G Simonnet

Summary

Publications

  1. ncbi request reprint Opioid-induced hyperalgesia: abnormal or normal pain?
    Guy Simonnet
    Laboratoire Homéostasie Allostasie Pathologie, Universite Victor Segalen Bordeaux 2, France
    Neuroreport 14:1-7. 2003
  2. ncbi request reprint [Complexity and physiology of the analgesic effects of opioids]
    G Simonnet
    Laboratoire Homéostasie allostasie pathologie EA 3666 Université Victor Ségalen, Bordeaux 2 146, rue Leo Saignat, 33076 Bordeaux, France
    Rev Med Suisse 1:1682-5. 2005
  3. ncbi request reprint Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process
    E Celerier
    Institut National de la Santé et de la Recherche Médicale U 259, Psychobiologie des Comportements Adaptatifs, Universite Victor Segalen Bordeaux 2, 33077 Bordeaux, France
    J Neurosci 21:4074-80. 2001
  4. ncbi request reprint Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats
    Baptiste Bessière
    Universite Bordeaux 2, Universite Bordeaux 1, CNRS, UMR 5227, Bordeaux, France
    Neuropharmacology 53:733-40. 2007
  5. ncbi request reprint Non-nociceptive environmental stress induces hyperalgesia, not analgesia, in pain and opioid-experienced rats
    Cyril Rivat
    Laboratoire Homéostasie Allostasie Pathologie, Universite Victor Segalen Bordeaux 2, Bordeaux 33076, France
    Neuropsychopharmacology 32:2217-28. 2007
  6. pmc RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia
    Frederic Simonin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 103:466-71. 2006
  7. ncbi request reprint Opioids: from analgesia to anti-hyperalgesia?
    Guy Simonnet
    Pain 118:8-9. 2005
  8. ncbi request reprint Nitrous oxide revisited: evidence for potent antihyperalgesic properties
    Philippe Richebe
    Department of Anesthesia and Intensive Care II, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France
    Anesthesiology 103:845-54. 2005
  9. ncbi request reprint Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cgamma gene
    Evelyne Celerier
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Doctor Aiguader 80, E 08003 Barcelona, Spain
    Neuropharmacology 46:264-72. 2004
  10. ncbi request reprint Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: prevention by the N-methyl-D-aspartate receptor antagonist ketamine
    Cyril Rivat
    INSERM U 259, Bordeaux, France, and Pain Analgesia INSERM Network, Bordeaux, France
    Anesthesiology 96:381-91. 2002

Collaborators

  • Cyril Rivat
  • R Maldonado
  • Jack H Jhamandas
  • Laure Pain
  • Brigitte L Kieffer
  • Daniel Sessler
  • Jean Paul Laulin
  • Philippe Richebe
  • Nicolas Chartrel
  • Jean Jacques Bourguignon
  • Frederic Simonin
  • Pierre Maurette
  • Baptiste Bessière
  • Emilie Laboureyras
  • Pascal Cosette
  • Thierry Jouenne
  • Jerome Leprince
  • Evelyne Celerier
  • Hubert Vaudry
  • Bruno Guignard
  • Marcel Chauvin
  • E Celerier
  • Angelo Contarino
  • Federica Bruzzone
  • Helene Tollemer
  • Martine Schmitt
  • Jean Costentin
  • Youssef Anouar
  • Isabelle Ségalas-Milazzo
  • Patrick Laurent
  • Marc Parmentier
  • Laure Guilhaudis
  • Jean Claude Beauvillain
  • Catherine Mollereau
  • Jean Claude do-Rego
  • Audrey Matifas
  • David MacTavish
  • Mauro Vallarino
  • Cyril Creton
  • Marc Lemaire
  • Jean Benoit Corcuff
  • Claude Lebrault
  • Laurence Desrues
  • Marie Christine Tonon
  • Carole Coste
  • William Morris
  • Hélène Costes
  • Cynthia Dujardin
  • Eric Cellier
  • M Le Moal
  • J P Laulin
  • J B Corcuff

Detail Information

Publications18

  1. ncbi request reprint Opioid-induced hyperalgesia: abnormal or normal pain?
    Guy Simonnet
    Laboratoire Homéostasie Allostasie Pathologie, Universite Victor Segalen Bordeaux 2, France
    Neuroreport 14:1-7. 2003
  2. ncbi request reprint [Complexity and physiology of the analgesic effects of opioids]
    G Simonnet
    Laboratoire Homéostasie allostasie pathologie EA 3666 Université Victor Ségalen, Bordeaux 2 146, rue Leo Saignat, 33076 Bordeaux, France
    Rev Med Suisse 1:1682-5. 2005
    ....
  3. ncbi request reprint Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process
    E Celerier
    Institut National de la Santé et de la Recherche Médicale U 259, Psychobiologie des Comportements Adaptatifs, Universite Victor Segalen Bordeaux 2, 33077 Bordeaux, France
    J Neurosci 21:4074-80. 2001
    ....
  4. ncbi request reprint Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats
    Baptiste Bessière
    Universite Bordeaux 2, Universite Bordeaux 1, CNRS, UMR 5227, Bordeaux, France
    Neuropharmacology 53:733-40. 2007
    ..These results suggest that a single exposure to N2O could improve post-injury pain management and facilitate rehabilitation especially when potent analgesics as opioids have to be used...
  5. ncbi request reprint Non-nociceptive environmental stress induces hyperalgesia, not analgesia, in pain and opioid-experienced rats
    Cyril Rivat
    Laboratoire Homéostasie Allostasie Pathologie, Universite Victor Segalen Bordeaux 2, Bordeaux 33076, France
    Neuropsychopharmacology 32:2217-28. 2007
    ..This latent pain sensitization model may be important for studying the transition from acute to chronic pain and individual differences in pain vulnerability associated with prior life events...
  6. pmc RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia
    Frederic Simonin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 103:466-71. 2006
    ..Our data indicate that NPFF receptors are part of a bona fide antiopioid system and that selective antagonists of these receptors could represent useful therapeutic agents for improving the efficacy of opioids in chronic pain treatment...
  7. ncbi request reprint Opioids: from analgesia to anti-hyperalgesia?
    Guy Simonnet
    Pain 118:8-9. 2005
  8. ncbi request reprint Nitrous oxide revisited: evidence for potent antihyperalgesic properties
    Philippe Richebe
    Department of Anesthesia and Intensive Care II, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France
    Anesthesiology 103:845-54. 2005
    ..Because nitrous oxide (N2O) has anti-N-methyl-D-aspartate properties, the purpose of this study was to evaluate nitrous oxide ability to prevent such an opioid-induced hyperalgesia in rats...
  9. ncbi request reprint Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cgamma gene
    Evelyne Celerier
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Doctor Aiguader 80, E 08003 Barcelona, Spain
    Neuropharmacology 46:264-72. 2004
    ..This study identifies the PKCgamma as a key element that links opioid receptor activation with the recruitment of opposite systems to opioid analgesia involved in a physiological compensatory pain enhancement...
  10. ncbi request reprint Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: prevention by the N-methyl-D-aspartate receptor antagonist ketamine
    Cyril Rivat
    INSERM U 259, Bordeaux, France, and Pain Analgesia INSERM Network, Bordeaux, France
    Anesthesiology 96:381-91. 2002
    ..In nonsuffering rats, this leads to a long-lasting enhancement in pain sensitivity. The current study assessed whether fentanyl could amplify carrageenan-induced hyperalgesia...
  11. ncbi request reprint The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance
    Jean Paul Laulin
    Universite Bordeaux 1, France
    Anesth Analg 94:1263-9, table of contents. 2002
    ..Although ketamine had no analgesic effect per se at the dose used herein, our results indicate that sustained NMDA-receptor blocking could be a fruitful therapy for improving postoperative morphine effectiveness...
  12. ncbi request reprint Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats
    Philippe Richebe
    Département d anesthésie et réanimation III, Centre Hospitalier et Universitaire, Bordeaux, France
    Anesthesiology 102:421-8. 2005
    ..Because N-methyl-d-aspartate receptor antagonists oppose both pain hypersensitivity and tolerance induced by opioids, the authors examined the capability of ketamine for improving exaggerated postoperative pain management...
  13. doi request reprint Preemptive antihyperalgesia to improve preemptive analgesia
    Guy Simonnet
    Anesthesiology 108:352-4. 2008
  14. ncbi request reprint [RF9, a powerful and selective antagonist of the neuropeptide FF receptors, prevents the development of the tolerance to opioids]
    Jean Jacques Bourguignon
    Med Sci (Paris) 22:579-80. 2006
  15. ncbi request reprint Structure and functions of the novel hypothalamic RFamide neuropeptides R-RFa and 26RFa in vertebrates
    Nicolas Chartrel
    European Institute for Peptide Research IFRMP23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, University of Rouen, 76821 Mont Saint Aignan, France
    Peptides 27:1110-20. 2006
    ..Indeed, 26RFa is a potent stimulator of appetite in mammals. Concurrently, recent data suggest that 26RFa exerts various neuroendocrine regulatory activities at the pituitary and adrenal level...
  16. ncbi request reprint Isolation, characterization, and distribution of a novel neuropeptide, Rana RFamide (R-RFa), in the brain of the European green frog Rana esculenta
    Nicolas Chartrel
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA CNRS, University of Rouen, 76821 Mont Saint Aignan, France
    J Comp Neurol 448:111-27. 2002
    ....
  17. ncbi request reprint Supplementing desflurane-remifentanil anesthesia with small-dose ketamine reduces perioperative opioid analgesic requirements
    Bruno Guignard
    Department of Anesthesiology, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, 9 avenue Charles de Gaulle, Boulogne Billancourt 92100, France
    Anesth Analg 95:103-8, table of contents. 2002
    ..Thus, intraoperative small-dose ketamine may be a useful adjuvant to intraoperative remifentanil...
  18. doi request reprint Delayed aversive effects of high-dose fentanyl. Prevention by a polyamine-deficient diet
    Laure Pain
    INSERM U666 GRERCA and Hôpitaux Universitaires de Strasbourg, Faculty of Medicine, 11 rue Humann, Strasbourg, France
    Behav Brain Res 190:119-23. 2008
    ..The 24-h delayed aversive effects of fentanyl were not observed in animals submitted to a polyamine-deficient diet, suggesting an NMDA-dependent mechanism...