James W Simpkins

Summary

Publications

  1. doi request reprint Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy
    James W Simpkins
    Institute for Aging and Alzheimer s Disease Research, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Horm Behav 63:278-83. 2013
  2. pmc Estrogen protection in Friedreich's ataxia skin fibroblasts
    Timothy E Richardson
    Institute for Aging and Alzheimer s Disease Research, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Endocrinology 152:2742-9. 2011
  3. pmc Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts
    Timothy E Richardson
    Institute for Aging and Alzheimer s Disease Research, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, United States of America
    PLoS ONE 7:e34600. 2012
  4. ncbi request reprint Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells
    Xiaofei Wang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Mol Pharmacol 70:395-404. 2006
  5. ncbi request reprint Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Brain Res 1008:147-54. 2004
  6. ncbi request reprint Neuroendocrine mechanism for tolerance to cerebral ischemia-reperfusion injury in male rats
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, Health Science Center at Fort Worth, University of North Texas, Fort Worth, Texas 76107, USA
    J Neurobiol 62:341-51. 2005
  7. pmc Reversing the Warburg effect as a treatment for glioblastoma
    Ethan Poteet
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Biol Chem 288:9153-64. 2013
  8. ncbi request reprint Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo
    Evelyn Perez
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res 1038:216-22. 2005
  9. pmc Mechanism of okadaic acid-induced neuronal death and the effect of estrogens
    Kun Don Yi
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Neurochem 108:732-40. 2009
  10. pmc Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner
    Zhang Zhang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Brain Res 1345:176-81. 2010

Collaborators

Detail Information

Publications70

  1. doi request reprint Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy
    James W Simpkins
    Institute for Aging and Alzheimer s Disease Research, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Horm Behav 63:278-83. 2013
    ..Finally, we offer evidence that part of the neuroprotection of these non-feminizing estrogens is due to enhancement in redox potential of the synthesized compounds...
  2. pmc Estrogen protection in Friedreich's ataxia skin fibroblasts
    Timothy E Richardson
    Institute for Aging and Alzheimer s Disease Research, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Endocrinology 152:2742-9. 2011
    ..These data show for the first time that phenolic E2-like compounds are potent protectors against oxidative stress-induced cell death in FRDA fibroblasts and are possible candidate drugs for the treatment and prevention of FRDA symptoms...
  3. pmc Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts
    Timothy E Richardson
    Institute for Aging and Alzheimer s Disease Research, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, United States of America
    PLoS ONE 7:e34600. 2012
    ..These data support the hypothesis that phenol ring containing estrogens are possible candidate drugs for the delay and/or prevention of FRDA symptoms...
  4. ncbi request reprint Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells
    Xiaofei Wang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Mol Pharmacol 70:395-404. 2006
    ..In conclusion, estrogens exert protective effects against oxidative stress by inhibiting lipid peroxidation and subsequently preserving Ca2+ homeostasis, mitochondrial membrane potential, and ATP levels...
  5. ncbi request reprint Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Brain Res 1008:147-54. 2004
    ..These studies also provide evidence that suppression of post-ischemic inflammation may play a critical role in estrogen-mediated neuroprotection...
  6. ncbi request reprint Neuroendocrine mechanism for tolerance to cerebral ischemia-reperfusion injury in male rats
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, Health Science Center at Fort Worth, University of North Texas, Fort Worth, Texas 76107, USA
    J Neurobiol 62:341-51. 2005
    ..In summary, stress-induced testosterone reduction contributes to ischemia tolerance in cerebral ischemia-reperfusion injury in males, which could be related to the loss of inhibition by testosterone of Hsp70 and -90 expression...
  7. pmc Reversing the Warburg effect as a treatment for glioblastoma
    Ethan Poteet
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Biol Chem 288:9153-64. 2013
    ..In summary, the current study provides the first in vitro proof of concept that reversal of Warburg effect might be a novel therapy for GBM...
  8. ncbi request reprint Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo
    Evelyn Perez
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res 1038:216-22. 2005
    ..Further, in view of the now known toxicities of chronic feminizing estrogen use in older women, non-feminizing estrogens may be a useful alternative for estrogen-induced brain protection...
  9. pmc Mechanism of okadaic acid-induced neuronal death and the effect of estrogens
    Kun Don Yi
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Neurochem 108:732-40. 2009
    ....
  10. pmc Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner
    Zhang Zhang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Brain Res 1345:176-81. 2010
    ..Our results show that cdk5 is involved in OA-induced tau hyperphosphorylation, and estrogens ameliorate the tau hyperphosphorylation, which may be mediated in part by ER...
  11. pmc Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection
    Kun Don Yi
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Endocrinology 149:5235-43. 2008
    ..Therefore, we conclude that in the face of cytotoxic challenges in vitro and in vivo, estrogens maintain the function of PP1, PP2A, and calcineurin...
  12. ncbi request reprint Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity
    D Maneesh Kumar
    Department of Cell Biology and Genetics, UNT Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Free Radic Biol Med 38:1152-63. 2005
    ..The data support the hypothesis that estrogen analogues may be useful in the treatment of neurodegenerative diseases, particularly in neuroprotection of retinal ganglion cells in ocular pathologies such as glaucoma...
  13. ncbi request reprint Role of parvalbumin in estrogen protection from ethanol withdrawal syndrome
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107 2699, USA
    Alcohol Clin Exp Res 29:1837-44. 2005
    ..This study examined whether ethanol exposure and/or ethanol withdrawal (EW) alter the levels of PA in a manner that is protected by 17beta-estradiol (E2)...
  14. ncbi request reprint Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochim Biophys Acta 1772:473-83. 2007
    ..We conclude that Cdk5 may be the principal protein kinase responsible for tau hyperphosphorylation and may be a hallmark of the tauopathies in this stroke model...
  15. ncbi request reprint Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis
    Ran Liu
    Department of Pharmacology and Neuroscience, Health Science Center at Fort Worth, University of North Texas, 76107, USA
    Stroke 33:2485-91. 2002
    ..Estrogen analogues with neuroprotective function but lacking hormonal properties would be more attractive. The present study was undertaken to determine the neuroprotective effects of a novel 2-adamantyl estrogen analogue, ZYC3...
  16. pmc Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    J Appl Physiol 105:510-7. 2008
    ..We conclude that IH conditioning during chronic ethanol consumption attenuates oxidative damage to the brain and mitigates behavioral abnormalities during subsequent EW. IH-induced ROS may evoke this powerful protection...
  17. ncbi request reprint Estrogen-like compounds for ischemic neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, 3500 Camp Bowie Blvd, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Stroke 35:2648-51. 2004
    ..These potent, nonfeminizing estrogen analogues are prime candidates for use in stroke neuroprotection...
  18. ncbi request reprint Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathology
    James W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Ann N Y Acad Sci 1052:233-42. 2005
    ....
  19. pmc Mitochondrial mechanisms of estrogen neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Biochim Biophys Acta 1800:1113-20. 2010
    ..As such, estrogens and novel non-hormonal analogs have come to figure prominently in our efforts to protect neurons against both acute brain injury and chronic neurodegeneration...
  20. pmc Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science, Fort Worth, TX 76107, USA
    Front Neuroendocrinol 30:93-105. 2009
    ..Collectively, these multifaceted, coordinated action of estrogens leads to their potency in protecting neurons from a wide variety of acute insults as well as chronic neurodegenerative processes...
  21. pmc Ethanol withdrawal provokes opening of the mitochondrial membrane permeability transition pore in an estrogen-preventable manner
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    J Pharmacol Exp Ther 328:692-8. 2009
    ..These findings suggest that EW provokes PTP opening partly but not entirely through the pro-oxidant nature and that E2 counteracts EW-associated factors to protect against the PTP opening...
  22. ncbi request reprint 17beta-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female rats
    Ran Liu
    Department of Pharmacology and Neuroscience, University of North Texas, Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res 1060:55-61. 2005
    ..Our results suggest an important role of estrogens as multiple targeting protectants against ischemic stroke on cellular as well as vascular components of central nervous system...
  23. ncbi request reprint Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    FEBS Lett 579:4591-9. 2005
    ..These results suggest that ischemia/reperfusion cerebral damage induces signalings at the G1/S cell-cycle transition, and may constitute a critical step in the neuronal apoptotic pathway in ischemia/reperfusion induced neuronal damage...
  24. pmc Mitochondrial localization of estrogen receptor beta
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Proc Natl Acad Sci U S A 101:4130-5. 2004
    ..In summary, this study demonstrated that ERbeta is localized to mitochondria, suggesting a role for mitochondrial ERbeta in estrogen effects on this important organelle...
  25. ncbi request reprint Estrogens as protectants of the neurovascular unit against ischemic stroke
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, Health Science Center, University of North Texas, Fort Worth, TX 76123, USA
    Curr Drug Targets CNS Neurol Disord 4:169-77. 2005
    ....
  26. ncbi request reprint Mitochondria play a central role in estrogen-induced neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76102, USA
    Curr Drug Targets CNS Neurol Disord 4:69-83. 2005
    ....
  27. pmc R- and S-equol have equivalent cytoprotective effects in Friedreich's ataxia
    Timothy E Richardson
    Institute for Aging and Alzheimer s Disease Research, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    BMC Pharmacol Toxicol 13:12. 2012
    ....
  28. pmc Neuroprotective actions of methylene blue and its derivatives
    Ethan Poteet
    Department of Pharmacology and Neuroscience, Institute for Alzheimer s Disease and Aging Research, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, United States of America
    PLoS ONE 7:e48279. 2012
    ..Our study indicated that MB could attenuate superoxide production by functioning as an alternative mitochondrial electron transfer carrier and as a regenerable anti-oxidant in mitochondria...
  29. doi request reprint Ethanol withdrawal acts as an age-specific stressor to activate cerebellar p38 kinase
    Marianna E Jung
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s disease, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Neurobiol Aging 32:2266-78. 2011
    ..E2 treatment mitigated each of the EW effects to a different extent. Collectively, pP38 may mediate the brain-aging changes associated with pro-oxidant EW at vulnerable ages and in vulnerable neurons in a manner protected by estrogen...
  30. ncbi request reprint Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats
    Yi Wen
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 279:22684-92. 2004
    ....
  31. pmc The assessment of non-feminizing estrogens for use in neuroprotection
    Kun Don Yi
    Institute for Aging and Alzheimer s Disease Research, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Brain Res 1379:61-70. 2011
    ..The success of this program of research suggests that strategies to optimize non-feminizing estrogens for use in postmenopausal women can be successful...
  32. pmc Alternative mitochondrial electron transfer as a novel strategy for neuroprotection
    Yi Wen
    Department of Pharmacology and Neuroscience, Institute for Alzheimer s Disease and Aging Research, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    J Biol Chem 286:16504-15. 2011
    ..The present study indicates that rerouting mitochondrial electron transfer by MB or similar molecules provides a novel strategy for neuroprotection against both chronic and acute neurological diseases involving mitochondrial dysfunction...
  33. ncbi request reprint Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cells
    Paul Aoun
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Eur J Pharmacol 472:65-71. 2003
    ..Our results demonstrate neuroprotective effects of 15d-PGJ2 and troglitazone that are likely independent of PPARgamma...
  34. pmc Estrogen receptor beta as a mitochondrial vulnerability factor
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 284:9540-8. 2009
    ..These data demonstrate that ERbeta is expressed in mitochondria and function as a mitochondrial vulnerability factor involved in Deltapsim maintenance, potentially through a mitochondrial transcription dependent mechanism...
  35. pmc Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemia
    Ran Liu
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Neurosci Lett 415:237-41. 2007
    ..These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window...
  36. ncbi request reprint Subcellular distribution of native estrogen receptor alpha and beta subtypes in cultured human lens epithelial cells
    Patrick R Cammarata
    Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA
    Exp Eye Res 78:861-71. 2004
    ....
  37. ncbi request reprint Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Brain Res 1022:30-8. 2004
    ..Finally, our results also suggest that neuronal apoptosis may be a therapeutic target in preventing tauopathy-related neurodegenerative diseases...
  38. ncbi request reprint A nonfeminizing estrogen analog protects against ethanol withdrawal toxicity in immortalized hippocampal cells
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    J Pharmacol Exp Ther 319:543-50. 2006
    ..Therefore, ZYC26 can be a potential alternative estrogen therapy for a cellular and oxidative imbalance associated with ethanol withdrawal...
  39. pmc Involvement of estrogen receptor β5 in the progression of glioma
    Wenjun Li
    Department of Pharmacology and Neuroscience, Institute for Alzheimer s Disease and Aging Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Brain Res 1503:97-107. 2013
    ..Our findings suggest hypoxia induced ERβ5 expression in glioma as a self-protective mechanism against tumor proliferation and that ERβ5 might serve as a therapeutic target for the treatment of glioma...
  40. ncbi request reprint Ethanol withdrawal reduces cerebellar parvalbumin expression in a manner reversed by estrogens
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Neurosci Lett 377:44-8. 2005
    ..These data suggest that E2 treatment protects against the PA-suppression associated with EW toxicity...
  41. ncbi request reprint Role of the GABAA system in behavioral, motoric, and cerebellar protection by estrogen during ethanol withdrawal
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas HSC at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Alcohol 31:49-61. 2003
    ..Also, results of the current study provide indirect evidence that the GABAergic system is involved in protective effects of E(2) against the EW syndrome...
  42. doi request reprint Ethanol withdrawal provokes mitochondrial injury in an estrogen preventable manner
    Marianna E Jung
    Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    J Bioenerg Biomembr 40:35-44. 2008
    ..These findings demonstrate that EW provokes oxidative injury to mitochondrial membranes in a manner that is exacerbated by estrogen deprivation...
  43. ncbi request reprint Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation
    Kun Don Yi
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    J Pharmacol Exp Ther 324:1188-95. 2008
    ....
  44. ncbi request reprint Novel mechanisms for estrogen-induced neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Exp Biol Med (Maywood) 231:514-21. 2006
    ..On the basis of this evidence, we discuss the clinical applicability of estrogens in treating various age-related disorders, including Alzheimer disease and stroke, and identify the caveats that must be considered...
  45. ncbi request reprint Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell line
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Neurochem 95:745-55. 2005
    ..These data suggest that the neuroprotective effects of estrogens are mediated in part by inhibition of PKCepsilon activity and membrane translocation...
  46. pmc Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Neurosci Lett 416:160-4. 2007
    ..Neither EW nor E2 altered the protein levels of the subunits. These findings suggest that a counteracting relationship exists between the effects of EW and E2 on the activity of COX in a subunit specific manner...
  47. doi request reprint Ethanol withdrawal hastens the aging of cytochrome c oxidase
    Marianna E Jung
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s disease, University of North Texas, Health Science Center at Fort Worth, Fort Worth, TX 76107 2699
    Neurobiol Aging 33:618.e21-32. 2012
    ..Collectively EW hastens but E2 delays the age-associated loss of COX activity. This EW effect is independent of cytochrome c but may involve the mitochondrial overload of BAX and membrane vulnerability...
  48. pmc Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke
    Ran Liu
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    J Pharmacol Exp Ther 332:1006-12. 2010
    ..Collectively, the present study suggests that estrogen could be a candidate for combination therapy with rtPA to attenuate its side effect and hence expand its short therapeutic window for treatment of ischemic stroke...
  49. doi request reprint An okadaic acid-induced model of tauopathy and cognitive deficiency
    Zhang Zhang
    Deptment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Brain Res 1359:233-46. 2010
    ....
  50. ncbi request reprint Estrogen protects against brain lipid peroxidation in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Pharmacol Biochem Behav 79:573-86. 2004
    ..These data suggest that EW rather than ethanol enhances brain lipid peroxidation that is transient and brain-region specific. Estrogens protect against the brain lipid peroxidation in a manner independent of blood ethanol concentrations...
  51. ncbi request reprint Role of the GABA-A system in estrogen-induced protection against brain lipid peroxidation in ethanol-withdrawn rats
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Alcohol Clin Exp Res 28:1907-15. 2004
    ..In this study, we examined the effect of the GABA-A antagonist bicuculline on the neuroprotective effect of E2 by assessing the oxidative marker thiobarbituric acid reactive substances (TBARS) during ethanol withdrawal (EW)...
  52. ncbi request reprint Role of protein phosphatases in estrogen-mediated neuroprotection
    Kun Don Yi
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Neurosci 25:7191-8. 2005
    ..These results suggest that 17beta-estradiol may protect cells against glutamate-induced oxidative stress and excitotoxicity by activating a combination of protein phosphatases...
  53. pmc Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative
    Katalin Prokai-Tatrai
    Department of Pharmacology and Neuroscience, UNT Health Science Center, Fort Worth, TX 76107, USA
    Steroids 73:280-8. 2008
    ..Taken together, our report argues for a previously unrecognized antioxidant cycle for estrogen-derived compounds...
  54. pmc Modulation of polymorphonuclear neutrophil functions by astrocytes
    Luokun Xie
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    J Neuroinflammation 7:53. 2010
    ..In the CNS, astrocytes are the most abundant glial cell population and participate in the local innate immune response triggered by a variety of insults. In the present study, we investigated the impacts of astrocytes on PMN function...
  55. ncbi request reprint The use of estrogens and related compounds in the treatment of damage from cerebral ischemia
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Ann N Y Acad Sci 1007:101-7. 2003
    ..Collectively, these data indicate that estrogens could prove to be useful therapies in preventing brain damage from strokes...
  56. pmc Pyruvate enhances neurological recovery following cardiopulmonary arrest and resuscitation
    Arti B Sharma
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Resuscitation 76:108-19. 2008
    ..This study tested whether acute pyruvate treatment during cardiopulmonary resuscitation can prevent neurological dysfunction and cerebral injury following cardiac arrest...
  57. ncbi request reprint Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells
    Paul Aoun
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Invest Ophthalmol Vis Sci 44:2999-3004. 2003
    ..Glaucoma and other retinal disorders are some of the major complications in diabetes. In the present study, the role that PPAR-gamma ligands play in protecting retinal ganglion cells (RGC-5) against glutamate insult was explored...
  58. ncbi request reprint nNOS is involved in estrogen mediated neuroprotection in neuroblastoma cells
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107l, USA
    Neuroreport 15:1515-8. 2004
    ..In SK-N-SH cells, the major estrogen receptor isoforms is estrogen receptor beta. Our current study suggests that increased activity of nNOS may be involved in the neuroprotection conferred by 17beta-estradiol...
  59. ncbi request reprint Role of protein kinase C in estrogen protection against apoptotic cerebellar cell death in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas HSC at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Alcohol 31:39-48. 2003
    ....
  60. pmc Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds
    Laszlo Prokai
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Pharmacol Ther 114:1-12. 2007
    ..This review highlights recent structure-activity studies that revealed the importance of antioxidant effects for neuroprotective estrogen analogues and derivatives...
  61. ncbi request reprint Increased beta-secretase activity and expression in rats following transient cerebral ischemia
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas, Health Science Center Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Brain Res 1009:1-8. 2004
    ....
  62. pmc Estrogen actions on mitochondria--physiological and pathological implications
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Mol Cell Endocrinol 290:51-9. 2008
    ....
  63. pmc Estrogens and neuroprotection in retinal diseases
    D Maneesh Kumar
    Department of Cell Biology, UNT Health Science Center, Fort Worth, TX 76107, USA
    Mol Vis 14:1480-6. 2008
    ....
  64. pmc Estrogens directly potentiate neuronal L-type Ca2+ channels
    Saumyendra N Sarkar
    Department of Pharmacology and Neuroscience and the Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Proc Natl Acad Sci U S A 105:15148-53. 2008
    ....
  65. ncbi request reprint Mitochondrial mechanisms of estrogen neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, 3500 Camp Bowie Boul, Fort Worth, TX 76102, USA
    Brain Res Rev 57:421-30. 2008
    ....
  66. ncbi request reprint A prototypical Sigma-1 receptor antagonist protects against brain ischemia
    John A Schetz
    Department of Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Brain Res 1181:1-9. 2007
    ....
  67. pmc Estrogen-induced signaling attenuates soluble Aβ peptide-mediated dysfunction of pathways in synaptic plasticity
    Shaun M Logan
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Brain Res 1383:1-12. 2011
    ..This study identifies E2-induced signaling that attenuates soluble Aβ peptide-mediated dysfunction of pathways in synaptic plasticity...
  68. ncbi request reprint Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1L/Homer 1c immunoreactive synaptic connections
    Simon Kaja
    University of North Texas Health Science Center at Fort Worth, Department of Pharmacology and Neuroscience, Fort Worth, Texas 76107 2699, USA
    Invest Ophthalmol Vis Sci 44:3155-62. 2003
    ..The present study quantitatively analyzed effects of estrogen administration on synaptic connections of neurons in the ganglion cell layer (GCL) of the retina...
  69. pmc The potential for estrogens in preventing Alzheimer's disease and vascular dementia
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER Focused On Resources for her Health, Education and Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Ther Adv Neurol Disord 2:31-49. 2009
    ..Several approaches to enhance brain specificity of estrogen action are now underway in an attempt to reduce the side effects of chronic estrogen therapy in AD...
  70. pmc Estrogens and progesterone as neuroprotectants: what animal models teach us
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Front Biosci 13:1083-9. 2008
    ....