Don D Sin

Summary

Publications

  1. pmc The effects of long-acting bronchodilators on total mortality in patients with stable chronic obstructive pulmonary disease
    Agnes Kliber
    Department of Medicine Respiratory Division, University of British Columbia, 6040 Iona Drive, Vancouver, V6T 2E8, Canada
    Respir Res 11:56. 2010
  2. pmc Effects of inhaled corticosteroids on airway inflammation in chronic obstructive pulmonary disease: a systematic review and meta-analysis
    Rachel Jen
    Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 7:587-95. 2012
  3. pmc Improved patient outcome with smoking cessation: when is it too late?
    Jane Wu
    Department of Medicine Division of Respirology, The University of British Columbia, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 6:259-67. 2011
  4. pmc The relationship between telomere length and mortality in chronic obstructive pulmonary disease (COPD)
    Jee Lee
    The Providence Heart and Lung Institute at St Paul s Hospital, The UBC James Hogg Research Centre and Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 7:e35567. 2012
  5. pmc Budesonide/Formoterol Enhances the Expression of Pro Surfactant Protein-B in Lungs of COPD Patients
    Soo Jung Um
    UBC James Hogg Research Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital Providence Health Care, University of British Columbia, Vancouver, BC, Canada Department of Medicine Division of Respiratory Medicine, Dong A University, Busan, Korea
    PLoS ONE 8:e83881. 2013
  6. pmc Potential role of stem cells in management of COPD
    Tillie L Hackett
    UBC James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 5:81-8. 2010
  7. pmc The relation of serum myeloperoxidase to disease progression and mortality in patients with chronic obstructive pulmonary disease (COPD)
    Hye Yun Park
    UBC James Hogg Research Center and The Institute of Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 8:e61315. 2013
  8. pmc Bacterial microbiome of lungs in COPD
    Marc A Sze
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 9:229-38. 2014
  9. pmc Lung inflammation in COPD: why does it matter?
    Jin Young Oh
    UBC James Hogg Research Center, St Paul s Hospital Vancouver, BC, Canada Division of Pulmonology, Department of Internal Medicine, Dongguk University Ilsan Hospital Goyang, South Korea
    F1000 Med Rep 4:23. 2012
  10. pmc Integrative approach to quality assessment of medical journals using impact factor, eigenfactor, and article influence scores
    Jacques Rizkallah
    Department of Medicine Respiratory Division and the Providence Heart and Lung Institute at St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 5:e10204. 2010

Detail Information

Publications98

  1. pmc The effects of long-acting bronchodilators on total mortality in patients with stable chronic obstructive pulmonary disease
    Agnes Kliber
    Department of Medicine Respiratory Division, University of British Columbia, 6040 Iona Drive, Vancouver, V6T 2E8, Canada
    Respir Res 11:56. 2010
    ..We performed a comprehensive systematic review and meta-analysis to evaluate the effects of long-acting bronchodilators on total mortality in stable COPD...
  2. pmc Effects of inhaled corticosteroids on airway inflammation in chronic obstructive pulmonary disease: a systematic review and meta-analysis
    Rachel Jen
    Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 7:587-95. 2012
    ..The effect of inhaled corticosteroids (ICS) on lung inflammation in COPD remains uncertain. We sought to determine the effects of ICS on inflammatory indices in bronchial biopsies and bronchoalveolar lavage fluid of patients with COPD...
  3. pmc Improved patient outcome with smoking cessation: when is it too late?
    Jane Wu
    Department of Medicine Division of Respirology, The University of British Columbia, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 6:259-67. 2011
    ..In this paper, we summarize the evidence for tobacco treatment and the methods by which smoking cessation can be promoted in smokers with lung disease...
  4. pmc The relationship between telomere length and mortality in chronic obstructive pulmonary disease (COPD)
    Jee Lee
    The Providence Heart and Lung Institute at St Paul s Hospital, The UBC James Hogg Research Centre and Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 7:e35567. 2012
    ..In conclusion, COPD patients have short leukocyte telomeres, which are in turn associated increased risk of total and cancer mortality. Accelerated aging is of particular relevance to cancer mortality in COPD...
  5. pmc Budesonide/Formoterol Enhances the Expression of Pro Surfactant Protein-B in Lungs of COPD Patients
    Soo Jung Um
    UBC James Hogg Research Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital Providence Health Care, University of British Columbia, Vancouver, BC, Canada Department of Medicine Division of Respiratory Medicine, Dong A University, Busan, Korea
    PLoS ONE 8:e83881. 2013
    ..The purpose of this study was to determine the relationship of surfactants and other pneumoproteins in bronchoalveolar lavage (BAL) fluid and plasma to airflow limitation and the effects of budesonide/formoterol on this relationship...
  6. pmc Potential role of stem cells in management of COPD
    Tillie L Hackett
    UBC James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 5:81-8. 2010
    ..Herein we review the current literature on the characterization of resident stem and progenitor cell niches within the lung, the contribution of mesenchymal stem cells to lung regeneration, and advances in bioengineering of lung tissue...
  7. pmc The relation of serum myeloperoxidase to disease progression and mortality in patients with chronic obstructive pulmonary disease (COPD)
    Hye Yun Park
    UBC James Hogg Research Center and The Institute of Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 8:e61315. 2013
    ....
  8. pmc Bacterial microbiome of lungs in COPD
    Marc A Sze
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 9:229-38. 2014
    ..This review summarizes the current knowledge concerning the lung microbiota in COPD and its potential implications for pathogenesis of the disease. ..
  9. pmc Lung inflammation in COPD: why does it matter?
    Jin Young Oh
    UBC James Hogg Research Center, St Paul s Hospital Vancouver, BC, Canada Division of Pulmonology, Department of Internal Medicine, Dongguk University Ilsan Hospital Goyang, South Korea
    F1000 Med Rep 4:23. 2012
    ..This article provides a synopsis of the possible role that lung inflammation plays in the pathogenesis of COPD...
  10. pmc Integrative approach to quality assessment of medical journals using impact factor, eigenfactor, and article influence scores
    Jacques Rizkallah
    Department of Medicine Respiratory Division and the Providence Heart and Lung Institute at St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 5:e10204. 2010
    ..The principal aim was to compare the temporal trends in IF, ES, and AIS on the rank order of leading medical journals over time...
  11. pmc Future impact of various interventions on the burden of COPD in Canada: a dynamic population model
    Mehdi Najafzadeh
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e46746. 2012
    ..The impact of other strategies such as interventions that predict risk of disease, reduce progression of disease, or reduce exacerbations has not been systematically studied...
  12. pmc Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease
    Don D Sin
    UBC James Hogg Research Centre, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Crit Care Med 183:1187-92. 2011
    ..There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum...
  13. doi request reprint The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, Canada
    Am J Respir Crit Care Med 177:1207-14. 2008
    ..Small studies have suggested that inhaled corticosteroids can suppress systemic inflammation in chronic obstructive pulmonary disease (COPD)...
  14. ncbi request reprint Endotoxin-induced cardiovascular dysfunction in mice: effect of simvastatin
    Koichi Suda
    Division of Respiratory Medicine, The University of British Columbia, the Providence Heart and Lung Institute and The James Hogg iCapture Center for Cardiovascular and Pulmonary Research St Paul s Hospital, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 111:1118-24. 2011
    ..SS significantly improved LPS-induced cardiovascular dysfunction possibly by reducing systemic expression of IL-6 and its downstream signaling pathways. These findings may explain how statins improve health outcomes in patients with ALI...
  15. pmc Club cell protein 16 and disease progression in chronic obstructive pulmonary disease
    Hye Yun Park
    1 University of British Columbia James Hogg Research Center and the Institute for Heart and Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 188:1413-9. 2013
    ..Club (Clara) cell protein 16 (CC-16) is a protein that is synthesized predominantly in the lungs and is detectable in serum. Its expression decreases with lung injury and smoking, and is thus a marker of bronchial cell dysfunction...
  16. pmc Marijuana and chronic obstructive lung disease: a population-based study
    Wan C Tan
    iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital and the University of British Columbia, Vancouver, Canada
    CMAJ 180:814-20. 2009
    ..Our aim was to determine the combined and independent effects of tobacco and marijuana smoking on respiratory symptoms and chronic obstructive pulmonary disease (COPD) in the general population...
  17. doi request reprint Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancer
    Don D Sin
    St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Chest 134:582-8. 2008
    ..Surfactant dysfunction has been implicated in both lung cancer and COPD. This study evaluated the relationship between surfactant protein D (SP-D) and the progression of bronchial dysplasia in heavy smokers...
  18. doi request reprint Budesonide and the risk of pneumonia: a meta-analysis of individual patient data
    Don D Sin
    Providence Heart and Lung Institute, St Paul s Hospital iCAPTURE Centre, and Department of Medicine Division of Respirology, University of British Columbia, Vancouver, BC, Canada
    Lancet 374:712-9. 2009
    ..We aimed to establish the effects of inhaled budesonide on the risk of pneumonia in such patients...
  19. ncbi request reprint The complex relationship of serum adiponectin to COPD outcomes COPD and adiponectin
    Ho Il Yoon
    University of British Columbia James Hogg Research Center, Vancouver, BC, Canada
    Chest 142:893-99. 2012
    ..Adiponectin is a hormone that has anti inflammatory, antidiabetic, and anti atherogenic activities. We investigated the relationship of serum adiponectin to health outcomes in COPD...
  20. pmc Effect of gene environment interactions on lung function and cardiovascular disease in COPD
    Tillie Louise Hackett
    University of British Columbia, James Hogg Research Laboratories, St Paul s Hospital, Division of Respirology, Department of Medicine, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 6:277-87. 2011
    ....
  21. doi request reprint Acute lung injury induces cardiovascular dysfunction: effects of IL-6 and budesonide/formoterol
    Koichi Suda
    Division of Respiratory Medicine, University of British Columbia, Providence Heart and Lung Institute, St Paul s Hospital, 1081 Burrard St, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Respir Cell Mol Biol 45:510-6. 2011
    ..ICS/LABA may reduce acute cardiovascular events related to ALI...
  22. doi request reprint The relationship between lung inflammation and cardiovascular disease
    Stephan van Eeden
    Division of Respiratory Medicine, Department of Medicine, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 186:11-6. 2012
    ....
  23. pmc What to do when a smoker's CT scan is "normal"?: Implications for lung cancer screening
    Joanna H Zurawska
    Department of Medicine, Division of Respiratory Medicine, University of British Columbia, BC, Canada
    Chest 141:1147-52. 2012
    ..In this article, we offer a possible low-cost strategy to risk-stratify smokers on the basis of spirometry measurements and emphysema scoring by radiologists on CT scans...
  24. ncbi request reprint Corticosteroids and adrenoceptor agonists: the compliments for combination therapy in chronic airways diseases
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, and Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, B C, Canada V6Z 1Y6
    Eur J Pharmacol 533:28-35. 2006
    ..There is a large clinical trial currently underway, which will provide mortality data by the year 2006. On balance, clinical evidence supports the use of combination therapy in moderate to severe asthma and COPD...
  25. pmc Aging does not enhance experimental cigarette smoke-induced COPD in the mouse
    Steven Zhou
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e71410. 2013
    ..We conclude, in this model, animal age does not affect the development of emphysema and small airway remodeling. ..
  26. ncbi request reprint Statins reduce ambient particulate matter-induced lung inflammation by promoting the clearance of particulate matter, < 10 μm from lung tissues
    Ryohei Miyata
    UBC James Hogg Research Centre, Institute for Heart Lung Health, St Paul s Hospital, The University of British Columbia, Vancouver, BC
    Chest 143:452-60. 2013
    ..The aim of this study was to determine the effect of statins on PM(10) -induced lung inflammation in vivo...
  27. pmc Can inhaled fluticasone alone or in combination with salmeterol reduce systemic inflammation in chronic obstructive pulmonary disease? Study protocol for a randomized controlled trial [NCT00120978]
    Don D Sin
    Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada
    BMC Pulm Med 6:3. 2006
    ....
  28. ncbi request reprint Do chronic inhaled steroids alone or in combination with a bronchodilator prolong life in chronic obstructive pulmonary disease patients?
    Don D Sin
    The University of British Columbia Respiratory Division, Vancouver, British Columbia, Canada
    Curr Opin Pulm Med 13:90-7. 2007
    ..Whether these medications prolong survival is uncertain...
  29. ncbi request reprint Endotoxin-induced translocation of interleukin-6 from lungs to the systemic circulation
    Eiji Tamagawa
    Division of Respiratory Medicine, The University of British Columbia, the Providence Heart and Lung Institute and The James Hogg iCapture Center for Cardiovascular and Pulmonary Research St Paul s Hospital, Vancouver, BC, Canada
    Innate Immun 15:251-8. 2009
    ..This murine model facilitates the estimation of cytokine translocation across the lungs and evaluation of compounds to modulate this gradient...
  30. pmc Bronchodilator responsiveness and reported respiratory symptoms in an adult population
    Wan C Tan
    UBC James Hogg Research Laboratories, Providence Heart Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e58932. 2013
    ..The relationship between patient-reported symptoms and objective measures of lung function is poorly understood...
  31. ncbi request reprint Effects of increased primary care access on process of care and health outcomes among patients with asthma who frequent emergency departments
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
    Am J Med 117:479-83. 2004
    ..This study was conducted to determine the effectiveness of a health professional-based intervention in improving process of care and health outcomes among asthmatic patients discharged from emergency departments...
  32. ncbi request reprint The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Chest 127:1952-9. 2005
    ..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking...
  33. pmc Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology
    James C Hogg
    University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Am J Respir Crit Care Med 176:454-9. 2007
    ..COPD is associated with reduced life expectancy...
  34. ncbi request reprint The determinants of poor respiratory health status in adults living with human immunodeficiency virus infection
    Janice M Leung
    1 UBC James Hogg Research Centre, Vancouver, BC, Canada
    AIDS Patient Care STDS 28:240-7. 2014
    ..Limitations of this analysis include the absence of available echocardiograms, diffusion capacity and lung volume testing, and an all-male cohort due to the demographics of the clinic population...
  35. pmc Treatment of mild chronic obstructive pulmonary disease
    Alex Chee
    Department of Medicine, Division of Respirology, The University of British Columbia and Providence Heart and Lung Institute and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 3:563-73. 2008
    ..Influenza and pneumococcal vaccination and pulmonary rehabilitation are other therapies that may be considered for select patients with mild disease. In this paper, we summarize the current standard of care for patients with mild COPD...
  36. pmc The lung tissue microbiome in chronic obstructive pulmonary disease
    Marc A Sze
    The James Hogg Research Centre, Providence Heart Lung Institute at St Paul s Hospital, Departments of Medicine and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 185:1073-80. 2012
    ..Based on surface brushings and bronchoalveolar lavage fluid, Hilty and coworkers demonstrated microbiomes in the human lung characteristic of asthma and chronic obstructive pulmonary disease (COPD), which have now been confirmed by others...
  37. pmc Recruitment for a provincial asthma study. Participation of network and non-network primary care physicians
    Don D Sin
    Department of Medicine, University of British Columbia, Vancouver
    Can Fam Physician 50:1251-4. 2004
  38. pmc The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis
    David A Ngan
    UBC James Hogg Research Centre, Institute for Heart Lung Health at St, Paul s Hospital and Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    BMC Pulm Med 12:3. 2012
    ..The relationship of plasma inflammatory biomarkers to lung function and hospitalization history remains largely unexplored...
  39. doi request reprint Sex-related differences in serum cotinine concentrations in daily cigarette smokers
    Wen Qi Gan
    The Heart and Lung Institute and the James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research at St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Nicotine Tob Res 10:1293-300. 2008
    ..These findings indicate that significant sex-related differences exist in serum cotinine levels among smokers, which suggests that self-reports may overestimate cigarette exposure in women compared with men...
  40. doi request reprint Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease
    Andrew Churg
    Department of Pathology and UBC James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 185:34-43. 2012
    ..Myeloperoxidase (MPO), a neutrophil and macrophage product, is important in bacterial killing, but also drives inflammatory reactions and tissue oxidation...
  41. doi request reprint Statins attenuate the development of atherosclerosis and endothelial dysfunction induced by exposure to urban particulate matter (PM10)
    Ryohei Miyata
    UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Toxicol Appl Pharmacol 272:1-11. 2013
    ..Taken together, statins protect against PM10-induced cardiovascular disease by reducing atherosclerosis and improving endothelial function via their anti-inflammatory properties. ..
  42. ncbi request reprint Systemic inflammation and mortality in chronic obstructive pulmonary disease
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul, s Hospital, Vancouver, Canada
    Can J Physiol Pharmacol 85:141-7. 2007
    ..Systemic inflammation may contribute substantially to the overall morbidity and mortality of COPD patients...
  43. doi request reprint Particulate matter induces translocation of IL-6 from the lung to the systemic circulation
    Takashi Kido
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 44:197-204. 2011
    ..These results support our hypothesis that exposure to PM(10) increases pulmonary inflammatory mediators that translocate to the circulation, contributing to systemic inflammation, with downstream effects such as vascular dysfunction...
  44. doi request reprint Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality
    John Hill
    Providence Heart and Lung Institute and The UBC James Hogg Research Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Eur Heart J 32:1918-25. 2011
    ..Surfactant protein-D (SP-D) is a lung-specific protein that is detectable in human plasma. We determined the relationship of circulating SP-D to cardiovascular disease (CVD) and total mortality in subjects with and without CVD...
  45. doi request reprint The airway epithelium: more than just a structural barrier
    Anthony Tam
    The UBC James Hogg Research Centre, Providence Heart and Lung Centre and Department of Medicine, University of British Columbia, UBC, Vancouver, BC, Canada
    Ther Adv Respir Dis 5:255-73. 2011
    ..In this paper, we review the current understanding of the airway epithelial response to injury and its interaction with inflammatory cells, in particular the neutrophil...
  46. doi request reprint Vascular risk in chronic obstructive pulmonary disease: role of inflammation and other mediators
    S F Paul Man
    Department of Medicine Division of Respiratory Medicine, University of British Columbia UBC, and the UBC James Hogg Centre for Cardiovascular and Pulmonary Research, Institute for Heart and Lung Health, St Paul s Hospital, Vancouver, BC, Canada
    Can J Cardiol 28:653-61. 2012
    ....
  47. pmc Lung eQTLs to help reveal the molecular underpinnings of asthma
    Ke Hao
    Merck Research Laboratories, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1003029. 2012
    ..This data resource offers much-needed support to pinpoint the causal genes and characterize the molecular function of gene variants associated with lung diseases...
  48. pmc Progression of airway dysplasia and C-reactive protein in smokers at high risk of lung cancer
    Don D Sin
    Division of Respirology, Department of Medicine, University of British Columbia, Canada V5Z 1L3
    Am J Respir Crit Care Med 173:535-9. 2006
    ..Chronic inflammation has been implicated in the development of airway dysplasia and lung cancer. It is unclear whether circulating biomarkers of inflammation could be used to predict progression of airway dysplasia...
  49. doi request reprint The effects of inhaled and oral corticosteroids on serum inflammatory biomarkers in COPD: an exploratory study
    S F Paul Man
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Ther Adv Respir Dis 3:73-80. 2009
    ..Several studies suggest that inhaled and oral corticosteroids repress systemic inflammation in chronic obstructive pulmonary disease (COPD). However, the cytokines that may respond to these medications are unclear...
  50. pmc Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study
    Don D Sin
    The University of British Columbia Respiratory Division, Vancouver, BC
    BMC Pulm Med 7:13. 2007
    ..The principal aim of this pilot study was to determine whether circulating surfactant protein D (SPD) or Clara Cell protein-16 (CC16) levels are associated with lung function or health status in patients with severe COPD...
  51. pmc Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction
    Eiji Tamagawa
    Division of Respiratory Medicine, University of British Columbia and James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Physiol Lung Cell Mol Physiol 295:L79-85. 2008
    ..This suggests that PM-induced lung and systemic inflammatory responses contribute to the adverse vascular events associated with exposure to air pollution...
  52. pmc Airway wall thickness assessed using computed tomography and optical coherence tomography
    Harvey O Coxson
    Department of Radiology, Vancouver General Hospital, 855 West 12th Avenue, Room 3350 JPN, Vancouver, BC, Canada
    Am J Respir Crit Care Med 177:1201-6. 2008
    ..Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less...
  53. ncbi request reprint Is the aging process accelerated in chronic obstructive pulmonary disease?
    Jee Lee
    Department of Medicine and the Providence Heart and Lung Institute at St Paul s Hospital, The University of British Columbia James Hogg Research Centre, Vancouver, British Columbia, Canada
    Curr Opin Pulm Med 17:90-7. 2011
    ..The purpose of this review is to provide a comprehensive overview of the senescence hypothesis of COPD and summarize methods that are used to assess cellular aging...
  54. ncbi request reprint Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Am J Respir Crit Care Med 170:760-5. 2004
    ..Inhaled and oral corticosteroids are effective in reducing serum CRP levels in patients with COPD and suggest their potential use for improving cardiovascular outcomes in COPD...
  55. pmc Connective tissue-activating peptide III: a novel blood biomarker for early lung cancer detection
    John Yee
    Division of Thoracic Surgery, Vancouver General Hospital, The University of British Columbia, Canada
    J Clin Oncol 27:2787-92. 2009
    ..There are no reliable blood biomarkers to detect early lung cancer. We used a novel strategy that allows discovery of differentially present proteins against a complex and variable background...
  56. ncbi request reprint The interactions between cigarette smoking and reduced lung function on systemic inflammation
    Wen Qi Gan
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room No 368A, 1081 Burrard St, Vancouver, BC, V6Z 1Y6 Canada
    Chest 127:558-64. 2005
    ..Low-grade systemic inflammation is commonly observed in conditions associated with reduced FEV(1). Active cigarette smoking, which is a leading risk factor for decreased FEV(1), can also independently induce systemic inflammation...
  57. ncbi request reprint Combination therapy of inhaled corticosteroids and long-acting beta2-adrenergics in management of patients with chronic obstructive pulmonary disease
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Curr Pharm Des 10:3547-60. 2004
    ..This article will present a comprehensive overview of the currently available clinical evidence for the use of combination therapy as well as the potential mechanisms of their actions in COPD...
  58. doi request reprint Pathobiologic mechanisms of chronic obstructive pulmonary disease
    Anthony Tam
    Department of Medicine, The UBC James Hogg Research Centre, Providence Heart and Lung Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Med Clin North Am 96:681-98. 2012
    ..Given the heterogeneity of the disease (and phenotypes), it is probably unrealistic that one pathway will fully explain COPD pathophysiology...
  59. ncbi request reprint Effects of corticosteroids on systemic inflammation in chronic obstructive pulmonary disease
    S F Paul Man
    Department of Medicine, University of British Columbia, Canada
    Proc Am Thorac Soc 2:78-82. 2005
    ..We found that withdrawal of inhaled corticosteroids increased serum CRP levels, and that reintroduction of inhaled fluticasone could suppress CRP levels...
  60. pmc Effects of inhaled corticosteroids on sputum cell counts in stable chronic obstructive pulmonary disease: a systematic review and a meta-analysis
    Wen Qi Gan
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital and the Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
    BMC Pulm Med 5:3. 2005
    ..We sought to determine the effects of inhaled corticosteroids on sputum indices of inflammation in stable COPD...
  61. doi request reprint TNFα antagonists for acute exacerbations of COPD: a randomised double-blind controlled trial
    Shawn D Aaron
    Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Thorax 68:142-8. 2013
    ....
  62. ncbi request reprint Inhaled corticosteroids in chronic obstructive pulmonary disease: is there a clinical benefit?
    S F Paul Man
    Department of Medicine, Pulmonary Division, St Paul s Hospital, Vancouver, British Columbia
    Drugs 65:579-91. 2005
    ..On balance, for those with moderate-to-severe COPD and those who experience frequent exacerbations, judicious use of inhaled corticosteroids alone or in combination with long-acting beta2-adrenoceptor agonists appears reasonable...
  63. doi request reprint Impact of cancers and cardiovascular diseases in chronic obstructive pulmonary disease
    Don D Sin
    Respiratory Division, Department of Medicine, University of British Columbia, Canada
    Curr Opin Pulm Med 14:115-21. 2008
    ..Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in patients with chronic obstructive pulmonary disease. The epidemiological and mechanistic evidence linking these disorders, however, is uncertain...
  64. ncbi request reprint Pharmacotherapy for mortality reduction in chronic obstructive pulmonary disease
    Don D Sin
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Proc Am Thorac Soc 3:624-9. 2006
    ..This article reviews some of the relevant epidemiologic and pathophysiologic processes that affect mortality in COPD and critically examines the effect of current COPD therapies on mortality...
  65. pmc Novel properties of statins: suppression of the systemic and bone marrow responses induced by exposure to ambient particulate matter (PM(10)) air pollution
    Ryohei Miyata
    UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, UK
    Am J Physiol Lung Cell Mol Physiol 303:L492-9. 2012
    ..01). We conclude that lovastatin downregulates the PM(10)-induced overactive bone marrow by attenuating PM(10)-induced systemic inflammatory responses...
  66. pmc Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis
    Wen Qi Gan
    James Hogg iCAPTURE Center for Cardiovascular and Respiratory Research, University of British Columbia, Vancouver, BC, Canada
    Respir Res 7:52. 2006
    ....
  67. ncbi request reprint Understanding the biological differences in susceptibility to chronic obstructive pulmonary disease between men and women
    Don D Sin
    University of British Columbia, Vancouver, British Columbia, Canada
    Proc Am Thorac Soc 4:671-4. 2007
    ..This article reviews this and other potential mechanisms that may confer increased susceptibility of COPD to female smokers...
  68. doi request reprint Surfactant protein D: a lung specific biomarker in COPD?
    Don D Sin
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Ther Adv Respir Dis 2:65-74. 2008
    ..In this paper, we review one promising systemic biomarker that ful"lls some of these criteria, surfactant protein D (SPD)...
  69. doi request reprint Biomarkers in chronic obstructive pulmonary disease
    Don D Sin
    Department of Medicine, Division of Respiratory Medicine, the University of British Columbia and The Providence Heart and Lung Institute, James Hogg iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Proc Am Thorac Soc 6:543-5. 2009
    ..In this article, we discuss the current barriers of biomarker discovery and propose possible criteria and methods for developing novel biomarkers in COPD...
  70. doi request reprint New and current clinical imaging techniques to study chronic obstructive pulmonary disease
    Harvey O Coxson
    Providence Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 180:588-97. 2009
    ..In this article, we provide an overview of these imaging modalities in the context of COPD and discuss their strengths as well as their limitations for providing quantitative COPD phenotypes...
  71. doi request reprint Unifying thoracic biomarkers: surfactant protein-D and beyond
    Jen Erh Jaw
    UBC James Hogg Research Center, The Institute for Heart and Lung Health, St Paul s Hospital and Department of Medicine Pulmonary Division, University of British Columbia, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Expert Rev Respir Med 6:147-54. 2012
    ..In this paper, we discuss surfactant protein-D and other pneumoproteins as promising biomarkers of COPD...
  72. ncbi request reprint Effects of nocturnal noninvasive mechanical ventilation on heart rate variability of patients with advanced COPD
    Don D Sin
    Pulmonary Division, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada
    Chest 131:156-63. 2007
    ....
  73. ncbi request reprint The growing burden of chronic obstructive pulmonary disease and lung cancer in women: examining sex differences in cigarette smoke metabolism
    Sigal Ben-Zaken Cohen
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, and the Department of Medicine, The University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Am J Respir Crit Care Med 176:113-20. 2007
    ..In this article, we explore CYP and other related pathways as potential mechanisms and targets of future research and novel discoveries to curb the growing epidemic of COPD and lung cancer in women...
  74. pmc The relationship between stage 1 and 2 non-small cell lung cancer and lung function in men and women
    Samir Malhotra
    Respiratory Division, Department of Medicine, University of British Columbia, British Columbia, Canada
    BMC Pulm Med 6:2. 2006
    ..Using a large tissue registry, we sought to determine the relationship between FEV1 and subtypes of NSCLC and determine whether this relationship is modified by gender...
  75. pmc The influence of gender on the effects of aspirin in preventing myocardial infarction
    Todd Yerman
    Department of Medicine Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital, Vancouver, British Columbia, Canada
    BMC Med 5:29. 2007
    ..We conducted a systematic review and meta-analysis to determine whether gender mix might play a role in explaining the large variation of aspirin efficacy across primary and secondary MI prevention trials...
  76. doi request reprint Everything prevents emphysema: are animal models of cigarette smoke-induced chronic obstructive pulmonary disease any use?
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 45:1111-5. 2011
    ..This approach, combined with the realization that human COPD probably needs early rather than late treatment, may make development of treatments based on animal models more relevant...
  77. ncbi request reprint Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality
    Don D Sin
    Department of Medicine, University of British Columbia, Canada
    Proc Am Thorac Soc 2:8-11. 2005
    ..These data indicate that chronic obstructive pulmonary disease is a powerful, independent risk factor for cardiovascular morbidity and mortality...
  78. pmc Quantification of lung surface area using computed tomography
    Ren Yuan
    University of British Columbia James Hogg Research Centre and the Heart and Lung Institute, St Paul s Hospital, Burrard Street, Vancouver, Canada
    Respir Res 11:153. 2010
    ..To incorporate both regional lung density measured by CT and cluster analysis of low attenuation areas for comparison with histological measurement of surface area per unit lung volume...
  79. pmc Small-airway obstruction and emphysema in chronic obstructive pulmonary disease
    John E McDonough
    University of British Columbia James Hogg Research Centre, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 365:1567-75. 2011
    ..We wanted to determine whether there was a relationship between small-airway obstruction and emphysematous destruction in COPD...
  80. ncbi request reprint Commentary: fuelling the fire--systemic inflammation and development of lung disease in the general community
    Don D Sin
    The James Hogg Icapture Center For Cardiovascular, Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Int J Epidemiol 35:1008-10. 2006
  81. pmc Acute exacerbation of chronic obstructive pulmonary disease: influence of social factors in determining length of hospital stay and readmission rates
    Alyson W M Wong
    The James iCAPTURE Centre for Cardiovascular and pulmonary Research, Heart and Lung Institute, St Paul s Hospital, Providence Healthcare, University of British Columbia, Vancouver, British Columbia, Canada
    Can Respir J 15:361-4. 2008
    ..Identifying factors that influence the time a patient spends in the hospital and readmission rates will allow for better use of scarce hospital resources...
  82. doi request reprint The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
    Jeremy A Hirota
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 129:1116-25.e6. 2012
    ..The airway epithelium is the first line of defense against inhaled insults and therefore must be capable of coordinating appropriate inflammatory and immune responses...
  83. doi request reprint Phenotyping airway disease with optical coherence tomography
    Harvey O Coxson
    Providence Heart and Lung Institute and The UBC James Hogg Research Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Respirology 16:34-43. 2011
    ..In this paper, we review the current state of knowledge of OCT and its possible application in airway diseases...
  84. pmc Pharmacotherapy in pulmonary arterial hypertension: a systematic review and meta-analysis
    Christopher J Ryerson
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Respir Res 11:12. 2010
    ..Previous meta-analyses of treatments for pulmonary arterial hypertension (PAH) have not shown mortality benefit from any individual class of medication...
  85. ncbi request reprint Systemic consequences of COPD
    Jan Tkac
    The University of British Columbia Respiratory Division, Vancouver, BC
    Ther Adv Respir Dis 1:47-59. 2007
    ..In this paper, we review some of the common and serious extra-pulmonary manifestations of COPD and the potential mechanisms by which they can be linked with COPD...
  86. doi request reprint Pathologic patterns and survival in chronic hypersensitivity pneumonitis
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Am J Surg Pathol 33:1765-70. 2009
    ..Most cases of chronic HP have distinctive pathologic features, but a small percentage of cases cannot be pathologically distinguished from UIP...
  87. doi request reprint The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease
    David A Ngan
    James Hogg Research Laboratories, Providence Heart Lung Institute at St Paul s Hospital and Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Ther Adv Respir Dis 3:113-29. 2009
    ..In this paper, we review the potential pathogenic contributions of GzmB to the pathogenesis of COPD...
  88. ncbi request reprint Chronic obstructive pulmonary disease: a novel risk factor for cardiovascular disease
    Don D Sin
    Department of Medicine, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Can J Physiol Pharmacol 83:8-13. 2005
    ..In this paper, we discuss the epidemiologic evidence linking COPD and cardiovascular events as well as the potential mechanism(s) which may be responsible for this association...
  89. ncbi request reprint Emerging drugs for the treatment of chronic obstructive pulmonary disease
    Samir Malhotra
    University of British Columbia and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Respiratory Division, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    Expert Opin Emerg Drugs 11:275-91. 2006
    ..Many of these drugs may enter the COPD market within the next decade. This paper reviews the molecular rationale for these emerging drugs and their potential efficacy in COPD...
  90. ncbi request reprint Chronic obstructive pulmonary disease: a chronic systemic inflammatory disease
    Stephan F van Eeden
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, and Respiratory Division, St Paul s Hospital, Vancouver, B C, Canada
    Respiration 75:224-38. 2008
    ..This review describes the nature of the systemic inflammatory response in COPD and the clinical manifestations associated with the systemic response, with a focus on the potential mechanisms for these adverse health effects...
  91. pmc The role of female hormones on lung function in chronic lung diseases
    Anthony Tam
    The UBC James Hogg Research Centre, Providence Heart Lung Centre and Department of Medicine, University of British Columbia UBC, Vancouver, BC, Canada
    BMC Womens Health 11:24. 2011
    ....
  92. doi request reprint Contemporary management of acute exacerbations of COPD: a systematic review and metaanalysis
    Bradley S Quon
    Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, BC, Canada
    Chest 133:756-66. 2008
    ..However, their clinical benefits in various settings are uncertain. We undertook a systematic review and metaanalysis to systematically evaluate the effectiveness of these therapies...
  93. ncbi request reprint Forced expiratory volume in 1 second and physical activity in the general population
    Don D Sin
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Am J Med 117:270-3. 2004
  94. doi request reprint Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling
    Joanne L Wright
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Crit Care Med 183:50-8. 2011
    ..the potential role of statins in treating chronic obstructive pulmonary disease (COPD) is controversial, and it is unclear what anatomic COPD lesions statins affect...
  95. doi request reprint Biomarkers of therapeutic response in patients with chronic obstructive pulmonary disease: a critical review of the literature
    Ho Il Yoon
    UBC James Hogg Research Center, The Providence Heart and Lung Institute, St Pauls Hospital, Vancouver, BC, Canada
    Drugs 71:1821-37. 2011
    ..However, the clinical data have been inconsistent. Non-specific inflammatory biomarkers such as C-reactive protein and interleukin-6 lack specificity for COPD and thus are of limited clinical usefulness...
  96. ncbi request reprint Prevalence of pulmonary embolism in acute exacerbations of COPD: a systematic review and metaanalysis
    Jacques Rizkallah
    Department of Medicine, Respiratory Division, University of British Columbia, Heart and Lung Center, James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research at St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Chest 135:786-93. 2009
    ....
  97. ncbi request reprint The tip of the "ICEBERGS": a National Conference to Combat the Growing Global Epidemic of COPD in women
    Don D Sin
    James Hogg iCAPTURE Center, St Paul s Hospital, Vancouver, BC, V6Z 1Y6 Canada
    Proc Am Thorac Soc 4:669-70. 2007
  98. ncbi request reprint Developments in drugs for the treatment of chronic obstructive pulmonary disease
    Tammy Sy Mui
    The Providence Heart and Lung Center, The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital and the Department of Medicine Respiratory Division, The University of British Columbia, Vancouver, BC, Canada
    Expert Rev Clin Immunol 4:365-77. 2008
    ..In this article, we will review the current paradigm of COPD pathogenesis and discuss some promising molecular targets that may be modified in the future to improve health outcomes of patients with COPD...