Birgit Simell

Summary

Publications

  1. doi Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis
    Birgit Simell
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Mannerheimintie 166, 00300 Helsinki, Finland
    Vaccine 29:1929-34. 2011
  2. pmc Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine
    Birgit Simell
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, Helsinki, Finland
    Clin Vaccine Immunol 19:96-9. 2012
  3. ncbi Antibodies to pneumococcal surface protein A families 1 and 2 in serum and saliva of children and the risk of pneumococcal acute otitis media
    Birgit Simell
    Department of Vaccines, National Public Health Institute, Mannerheimintie 166, Helsinki, Finland
    J Infect Dis 196:1528-36. 2007
  4. pmc Serum IgM antibodies contribute to high levels of opsonophagocytic activities in toddlers immunized with a single dose of the 9-valent pneumococcal conjugate vaccine
    Birgit Simell
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Clin Vaccine Immunol 19:1618-23. 2012
  5. pmc Effects of ageing and gender on naturally acquired antibodies to pneumococcal capsular polysaccharides and virulence-associated proteins
    Birgit Simell
    Department of Vaccines, National Public Health Institute, Helsinki, Finland
    Clin Vaccine Immunol 15:1391-7. 2008
  6. doi Pneumococcal carriage and acute otitis media induce serum antibodies to pneumococcal surface proteins CbpA and PhtD in children
    Birgit Simell
    National Institute for Health and Welfare, Helsinki, Finland
    Vaccine 27:4615-21. 2009
  7. pmc Serum antibodies to pneumococcal neuraminidase NanA in relation to pneumococcal carriage and acute otitis media
    Birgit Simell
    Vaccine Immunology Laboratory, National Public Health Institute, Mannerheimintie 166, 0300 Helsinki, Finland
    Clin Vaccine Immunol 13:1177-9. 2006
  8. ncbi Serum antibodies to the pneumococcal surface proteins PhtB and PhtE in Finnish infants and adults
    Emma Holmlund
    The National Public Health Institute, Helsinki, Finland
    Pediatr Infect Dis J 26:447-9. 2007
  9. ncbi The fundamental link between pneumococcal carriage and disease
    Birgit Simell
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Expert Rev Vaccines 11:841-55. 2012
  10. ncbi Pneumococcal carriage and otitis media induce salivary antibodies to pneumococcal capsular polysaccharides in children
    Birgit Simell
    Department of Vaccines, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    J Infect Dis 186:1106-14. 2002

Detail Information

Publications10

  1. doi Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis
    Birgit Simell
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Mannerheimintie 166, 00300 Helsinki, Finland
    Vaccine 29:1929-34. 2011
    ....
  2. pmc Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine
    Birgit Simell
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare THL, Helsinki, Finland
    Clin Vaccine Immunol 19:96-9. 2012
    ..Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage...
  3. ncbi Antibodies to pneumococcal surface protein A families 1 and 2 in serum and saliva of children and the risk of pneumococcal acute otitis media
    Birgit Simell
    Department of Vaccines, National Public Health Institute, Mannerheimintie 166, Helsinki, Finland
    J Infect Dis 196:1528-36. 2007
    ..We assessed the development of human serum and salivary antibodies against the PspA families 1 (PspA1) and 2 (PspA2) in early childhood and their role in the prevention of pneumococcal acute otitis media (AOM)...
  4. pmc Serum IgM antibodies contribute to high levels of opsonophagocytic activities in toddlers immunized with a single dose of the 9-valent pneumococcal conjugate vaccine
    Birgit Simell
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Clin Vaccine Immunol 19:1618-23. 2012
    ..Our results suggest that IgM contributes to OPA 1 month after a single PCV9 vaccination in toddlers and that functionally active IgM and IgG antibodies persist for at least a year...
  5. pmc Effects of ageing and gender on naturally acquired antibodies to pneumococcal capsular polysaccharides and virulence-associated proteins
    Birgit Simell
    Department of Vaccines, National Public Health Institute, Helsinki, Finland
    Clin Vaccine Immunol 15:1391-7. 2008
    ..Age, gender, and the nature of the antigen have substantial and varying effects on the antibody concentrations in the sera of adults...
  6. doi Pneumococcal carriage and acute otitis media induce serum antibodies to pneumococcal surface proteins CbpA and PhtD in children
    Birgit Simell
    National Institute for Health and Welfare, Helsinki, Finland
    Vaccine 27:4615-21. 2009
    ..In conclusion, pneumococcal exposure induces the development of serum anti-CbpA and -PhtD in early childhood. Anti-CbpA antibodies may play a role in the prevention of subsequent pneumococcal AOM during the second year of life...
  7. pmc Serum antibodies to pneumococcal neuraminidase NanA in relation to pneumococcal carriage and acute otitis media
    Birgit Simell
    Vaccine Immunology Laboratory, National Public Health Institute, Mannerheimintie 166, 0300 Helsinki, Finland
    Clin Vaccine Immunol 13:1177-9. 2006
    ..The antibody concentrations at neither 12 nor 18 months were significantly associated with the risk of subsequent pneumococcal carriage or acute otitis media...
  8. ncbi Serum antibodies to the pneumococcal surface proteins PhtB and PhtE in Finnish infants and adults
    Emma Holmlund
    The National Public Health Institute, Helsinki, Finland
    Pediatr Infect Dis J 26:447-9. 2007
    ..The anti-PhtB or -PhtE antibody concentrations were not significantly associated with a decreased risk of subsequent pneumococcal acute otitis media...
  9. ncbi The fundamental link between pneumococcal carriage and disease
    Birgit Simell
    Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    Expert Rev Vaccines 11:841-55. 2012
    ..Based on such a causal link between carriage and disease, the authors emphasize the role of information on pneumococcal carriage in vaccine trials and in public health decision-making...
  10. ncbi Pneumococcal carriage and otitis media induce salivary antibodies to pneumococcal capsular polysaccharides in children
    Birgit Simell
    Department of Vaccines, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    J Infect Dis 186:1106-14. 2002
    ..The IgA and S-Ig concentrations correlated strongly, which suggests that the anti-Pnc-PS IgA was secretory. Salivary anti-Pnc-PS IgG was detected only rarely...