Vincenzo Silani

Summary

Publications

  1. ncbi request reprint Stem cells in the treatment of amyotrophic lateral sclerosis (ALS)
    Vincenzo Silani
    Department of Neurology, Laboratory of Neuroscience, Dino Ferrari Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Via Spagnoletto 3, 1 20149 Milano, Italy
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:173-81. 2002
  2. ncbi request reprint Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop
    Albert C Ludolph
    Department of Neurology, University of Ulm, Ulm, Germany
    Amyotroph Lateral Scler 8:217-23. 2007
  3. pmc Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options
    Sonja Körner
    Department of Neurology, Hannover Medical School, Carl Neuberg Str, 1, Hannover 30625, Germany
    BMC Neurol 13:84. 2013
  4. doi request reprint The diagnosis of Amyotrophic lateral sclerosis in 2010
    Vincenzo Silani
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, Universita degli Studi di Milano, Milan, Italy
    Arch Ital Biol 149:5-27. 2011
  5. ncbi request reprint Stem cell transplantation in multiple sclerosis: safety and ethics
    Vincenzo Silani
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Milano, Italy
    J Neurol Sci 265:116-21. 2008
  6. ncbi request reprint Cell-replacement therapy with stem cells in neurodegenerative diseases
    Vincenzo Silani
    Department of Neurology and Laboratory of Neuroscience Dino Ferrari Center, University of Milan Medical School IRCCS Istituto Auxologico Italiano
    Curr Neurovasc Res 1:283-9. 2004
  7. ncbi request reprint Stem therapy for ALS: hope and reality
    Vincenzo Silani
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:8-10. 2003
  8. ncbi request reprint Stem cells in amyotrophic lateral sclerosis: motor neuron protection or replacement?
    V Silani
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, Università degli Studi di Milano IRCCS Istituto Auxologico Italiano, Milano, Italy
    CNS Neurol Disord Drug Targets 9:314-24. 2010
  9. doi request reprint Ubiquilin 2 mutations in Italian patients with amyotrophic lateral sclerosis and frontotemporal dementia
    Cinzia Gellera
    Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
    J Neurol Neurosurg Psychiatry 84:183-7. 2013
  10. doi request reprint C9ORF72 repeat expansion in a large Italian ALS cohort: evidence of a founder effect
    Antonia Ratti
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Neurobiol Aging 33:2528.e7-14. 2012

Detail Information

Publications52

  1. ncbi request reprint Stem cells in the treatment of amyotrophic lateral sclerosis (ALS)
    Vincenzo Silani
    Department of Neurology, Laboratory of Neuroscience, Dino Ferrari Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Via Spagnoletto 3, 1 20149 Milano, Italy
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:173-81. 2002
    ..Stem cell technology is at an early stage but the desperate need for a therapy in ALS patients may legitimize clinical trials in absence of conclusive scientific evidence. This paper discusses the premises for stem cell therapy in ALS...
  2. ncbi request reprint Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop
    Albert C Ludolph
    Department of Neurology, University of Ulm, Ulm, Germany
    Amyotroph Lateral Scler 8:217-23. 2007
    ..In this workshop, clinical and preclinical researchers established in the field of ALS/MND met in Holland in March 2006 in order to establish guidelines for the community for drug testing in mouse models...
  3. pmc Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options
    Sonja Körner
    Department of Neurology, Hannover Medical School, Carl Neuberg Str, 1, Hannover 30625, Germany
    BMC Neurol 13:84. 2013
    ..In this study we investigated possible causes of weight loss in ALS, its impact on mood/quality of life (QOL) and the benefit of high calorie nutritional/other dietary supplements and percutaneous endoscopic gastrostomy (PEG)...
  4. doi request reprint The diagnosis of Amyotrophic lateral sclerosis in 2010
    Vincenzo Silani
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, Universita degli Studi di Milano, Milan, Italy
    Arch Ital Biol 149:5-27. 2011
    ..Prompt diagnosis, sensitive communication of the diagnosis, the involvement of the patient and family, a positive care plan are pre-requisites for the good clinical management of ALS patients...
  5. ncbi request reprint Stem cell transplantation in multiple sclerosis: safety and ethics
    Vincenzo Silani
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Milano, Italy
    J Neurol Sci 265:116-21. 2008
    ..In conclusion, although HCST is today an established therapeutical option for MS patients, safety and ethical issues need to be further clarified...
  6. ncbi request reprint Cell-replacement therapy with stem cells in neurodegenerative diseases
    Vincenzo Silani
    Department of Neurology and Laboratory of Neuroscience Dino Ferrari Center, University of Milan Medical School IRCCS Istituto Auxologico Italiano
    Curr Neurovasc Res 1:283-9. 2004
    ....
  7. ncbi request reprint Stem therapy for ALS: hope and reality
    Vincenzo Silani
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:8-10. 2003
    ..Foetal cells are, in addition, post-mitotic and cannot be expanded or stored for long periods, necessitating close synchronisation of tissue donation and neurosurgery...
  8. ncbi request reprint Stem cells in amyotrophic lateral sclerosis: motor neuron protection or replacement?
    V Silani
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, Università degli Studi di Milano IRCCS Istituto Auxologico Italiano, Milano, Italy
    CNS Neurol Disord Drug Targets 9:314-24. 2010
    ..The review discusses relevant topics regarding the application of stem cell research to ALS focusing on their therapeutic relevance and mechanisms of action...
  9. doi request reprint Ubiquilin 2 mutations in Italian patients with amyotrophic lateral sclerosis and frontotemporal dementia
    Cinzia Gellera
    Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
    J Neurol Neurosurg Psychiatry 84:183-7. 2013
    ..The aim of our study was to analyse the UBQLN2 gene in a large cohort of patients with familial (FALS) and sporadic (SALS) amyotrophic lateral sclerosis, with or without frontotemporal dementia (FTD), and in patients with FTD...
  10. doi request reprint C9ORF72 repeat expansion in a large Italian ALS cohort: evidence of a founder effect
    Antonia Ratti
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Neurobiol Aging 33:2528.e7-14. 2012
    ....
  11. pmc Screening of the PFN1 gene in sporadic amyotrophic lateral sclerosis and in frontotemporal dementia
    Cinzia Tiloca
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Neurobiol Aging 34:1517.e9-10. 2013
    ..G15G in another patient, but none in a panel of 1512 control subjects. Our results suggest that PFN1 mutations in sporadic ALS and in FTD are rare, at least in the Italian population...
  12. doi request reprint Oligoclonal bands in the cerebrospinal fluid of amyotrophic lateral sclerosis patients with disease-associated mutations
    Nicola Ticozzi
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy
    J Neurol 260:85-92. 2013
    ..The role of mutant TARDBP and ANG genes on BBB integrity of ALS patients warrants further investigation...
  13. doi request reprint ATAXIN2 CAG-repeat length in Italian patients with amyotrophic lateral sclerosis: risk factor or variant phenotype? Implication for genetic testing and counseling
    Cinzia Gellera
    Genetics of Neurodegenerative and Metabolic Disorders, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milano, Italy
    Neurobiol Aging 33:1847.e15-21. 2012
    ..Overlapping phenotypes should be considered in genetic testing and counseling, both for patients and at-risk family members...
  14. doi request reprint Neuroprotective effects of human mesenchymal stem cells on neural cultures exposed to 6-hydroxydopamine: implications for reparative therapy in Parkinson's disease
    Lidia Cova
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano 20149, Milan, Italy
    Apoptosis 17:289-304. 2012
    ..Our findings provide novel insights for the development of therapeutic strategies designed to counteract the neurodegenerative processes of PD...
  15. doi request reprint Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease
    Lidia Cova
    Department of Neurology and Laboratory of Neuroscience, Centro Dino Ferrari, Università degli Studi di Milano IRCCS Istituto Auxologico Italiano, 20149 Milan, Italy
    Brain Res 1311:12-27. 2010
    ..Altogether, our data provide remarkable cues regarding the potential of hMSCs in promoting endogenous reparative mechanisms that may prove applicable and beneficial for PD treatment...
  16. doi request reprint Resting state functional connectivity alterations in primary lateral sclerosis
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Neurobiol Aging 35:916-25. 2014
    ..In addition, higher functional connectivity correlated with greater structural damage to network-specific white matter tracts. This study shows clinically meaningful increased resting state functional connectivity in PLS. ..
  17. doi request reprint Analysis of hnRNPA1, A2/B1, and A3 genes in patients with amyotrophic lateral sclerosis
    Daniela Calini
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095 Cusano Milanino, Milan, Italy
    Neurobiol Aging 34:2695.e11-2. 2013
    ..We failed to find variants in each cohort. Our results suggest that mutations in hnRNPA1, A2/B1, and A3 genes are a rare finding in ALS. ..
  18. pmc TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells
    Claudia Colombrita
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy
    J Biol Chem 287:15635-47. 2012
    ....
  19. ncbi request reprint Validation of a Neuro Virtual Reality-based version of the Multiple Errands Test for the assessment of executive functions
    Simona Raspelli
    Applied Technology for Neuro Psychology Lab, Istituto Auxologico Italiano, Milan, Italy
    Stud Health Technol Inform 167:92-7. 2011
    ....
  20. doi request reprint TDP-43 is recruited to stress granules in conditions of oxidative insult
    Claudia Colombrita
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, Università degli Studi di Milano IRCCS Istituto Auxologico Italiano, Milan, Italy
    J Neurochem 111:1051-61. 2009
    ..Although SGs were not evident in ALS brains, we speculate that an altered control of mRNA translation in stressful conditions may trigger motor neuron degeneration at early stages of the disease...
  21. doi request reprint Metalloproteinase alterations in the bone marrow of ALS patients
    Patrizia Bossolasco
    Fondazione Matarelli, Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Universita degli Studi di Milano, Via Vanvitelli, 32 20129, Milan, Italy
    J Mol Med (Berl) 88:553-64. 2010
    ..Therefore, therapeutic implantation of autologous BM derived SC in ALS patients needs to be carefully reevaluated...
  22. doi request reprint C9orf72 repeat expansions are restricted to the ALS-FTD spectrum
    Nicola Ticozzi
    Department of Neurology and Laboratory of Neuroscience, Istituto di Ricovero e Cura a Carattere Scientifico Istituto Auxologico Italiano, Milan, Italy Department of Pathophysiology and Transplantation, Dino Ferrari Center, Universita degli Studi di Milano, Milan, Italy Electronic address
    Neurobiol Aging 35:936.e13-7. 2014
    ....
  23. ncbi request reprint Stem cell therapy for neurodegenerative diseases: the issue of transdifferentiation
    Lidia Cova
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Stem Cells Dev 13:121-31. 2004
    ..This review summarizes recent advances gained in stem cell research applied to neurodegenerative diseases with a special emphasis to the criticisms put forward...
  24. pmc Impaired expression of insulin-like growth factor-1 system in skeletal muscle of amyotrophic lateral sclerosis patients
    Christian Lunetta
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, IRCCS Istituto Auxologico Italiano, Universita degli Studi di Milano, Milano, Italy
    Muscle Nerve 45:200-8. 2012
    ..Adult muscle fibers are a source of growth factors, including insulin-like growth factor-1 (IGF-1). These factors influence neuronal survival, axonal growth, and maintenance of synaptic connections...
  25. pmc Low anaerobic threshold and increased skeletal muscle lactate production in subjects with Huntington's disease
    Andrea Ciammola
    Department of Neurology, Centro Dino Ferrari Università degli Studi di Milano IRCCS Istituto Auxologico Italiano, Milan, Italy
    Mov Disord 26:130-7. 2011
    ....
  26. doi request reprint Huntington's disease: the current state of research with peripheral tissues
    Jenny Sassone
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, IRCCS Istituto Auxologico Italiano, University of Milan Medical School, Via Spagnoletto 3, 20149, Milan, Italy
    Exp Neurol 219:385-97. 2009
    ....
  27. ncbi request reprint Stem-cell therapy for amyotrophic lateral sclerosis
    Vincenzo Silani
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Centre, University of Milan Medical School IRCCS Istituto Auxologico Italiano, Milano, Italy
    Lancet 364:200-2. 2004
    ..Therefore, autologous or allogeneic stem cells, undifferentiated or transdifferentiated and manipulated epigenetically or genetically, could be a candidate source for local or systemic cell-therapies in ALS...
  28. ncbi request reprint Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis
    PierLuigi Baron
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan Medical School, IRCCS Ospedale Maggiore Policlinico, Via S Sforza 35, 20122 Milan, Italy
    Muscle Nerve 32:541-4. 2005
    ..Our findings suggest a role for MCP-1 as an important molecular mediator of the injury response in ALS...
  29. ncbi request reprint Molecular and phenotypical characterization of human amniotic fluid cells and their differentiation potential
    Tiziana Montemurro
    Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Biomed Mater Eng 18:183-5. 2008
  30. doi request reprint Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD)
    Stefano Zago
    Department of Neurological Sciences, Universita degli Studi di Milano, Medical School IRCCS, Fondazione Ca Granda Ospedale Maggiore Policlinico, IRCCS Istituto Auxologico Italiano, Milano, Italy
    Arch Ital Biol 149:39-56. 2011
    ..It is our intent to provide a brief overview of the relationships between ALS and FTD...
  31. doi request reprint Biocompatible fluorescent nanoparticles for in vivo stem cell tracking
    Lidia Cova
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Nanotechnology 24:245603. 2013
    ..Our data suggest that these finely tunable and biocompatible fluoNPs can be exploited for the longitudinal tracking of stem cells...
  32. doi request reprint Cobalamin as a regulator of serum and cerebrospinal fluid levels of normal prions
    Giuseppe Scalabrino
    Città Studi Department, Laboratory of Neuropathology, University of Milan, Milan, Italy
    J Clin Neurosci 20:134-8. 2013
    ..We found a correlation between Cbl and PrP(C) levels in the serum and CSF of Cbl-D patients, which suggests that Cbl may regulate the PrP(C) levels in the serum and CSF in humans...
  33. ncbi request reprint Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis
    Cinzia Gellera
    Division of Biochemistry and Genetics, Fondazione IRCCS Instituto Neurologico Carlo Besta, Milan, Italy
    Neurogenetics 9:33-40. 2008
    ..Our results provide further evidence of a tight link between angiogenesis and ALS pathogenesis and suggest that mutations in ANG gene are associated with an increased risk to develop ALS...
  34. doi request reprint Mutational analysis of VCP gene in familial amyotrophic lateral sclerosis
    Cinzia Tiloca
    Department of Neurology and Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy
    Neurobiol Aging 33:630.e1-2. 2012
    ..Bioinformatical analyses predicted no changes in splicing process or microRNA binding sites. Our results do not confirm a main contribution of VCP gene to familial ALS in the Italian population...
  35. pmc Aripiprazole in the treatment of Huntington's disease: a case series
    Andrea Ciammola
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Centre, University of Milan Medical School IRCCS Istituto Auxologico Italiano, Milano, Italy
    Neuropsychiatr Dis Treat 5:1-4. 2009
    ....
  36. pmc Dose dependent side effect of superparamagnetic iron oxide nanoparticle labeling on cell motility in two fetal stem cell populations
    Valentina Diana
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Cusano Milanino, Italy
    PLoS ONE 8:e78435. 2013
    ....
  37. doi request reprint Intracerebral haemorrhage, a possible presentation in Churg-Strauss syndrome: case report and review of the literature
    Niccolò E Mencacci
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Centre, Università degli Studi di Milano IRCCS Istituto Auxologico Italiano, Milan, Italy
    J Neurol Sci 301:107-11. 2011
    ..Our case points out that intracerebral haemorrhage can be, despite rare, a presenting feature of CSS. Previously reported patients affected by cerebral haemorrhage and CSS are summarized and briefly reviewed...
  38. pmc Longitudinal tracking of human fetal cells labeled with super paramagnetic iron oxide nanoparticles in the brain of mice with motor neuron disease
    Paolo Bigini
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    PLoS ONE 7:e32326. 2012
    ....
  39. doi request reprint Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV
    Antonia Ratti
    Department of Neurological Sciences, Dino Ferrari Centre, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, 20095 Cusano, Milan, Italy
    J Biol Chem 283:7531-41. 2008
    ....
  40. ncbi request reprint Induction of neurotrophin expression via human adult mesenchymal stem cells: implication for cell therapy in neurodegenerative diseases
    Federica Pisati
    Fondazione IRCCS Ospedale Maggiore, Department of Neurological Sciences, Stem Cell Laboratory, Dino Ferrari Center, University of Milan, Milan, Italy
    Cell Transplant 16:41-55. 2007
    ..hMSCs are further defined in their transplantation potential for treating neurological disorders...
  41. doi request reprint ELAV proteins along evolution: back to the nucleus?
    Claudia Colombrita
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Via Zucchi, 18, 20095 Cusano Milanino Milan, Italy Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Dino Ferrari Center, Universita degli Studi di Milano, Via Sforza, 35, 20122 Milan, Italy
    Mol Cell Neurosci 56:447-55. 2013
    ..This article is part of a Special Issue entitled 'RNA and splicing regulation in neurodegeneration'. ..
  42. doi request reprint Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for ALS
    Ettore Beghi
    Dipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche Mario Negri, Via G La Masa 19, Milan, Italy
    Amyotroph Lateral Scler Frontotemporal Degener 14:397-405. 2013
    ..Median survival was 45 months (ALC) and 22 months (placebo) (p = 0.0176). MRC, QoL and adverse events were similar. In conclusion, ALC may be effective, well-tolerated and safe in ALS. A pivotal phase III trial is needed...
  43. doi request reprint Charles Bonnet syndrome: two case reports and review of the literature
    Alberto Lerario
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, 20149 Milan, Italy
    J Neurol 260:1180-6. 2013
    ..Nonpharmacological interventions aimed to reduce the visual pathway deprivation. Reassurance of the benign nature of CBS is essential to support patients and reduce caregiver's burden...
  44. doi request reprint Wake-up stroke and TIA due to paradoxical embolism during long obstructive sleep apnoeas: a cross-sectional study
    Alfonso Ciccone
    Stroke Unit and Department of Neurology, Niguarda Ca Granda Hospital, Milan, Italy
    Thorax 68:97-104. 2013
    ..We investigated whether the combination of LOSA and RLSh is associated with ischaemic stroke or transient ischaemic attack (TIA) on waking (wake-up stroke)...
  45. doi request reprint Carotid artery stenting in patients with acute coronary syndrome: a possible primary therapy for symptomatic carotid stenosis
    Renato Casana
    Department of Surgery, Istituto Auxologico Italiano IRCCS, Milan, Italy
    J Endovasc Ther 20:546-51. 2013
    ..To report the results of carotid artery stenting (CAS) in symptomatic patients (stroke/transient ischemic attack) after recent percutaneous transluminal coronary angioplasty (PTCA) for acute coronary syndrome (ACS)...
  46. pmc Extramotor damage is associated with cognition in primary lateral sclerosis patients
    Elisa Canu
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    PLoS ONE 8:e82017. 2013
    ....
  47. doi request reprint Vascular and parenchymal lesions along with enhanced neurogenesis characterize the brain of asymptomatic stroke-prone spontaneous hypertensive rats
    Lidia Cova
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano
    J Hypertens 31:1618-28. 2013
    ..Here, we focus on cerebral abnormalities preceding lesions detectable by MRI...
  48. ncbi request reprint Implementation of the multiple errands test in a NeuroVR-supermarket: a possible approach
    Simona Raspelli
    Applied Technology for Neuro Psychology Lab, Istituto Auxologico Italiano, Milano, Milan, Italy
    Stud Health Technol Inform 154:115-9. 2010
    ..The specific goal of this study was to conduct a pilot study using the virtual version of MET (VMET) with both control subjects and patients with cognitive impairment derived from stroke...
  49. doi request reprint Mitochondrial respiratory chain dysfunction in muscle from patients with amyotrophic lateral sclerosis
    Veronica Crugnola
    Department of Neurological Sciences, Dino Ferrari Center, Universita degli Studi di Milano, Scientific Institute for Research and Treatment Foundation Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Arch Neurol 67:849-54. 2010
    ..Although defects of the mitochondrial respiratory chain have been described in several ALS patients, their pathogenic significance is unclear...
  50. ncbi request reprint Good practice in the management of amyotrophic lateral sclerosis: clinical guidelines. An evidence-based review with good practice points. EALSC Working Group
    Peter Munch Andersen
    Department of Neurology, Umea University Hospital, Umea, Sweden
    Amyotroph Lateral Scler 8:195-213. 2007
    ..During the course of the disease, every effort should be made to maintain patient autonomy. Advance directives for palliative end of life care are important and should be discussed early with the patient and relatives if they so wish...
  51. ncbi request reprint Report from the Italian Ministerial Committee regarding the diagnosis, care and assistance of patients with ALS
    Caterina Bendotti
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:5-7. 2005
  52. ncbi request reprint A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA
    Antonia Ratti
    Department of Neuroscience, Dino Ferrari Centre, University of Milan IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095 Cusano Milanino, Italy
    J Cell Sci 119:1442-52. 2006
    ..We propose that ELAV RNA-binding proteins exert an important post-transcriptional control on Musashi-1 expression in the transition from proliferation to neural differentiation of stem/progenitor cells...