Mechanosensing and mechanochemical transduction: how is mechanical energy sensed and converted into chemical energy in an extracellular matrix?Frederick H Silver
Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Crit Rev Biomed Eng 31:255-331. 2003
..These are some of the mechanisms that have evolved in vertebrates by which cells respond to changes in external forces that lead to changes in tissue strcture and function...
- Do changes in the mechanical properties of articular cartilage promote catabolic destruction of cartilage and osteoarthritis?
Frederick H Silver
Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
Matrix Biol 23:467-76. 2004
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- The effects of prestrain and collagen fibril alignment on in vitro mineralization of self-assembled collagen fibers
Joseph W Freeman
Department of Pathology and Laboratory Medicine and Surgery, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
Connect Tissue Res 46:107-15. 2005
..We concluded that organized collagen-collagen interactions appear to be an important characteristic required for elastic energy storage in tendon...
- Mechanobiology of cartilage: how do internal and external stresses affect mechanochemical transduction and elastic energy storage?
Frederick H Silver
Division of Biomaterials, Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
Biomech Model Mechanobiol 1:219-38. 2002
..In addition, we analyze how passive and active internal stresses affect mechanochemical transduction in cartilage, and how this may affect cartilage behavior in health and disease...
- Mechanical behavior of vessel wall: a comparative study of aorta, vena cava, and carotid artery
Frederick H Silver
Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Ann Biomed Eng 31:793-803. 2003
..It is concluded that the series arrangement of collagen and smooth muscle may be important in mechanochemical transduction in vessel walls and that the exact quantity and arrangement of these components may differ in different vessels...
- Analysis of mineral deposition in turkey tendons and self-assembled collagen fibers using mechanical techniques
Joseph W Freeman
Department of Pathology and Laboratory Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Connect Tissue Res 45:131-41. 2004
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- Elastic energy storage in unmineralized and mineralized extracellular matrices (ECMs): a comparison between molecular modeling and experimental measurements
Joseph W Freeman
Department of Pathology and Laboratory of Medicine, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
J Theor Biol 229:371-81. 2004
..This study demonstrates the potential importance of molecular modeling in the design of new biomaterials...
- Collagen self-assembly and the development of tendon mechanical properties
Frederick H Silver
Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
J Biomech 36:1529-53. 2003
..In contrast, after birth when locomotion begins, the mechanical response is dominated by elastic stretching of crosslinked collagen molecules...
- Viscoelastic properties of acid- and alkaline-treated human dermis: a correlation between total surface charge and elastic modulus
Gurinder P Seehra
Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA
Skin Res Technol 12:190-8. 2006
..It is hypothesized that elastic energy storage is associated with the stretching of pairs of charged amino acid residues that are found primarily in the flexible regions of collagen molecules...
- Mechanobiology of force transduction in dermal tissue
Frederick H Silver
Division of Biomaterials, Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Skin Res Technol 9:3-23. 2003
..The purpose of this review is to analyse how internal and external mechanical loads are applied at the macromolecular and cellular levels in the epidermis and dermis...
- Mechanical implications of the domain structure of fiber-forming collagens: comparison of the molecular and fibrillar flexibilities of the alpha1-chains found in types I-III collagen
Frederick H Silver
Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854 USA
J Theor Biol 216:243-54. 2002
..Impaired elastic energy storage by extracellular matrices may lead to cellular damage and changes in signaling by mechanochemical transduction at the extracellular matrix-cell interface...
- Viscoelastic properties of self-assembled type I collagen fibers: molecular basis of elastic and viscous behaviors
Frederick H Silver
Division of Biomaterials, Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Connect Tissue Res 43:569-80. 2002
..It is hypothesized that at high strain rates subfibrillar subunits appear to "hydroplane" by each other on a layer of loosely bound water...
- Invited Review: Role of mechanophysiology in aging of ECM: effects of changes in mechanochemical transduction
Frederick H Silver
Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Appl Physiol 95:2134-41. 2003
..Studies pertaining to the interactions among mechanical forces, growth factors, hormones, and their receptors will better define the relationship between mechanochemical transduction processes and cellular behavior in aging tissues...
- Elastic energy storage in human articular cartilage: estimation of the elastic modulus for type II collagen and changes associated with osteoarthritis
Frederick H Silver
Division of Biomaterials, Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
Matrix Biol 21:129-37. 2002
..Enzymatic cleavage of cartilage proteoglycans and collagen observed in osteoarthritis may lead to fibrillation and fissure formation as a result of impaired energy storage capability of cartilage...
- Deposition of apatite in mineralizing vertebrate extracellular matrices: A model of possible nucleation sites on type I collagen
Frederick H Silver
Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ, USA
Connect Tissue Res 52:242-54. 2011
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