Frederick H Silver

Summary

Publications

  1. ncbi request reprint Mechanosensing and mechanochemical transduction: how is mechanical energy sensed and converted into chemical energy in an extracellular matrix?
    Frederick H Silver
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Crit Rev Biomed Eng 31:255-331. 2003
  2. ncbi request reprint Do changes in the mechanical properties of articular cartilage promote catabolic destruction of cartilage and osteoarthritis?
    Frederick H Silver
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Matrix Biol 23:467-76. 2004
  3. ncbi request reprint The effects of prestrain and collagen fibril alignment on in vitro mineralization of self-assembled collagen fibers
    Joseph W Freeman
    Department of Pathology and Laboratory Medicine and Surgery, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Connect Tissue Res 46:107-15. 2005
  4. ncbi request reprint Mechanobiology of cartilage: how do internal and external stresses affect mechanochemical transduction and elastic energy storage?
    Frederick H Silver
    Division of Biomaterials, Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Biomech Model Mechanobiol 1:219-38. 2002
  5. ncbi request reprint Mechanical behavior of vessel wall: a comparative study of aorta, vena cava, and carotid artery
    Frederick H Silver
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Ann Biomed Eng 31:793-803. 2003
  6. ncbi request reprint Analysis of mineral deposition in turkey tendons and self-assembled collagen fibers using mechanical techniques
    Joseph W Freeman
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Connect Tissue Res 45:131-41. 2004
  7. ncbi request reprint Elastic energy storage in unmineralized and mineralized extracellular matrices (ECMs): a comparison between molecular modeling and experimental measurements
    Joseph W Freeman
    Department of Pathology and Laboratory of Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Theor Biol 229:371-81. 2004
  8. ncbi request reprint Collagen self-assembly and the development of tendon mechanical properties
    Frederick H Silver
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Biomech 36:1529-53. 2003
  9. ncbi request reprint Viscoelastic properties of acid- and alkaline-treated human dermis: a correlation between total surface charge and elastic modulus
    Gurinder P Seehra
    Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA
    Skin Res Technol 12:190-8. 2006
  10. ncbi request reprint Mechanobiology of force transduction in dermal tissue
    Frederick H Silver
    Division of Biomaterials, Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Skin Res Technol 9:3-23. 2003

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Mechanosensing and mechanochemical transduction: how is mechanical energy sensed and converted into chemical energy in an extracellular matrix?
    Frederick H Silver
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Crit Rev Biomed Eng 31:255-331. 2003
    ..These are some of the mechanisms that have evolved in vertebrates by which cells respond to changes in external forces that lead to changes in tissue strcture and function...
  2. ncbi request reprint Do changes in the mechanical properties of articular cartilage promote catabolic destruction of cartilage and osteoarthritis?
    Frederick H Silver
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Matrix Biol 23:467-76. 2004
    ....
  3. ncbi request reprint The effects of prestrain and collagen fibril alignment on in vitro mineralization of self-assembled collagen fibers
    Joseph W Freeman
    Department of Pathology and Laboratory Medicine and Surgery, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Connect Tissue Res 46:107-15. 2005
    ..We concluded that organized collagen-collagen interactions appear to be an important characteristic required for elastic energy storage in tendon...
  4. ncbi request reprint Mechanobiology of cartilage: how do internal and external stresses affect mechanochemical transduction and elastic energy storage?
    Frederick H Silver
    Division of Biomaterials, Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Biomech Model Mechanobiol 1:219-38. 2002
    ..In addition, we analyze how passive and active internal stresses affect mechanochemical transduction in cartilage, and how this may affect cartilage behavior in health and disease...
  5. ncbi request reprint Mechanical behavior of vessel wall: a comparative study of aorta, vena cava, and carotid artery
    Frederick H Silver
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Ann Biomed Eng 31:793-803. 2003
    ..It is concluded that the series arrangement of collagen and smooth muscle may be important in mechanochemical transduction in vessel walls and that the exact quantity and arrangement of these components may differ in different vessels...
  6. ncbi request reprint Analysis of mineral deposition in turkey tendons and self-assembled collagen fibers using mechanical techniques
    Joseph W Freeman
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Connect Tissue Res 45:131-41. 2004
    ....
  7. ncbi request reprint Elastic energy storage in unmineralized and mineralized extracellular matrices (ECMs): a comparison between molecular modeling and experimental measurements
    Joseph W Freeman
    Department of Pathology and Laboratory of Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Theor Biol 229:371-81. 2004
    ..This study demonstrates the potential importance of molecular modeling in the design of new biomaterials...
  8. ncbi request reprint Collagen self-assembly and the development of tendon mechanical properties
    Frederick H Silver
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Biomech 36:1529-53. 2003
    ..In contrast, after birth when locomotion begins, the mechanical response is dominated by elastic stretching of crosslinked collagen molecules...
  9. ncbi request reprint Viscoelastic properties of acid- and alkaline-treated human dermis: a correlation between total surface charge and elastic modulus
    Gurinder P Seehra
    Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA
    Skin Res Technol 12:190-8. 2006
    ..Thus energy storage (elastic properties) and dissipation (viscous properties) are important characteristics of extracellular matrices...
  10. ncbi request reprint Mechanobiology of force transduction in dermal tissue
    Frederick H Silver
    Division of Biomaterials, Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Skin Res Technol 9:3-23. 2003
    ..The purpose of this review is to analyse how internal and external mechanical loads are applied at the macromolecular and cellular levels in the epidermis and dermis...
  11. ncbi request reprint Mechanical implications of the domain structure of fiber-forming collagens: comparison of the molecular and fibrillar flexibilities of the alpha1-chains found in types I-III collagen
    Frederick H Silver
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854 USA
    J Theor Biol 216:243-54. 2002
    ..Impaired elastic energy storage by extracellular matrices may lead to cellular damage and changes in signaling by mechanochemical transduction at the extracellular matrix-cell interface...
  12. ncbi request reprint Viscoelastic properties of self-assembled type I collagen fibers: molecular basis of elastic and viscous behaviors
    Frederick H Silver
    Division of Biomaterials, Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Connect Tissue Res 43:569-80. 2002
    ..It is hypothesized that at high strain rates subfibrillar subunits appear to "hydroplane" by each other on a layer of loosely bound water...
  13. ncbi request reprint Invited Review: Role of mechanophysiology in aging of ECM: effects of changes in mechanochemical transduction
    Frederick H Silver
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Appl Physiol (1985) 95:2134-41. 2003
    ..Studies pertaining to the interactions among mechanical forces, growth factors, hormones, and their receptors will better define the relationship between mechanochemical transduction processes and cellular behavior in aging tissues...
  14. ncbi request reprint Elastic energy storage in human articular cartilage: estimation of the elastic modulus for type II collagen and changes associated with osteoarthritis
    Frederick H Silver
    Division of Biomaterials, Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Matrix Biol 21:129-37. 2002
    ..Enzymatic cleavage of cartilage proteoglycans and collagen observed in osteoarthritis may lead to fibrillation and fissure formation as a result of impaired energy storage capability of cartilage...
  15. doi request reprint Deposition of apatite in mineralizing vertebrate extracellular matrices: A model of possible nucleation sites on type I collagen
    Frederick H Silver
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Connect Tissue Res 52:242-54. 2011
    ....