathologic patterns and survival in chronic hypersensitivity pneumonitis
Andrew Churg
Department of Pathology, University of British Columbia, Vancouver, BC, Canada
Am J Surg Pathol 33:1765-70. 2009
..Most cases of chronic HP have distinctive pathologic features, but a small percentage of cases cannot be pathologically distinguished from UIP...
- Systemic consequences of COPD
Jan Tkac
The University of British Columbia Respiratory Division, Vancouver, BC
Ther Adv Respir Dis 1:47-59. 2007
..In this paper, we review some of the common and serious extra-pulmonary manifestations of COPD and the potential mechanisms by which they can be linked with COPD...
- The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease
David A Ngan
James Hogg Research Laboratories, Providence Heart Lung Institute at St Paul s Hospital and Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Ther Adv Respir Dis 3:113-29. 2009
..In this paper, we review the potential pathogenic contributions of GzmB to the pathogenesis of COPD...
- Chronic obstructive pulmonary disease: a novel risk factor for cardiovascular disease
Don D Sin
Department of Medicine, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
Can J Physiol Pharmacol 83:8-13. 2005
..In this paper, we discuss the epidemiologic evidence linking COPD and cardiovascular events as well as the potential mechanism(s) which may be responsible for this association...
- Vascular risk in chronic obstructive pulmonary disease: role of inflammation and other mediators
S F Paul Man
Department of Medicine Division of Respiratory Medicine, University of British Columbia UBC, and the UBC James Hogg Centre for Cardiovascular and Pulmonary Research, Institute for Heart and Lung Health, St Paul s Hospital, Vancouver, BC, Canada
Can J Cardiol 28:653-61. 2012
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- Emerging drugs for the treatment of chronic obstructive pulmonary disease
Samir Malhotra
University of British Columbia and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Respiratory Division, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
Expert Opin Emerg Drugs 11:275-91. 2006
..Many of these drugs may enter the COPD market within the next decade. This paper reviews the molecular rationale for these emerging drugs and their potential efficacy in COPD...
- The role of female hormones on lung function in chronic lung diseases
Anthony Tam
The UBC James Hogg Research Centre, Providence Heart Lung Centre and Department of Medicine, University of British Columbia UBC, Vancouver, BC, Canada
BMC Womens Health 11:24. 2011
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- Chronic obstructive pulmonary disease: a chronic systemic inflammatory disease
Stephan F van Eeden
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, and Respiratory Division, St Paul s Hospital, Vancouver, B C, Canada
Respiration 75:224-38. 2008
..This review describes the nature of the systemic inflammatory response in COPD and the clinical manifestations associated with the systemic response, with a focus on the potential mechanisms for these adverse health effects...
- Contemporary management of acute exacerbations of COPD: a systematic review and metaanalysis
Bradley S Quon
Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, BC, Canada
Chest 133:756-66. 2008
..However, their clinical benefits in various settings are uncertain. We undertook a systematic review and metaanalysis to systematically evaluate the effectiveness of these therapies...
- Forced expiratory volume in 1 second and physical activity in the general population
Don D Sin
Department of Medicine, University of British Columbia, Vancouver, Canada
Am J Med 117:270-3. 2004
- Biomarkers of therapeutic response in patients with chronic obstructive pulmonary disease: a critical review of the literature
Ho Il Yoon
UBC James Hogg Research Center, The Providence Heart and Lung Institute, St Pauls Hospital, Vancouver, BC, Canada
Drugs 71:1821-37. 2011
..However, the clinical data have been inconsistent. Non-specific inflammatory biomarkers such as C-reactive protein and interleukin-6 lack specificity for COPD and thus are of limited clinical usefulness...
- The tip of the "ICEBERGS": a National Conference to Combat the Growing Global Epidemic of COPD in women
Don D Sin
James Hogg iCAPTURE Center, St. Paul's Hospital, Vancouver, BC, V6Z 1Y6 Canada
Proc Am Thorac Soc 4:669-70. 2007
- Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling
Joanne L Wright
Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
Am J Respir Crit Care Med 183:50-8. 2011
..the potential role of statins in treating chronic obstructive pulmonary disease (COPD) is controversial, and it is unclear what anatomic COPD lesions statins affect...
- Prevalence of pulmonary embolism in acute exacerbations of COPD: a systematic review and metaanalysis
Jacques Rizkallah
Department of Medicine, Respiratory Division, University of British Columbia, Heart and Lung Center, James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research at St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Chest 135:786-93. 2009
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- Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease
Don D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
Am J Respir Crit Care Med 170:760-5. 2004
..Inhaled and oral corticosteroids are effective in reducing serum CRP levels in patients with COPD and suggest their potential use for improving cardiovascular outcomes in COPD...
- Effects of inhaled corticosteroids on airway inflammation in chronic obstructive pulmonary disease: a systematic review and meta-analysis
Rachel Jen
Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, BC, Canada
Int J Chron Obstruct Pulmon Dis 7:587-95. 2012
..The effect of inhaled corticosteroids (ICS) on lung inflammation in COPD remains uncertain. We sought to determine the effects of ICS on inflammatory indices in bronchial biopsies and bronchoalveolar lavage fluid of patients with COPD...
- Potential role of stem cells in management of COPD
Tillie L Hackett
UBC James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, Vancouver, BC, Canada
Int J Chron Obstruct Pulmon Dis 5:81-8. 2010
..Herein we review the current literature on the characterization of resident stem and progenitor cell niches within the lung, the contribution of mesenchymal stem cells to lung regeneration, and advances in bioengineering of lung tissue...
- Developments in drugs for the treatment of chronic obstructive pulmonary disease
Tammy Sy Mui
The Providence Heart and Lung Center, The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital and the Department of Medicine Respiratory Division, The University of British Columbia, Vancouver, BC, Canada
Expert Rev Clin Immunol 4:365-77. 2008
..In this article, we will review the current paradigm of COPD pathogenesis and discuss some promising molecular targets that may be modified in the future to improve health outcomes of patients with COPD...
